KEGG REACTION: R08390

REACTION: R08390

Entry

R08390                      Reaction

Definition

Retinoate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> all-trans-18-Hydroxyretinoic acid + [Oxidized NADPH---hemoprotein reductase] + H2O

Equation

C00777 + C03024 + C00007 <=> C16679 + C03161 + C00001

Comment

CYP1A1, CYP2A6, CYP2B6, CYP2C8/9/18, CYP3A4/5/7, CYP26, CYP4A11

Reaction class

RC00724

C00777_C16679

Enzyme

1.14.14.1 1.14.14.-

Pathway

rn00830

Retinol metabolism

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1
     R08390  Retinoate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> all-trans-18-Hydroxyretinoic acid + [Oxidized NADPH---hemoprotein reductase] + H2O
    1.14.14.-
     R08390  Retinoate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> all-trans-18-Hydroxyretinoic acid + [Oxidized NADPH---hemoprotein reductase] + H2O

Orthology

K07408

cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]

K07411

cytochrome P450 family 2 subfamily A [EC:1.14.14.1]

K07412

cytochrome P450 family 2 subfamily B [EC:1.14.14.1]

K07413

cytochrome P450 family 2 subfamily C [EC:1.14.14.1]

K07424

cytochrome P450 family 3 subfamily A [EC:1.14.14.1]

K07425