KEGG   REACTION: R10685
Entry
R10685                      Reaction                               
Name
NAD+:glycine ADP-D-ribosyltransferase (dehydroalanine-producing)
Definition
NAD+ + Glycine + [Protein]-L-cysteine <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + Nicotinamide + [Protein]-dehydroalanine + 3 H2O
Equation
Comment
thiamine thiazole synthase
multi-step reaction
Sulfur donor is enzyme itself (one cystein residue looses H2S to form dehydroalanie residue)
Reaction class
RC00033  C00003_C00153
RC03253  C00003_C20784
RC03254  C00037_C20784
Enzyme
Pathway
rn00730  Thiamine metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00897  Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP
M00898  Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.60
     R10685  NAD+ + Glycine + [Protein]-L-cysteine <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + Nicotinamide + [Protein]-dehydroalanine + 3 H2O
Orthology
K03146  cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60]
Other DBs
RHEA: 55711
LinkDB

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