KEGG   REACTION: R11762
Entry
R11762                      Reaction                               
Definition
6-Lactoyl-5,6,7,8-tetrahydropterin <=> 6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Equation
C04244 <=> C21640
Comment
a part of three-step reaction (see R08208, R01813+R11762+R11763)
isomerization
Reaction class
RC03490  C04244_C21640
Enzyme
1.1.1.153
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.153
     R11762  6-Lactoyl-5,6,7,8-tetrahydropterin <=> 6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Orthology
K00072  sepiapterin reductase [EC:1.1.1.153]
Reference
1  [PMID:21867484]
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
2  [PMID:9405351]
  Authors
Auerbach G, Herrmann A, Gutlich M, Fischer M, Jacob U, Bacher A, Huber R.
  Title
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.
  Journal
EMBO J 16:7219-30 (1997)
DOI:10.1093/emboj/16.24.7219
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