REACTION: R07046
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Entry
R07046 Reaction
Definition
Arachidonate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19(S)-HETE + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C00219
+
C03024
+
C00007
<=>
C14749
+
C03161
+
C00001
Comment
CYP2E1, CYP2J9, CYP2U1, CYP1A2, CYP2C19, CYP3A5, CYP4A11, CYP4F8
Reaction class
RC01710
C00219_C14749
Enzyme
1.14.14.1
1.14.14.80
1.14.14.-
Pathway
rn00590
Arachidonic acid metabolism
rn01100
Metabolic pathways
Brite
Enzymatic reactions [BR:
br08201
]
1. Oxidoreductase reactions
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.1
R07046 Arachidonate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19(S)-HETE + [Oxidized NADPH---hemoprotein reductase] + H2O
1.14.14.80
R07046 Arachidonate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19(S)-HETE + [Oxidized NADPH---hemoprotein reductase] + H2O
1.14.14.-
R07046 Arachidonate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19(S)-HETE + [Oxidized NADPH---hemoprotein reductase] + H2O
BRITE hierarchy
Orthology
K07415
cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]
K07418
cytochrome P450 family 2 subfamily J [EC:
1.14.14.1
1.14.14.73
1.14.14.74
1.14.14.75
]
K07422
long-chain fatty acid omega-monooxygenase [EC:
1.14.14.80
]
K07425
long-chain fatty acid omega-monooxygenase [EC:
1.14.14.80
]
K17721
cytochrome P450 family 2 subfamily C19 [EC:
1.14.14.51
1.14.14.52
1.14.14.53
1.14.14.75
1.14.14.-]
K17728
cytochrome P450 family 4 subfamily F8 [EC:
1.14.14.1
]
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