Ursus americanus (American black bear): 123777569 Help Entry 123777569         CDS       T07931                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism uar  Ursus americanus (American black bear) Pathway uar04010   MAPK signaling pathway uar04014   Ras signaling pathway uar04015   Rap1 signaling pathway uar04022   cGMP-PKG signaling pathway uar04066   HIF-1 signaling pathway uar04068   FoxO signaling pathway uar04072   Phospholipase D signaling pathway uar04150   mTOR signaling pathway uar04151   PI3K-Akt signaling pathway uar04152   AMPK signaling pathway uar04211   Longevity regulating pathway uar04213   Longevity regulating pathway - multiple species uar04520   Adherens junction uar04910   Insulin signaling pathway uar04913   Ovarian steroidogenesis uar04923   Regulation of lipolysis in adipocytes uar04930   Type II diabetes mellitus uar04931   Insulin resistance uar04932   Non-alcoholic fatty liver disease uar04960   Aldosterone-regulated sodium reabsorption uar05010   Alzheimer disease uar05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:uar00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     123777569 (INSR)    04014 Ras signaling pathway     123777569 (INSR)    04015 Rap1 signaling pathway     123777569 (INSR)    04066 HIF-1 signaling pathway     123777569 (INSR)    04068 FoxO signaling pathway     123777569 (INSR)    04072 Phospholipase D signaling pathway     123777569 (INSR)    04022 cGMP-PKG signaling pathway     123777569 (INSR)    04151 PI3K-Akt signaling pathway     123777569 (INSR)    04152 AMPK signaling pathway     123777569 (INSR)    04150 mTOR signaling pathway     123777569 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     123777569 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     123777569 (INSR)    04923 Regulation of lipolysis in adipocytes     123777569 (INSR)    04913 Ovarian steroidogenesis     123777569 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     123777569 (INSR)   09149 Aging    04211 Longevity regulating pathway     123777569 (INSR)    04213 Longevity regulating pathway - multiple species     123777569 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     123777569 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     123777569 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     123777569 (INSR)    04932 Non-alcoholic fatty liver disease     123777569 (INSR)    04931 Insulin resistance     123777569 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:uar01001]     123777569 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:uar04090]     123777569 (INSR) Enzymes [BR:uar01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      123777569 (INSR) Protein kinases [BR:uar01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    123777569 (INSR) CD molecules [BR:uar04090]  Proteins   123777569 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  123777569 NCBI-ProteinID:  XP_045630274 LinkDB All DBs Position Unknown AA seq 1381 aa AA seqDB search MGAGAGRGAATAPLLLAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKNSRRQG CHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQELRGC TVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELYELDYCLKGLKLPSRTWSPPFEAEGSQKHNQSEYEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFVPRKSSSSPGAEDTRPSRKRRALGDVANVTAAPPTVPGF PNTSTSAPTSPEEHKPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYVS ARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVS RRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIGP LIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPRE KITLLRELGQGSFGMVYEGDARDVVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGF TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAA EIADGMAYLNAKKFVHRDLAARNCMVAHDFTVRDGDFGMTRDIYETDYYRKGGKGLLPVR WMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNC PERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEMEF EDMESVPLDRASHSQREEAGGRDGGSSLGLKRNYEEHIPYTHMNGGKKNGRILTLPRSNP S NT seq 4146 nt NT seq  +upstreamnt  +downstreamnt atgggcgccggggctgggcggggggcggcgaccgcgccgctgctgctggcggtggccgcg ctgctgctgggtgccgcgggccacctgtaccccggagaggtgtgtcctggcatggatatc cggaacaacctcacgaggttgcatgagctggccaactgctcagtcatcgaaggacatttg cagatactgttgatgttcaaaacgaggcccgaggatttccgagacctcagtttccccaaa ctcatcatgatcaccgattacttgctgctcttccgggtctacgggctggagagcctgaag gacctgttccccaacctcacggtcatccggggatcgcgcctcttcttcaactacgcgctg gtcatcttcgagatggttcacttgaaggagcttggcctctatagcttgatgaacattacc aggggctccgtccgcatcgagaagaataatgagctctgctacctggccaccatcgactgg tcacgcatcctggattccgtggaggataattacattgtgctgaacaaagacgacaatgag gagtgtggggacatctgtccaggcactgcaaagggcaagaccaactgccctgccactgtc atcaacgggcagtttgtcgagaggtgttggacacacagccactgccagaaagtttgtccc accatctgcaagtcgcacggctgcaccgccgagggcctctgctgccacagcgagtgttta ggcaattgctccgagcccgatgaccccaccaagtgcgtggcctgtcgcaacttctacctg gatggcaggtgcgtggagacctgcccgcccccgtactaccacttccaagactggcgctgc gtgaacttcagcttctgccaggatttgcacaacaaatgcaagaactcccggagacagggc tgccaccagtacgtcattcacaataacaagtgcatccccgagtgcccctctggctacacg atgaattccagcaacctgatgtgcaccccatgcctgggcccctgtcccaaggtctgccac atcctggagggcgagaagaccatcgactcggtgacctctgcccaggagcttcgaggctgc actgttgtcaacggaagcctcatcatcaacattcgagggggcaacaacctggcagctgag ctggaggccaacctcggactcattgaagaaatttccgggtatctgaaaatccggagatcc tacgctcttgtgtccctttcctttttccggaagttacggctgattcgaggagagaccttg gaaatcgggaactactctttctacgccttggacaaccagaacctaaggcagctgtgggac tggagcaaacacaacctcaccatcactcaggggaagctcttcttccactataatcccaaa ctctgcttgtcggaaattcacaagatggaggaagtttcaggaaccaaggggcgccaggag aggaacgacattgccctgaagaccaatggggaccaggcgtcttgtgaaaatgaactcctt aaattttcttacattcggacatcatatgacaagatcttgctgaaatgggagccatactgg ccccctgacttccgagacctcctgggcttcatgcttttctacaaagaggccccttatcag aatgtgaccgagttcgacgggcaggacgcgtgtggctccaacagctggacggtggtggac attgacccgcctctgcggtccaatgaccccaagtcacagaaccacccagggtggctgatg cggggtctcaagccctggacccagtatgccatctttgtcaagaccttggtcaccttttct gatgaacgccgcacgtacggggccaagagtgacatcatctatgtgcagacagatgccact aacccttccgtccccctggatccaatctccgtctcgaattcctcatcccagattattctg aagtggaagcctccctctgaccccaacggcaacatcacacactacctggttttctgggag aggcaggcagaagacagtgagctgtatgaattggattattgcctcaaagggttgaagctg ccctcccgcacctggtctccgccgttcgaggccgagggctcgcagaagcacaaccagagt gagtacgaggagtctgccggcgagtgctgttcctgccccaagacggactctcagatcctc aaggagctggaggagtcctcgttcaggaagaccttcgaggattacctgcacaatgtggtg ttcgtccccagaaaatcctcttcaagccctggtgctgaggacactaggccatcgcggaaa cgcagggccctcggtgacgttgccaatgtgacggcggccccgcccacggttccgggtttc cccaacacctccaccagcgcacccacgagcccggaggagcacaagcccttcgagaaagtg gtgaacaaggaatccctggtcatctctgggctgcgtcacttcactggctaccgcatcgag ctgcaggcttgcaaccaagactccccagaggagaggtgcagcgtggcggcttatgtcagc gccaggaccatgcccgaagctaaggcagacgacattgttggccctgtgacccacgaaatc ttcgagaacaacgttgttcacttgatgtggcaggagccaaaggagcccaacggtctgatc gtgttgtatgaagtgagttaccgacgctacggtgatgaggagctgcacctctgtgtctcc cgcagacactttgctctggagcggggctgcaggctgcgtgggctgccgccggggaattac agcgtgcgagtccgggccacctccctggctggcaacggctcctggacagaagccacttac ttctacgtgacagactatttagatgtcccatcgaatattgcaaaaatcatcatcggcccc ctcatctttgtctttctcttcagtgttgtgattggaagtatttacctgttcctgagaaag aggcagccggatgggccactgggaccgctgtatgcttcttcaaaccctgagtacctcagt gcgagtgatgtgtttccatgttctgtgtatgtgccggacgagtgggaggtcccccgggag aagatcactctgctgcgtgagctggggcagggctccttcggcatggtgtatgaaggcgac gccagagacgtcgtcaagggcgaggcggagacccgcgtggcggtgaagacggtcaatgag tcggccagtctgcgggagaggatcgagtttctcaacgaggcctcggtcatgaagggcttc acctgtcatcacgtggtccgcctcctgggggtggtgtccaagggccagccgacgctggtg gtgatggagctgatggcccatggagacctgaagagctacctccgctccctgcggccggag gctgagaataaccccggccgccctccccctaccctgcaagagatgattcagatggcggcg gagatcgccgacgggatggcctacctgaacgccaagaagttcgtgcaccgggatctcgcg gcccgaaactgcatggtcgcccacgacttcaccgtgagagatggtgactttgggatgacc agagacatctatgaaacggattactaccggaaaggaggcaagggtctgctccccgtgcgg tggatggccccggaatccctgaaggacggggtctttaccacttcttctgacatgtggtcc tttggcgtggtcctttgggaaatcaccagcttggcagaacagccataccagggtctgtct aatgaacaggtgttgaaattcgtcatggatggagggtatctggatcaacccgacaattgt ccagagagagtcaccgacctgatgcgcatgtgctggcagttcaatcccaagatgcggccc accttcctggagatcgtcgacctgctcaaggacgacctgcaccccagctttccggaagtt tccttcttccatagcgaggagaacaaggcgcctgagagcgaggagctggagatggagttc gaggacatggagagtgtccccctggatcgggcctcacactctcagagggaggaggccggg ggccgggatggagggtcctccctgggcctcaagcgaaactacgaggagcacatcccctac acccacatgaacgggggcaagaaaaacggacggattctgactctgccgaggtcgaatcct tcctaa

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