Equus caballus (horse): 100066248 Help Entry 100066248         CDS       T01058                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism ecb  Equus caballus (horse) Pathway ecb04010   MAPK signaling pathway ecb04014   Ras signaling pathway ecb04015   Rap1 signaling pathway ecb04022   cGMP-PKG signaling pathway ecb04066   HIF-1 signaling pathway ecb04068   FoxO signaling pathway ecb04072   Phospholipase D signaling pathway ecb04150   mTOR signaling pathway ecb04151   PI3K-Akt signaling pathway ecb04152   AMPK signaling pathway ecb04211   Longevity regulating pathway ecb04213   Longevity regulating pathway - multiple species ecb04520   Adherens junction ecb04910   Insulin signaling pathway ecb04913   Ovarian steroidogenesis ecb04923   Regulation of lipolysis in adipocytes ecb04930   Type II diabetes mellitus ecb04931   Insulin resistance ecb04932   Non-alcoholic fatty liver disease ecb04960   Aldosterone-regulated sodium reabsorption ecb05010   Alzheimer disease ecb05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ecb00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100066248 (INSR)    04014 Ras signaling pathway     100066248 (INSR)    04015 Rap1 signaling pathway     100066248 (INSR)    04066 HIF-1 signaling pathway     100066248 (INSR)    04068 FoxO signaling pathway     100066248 (INSR)    04072 Phospholipase D signaling pathway     100066248 (INSR)    04022 cGMP-PKG signaling pathway     100066248 (INSR)    04151 PI3K-Akt signaling pathway     100066248 (INSR)    04152 AMPK signaling pathway     100066248 (INSR)    04150 mTOR signaling pathway     100066248 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     100066248 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     100066248 (INSR)    04923 Regulation of lipolysis in adipocytes     100066248 (INSR)    04913 Ovarian steroidogenesis     100066248 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     100066248 (INSR)   09149 Aging    04211 Longevity regulating pathway     100066248 (INSR)    04213 Longevity regulating pathway - multiple species     100066248 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     100066248 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     100066248 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     100066248 (INSR)    04932 Non-alcoholic fatty liver disease     100066248 (INSR)    04931 Insulin resistance     100066248 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ecb01001]     100066248 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:ecb04090]     100066248 (INSR) Enzymes [BR:ecb01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100066248 (INSR) Protein kinases [BR:ecb01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    100066248 (INSR) CD molecules [BR:ecb04090]  Proteins   100066248 (INSR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like fn3 Insulin_TMD Kinase-like DUF4476 Motif Other DBs NCBI-GeneID:  100066248 NCBI-ProteinID:  XP_023500375 Ensembl:  ENSECAG00000010127 VGNC:  19083 LinkDB All DBs Position 7:complement(5065196..5193449) Genome browser AA seq 1397 aa AA seqDB search MGAGGRRGAAAAPLLVAVAALLVGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTADGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKNSRRQG CHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLTFSHIRTSSDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTNATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQEEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKHNQSEYEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFVPRKSSSGPGAEDTRPSRKRRALADVGNVTVAVPTVPGF PNTSSTSTPTSSEERRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYV SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCV SRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLLNVVQECRHTDI LFHDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDV FPCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASL RERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENN PGRPPPTLQEMVQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY ETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQV LKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFH SEENKAPESEELEMEFEDMENVPLDRSSHSQREEAGGRDAGSSLGLKRNYEEHIPYTHMN GGKKNGRILTLPRSNPS NT seq 4194 nt NT seq  +upstreamnt  +downstreamnt atgggcgcagggggccggcggggggcggcggccgcgccgctcctggtggccgtggcggcg ctgctggtgggcgccgcgggccacctgtaccccggagaggtgtgccctggcatggatatc cggaacaacctcacgaggctgcacgaactggccaactgctccgtcattgaaggacacttg cagattctgttgatgtttaaaacgaggcctgaggatttccgagacctcagtttccccaaa ctcatcatgatcactgattacttgctgctcttccgggtgtacgggctggagagcctgaag gacctgttccccaacctcacggtcatccggggctctcgtctcttcttcaactacgcgctg gtcatcttcgagatggttcacctgaaggagcttggcctctacaacctgatgaacatcacc cgcggctccgtccgcatagagaagaacaacgagctgtgctacctggccaccattgactgg tcacgcattctggactcggtggaagataattacattgtgctgaacaaggacgacaatgag gagtgcggggacatttgtccaggcaccgccaagggcaagaccaactgccccgccactgtc atcaacggacagtttgttgagcggtgctggacgcacagccattgccagaaagtttgcccg accatctgtaagtcacacggctgcaccgcggacggcctctgctgccacagcgagtgttta ggcaactgctctgagcccgacgaccccaccaagtgcgtggcctgccgcaacttctacctg gacggcaggtgtgtggagacctgcccgcccccgtactatcacttccaagactggcgctgt gtcaacttcagcttctgccaggacctgcacaacaaatgcaagaactcccgaaggcagggc tgccatcagtacgtcattcacaataacaagtgcatccctgagtgtccctctgggtacacg atgaattccagcaacttgatgtgtaccccgtgcctgggtccctgtcccaaggtgtgccac ctcctggaaggcgagaagaccatcgactcggtgacgtccgcccaggagctccgaggctgc acggtcatcaacgggagcctgatcatcaacatccgagggggcaacaacctggcagctgag ctagaggccaaccttggactcattgaagaaatttcagggtatctgaaaatccgccggtcc tacgctctcgtgtcgctttccttcttccggaagttacgcctaattcggggagagaccttg gaaatcgggaactactcattctacgccttggacaaccagaacctgaggcagctatgggac tggagcaagcacaacctcaccatcactcaggggaaactcttcttccactataatcccaaa ctctgcttgtcggaaattcacaagatggaggaagtttcaggaaccaaagggcgccaggag aggaacgacatcgccctgaagaccaacggggaccaggcgtcctgtgaaaatgagttactt acattttctcacattcggacatcttctgacaagatcttgctgaaatgggagccatattgg ccccccgacttccgagacctcttgggcttcatgctcttctataaagaggccccttatcag aacgtgacggagtttgatgggcaggatgcctgtggctccaacagctggacggtagtggac attgacccacctctgaggtccaacgaccccaagtcacagaaccaccccgggtggctgatg cgaggtctcaaaccctggacccagtatgccatctttgtcaagaccttggtcaccttttct gatgaacgccggacatacggggccaagagcgacatcatctatgtccagacaaatgccacg aacccgtctgtccccctggatcccatctccgtttctaattcctcatcccagattattctg aagtggaagcccccctctgaccccaatgggaacatcacacactacctggttttctgggag aggcaggaggaagacagcgagctgtacgagttggattattgcctcaaaggcttgaagctg ccctccaggacctggtctccaccgtttgagtctgaggggtcccagaagcacaatcagagt gagtacgaggagtctgccggcgaatgctgctcctgcccgaagaccgactcccagatcctg aaggagctggaggagtcctcgttcaggaagacgttcgaggactatctgcacaatgtggtt tttgtccccagaaaatcctcttcaggccctggtgccgaggacactagaccgtctcggaaa cgcagggcgcttgctgatgtcgggaatgtgacggtggccgtgcccacggttccgggtttc cctaatacctcctccaccagcacgcccacgagctcagaggagcgcagacccttcgagaaa gtggtgaacaaggagtcgctggtcatctccggcctgcgccattttaccgggtatcgcatc gagcttcaggcttgcaaccaagattcccccgaagagaggtgcagtgtggccgcctatgtc agtgccaggaccatgcctgaagccaaggcggacgacatcgttggccccgtgactcacgaa atcttcgagaacaatgtcgttcacttgatgtggcaggagcccaaagaacccaacggtctg atcgtgctgtacgaagtgagttatcggcgatacggcgatgaggagctgcatctctgtgtg tctcgcagacattttgccctggagcggggctgccggctgcgtgggctgccgccagggaac tacagtgtgcgagtgcgggccacctccctggcaggcaatggctcctggaccgaagccact tatttctacgtgacagactatttgctcaatgttgtccaagagtgcagacatacggacatt ctttttcacgacgtcccatcaaatattgcaaaaatcatcatcggccccctcatctttgtc tttctcttcagtgtggtcattggaagcatttacctcttcttgagaaagaggcagccagat gggcccctgggaccgctgtacgcttcctcaaaccctgagtacctcagcgccagtgatgtg tttccctgctctgtgtacgtgccggacgagtgggaggtgcctcgggagaagatcaccctc ctgcgggagctggggcagggctccttcggcatggtgtatgaaggcaacgccagggacatc gtcaagggcgaggcggagacccgcgtggcggtgaagacagtcaacgagtctgccagtctg cgagagaggatcgagtttctcaacgaggcctcagtcatgaagggcttcacctgccatcac gtggtccgcctcctgggggtggtatcgaaaggccagccaacgctggtggtgatggagttg atggctcatggagacctgaagagctacctccgttccctgcggccggaggctgagaataac cctggccgccctccccctaccctgcaagagatggttcagatggcggcggagatcgccgac gggatggcgtacctgaacgccaagaagtttgtgcaccgggacctggcagctcgaaactgc atggtcgcccacgattttaccgtcaaaatcggagactttggaatgaccagagacatctac gaaacggattactaccggaaaggaggcaaggggctgctccccgtgaggtggatggctcct gaatccctgaaggacggggtctttactacttcttctgacatgtggtcctttggcgtggtc ctttgggaaatcaccagcttggcagaacagccttaccaaggcctgtctaatgagcaggtg ttgaaatttgtcatggatggagggtatctggatcaacccgacaattgtcccgagagagtc accgacctgatgcgtatgtgctggcagttcaaccccaagatgcggccgaccttcctggag attgtcgacctgctcaaggatgacctgcaccccagctttccagaagtttccttcttccac agcgaggagaacaaggcccccgagagcgaggagctggagatggagtttgaggacatggag aacgtccccctggatcggtcctcacattcccagagggaggaggccgggggccgggatgca gggtcctcgctgggtctaaagcggaactatgaggaacacatcccgtacactcacatgaac gggggcaagaaaaatgggcggattctgactctgccgaggtcaaatccttcctaa

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