KEGG   ORTHOLOGY: K17721
Entry
K17721                      KO                                     
Symbol
CYP2C19
Name
cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R07046  
R07055  
R07056  
R08275  
R08285  
R08343  
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
   00591 Linoleic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.75  fenbendazole monooxygenase (4'-hydroxylating)
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Other DBs
GO: 0018675 0018676 0052741
Genes
HSA: 1557(CYP2C19)
PTR: 740956(CYP2C19)
PPS: 100995695(CYP2C19)
GGO: 101151965
PON: 100439483
NLE: 100601437
HMH: 116457271
CJC: 100389947(CYP2C19)
SBQ: 101041912
CIMI: 108281686(CYP2C19)
CSYR: 103277060
PCOQ: 105822723
OGA: 100950266
MMMA: 107149734
GAS: 123236335 123238232
 » show all
Reference
PMID:2009263
  Authors
Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA
  Title
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.
  Journal
Biochemistry 30:3247-55 (1991)
DOI:10.1021/bi00227a012
  Sequence
[hsa:1557]
LinkDB

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