REACTION: R10052
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Entry
R10052 Reaction
Name
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Definition
(2R,3S)-3-Isopropylmalate + NAD+ <=> 4-Methyl-2-oxopentanoate + CO2 + NADH + H+
Equation
C04411
+
C00003
<=>
C00233
+
C00011
+
C00004
+
C00080
Comment
two-step reaction (see
R04426+R01652
)
Reaction class
RC00001
C00003_C00004
RC03036
C00233_C04411
Enzyme
1.1.1.85
Pathway
rn01210
2-Oxocarboxylic acid metabolism
rn01230
Biosynthesis of amino acids
Brite
Enzymatic reactions [BR:
br08201
]
1. Oxidoreductase reactions
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.85
R10052 (2R,3S)-3-Isopropylmalate + NAD+ <=> 4-Methyl-2-oxopentanoate + CO2 + NADH + H+
BRITE hierarchy
Orthology
K00052
3-isopropylmalate dehydrogenase [EC:
1.1.1.85
]
K21360
3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:
1.1.1.85
1.1.1.-]
Other DBs
RHEA:
32274
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