| Entry |
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| Symbol |
erm(32), tlrB
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| Name |
(KEGG) 23S rRNA (guanine748-N1)-methyltransferase (EC:2.1.1.188)
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| KO |
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| Taxonomy |
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| Lineage |
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces |
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| Organism |
Streptomyces fradiae
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| AA seq |
280 aa
MRKNVVRYLRCPHCAAPLRSSDRTLRCENGHTFDVARQGYVNLLRRPTKLAADTTDMVAA
RAALLDSGHYAPLTERLAGTARRAAGAGAPDCVVDIGGGTGHHLARVLEEFEDAEGLLLD
MSKPAVRRAARAHPRASSAVADVWDTLPLRDGAAAMALNVFAPRNPPEIRRILRPGGTLL
VVTPQQDHLAELVDALGLLRVRDHKEGRLAEQLAPHFEAVGQERLRTTLRLDHDALGRVV
AMGPSSWHQDPDELARRIAELPGIHEVTLSVTFTVCRPLP |
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| Reference |
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| Authors |
Wilson VT, Cundliffe E |
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| Title |
Molecular analysis of tlrB, an antibiotic-resistance gene from tylosin-producing Streptomyces fradiae, and discovery of a novel resistance mechanism. |
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| Journal |
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| Reference |
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| Authors |
Liu M, Kirpekar F, Van Wezel GP, Douthwaite S |
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| Title |
The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA. |
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| Journal |
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