KEGG   ORTHOLOGY: K17690
Entry
K17690            Tight     KO                                     
Symbol
CYP3A5
Name
cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R02356  
R03408  
R08286  
R08287  
R08390  
R08391  
R08392  
R09404  
R09408  
Disease
H01633  High blood pressure
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
   00982 Drug metabolism - cytochrome P450
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
Genes
HSA: 1577(CYP3A5)
PTR: 737374(CYP3A5)
PPS: 100976333(CYP3A5)
GGO: 101147010
PON: 100434899
NLE: 100591599
HMH: 116810915
MCC: 678692(CYP3A5)
MCF: 102146134(CYP3A5)
MTHB: 126950477
MNI: 105497418
CSAB: 103246770(CYP3A5)
PANU: 100997418
TGE: 112621194
MLEU: 105543710
RRO: 104672095
RBB: 108538163
TFN: 117072035
PTEH: 111526378
CANG: 105513065
CJC: 100404952(CYP3A5) 100405792(CYP3A90)
SBQ: 101037736
CIMI: 108308035(CYP3A5)
 » show all
Reference
PMID:2732228
  Authors
Aoyama T, Yamano S, Waxman DJ, Lapenson DP, Meyer UA, Fischer V, Tyndale R, Inaba T, Kalow W, Gelboin HV, et al.
  Title
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.
  Journal
J Biol Chem 264:10388-95 (1989)
  Sequence
[hsa:1577]
Reference
PMID:14562963
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x
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