KEGG   REACTION: R08391
Entry
R08391                      Reaction                               
Definition
Retinoate + NADPH + H+ + Oxygen <=> all-trans-5,6-Epoxyretinoic acid + NADP+ + H2O
Equation
C00777 + C00005 + C00080 + C00007 <=> C16680 + C00006 + C00001
Comment
CYP2A6, CYP2B6, CYP3A4/5, CYP2S1, CYP26
Reaction class
RC00001  C00005_C00006
RC01624  C00777_C16680
Enzyme
1.14.14.1       1.14.14.-
Pathway
rn00830  Retinol metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1
     R08391  Retinoate + NADPH + H+ + Oxygen <=> all-trans-5,6-Epoxyretinoic acid + NADP+ + H2O
    1.14.14.-
     R08391  Retinoate + NADPH + H+ + Oxygen <=> all-trans-5,6-Epoxyretinoic acid + NADP+ + H2O
Orthology
K07411  cytochrome P450 family 2 subfamily A [EC:1.14.14.1]
K07412  cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
K07420  cytochrome P450 family 2 subfamily S1 [EC:1.14.14.1]
K07424  cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
K17683  cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
K17689  cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
K17690  cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]
K17709  cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
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