KEGG   REACTION: R03270
Entry
R03270                      Reaction                               
Definition
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
Equation
C05125 + C15972 <=> C16255 + C00068
Comment
2-oxoglutarate dehydrogenase complex: pyruvate dehydrogenase (see R01699)
second step of two-step reaction (R01699 or R00014+R03270)
following after R00014
Reaction class
RC00027  C00068_C05125
RC00627  C15972_C16255
RC02882  C05125_C16255
Enzyme
1.2.4.1
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00620  Pyruvate metabolism
rn00785  Lipoic acid metabolism
Module
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1
     R03270  2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
Orthology
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
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