KEGG   REACTION: R08287
Entry
R08287                      Reaction                               
Definition
Ifosfamide <=> 2-Dechloroethylifosfamide + Chloroacetaldehyde
Equation
Comment
CYP2B6, CYP3A4/5
incomplete reaction
Reaction class
RC00225  C06754_C07047
RC02230  C07047_C16555
Enzyme
1.14.14.1       1.14.14.-
Pathway
rn00982  Drug metabolism - cytochrome P450
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1
     R08287  Ifosfamide <=> 2-Dechloroethylifosfamide + Chloroacetaldehyde
    1.14.14.-
     R08287  Ifosfamide <=> 2-Dechloroethylifosfamide + Chloroacetaldehyde
Orthology
K17689  cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
K17690  cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]
K17709  cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
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