KEGG ORTHOLOGY: K04527

ORTHOLOGY: K04527

Entry

K04527                      KO

Symbol

INSR, CD220

Name

insulin receptor [EC:2.7.10.1]

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04022

cGMP-PKG signaling pathway

map04066

HIF-1 signaling pathway

map04068

FoxO signaling pathway

map04072

Phospholipase D signaling pathway

map04150

mTOR signaling pathway

map04151

PI3K-Akt signaling pathway

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map04212

Longevity regulating pathway - worm

map04213

Longevity regulating pathway - multiple species

map04361

Axon regeneration

map04520

Adherens junction

map04910

Insulin signaling pathway

map04913

Ovarian steroidogenesis

map04923

Regulation of lipolysis in adipocytes

map04930

Type II diabetes mellitus

map04931

Insulin resistance

map04932

Non-alcoholic fatty liver disease

map04960

Aldosterone-regulated sodium reabsorption

map05010

Alzheimer disease

map05415

Diabetic cardiomyopathy

Disease

H00719

Leprechaunism

H00942

Rabson-Mendenhall syndrome

H01228

Insulin-resistant diabetes mellitus with acanthosis nigricans

H01267

Familial hyperinsulinemic hypoglycemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04527  INSR, CD220; insulin receptor
   04014 Ras signaling pathway
    K04527  INSR, CD220; insulin receptor
   04015 Rap1 signaling pathway
    K04527  INSR, CD220; insulin receptor
   04066 HIF-1 signaling pathway
    K04527  INSR, CD220; insulin receptor
   04068 FoxO signaling pathway
    K04527  INSR, CD220; insulin receptor
   04072 Phospholipase D signaling pathway
    K04527  INSR, CD220; insulin receptor
   04022 cGMP-PKG signaling pathway
    K04527  INSR, CD220; insulin receptor
   04151 PI3K-Akt signaling pathway
    K04527  INSR, CD220; insulin receptor
   04152 AMPK signaling pathway
    K04527  INSR, CD220; insulin receptor
   04150 mTOR signaling pathway
    K04527  INSR, CD220; insulin receptor
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04527  INSR, CD220; insulin receptor
09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04527  INSR, CD220; insulin receptor
   04923 Regulation of lipolysis in adipocytes
    K04527  INSR, CD220; insulin receptor
   04913 Ovarian steroidogenesis
    K04527  INSR, CD220; insulin receptor
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04527  INSR, CD220; insulin receptor
  09158 Development and regeneration
   04361 Axon regeneration
    K04527  INSR, CD220; insulin receptor
  09149 Aging
   04211 Longevity regulating pathway
    K04527  INSR, CD220; insulin receptor
   04212 Longevity regulating pathway - worm
    K04527  INSR, CD220; insulin receptor
   04213 Longevity regulating pathway - multiple species
    K04527  INSR, CD220; insulin receptor
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04527  INSR, CD220; insulin receptor
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K04527  INSR, CD220; insulin receptor
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04527  INSR, CD220; insulin receptor
   04932 Non-alcoholic fatty liver disease
    K04527  INSR, CD220; insulin receptor
   04931 Insulin resistance
    K04527  INSR, CD220; insulin receptor
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04527  INSR, CD220; insulin receptor
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04527  INSR, CD220; insulin receptor
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04527  INSR, CD220; insulin receptor
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  INSR family [OT]
   K04527  INSR, CD220; insulin receptor
CD molecules [BR:ko04090]
Proteins
  K04527  CD220, INSR; insulin receptor

Other DBs

GO:

0005009

Genes

HSA:	3643(INSR)

PTR:	455649(INSR)

PPS:	100991905(INSR)

GGO:	101144696(INSR)

PON:	100451422(INSR)

NLE:	100597533(INSR)

HMH:	116479486(INSR)

MCC:	706009(INSR)

MCF:	102139081(INSR)

MTHB:

126942469

MNI:	105487005(INSR)

CSAB:

103234346(INSR)

CATY:

105589163(INSR)

PANU:

101012351(INSR)

TGE:	112613164(INSR)

MLEU:

105541159(INSR)

RRO:	104679498(INSR)

RBB:	108534554(INSR)

TFN:	117076717(INSR)

PTEH:

111522649(INSR)

CANG:

105512899(INSR)

CJC:	100403400(INSR)

SBQ:	101028986(INSR)

CIMI:

108304133(INSR)

CSYR:

103273081(INSR)

MMUR:

105869687

LCAT:

123635850(INSR)

PCOQ:

105811840(INSR)

OGA:	100962237(INSR)

MMU:	16337(Insr)

MCAL:

110300622(Insr)

MPAH:

110336317(Insr)

RNO:	24954(Insr)

MCOC:

116068825(Insr)

ANU:	117697878(Insr)

CGE:	100766818(Insr)

MAUA:

121134754 121136483(Insr)

PROB:

127237189(Insr)

PLEU:

114683184(Insr)

MORG:

121465153(Insr)

MFOT:

126491593

AAMP:

119825604(Insr)

NGI:	103743312(Insr)

HGL:	101722168(Insr)

CPOC:

100718484(Insr)

CCAN:

109694006(Insr)

DORD:

105998714(Insr)

DSP:	122119565(Insr)

PLOP:

125348697(Insr)

NCAR:

124968393

MMMA:

107157473(Insr)

OCU:

100008911

OPI:	101530887(INSR)

TUP:	102469167(INSR)

GVR:

103604564

CFA:	484990(INSR)

CLUD:

112666443(INSR)

VVP:	112909702(INSR)

VLG:	121494318(INSR)

NPO:	129521674(INSR)

AML:	100473956(INSR)

UMR:	103676308(INSR)

UAH:	113242935(INSR)

UAR:	123777569(INSR)

ELK:

111161798

LLV:

125085453

MPUF:

101677072(INSR)

MNP:	132010913(INSR)

MLK:	131823456(INSR)

NVS:	122909778(INSR)

ORO:	101363371(INSR)

EJU:	114200877(INSR)

ZCA:	113916517(INSR)

MLX:	118005442(INSR)

NSU:	110593671(INSR)

LWW:	102730888(INSR)

FCA:	100127108(INSR)

PYU:	121013826(INSR)

PCOO:

112852904(INSR)

PBG:	122488640(INSR)

PVIV:

125149652(INSR)

LRUF:

124523268

PTG:	102967156(INSR)

PPAD:

109254164(INSR)

PUC:

125928720

AJU:

106979040

HHV:	120244875(INSR)

BTA:	408017(INSR)

BOM:	102285317(INSR)

BBUB:

102391024(INSR)

BBIS:

104979781(INSR)

CHX:	102168996(INSR)

OAS:	443431(INSR)

BTAX:

128050313(INSR)

ODA:	120863920(INSR)

CCAD:

122440366(INSR)

MBEZ:

129558099(INSR)

SSC:	396755(INSR)

CFR:	102522017(INSR)

CBAI:

105078270(INSR)

CDK:	105087555(INSR)

VPC:	102544508(INSR)

BACU:

103018249(INSR)

BMUS:

118892062(INSR)

LVE:	103085622(INSR)

OOR:	101283355(INSR)

DLE:	111165931(INSR)

PSIU:

116751331(INSR)

NASI:

112400209(INSR)

ECB:	100066248(INSR)

EAI:	106844524(INSR)

MYB:	102252005(INSR)

MYD:	102766590(INSR)

MMYO:

118659286(INSR)

MLF:	102437355(INSR)

PKL:	118725880(INSR)

EFUS:

103295001(INSR)

MNA:	107540632(INSR)

DRO:	112296365(INSR)

SHON:

118987715(INSR)

AJM:	119045329(INSR)

PDIC:

114509225(INSR)

PHAS:

123811181(INSR)

MMF:	118615134(INSR)

PPAM:

129064990(INSR)

HAI:	109396062(INSR)

RFQ:	117037841(INSR)

PALE:

102879346(INSR)

PGIG:

120599285(INSR)

PVP:	105307438(INSR)

RAY:	107519908(INSR)

MJV:	108404652(INSR)

TOD:	119240421(INSR)

SARA:

101540495(INSR)

SETR:

126031127(INSR)

LAV:	100668116(INSR)

TMU:

101360415

ETF:	101657077(INSR)

DNM:	101431970(INSR)

MDO:	100027215(INSR)

GAS:	123256825(INSR)

SHR:	100929204(INSR)

AFZ:

127545340

PCW:	110203364(INSR)

OAA:	100079104(INSR)

GGA:	420133(INSR)

PCOC:

116235701(INSR)

MGP:	100550007(INSR)

CJO:	107325585(INSR)

TPAI:

128088836(INSR)

LMUT:

125684790(INSR)

NMEL:

110389023(INSR)

APLA:

101795803(INSR)

ACYG:

106044962(INSR)

CATA:

118258731(INSR)

AFUL:

116499030(INSR)

TGU:	100228094(INSR)

LSR:	110479633(INSR)

SCAN:

103821923(INSR)

PMOA:

120498117(INSR)

OTC:	121341361(INSR)

PRUF:

121360714(INSR)

GFR:	102036061(INSR)

FAB:	101813861(INSR)

OMA:	130264629(INSR)

PHI:	102105828(INSR)

PMAJ:

107215564(INSR)

CCAE:

111940344(INSR)

CCW:	104696982(INSR)

CBRC:

103622109(INSR)

ETL:	114069501(INSR)

ZAB:	102069793(INSR)

ACHL:

103800983

SVG:	106857106(INSR)

MMEA:

130585531(INSR)

HRT:	120763323(INSR)

FPG:	101914421(INSR)

FCH:	102056291(INSR)

CLV:	102085804(INSR)

EGZ:	104124372(INSR)

NNI:	104018719(INSR)

PCRI:

104033691(INSR)

PLET:

104617295

EHS:	104512268(INSR)

PCAO:

104046138(INSR)

TALA:

104364445 116965112

PADL:

103926439(INSR)

AFOR:

103902914(INSR)

ACHC:

115348898(INSR)

HALD:

104322774(INSR)

HLE:	104828493(INSR)

AGEN:

126042384

GCL:

127025531

CCRI:

104160448(INSR)

CSTI:

104552904(INSR)

CMAC:

104478591

MUI:	104542502(INSR)

BREG:

104638295(INSR)

FGA:	104083384(INSR)

GSTE:

104259893(INSR)

LDI:	104347584(INSR)

MNB:	103769292(INSR)

OHA:	104328943(INSR)

NNT:	104407859(INSR)

SHAB:

115618288(INSR)

DPUB:

104300798(INSR)

PGUU:

104468784(INSR)

ACAR:

104523070(INSR)

CPEA:

104388871(INSR)

CVF:	104295405(INSR)

RTD:	128900503(INSR)

CUCA:

104060956(INSR)

TEO:

104372310

BRHI:

104497058(INSR)

AAM:	106495607(INSR)

AROW:

112966718(INSR)

NPD:	112943851(INSR)

TGT:	104567607(INSR)

DNE:	112986563(INSR)

SCAM:

104146182(INSR)

ASN:	102378715(INSR)

AMJ:	102558884(INSR)

CPOO:

109312363(INSR)

GGN:	109295003(INSR)

PSS:	102459083(INSR)

CMY:	102935205(INSR)

CCAY:

125627278(INSR)

DCC:	119848198(INSR)

CPIC:

101947783(INSR)

TST:

117869064

CABI:

116826238(INSR)

MRV:	120391598(INSR)

ACS:	100567954(insr)

ASAO:

132780958(INSR)

PVT:	110072679(INSR)

SUND:

121916648

CTIG:

120305990(INSR)

TSR:	106546257(INSR)

PGUT:

117677421(INSR)

APRI:

131188177(INSR)

PTEX:

113435201(INSR)

NSS:	113414184(INSR)

VKO:	123025167(INSR)

PMUA:

114588308(INSR)

PRAF:

128405508(INSR)

ZVI:	118085901(INSR)

HCG:	128343152(INSR)

GJA:	107121673(INSR)

STOW:

125432863(INSR)

EMC:

129330829

XLA:	100158430(insr.S) 398006(insr.L)

XTR:	100492718(insr)

NPR:	108785893(INSR)

RTEM:

120909484(INSR)

BBUF:

120989403(INSR)

BGAR:

122920525(INSR)

MUO:	115480111(INSR)

GSH:	117365942(INSR)

DRE:	245699(insra) 245700(insrb)

SRX:	107706379 107738166 107755985

SANH:

107659406 107668948 107695633 107704428

SGH:	107558844 107586934 107591352 107593049

CCAR:

109046541

CAUA:

113040224 113045021 113064746 113099711 113119199

CGIB:

127943254 127951307 127987380 128031694

PTET:

122327303(insrb) 122359571(insra)

LROH:

127153917(insrb) 127175297(insra)

OMC:	131530059(insrb) 131553823(insra)

PPRM:

120465058(insra) 120486240 120486241

RKG:	130071496(insra) 130105744(insrb)

MAMB:

125251149(insra) 125263650(insrb)

CIDE:

127521177 127525545

MASI:

127438114 127439259 127441273 127442204

TROS:

130549201(insrb) 130554143(insra)

TDW:	130417971(insra) 130429588(insrb)

MANU:

129441878(insra) 129454089(insrb)

IPU:	108267827(insra)

IFU:	128609860(insra) 128613547(insrb)

PHYP:

113540093

SMEO:

124388066(insra) 124391139(insrb)

TFD:	113647079(insra) 113650213(insrb)

TVC:	132848150(insra) 132854687(insrb)

AMEX:

103034736 103039445

CMAO:

118818705(insrb) 118826559(insra)

EEE:

113584152

CHAR:

105889494(insra) 105900980(insrb)

TRU:	101074083 101074430

TFS:	130528389(insrb) 130538297(insra)

TNG:	GSTEN00027765G001 GSTEN00028880G001

LCO:	104920253 104926189

NCC:	104961264(insr)

TBEN:

117500262(insra)

CGOB:

115006808 115022820

PGEO:

117463029(insra)

GACU:

117541280(insra)

EMAC:

134865781(insra) 134870225(insrb)

ELY:	117253876(insrb) 117271532(insra)

EFO:	125895265(insrb) 125901820(insra)

PLEP:

121950966(insra) 121966672(insrb)

SLUC:

116045912(insra) 116055274(insrb)

ECRA:

117950623(insrb) 117953563(insra)

ESP:	116695992 116698703

PFLV:

114562075 114564739

GAT:	120816187(insra) 120823782(insrb)

PPUG:

119209490(insra) 119217181(insrb)

AFB:	129089410(insra) 129094199(insrb)

CLUM:

117729437(insrb) 117745971(insra)

PSWI:

130197581(insra)

MSAM:

119900689 119901871(insra)

SCHU:

122878004(insrb) 122887603(insra)

CUD:	121512148 121520772

ALAT:

119010790(insra) 119029294(insrb)

MZE:	101469999 101480309

ONL:	100696191 100697854

OAU:	116313412(insra) 116324903(insrb)

OLA:	101166254 101168764

OML:	112147354(insra) 112150803(insrb)

CSAI:

133452418 133458429(insrb)

XMA:	102227076 102238226(insr)

XCO:	114146472(insr) 114150578

XHE:	116721171(insr) 116725365

PRET:

103479883(insr)

PFOR:

103138516 103146076(insr)

PLAI:

106960374(insr)

PMEI:

106916182 106925119

GAF:	122838631(insrb) 122841621(insra)

PPRL:

129369059(insrb) 129377982(insra)

CVG:	107094230(insr) 107100834

CTUL:

119787886(insra)

GMU:	124869846(insra) 124874283(insrb)

NFU:	107383587 107392644

KMR:	108230621(insrb) 108232893(insra)

ALIM:

106511880 106516858(insr)

NWH:	119415203(insra) 119430640(insrb)

AOCE:

111565521(insr) 111569056

MCEP:

125009551(insrb) 125010721(insra)

CSEM:

103393515 103396460

POV:	109625760 109643727

SSEN:

122768741(insra) 122780300

HHIP:

117760725(insrb) 117778848(insra)

HSP:	118118019(insra) 118120869(insrb)

SMAU:

118310315(insra) 118318263(insrb)

LCF:	108881334(insrb) 108884165(insra)

SDU:	111231251 111237924

SLAL:

111650192 111669127

XGL:	120791188(insrb) 120798578(insra)

HCQ:	109507385 109522033

SSCV:

125973398 125984519

SBIA:

133504092(insrb) 133511208(insra)

PEE:	133406145(insrb) 133411346(insra)

PTAO:

133481278(insrb) 133489349(insra)

BPEC:

110160177 110164155

MALB:

109955317 109967473

BSPL:

114844025(insra) 114854523(insrb)

SJO:	128362171(insrb) 128369270

SASA:

106560567 106583950 106600510

STRU:

115157526 115158830 115169288 115192162

OTW:	112226585 112251212 112251449 112260900

OMY:	100135870(insrb) 100135871 100136604 100272218

OGO:	123996566(insrb) 124009618 124037972

ONE:	115102893 115145273

OKI:	109872364 109874785 109879511 109898192

OKE:	118358912 118377063 118394862 118402477

SALP:

111956472 111979632

SNH:	120020095 120052701 120055081(insrb) 120056144

CCLU:

121534131 121535412(insra) 121540392 121581272

ELS:	105005877 105022623

SFM:	108919869 108921393

PKI:	111847562 111860235

AANG:

118225873(insrb) 118229991

LOC:	102696537(insr)

PSPA:

ARUT:

PSEX:

CMK:

CPLA:

HOC:

LERI:

PMRN:

LRJ:	133354143 133355163

BFO:

CIN:

SCLV:

LPIC:

GFS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

CPII:

CNS:	116337004 116348943

BCOO:

119076659 119079992 119079993

AME:	411297 725827(InR-2)

ACER:

108000589 108002859

ALAB:

122713199 122717260

ADR:	102675737 102678672

AFLR:

100866131 100871708

BIM:	100744431 100748223

BBIF:

117206482 117207938

BVK:	117234172 117236734

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:	122529705 122535333

CCAL:

108622672 108623880

OBB:	114872824 114872829

OLG:	117600336 117606071

MGEN:

NMEA:

CGIG:

PFUC:

VPS:

VCRB:

LBD:

CGLO:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:	124184530 124186473

NLO:	107217407 107223249

NVG:	124307776 124309268

AROA:

105688265 105688867

TCA:	661524(InR)

SOY:	115875018 115877509

AGRG:

126749108

CSET:

123322429

AGB:	108911096 108916914

LDC:	111509794 111510348 111518030

APLN:

108740223 108741146 108742676

PPYR:

116165466 116180279

OTU:	111413984 111414228

BMOR:

692560(InR)

BMAN:

114247231

MSEX:

115443779

DPL:	KGM_215776

BANY:

112052096

MJU:

123870062

NIQ:

126775688

VCD:	124535856 124543882

MCIX:

123657389 123661200

PMAC:

106717572

PPOT:

106100349 106108942

PXU:	106121812 106124280

PRAP:

111003916

PBX:

123716137

PNAP:

125050653

ZCE:	119829235 119832984

CCRC:

123692863

AAGE:

121730475

HAW:	110377777(inr)

HZE:

124634694

TNL:

113501838

SLIU:

111353383

OFU:	114351742 114355967

PXY:

CFEL:

CCRN:

ACOO:

DVT:	126893737 126904500

DCI:

103516039

HHAL:

106678822 106684431

NLU:

111047475

HVI:	124355122 124357607 124357734 124357735

MQU:	128985042 128986267 128986289 128986905 128996345

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

134528222 134528225 134542368

IEL:

124164938

DMK:	116918287 116918296

PJA:	122249520 122260807 122263862

PCHN:

125027976 125029419 125029918 125029920 125030009 125044057

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:	135195519 135211293 135222840 135225872

HAZT:

108676308

LSM:

121115991

TCF:	131879045 131879906

PPOI:

119098189 119103263

VDE:

111253591

VJA:

111262602

DFR:	124490982 124497719

ABRU:

129955414 129965729

UDV:	129216231 129228345

SDM:

118191077

LPOL:

106459994 106469453

PMEO:

129600977

CEL:	CELE_Y55D5A.5(daf-2)

CBR:	CBG_15732(Cbr-daf-2)

PVUL:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MCAF:

MMER:

123522998 123522999 123533007

RPHI:

132747199 132747200

DPOL:

127850915

OSN:

115209076

SMM:	Smp_009990

NVE:

5519848

ATEN:

116294618

XEN:

124454787

HSY:	130635420 130636619

TAD:	TRIADDRAFT_22855

» show all

Reference

PMID:2859121

Authors

Ebina Y, Ellis L, Jarnagin K, Edery M, Graf L, Clauser E, Ou JH, Masiarz F, Kan YW, Goldfine ID, et al.

Title

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.

Journal

Cell 40:747-58 (1985)
DOI:10.1016/0092-8674(85)90334-4

Sequence

[hsa:3643]

Reference

PMID:17347799

Authors

Youngren JF

Title

Regulation of insulin receptor function.

Journal

Cell Mol Life Sci 64:873-91 (2007)
DOI:10.1007/s00018-007-6359-9

Sequence

[rno:24954]

LinkDB

DBGET integrated database retrieval system