KEGG ORTHOLOGY: K11787

ORTHOLOGY: K11787

Entry

K11787                      KO

Symbol

GART

Name

phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1]

Pathway

map00230

Purine metabolism

map00670

One carbon pool by folate

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01523

Antifolate resistance

Module

M00048

De novo purine biosynthesis, PRPP + glutamine => IMP

Reaction

R04144

5-phospho-D-ribosylamine:glycine ligase (ADP-forming)

R04208

2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)

R04325

10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

R04326

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K11787  GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K11787  GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase
09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K11787  GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.2.2  phosphoribosylglycinamide formyltransferase 1
     K11787  GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase
6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.1  phosphoribosylformylglycinamidine cyclo-ligase
     K11787  GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.13  phosphoribosylamine---glycine ligase
     K11787  GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase

Other DBs

GO:	0004637 0004644 0004641

Genes

HSA:	2618(GART)

PTR:	107970128(GART)

PPS:	100991318(GART)

GGO:	101142154(GART)

PON:	100444934(GART)

NLE:	100585363(GART)

HMH:	116482425(GART)

MCC:	704926(GART)

MCF:	101925128(GART)

MTHB:

126951660

MNI:	105472697(GART)

CSAB:

103216649(GART)

CATY:

105575385(GART)

PANU:

100137547(GART)

TGE:	112620929(GART)

MLEU:

105553148(GART)

RRO:	104658753(GART)

RBB:	108536859(GART)

TFN:	117095719(GART)

PTEH:

111525392(GART)

CANG:

105517524(GART)

CJC:	100412337(GART)

SBQ:	101032514(GART)

MMUR:

105861505(GART)

LCAT:

123630702(GART)

PCOQ:

105820825(GART)

OGA:	100957350(GART)

MMU:	14450(Gart)

MCAL:

110311510(Gart)

MPAH:

110329397(Gart)

RNO:	288259(Gart)

MCOC:

116086139(Gart)

ANU:	117717807(Gart)

MUN:	110541947(Gart)

CGE:	100689446(Gart)

MAUA:

101828280(Gart)

PROB:

127227519(Gart)

PLEU:

114698431(Gart)

MORG:

121444517 121461903(Gart)

MFOT:

126515251

AAMP:

119825547(Gart)

NGI:	103736448(Gart)

HGL:	101697318(Gart)

CPOC:

100729412(Gart)

DORD:

105994021(Gart)

DSP:	122114228(Gart)

PLOP:

125351494(Gart)

NCAR:

124993425

MMMA:

107136445(Gart)

OCU:	100328811(GART)

OPI:	101529478(GART)

TUP:	102487990(GART)

GVR:	103586004(GART)

CFA:	100856570(GART)

CLUD:

112661742(GART)

VVP:	112909277(GART)

VLG:	121479445(GART)

NPO:	129502188(GART)

AML:	100479165(GART)

UMR:	103673116(GART)

UAH:	113264297(GART)

UAR:	123784210(GART)

ELK:

111155699

LLV:

125094922

MPUF:

101676521(GART)

MNP:	132012366(GART)

MLK:	131825329(GART)

NVS:	122908323(GART)

ORO:	101384632(GART)

EJU:	114218318(GART)

ZCA:	113918308(GART)

MLX:	118018835(GART)

NSU:	110570111(GART)

LWW:	102750243(GART)

FCA:	101087772(GART)

PYU:	121035984(GART)

PCOO:

112849369(GART)

PBG:	122491215(GART)

PVIV:

125174755(GART)

LRUF:

124526344

PTG:	102956979(GART)

PPAD:

109249721(GART)

PUC:

125921703

AJU:

106966453

HHV:	120229609(GART)

BTA:	281183(GART)

BOM:	102276357(GART)

BIU:	109567366(GART)

BBUB:

102392383(GART)

BBIS:

105004616(GART)

CHX:	102172194(GART)

OAS:	101121731(GART)

BTAX:

128045342(GART)

ODA:	120854436(GART)

CCAD:

122428721(GART)

MBEZ:

129552531(GART)

SSC:	100620652(GART)

CFR:	102517474(GART)

CBAI:

105070227(GART)

CDK:	105089861(GART)

VPC:	102526238(GART)

BACU:

102999179(GART)

BMUS:

118894582(GART)

LVE:	103080650(GART)

OOR:	101285238(GART)

DLE:	111163810(GART)

PSIU:

116753349(GART)

NASI:

112408602(GART)

ECB:	100052316(GART)

EPZ:	103549081(GART)

EAI:	106832833(GART)

MYB:	102262953(GART)

MYD:	102772036(GART)

MMYO:

118677255(GART)

MLF:	102424778(GART)

PKL:	118716057(GART)

EFUS:

103289924(GART)

MNA:	107537466(GART)

DRO:	112305577(GART)

SHON:

118983252(GART)

AJM:	119035718(GART)

PDIC:

114490038(GART)

PHAS:

123828053(GART)

MMF:	118617075(GART)

PPAM:

129074257(GART)

HAI:	109373228(GART)

RFQ:	117035821(GART)

PALE:

102893033(GART)

PGIG:

120598631(GART)

PVP:	105295844(GART)

RAY:	107519587(GART)

MJV:	108396821(GART)

TOD:	119257226(GART)

SARA:

101558115(GART)

SETR:

126026039(GART)

LAV:	100672037(GART)

TMU:

101354872

ETF:	101653802(GART)

DNM:	101434283(GART)

MDO:	100026350(GART)

GAS:	123242454(GART)

SHR:	100925249(GART)

AFZ:

127553854

PCW:	110214813(GART)

OAA:	100083317(GART) 100083336

GGA:	395315(GART) 427977(GART-B)

PCOC:

116241974 116241995(GART)

MGP:	100539128(GART) 100542357

CJO:	107322963 107322977(GART)

TPAI:

128076347(GART) 128076363

LMUT:

125697151 125697160(GART)

NMEL:

110402500 110402542

APLA:

101790581 101803101

ACYG:

106043414(GART) 106043431

CATA:

118247664 118247791

AFUL:

116491147(GART)

TGU:	100217856(GART) 100222702

LSR:	110479223(GART) 110479231

SCAN:

103824404(GART) 103824418

PMOA:

120504004 120504005(GART)

OTC:	121334741 121334747(GART)

PRUF:

121356332(GART) 121356339

GFR:	102045486(GART) 102045650

FAB:	101816412(GART) 101817498

PHI:	102100614 102109787

PMAJ:

107200378(GART) 107200385

CCAE:

111928826(GART) 111928969

CCW:	104698062(GART) 104698091

CBRC:

103621821(GART) 103621832

ETL:	114070711(GART)

ZAB:	102071268 102071439(GART)

ACHL:

103803702(GART) 103803703

SVG:	106864103 106864106(GART)

MMEA:

130583757 130583761(GART)

HRT:	120748479 120748480(GART)

FPG:	101917332(GART) 101920107

FCH:	102054569 102058598(GART)

CLV:	102088577 102096509(GART)

EGZ:	104128165 104128228

NNI:	104020123(GART) 104020174

PCRI:

104037837(GART) 104037838

PLET:

104625314(GART) 104625315

EHS:

104506534

PCAO:

104042539(GART) 104042541

ACUN:

113479892(GART) 113485589

TALA:

104361255(GART) 104361256

PADL:

103920259(GART) 103920317

AFOR:

103901972(GART) 103902070

ACHC:

115343826 115343827

HALD:

104310807(GART) 104317815

HLE:	104839829(GART) 104839852

AGEN:

126053197 126053198

GCL:	127029447 127029448

CCRI:

104164340

CSTI:

104550213 104553807

CMAC:

104479807(GART) 104479808

MUI:	104538196(GART) 104538206

BREG:

104629714(GART) 104633093

FGA:	104076686(GART) 104076687

GSTE:

104257467(GART) 104257468

LDI:	104339807(GART) 104348762

MNB:	103781336(GART)

OHA:	104328348(GART) 104328369

NNT:	104413784(GART) 104413785

SHAB:

115601471 115601577

DPUB:

104306412(GART) 104306427

PGUU:

104468469(GART) 104468477

ACAR:

104531470(GART) 104531471

CPEA:

104395001(GART) 104395018

AVIT:

104267149(GART) 104279688

CVF:	104295172(GART) 104295199

RTD:	128910073 128910101(GART)

CUCA:

104064755(GART) 104064788

TEO:	104369892 104375614

BRHI:

104489356(GART) 104489357

AAM:	106494893 106494960

AROW:

112971849 112971877

NPD:	112948158(GART) 112948159

TGT:	104566670 104566671

DNE:	112988207 112988210

SCAM:

104139449(GART) 104139486

ASN:	102378888(GART) 102384374

AMJ:	102567665(GART) 102569060

CPOO:

109305783 109305785(GART)

GGN:	109302469 109302471(GART)

PSS:	102460115(GART) 102461235

CMY:	102929919 102946476(GART)

CCAY:

125644196 125644210

DCC:	119851722(GART)

CPIC:

101943710 101946162

TST:	117867212 117867315

CABI:

116828284 116828286(GART)

MRV:	120371872(GART) 120388475

ACS:	100561300(gart) 100565628

ASAO:

132771882 132771886(GART)

PVT:	110080382(GART) 110080394

SUND:

121925252 121926976

PBI:	103048917 103067155(GART)

PMUR:

107290481 107290689

CTIG:

120296883(GART) 120319339

TSR:	106546638 106552129

PGUT:

117657118 117676320

APRI:

131199997 131200267

PTEX:

113436265(GART) 113436266

NSS:

113409759

VKO:	123029412(GART) 123029413

PMUA:

114596055 114596056

PRAF:

128412988 128412989

ZVI:	118084947 118085722

HCG:	128350497 128351301(GART)

GJA:	107121922 107121925

STOW:

125431150 125431306

EMC:	129326118(GART) 129326119

XLA:	100101294(gart.L) 108707418

XTR:	100485140 496927(gart)

NPR:	108787812(GART)

RTEM:

120927909

BBUF:

120994518 120994519 120997670

BGAR:

122928736 122930815 122931865

MUO:	115458905 115469475 115469740

GSH:	117362792 117362793

DRE:	58141(gart)

SRX:	107726994(gart)

SANH:

107689944(gart)

SGH:	107572075(gart)

CAUA:

113080559(gart)

CGIB:

128014879

PTET:

122345465(gart)

LROH:

127176952(gart)

OMC:	131541437(gart)

PPRM:

120460481(gart)

RKG:	130096677(gart)

MAMB:

125272981(gart)

CIDE:

127521026 127521035

MASI:

127443362 127445337

TROS:

130553611(gart)

TDW:	130411669(gart)

MANU:

129445126(gart)

IPU:

108258901

IFU:

128602443

PHYP:

113537379(gart)

SMEO:

124377913(gart)

TFD:	113648820(gart)

TVC:	132839158(gart)

TRN:	134328218(gart)

AMEX:

103047427(gart)

CMAO:

118798247(gart)

EEE:	113574576(gart)

CHAR:

105889596(gart)

TRU:	101075229(gart)

TFS:	130522795(gart)

TNG:	GSTEN00015817G001

LCO:	104932032(gart)

TBEN:

117499100(gart)

CGOB:

115018514(gart)

PGEO:

117460495(gart)

GACU:

117562721(gart)

EMAC:

134861148(gart)

ELY:	117250198(gart)

EFO:	125884966(gart)

PLEP:

121962768(gart)

SLUC:

116044481(gart)

ECRA:

117939248(gart)

ESP:	116673898(gart)

PFLV:

114550974(gart)

GAT:	120816512 120824714

PPUG:

119219556(gart)

AFB:	129111834(gart)

CLUM:

117744041(gart)

PSWI:

130204641(gart)

MSAM:

119904058(gart)

SCHU:

122872421(gart)

CUD:	121506446(gart)

ALAT:

119015498(gart)

MZE:	101485338(gart)

ONL:	100706422(gart)

OAU:	116318479(gart)

OLA:	100049526(gart)

OML:	112160056(gart)

CSAI:

133424921(gart)

XMA:	102236613(gart)

XCO:	114140906(gart)

XHE:	116715899 116715900 116733649

PRET:

103476711(gart)

PFOR:

103156856(gart)

PLAI:

106940411(gart)

PMEI:

106910957(gart)

PPRL:

129353818

CVG:	107098796(gart)

CTUL:

119791183(gart)

GMU:	124861553(gart)

NFU:	107380853(gart)

KMR:	108245013(gart)

ALIM:

106523921(gart)

NWH:	119428902(gart)

AOCE:

111587765(gart) 111587996

MCEP:

125000871(garT)

CSEM:

103389466(gart)

POV:

109645513

SSEN:

122760284(gart)

HHIP:

117775805(gart)

HSP:	118103684(gart)

PPLT:

128431133(gart)

SMAU:

118309820(gart)

LCF:

108894876

SDU:	111236692(gart)

SLAL:

111644444(gart) 111652198

XGL:	120797986(gart)

HCQ:	109528647(gart)

SSCV:

125988523

SBIA:

133504926(gart)

PEE:	133412147(gart)

PTAO:

133477564(gart)

BPEC:

110153183(gart)

MALB:

109952606(gart)

BSPL:

114848658(gart)

SJO:	128354124(gart)

SASA:

106575120(gart)

STRU:

115179838(gart)

OTW:	112254021(gart)

OMY:	110527589(gart)

OGO:	124008143(gart)

ONE:	115134535(gart)

OKI:	109890454(gart)

OKE:	118363981 118370117(gart)

SALP:

111953616 111971034

SNH:	120033148(gart) 120051214

CCLU:

121535944

ELS:	105008058(gart)

SFM:	108938543(gart)

PKI:	111855964(gart)

AANG:

118214096(gart)

LOC:	102689420(gart)

PSPA:

121321000 121327997

ARUT:

117406364 117972905 117973046(gart)

PSEX:

120522674(gart)

LCM:	102366881(GART)

CMK:	103186759(gart)

RTP:	109913465(gart)

CPLA:

122555362(gart)

HOC:	132821148(gart)

LERI:

129702967(gart)

PMRN:

116956021(GART)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG31628(Gart)

DER:

6541431

DSE:

6611485

DSI:	Dsimw501_GD22518(Dsim_GD22518)

DYA:	Dyak_GE18382

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI11847

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108374194 108374353

AOQ:

129246916

TDA:	119663989 119687261

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

109407245 109414311 115254028

CQU:	CpipJ_CPIJ009144

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206359

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105384475 105391129

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:	124366829 124374088

MQU:	129001988 129003773

PHU:	Phum_PHUM292430

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F38B6.4(F38B6.4)

CBR:

CBG_10863

CRQ:	GCK72_024627

NAI:	NECAME_16045

TSP:	Tsp_11763a

HRO:	HELRODRAFT_193551

LGI:	LOTGIDRAFT_207583

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111132060 111135731

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_61620

MBR:	MONBRDRAFT_21490

ACAN:

ACA1_270360

SMIN:

v1.2.022838.t1(symbB.v1.2.022838.t1) v1.2.024758.t1(symbB.v1.2.024758.t1)

AAF:	AURANDRAFT_64345

DEX:	HWD60_10980

» show all

Reference

PMID:2183217

Authors

Schild D, Brake AJ, Kiefer MC, Young D, Barr PJ

Title

Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations.

Journal

Proc Natl Acad Sci U S A 87:2916-20 (1990)
DOI:10.1073/pnas.87.8.2916

Sequence

[hsa:2618]

LinkDB

DBGET integrated database retrieval system