KEGG   REACTION: R10054
Entry
R10054                      Reaction                               
Name
L-lysine:NAD+ 6-oxidoreductase (deaminating)
Definition
L-Lysine + NAD+ <=> (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + NADH + H+ + Ammonia
Equation
C00047 + C00003 <=> C00450 + C00004 + C00080 + C00014
Comment
two-step reaction (see R00446+R02317)
Reaction class
RC00001  C00003_C00004
RC00353  C00047_C00450
Enzyme
1.4.1.18
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.18
     R10054  L-Lysine + NAD+ <=> (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + NADH + H+ + Ammonia
Other DBs
RHEA: 12411
LinkDB

KEGG   REACTION: R00446
Entry
R00446                      Reaction                               
Name
L-lysine:NAD+ 6-oxidoreductase (deaminating)
Definition
L-Lysine + NAD+ + H2O <=> L-2-Aminoadipate 6-semialdehyde + NADH + Ammonia + H+
Equation
C00047 + C00003 + C00001 <=> C04076 + C00004 + C00014 + C00080
Comment
first step of two-step reaction (see R10054, R00446+R02317)
Reaction class
RC00001  C00003_C00004
RC00062  C00047_C04076
Enzyme
1.4.1.18
Pathway
rn00960  Tropane, piperidine and pyridine alkaloid biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.18
     R00446  L-Lysine + NAD+ + H2O <=> L-2-Aminoadipate 6-semialdehyde + NADH + Ammonia + H+
Orthology
K19064  lysine 6-dehydrogenase [EC:1.4.1.18]
Other DBs
RHEA: 25120
LinkDB

KEGG   REACTION: R02317
Entry
R02317                      Reaction                               
Name
(S)-2-amino-6-oxohexanoate hydro-lyase (spontaneous)
Definition
(S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + H2O <=> L-2-Aminoadipate 6-semialdehyde
Equation
C00450 + C00001 <=> C04076
Comment
spontaneous
the second step of two-step reaction (see R10054, R00446+R02317)
the first step of two-step reaction (see R03102, R02317+R11231 / R03103, R02317+R11232)
Reaction class
RC00694  C00450_C04076
Enzyme
1.2.1.31        1.4.1.18
Pathway
rn00310  Lysine degradation
rn00960  Tropane, piperidine and pyridine alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Module
M00960  Lysine degradation, bacteria, L-lysine => D-lysine => succinate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.31
     R02317  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + H2O <=> L-2-Aminoadipate 6-semialdehyde
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.18
     R02317  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate + H2O <=> L-2-Aminoadipate 6-semialdehyde
Orthology
K19064  lysine 6-dehydrogenase [EC:1.4.1.18]
Other DBs
RHEA: 25124
LinkDB

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