KEGG   REACTION: R03194
Entry
R03194                      Reaction                               
Name
S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase
Definition
2 S-Adenosyl-L-methionine + Uroporphyrinogen III <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2
Equation
2 C00019 + C01051 <=> 2 C00021 + C02463
Comment
multifunctional enzyme: siroheme synthase: uroporphyrinogen III methyltransferase (R03194+R03947+R02864)
subsequently R03947
two-step reaction (R07237+R07238)
Reaction class
RC00003  C00019_C00021
RC00871  C01051_C02463
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
M00924  Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
M00925  Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.107
     R03194  2 S-Adenosyl-L-methionine + Uroporphyrinogen III <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2
Orthology
K00589  uroporphyrin-III C-methyltransferase [EC:2.1.1.107]
K02302  uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4]
K02303  uroporphyrin-III C-methyltransferase [EC:2.1.1.107]
K02496  uroporphyrin-III C-methyltransferase [EC:2.1.1.107]
K13542  uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]
K13543  uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]
Other DBs
RHEA: 32462
LinkDB

KEGG   REACTION: R03947
Entry
R03947                      Reaction                               
Name
S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase
Definition
Precorrin 2 + NAD+ <=> Sirohydrochlorin + NADH + H+
Equation
Comment
multifunctional enzyme: siroheme synthase: precorrin-2 dehydrogenase (R03194+R03947+R02864)
following after R03194, subsequently R02864
Reaction class
RC00001  C00003_C00004
RC01034  C02463_C05778
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
M00924  Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.76
     R03947  Precorrin 2 + NAD+ <=> Sirohydrochlorin + NADH + H+
Orthology
K02302  uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4]
K02304  precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:1.3.1.76 4.99.1.4]
K24866  precorrin-2 dehydrogenase [EC:1.3.1.76]
Other DBs
RHEA: 15616
LinkDB

KEGG   REACTION: R02864
Entry
R02864                      Reaction                               
Name
S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase
Definition
Siroheme + 2 H+ <=> Fe2+ + Sirohydrochlorin
Equation
Comment
multifunctional enzyme: siroheme synthase: sirohydrochlorin ferrochelatase (R03194+R03947+R02864)
following after R03947
Reaction class
RC01012  C00748_C05778
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.99  Other lyases
   4.99.1  Sole sub-subclass for lyases that do not belong in the other subclasses
    4.99.1.4
     R02864  Siroheme + 2 H+ <=> Fe2+ + Sirohydrochlorin
Orthology
K02302  uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4]
K02304  precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:1.3.1.76 4.99.1.4]
K03794  sirohydrochlorin ferrochelatase [EC:4.99.1.4]
Other DBs
RHEA: 24363
LinkDB

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