Hylobates moloch (silvery gibbon): 116479486 Help Entry 116479486         CDS       T08803                                  Symbol INSR Name (RefSeq) insulin receptor   KO K04527   insulin receptor [EC:2.7.10.1] Organism hmh  Hylobates moloch (silvery gibbon) Pathway hmh04010   MAPK signaling pathway hmh04014   Ras signaling pathway hmh04015   Rap1 signaling pathway hmh04022   cGMP-PKG signaling pathway hmh04066   HIF-1 signaling pathway hmh04068   FoxO signaling pathway hmh04072   Phospholipase D signaling pathway hmh04150   mTOR signaling pathway hmh04151   PI3K-Akt signaling pathway hmh04152   AMPK signaling pathway hmh04211   Longevity regulating pathway hmh04213   Longevity regulating pathway - multiple species hmh04520   Adherens junction hmh04910   Insulin signaling pathway hmh04913   Ovarian steroidogenesis hmh04923   Regulation of lipolysis in adipocytes hmh04930   Type II diabetes mellitus hmh04931   Insulin resistance hmh04932   Non-alcoholic fatty liver disease hmh04960   Aldosterone-regulated sodium reabsorption hmh05010   Alzheimer disease hmh05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:hmh00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     116479486 (INSR)    04014 Ras signaling pathway     116479486 (INSR)    04015 Rap1 signaling pathway     116479486 (INSR)    04066 HIF-1 signaling pathway     116479486 (INSR)    04068 FoxO signaling pathway     116479486 (INSR)    04072 Phospholipase D signaling pathway     116479486 (INSR)    04022 cGMP-PKG signaling pathway     116479486 (INSR)    04151 PI3K-Akt signaling pathway     116479486 (INSR)    04152 AMPK signaling pathway     116479486 (INSR)    04150 mTOR signaling pathway     116479486 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     116479486 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     116479486 (INSR)    04923 Regulation of lipolysis in adipocytes     116479486 (INSR)    04913 Ovarian steroidogenesis     116479486 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     116479486 (INSR)   09149 Aging    04211 Longevity regulating pathway     116479486 (INSR)    04213 Longevity regulating pathway - multiple species     116479486 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     116479486 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     116479486 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     116479486 (INSR)    04932 Non-alcoholic fatty liver disease     116479486 (INSR)    04931 Insulin resistance     116479486 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hmh01001]     116479486 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:hmh04090]     116479486 (INSR) Enzymes [BR:hmh01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      116479486 (INSR) Protein kinases [BR:hmh01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    116479486 (INSR) CD molecules [BR:hmh04090]  Proteins   116479486 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  116479486 NCBI-ProteinID:  XP_058281730 EnsemblRapid:  ENSHMOG00005026298 LinkDB All DBs Position Unknown AA seq 1329 aa AA seqDB search MGTGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPLRSTDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELFELDYCLKGECGQLCWDWWGLHTKTSSGTGAEDPRPSRKRRSLGDVGNVTAA VPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEER CSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGD EELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSN IAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVP DEWEVPREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTL QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKG GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGG YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPE SEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRI LTLPRSNPS NT seq 3990 nt NT seq  +upstreamnt  +downstreamnt atgggcaccgggggccggcggggggcggcggcggcgccgctgctggtggcggtggccgcg ctgctattgggcgccgcgggccacctgtaccccggagaggtgtgtcccggcatggatatc cggaacaacctcactaggttgcatgagctggagaattgctctgtcatcgaaggacacttg cagatactcttgatgttcaaaacgaggcccgaagatttccgagacctcagtttccccaaa ctcataatgatcactgattacttgctgctcttccgtgtctatgggctcgagagcctgaag gacctgttccccaacctcacggtcatccggggatcacgactgttctttaactatgcgctg gtcatcttcgagatggttcacctcaaggaactcggcctctacaacctgatgaacatcacc cggggttctgtccgcatcgagaagaacaatgagctctgttacttggccactatcgactgg tcccgtatcctggattctgtggaggataattacatcgtattgaacaaagatgacaacgag gagtgtggagacatctgtccgggtaccgcgaagggcaaaaccaactgcccagccaccgtc atcaacgggcagtttgtcgaacggtgttggactcatagtcactgccagaaagtttgcccg accatctgtaagtcacatggctgcactgccgaaggcctctgttgccacagcgagtgcctg ggcaactgttctgagcccgatgaccccaccaagtgcgtggcctgccgcaacttctacctg gacggcagatgtgtggagacctgcccgcccccgtactaccacttccaggactggcgctgt gtgaacttcagcttctgccaggacctgcaccacaaatgcaagaactcgcggaggcagggt tgccaccagtacgtcattcacaacaacaagtgcatccctgagtgtccctccgggtacacg atgaattccagcaacttgctgtgcaccccatgcctgggtccctgtcccaaggtgtgccac ctcctagaaggcgagaagaccatcgactcggtgacgtctgcccaggagctccgaggatgc accgtcatcaacgggagtctgatcatcaacattcgaggaggcaacaatctggcagctgag ctagaagccaacctcggcctcattgaagaaatttcaggttatctaaaaatccgccgatcc tacgctctggtgtcactttccttcttccggaagttacgtctgattcgaggagagaccttg gaaatcgggaactactccttctatgccttggacaaccagaacctaaggcagctctgggat tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataaccccaaa ctctgcttgtcagaaatccacaagatggaagaagtttcaggaaccaaggggcgccaggag agaaatgacattgccctgaagaccaatggggaccaggcatcctgtgaaaatgagttactt aaattttcttacattcggacatcttttgacaagatcttgctgagatgggagccgtactgg ccccccgacttccgagacctcttggggttcatgctgttctacaaagaggccccttatcag aatgtgacggagttcgacgggcaggatgcgtgtggttccaacagttggacggtggtagac attgacccacccctgaggtccaccgaccccaaatctcagaaccacccaggatggctgatg cggggtctcaagccctggacccagtatgccatctttgtgaagaccctggtcaccttttcg gatgaacgccggacctatggggccaagagtgacatcatttatgtccagacagatgccacc aacccctccgtgcccctggatccaatctcagtgtctaactcatcatcccagattattctg aagtggaaacccccctccgaccccaatggcaacatcacccactacctggttttctgggag aggcaggcggaagacagtgagctgttcgagctggattattgcctcaaaggtgagtgcggg cagctgtgctgggattggtggggtttgcacacaaaaacctcttcaggcactggtgccgag gaccctaggccatctcggaaacgcaggtcccttggcgatgttgggaatgtgacggcagct gtgcccacggtggcagctttccccaacacttcctcaaccagcgtgcccacgagtccggag gagcacaggccctttgagaaggtggtgaacaaggagtcgctggtcatctccggcttgcga cacttcacgggctatcgcatcgagctgcaggcttgcaaccaagacacccctgaggaacgg tgcagtgtggcagcctacgtcagtgccaggaccatgcctgaagccaaggctgatgacatc gtcggccctgtgacgcacgaaatctttgagaacaacgtcgtccacttgatgtggcaggag ccgaaggagcccaatggtctgattgtgctgtatgaagtgagttatcggcgatatggcgat gaggagctgcatctctgcgtctcccgcaagcacttcgctctggaacggggctgcaggctg cgcgggctgtcgccggggaactacagcgtgcgagtccgggccacctccctcgcgggcaac ggctcctggacagaacccacctatttctacgtgacagactatttagatgtcccgtcaaat attgcaaaaattatcatcggccccctcatctttgtctttctcttcagtgttgtgattgga agtatttatctattcctgagaaagaggcagccagatgggccactgggaccactttacgct tcttcaaatcctgagtatctcagtgccagtgatgtgtttccatgctctgtgtacgtgccg gacgagtgggaggtgcctcgagagaagatcaccctccttcgagagctggggcagggctcc ttcggcatggtgtatgagggcaacgccagggacatcatcaagggtgaggcagagacccgc gtggcggtgaagacggtcaacgagtcagccagtctccgagagcggattgagttcctcaat gaggcctcggtcatgaagggcttcacctgccatcacgtggtgcgcctcctgggagtggtg tccaagggccagcccacgctggtggtgatggagctgatggctcacggagacctgaagagc tacctccgttctctgcggccagaggctgagaataatcctggccgccctccccctaccctg caagagatgattcagatggcggcagagattgctgacgggatggcctacctgaacgccaag aagtttgtgcatcgggacctggcagcgagaaactgcatggtcgcccatgattttactgtc aaaattggagactttggaatgaccagagacatctatgaaacggattactaccggaaaggg ggcaagggtctactccctgtacggtggatggcgccagagtccctgaaggatggggtcttt accacttcttctgacatgtggtcctttggcgtggtcctttgggaaatcaccagcttggca gaacagccttaccaaggcctgtctaatgaacaggtgttgaaatttgtcatggatggaggg tatctggatcaacctgacaactgtccagagagagtcactgacctcatgcgcatgtgctgg caattcaaccccaagatgaggccaaccttcctggagattgtcaacctgctcaaggacgac ctgcaccccagctttccggaggtgtcgttcttccacagcgaggagaacaaggctcccgag agtgaggagctggagatggagtttgaggacatggagaatgtgcccttggaccgttcctca cactgtcagagggaggaggcggggggccgggatggagggtcctcgctaggtttcaagcgg agctacgaggaacacatcccttacacacacatgaacggaggcaagaaaaacgggcggatt ctgaccttgcctcggtccaatccttcctaa

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