Bubalus bubalis (water buffalo): 102392383
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Entry
102392383 CDS
T05912
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3 isoform X1
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
bbub
Bubalus bubalis (water buffalo)
Pathway
bbub00230
Purine metabolism
bbub00670
One carbon pool by folate
bbub01100
Metabolic pathways
bbub01523
Antifolate resistance
Module
bbub_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
bbub00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
102392383 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
102392383 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
102392383 (GART)
Enzymes [BR:
bbub01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
102392383 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
102392383 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
102392383 (GART)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
ATP-grasp_2
ATP-grasp_3
CPSase_L_D2
Dala_Dala_lig_C
ATP-grasp_4
RimK
Motif
Other DBs
NCBI-GeneID:
102392383
NCBI-ProteinID:
XP_006048299
EnsemblRapid:
ENSBBUG00015004857
LinkDB
All DBs
Position
1:47223057..47251287
Genome browser
AA seq
1065 aa
AA seq
DB search
MRGVCAPDSARPTSGARGVRSDPERSAKVYARAPRSPPGSLAFLFLLNSCFADSTMAARV
LVIGNGGREHTLAWKLAQSTHVKQVLVTPGNAGTACSEKISNTDISISDHAALVQFCKDE
KIEFVVVGPEAPLAAGIVGNLNSVGVRCFGPTAQAAQLESSKRFAKEFMDRHGISTARWR
AFTKPKEACDFIMSADFPALVVKASGLAAGKGVIVAKSKEEACEAVREIMQGKAFGEAGE
TVVIEELLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDKGPNTGGMGAYCPAPQVSKD
LLLKIKNTILQRTVDGMQEEGMPYTGVLYAGIMLTKNGPKVLEFNCRFGDPECQVILPLL
KSDLYEVIQSILDGLLCTSLPVWLDNCAAVTVVMASKGYPGDYTKGVEITGIPEAQALGL
EVFQAGTALKDGKVVTNGGRVLTVTAIRENLISALEEARKGLAAIKFEGAVYRKDIGFRA
IAFLQQPRGLTYKESGVDIAAGNTLVQKIKPLAKATSRPGCDVDLGGFAGLFDLKAAGFT
DPLLACGTDGVGTKLKIAQQCSKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDL
RTTEAVIAGIAKACRKAGCALLGGETAEMPGMYPPGEYDLAGFAIGAMERDQKLPQLERI
TEGDAVIGIASSGLHSNGFSLVRKIVAKSSLEYSSPAPDGCGDQTLGDLLLTPTRIYSHS
LLPVLRSGRVKAIAHITGGGLLENIPRVLPQKLGVNLDAQTWRVPRIFSWLQQEGHLSEE
EMARTFNCGIGAALVVSEDLVKQTLQDIEQHQEEACVIGRVVACPEGSPRVKVEHLIETM
QINGSVLENGTLRNHFSVQPKKARVAVLISGTGSNLQALIDSTREPRSLAHIVVVISNKA
AVAGLDKAEKAGIPTRVINHKLYKNRAAFDTAIDEVLEEFSTDIVCLAGFMRILSGPFVR
KWNGKMLNIHPSLLPSFKGSNAHEQVLAAGVTITGCTVHFVAEDVDAGQIILQEAVPVKR
GDTVETLSERVKLAEHKIFPSALQLVASGAVRLGENGRICWVTEE
NT seq
3198 nt
NT seq
+upstream
nt +downstream
nt
atgcgaggggtgtgcgcgccggattccgcgcgcccaacttccggcgcgcgtggcgtgcgt
tccgatccagagcgctcggcgaaggtctacgcgcgggccccaaggtccccccctggatcg
ctggctttcctcttcctgctgaattcctgctttgcagatagcacaatggcagcccgagta
cttgtcattggcaatggaggacgggaacacacgctggcctggaaacttgcacagtctact
catgtcaaacaagtgttggttaccccaggaaatgcaggcactgcctgctctgagaagatt
tcaaatactgacatatcaatcagtgatcatgctgcccttgtgcagttctgcaaagatgag
aaaattgaatttgtagttgttggaccagaggcacctctagctgctggaattgttgggaac
ctgaactctgtgggagttcggtgctttggccccacagcacaagcagctcagttagagtcc
agcaagagatttgccaaagagtttatggaccgacatggaatctcaactgcaagatggaga
gctttcactaaacctaaagaagcctgtgacttcattatgagcgcagacttccctgctttg
gttgtgaaggccagtggtcttgcagctgggaaaggggtaattgttgccaagagcaaagaa
gaggcctgtgaagctgtcagagagattatgcagggtaaagctttcggagaagcaggagaa
acagttgtcattgaagaacttcttgaaggagaagaggtgtcttgtctgtgcttcactgat
ggacggactgtggcccccatgcccccagcacaggaccataagcgattgctggagggcgac
aagggccccaacacgggaggaatgggagcctactgtccagcccctcaggtttctaaggat
ttgttgctaaaaattaaaaatactattcttcagaggacagtggatggcatgcaggaggag
ggtatgccatacacaggtgtcctctatgctggtataatgctgaccaagaacggccccaaa
gttctggaatttaattgccgtttcggtgatccagagtgccaagtgatcctcccacttctt
aaaagtgatctttatgaagtgattcagtctatcttagatggcttgctctgcacttctctg
cctgtttggctggacaactgtgctgctgtaactgtggtcatggcaagtaaaggttatcca
ggagactacaccaagggtgtagagataacagggattcctgaggctcaggctttaggactg
gaggtgttccaagcaggcactgccctaaaagatggcaaggtggtgactaacgggggtagg
gtccttactgtcacggccatcagggaaaatctcatctcagctcttgaagaagccaggaag
ggacttgccgctataaagtttgagggagctgtttataggaaagacatcggctttcgagcc
atagctttcctccagcagcccaggggcctgacttacaaggaatctggggtagacattgca
gctggtaatacgctggtccagaaaattaaacctttagcgaaggccacctccagaccaggc
tgtgatgttgatcttggaggttttgctggtctttttgatttgaaagcagctggtttcacc
gatcctcttctggcttgtggaacagatggcgttgggacgaaactgaagattgcccagcag
tgcagtaaacatgacaccattggtcaggatttggttgcgatgtgtgtaaatgacattctg
gcacaaggagcagagcccctctttttcctcgattacttttcctgtggaaaacttgacctc
cgtactactgaagctgttatcgctgggatcgccaaagcttgtagaaaggctggatgtgct
ctcctcggaggtgaaacggcagagatgcctggcatgtaccctcctggagagtatgatcta
gctggttttgccattggcgccatggagcgggatcagaaacttcctcaactggaaagaatc
acggaaggggatgctgttattggaatcgcttcatctggtcttcacagcaacggattcagc
cttgtgaggaaaattgtagcaaaatcctctctcgagtactcttctccagcacctgatggc
tgtggtgaccagaccttaggtgacttacttctaaccccaaccagaatctacagccactca
ctgttacctgtcctgcgttcaggacgtgttaaggccattgcgcatattactggtggagga
ttactggaaaacatccccagagtcctccctcagaaattgggggtgaatttagatgcccag
acctggagggtccccaggatcttctcatggttacagcaggaaggccacctctctgaagag
gagatggccagaacatttaactgtgggattggggctgccctcgtggtatcagaggacctg
gtgaagcagactctgcaggatattgagcagcaccaggaagaagcctgcgtgatcggcaga
gtggttgcgtgtcccgaaggttctcctcgtgtgaaagtcgagcatctgattgaaaccatg
caaataaatggatcagtattggagaatggaaccctgagaaatcatttctctgttcaaccg
aaaaaggcaagagtagctgtcttaatttctgggacaggatcgaacctccaagctctcata
gacagcactagggagccaaggagcttggcacacattgtcgttgtgatctccaacaaagct
gcagtggctggcttagataaagcagaaaaagccgggattcccacgagagtaattaatcat
aaattatataaaaatcgtgcagcatttgacactgcaattgacgaagtccttgaagagttc
tccacagacatagtctgtcttgcaggattcatgagaattttgtctggccccttcgtcaga
aaatggaatgggaaaatgctcaatatccacccatccttgctcccttcttttaagggttca
aatgcccatgaacaagtcctggccgctggggtcacaatcaccgggtgcaccgtgcacttt
gtagctgaagatgtagatgctggtcaaattatcttacaggaagccgttccagtgaagagg
ggtgacactgttgaaactctatctgagagagtaaaattagcagaacataaaatatttccc
tcagccctccagctggtggccagtggagctgtgcggcttggagaaaatggcagaatctgt
tgggtcacagaggagtga
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