KEGG   REACTION: R13166
Entry
R13166                      Reaction                               
Definition
2-Oxoadipate + Thiamin diphosphate <=> 4-Carboxy-1-hydroxybutyryl-ThPP + CO2
Equation
C00322 + C00068 <=> C22667 + C00011
Comment
2-oxoadipate dehydrogenase complex: 2-oxoadipate dehydrogenase (see R01940)
TPP-dependent enzymatic reaction (see R13166+R13167)
subsequently R13167
Reaction class
RC00027  C00068_C22667
RC02743  C00322_C22667
Enzyme
1.2.4.-
Pathway
rn00310  Lysine degradation
rn00785  Lipoic acid metabolism
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.-
     R13166  2-Oxoadipate + Thiamin diphosphate <=> 4-Carboxy-1-hydroxybutyryl-ThPP + CO2
Orthology
K15791  2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-]
Reference
1  [PMID:29191460]
  Authors
Nemeria NS, Gerfen G, Nareddy PR, Yang L, Zhang X, Szostak M, Jordan F
  Title
The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species.
  Journal
Free Radic Biol Med 115:136-145 (2018)
DOI:10.1016/j.freeradbiomed.2017.11.018
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