Homo sapiens (human): 148022
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Entry
148022 CDS
T01001
Symbol
TICAM1, IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF
Name
(RefSeq) TIR domain containing adaptor molecule 1
KO
K05842
toll-like receptor adapter molecule 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04064
NF-kappa B signaling pathway
hsa04217
Necroptosis
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04936
Alcoholic liver disease
hsa05133
Pertussis
hsa05135
Yersinia infection
hsa05142
Chagas disease
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05417
Lipid and atherosclerosis
Network
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166
Human papillomavirus (HPV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06263
Hepatocellular carcinoma
nt06517
TLR signaling
nt06527
Necroptosis
Element
N00148
TLR3-IRF7 signaling pathway
N00149
TLR3-IRF3 signaling pathway
N00516
HCV NS3/4A to TLR3-IRF3 signaling pathway
N00553
TLR4-IRF3/7 signaling pathway
N00555
HBV HBe to TLR4-IRF3/7 signaling pathway
N00563
TLR3-NFKB signaling pathway
N01633
TLR3-RIPK3 signaling pathway
N01634
TLR4-RIPK3 signaling pathway
Disease
H02536
Infection-induced acute encephalopathy
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
148022 (TICAM1)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
148022 (TICAM1)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
148022 (TICAM1)
04621 NOD-like receptor signaling pathway
148022 (TICAM1)
09160 Human Diseases
09161 Cancer: overview
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
148022 (TICAM1)
09172 Infectious disease: viral
05161 Hepatitis B
148022 (TICAM1)
05160 Hepatitis C
148022 (TICAM1)
05164 Influenza A
148022 (TICAM1)
05168 Herpes simplex virus 1 infection
148022 (TICAM1)
05167 Kaposi sarcoma-associated herpesvirus infection
148022 (TICAM1)
05165 Human papillomavirus infection
148022 (TICAM1)
09171 Infectious disease: bacterial
05135 Yersinia infection
148022 (TICAM1)
05133 Pertussis
148022 (TICAM1)
09174 Infectious disease: parasitic
05142 Chagas disease
148022 (TICAM1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
148022 (TICAM1)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
148022 (TICAM1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
TRIF-NTD
RHIM
TIR_2
DUF4335
Motif
Other DBs
NCBI-GeneID:
148022
NCBI-ProteinID:
NP_891549
OMIM:
607601
HGNC:
18348
Ensembl:
ENSG00000127666
UniProt:
Q8IUC6
Structure
PDB
LinkDB
All DBs
Position
19:complement(4815932..4831712)
Genome browser
AA seq
712 aa
AA seq
DB search
MACTGPSLPSAFDILGAAGQDKLLYLKHKLKTPRPGCQGQDLLHAMVLLKLGQETEARIS
LEALKADAVARLVARQWAGVDSTEDPEEPPDVSWAVARLYHLLAEEKLCPASLRDVAYQE
AVRTLSSRDDHRLGELQDEARNRCGWDIAGDPGSIRTLQSNLGCLPPSSALPSGTRSLPR
PIDGVSDWSQGCSLRSTGSPASLASNLEISQSPTMPFLSLHRSPHGPSKLCDDPQASLVP
EPVPGGCQEPEEMSWPPSGEIASPPELPSSPPPGLPEVAPDATSTGLPDTPAAPETSTNY
PVECTEGSAGPQSLPLPILEPVKNPCSVKDQTPLQLSVEDTTSPNTKPCPPTPTTPETSP
PPPPPPPSSTPCSAHLTPSSLFPSSLESSSEQKFYNFVILHARADEHIALRVREKLEALG
VPDGATFCEDFQVPGRGELSCLQDAIDHSAFIILLLTSNFDCRLSLHQVNQAMMSNLTRQ
GSPDCVIPFLPLESSPAQLSSDTASLLSGLVRLDEHSQIFARKVANTFKPHRLQARKAMW
RKEQDTRALREQSQHLDGERMQAAALNAAYSAYLQSYLSYQAQMEQLQVAFGSHMSFGTG
APYGARMPFGGQVPLGAPPPFPTWPGCPQPPPLHAWQAGTPPPPSPQPAAFPQSLPFPQS
PAFPTASPAPPQSPGLQPLIIHHAQMVQLGLNNHMWNQRGSQAPEDKTQEAE
NT seq
2139 nt
NT seq
+upstream
nt +downstream
nt
atggcctgcacaggcccatcacttcctagcgccttcgacattctaggtgcagcaggccag
gacaagctcttgtatctgaagcacaaactgaagaccccacgcccaggctgccaggggcag
gacctcctgcatgccatggttctcctgaagctgggccaggaaactgaggccaggatctct
ctagaggcattgaaggccgatgcggtggcccggctggtggcccgccagtgggctggcgtg
gacagcaccgaggacccagaggagcccccagatgtgtcctgggctgtggcccgcttgtac
cacctgctggctgaggagaagctgtgccccgcctcgctgcgggacgtggcctaccaggaa
gccgtccgcaccctcagctccagggacgaccaccggctgggggaacttcaggatgaggcc
cgaaaccggtgtgggtgggacattgctggggatccagggagcatccggacgctccagtcc
aatctgggctgcctcccaccatcctcggctttgccctctgggaccaggagcctcccacgc
cccattgacggtgtttcggactggagccaagggtgctccctgcgatccactggcagccct
gcctccctggccagcaacttggaaatcagccagtcccctaccatgcccttcctcagcctg
caccgcagcccacatgggcccagcaagctctgtgacgacccccaggccagcttggtgccc
gagcctgtccccggtggctgccaggagcctgaggagatgagctggccgccatcgggggag
attgccagcccaccagagctgccaagcagcccacctcctgggcttcccgaagtggcccca
gatgcaacctccactggcctccctgatacccccgcagctccagaaaccagcaccaactac
ccagtggagtgcaccgaggggtctgcaggcccccagtctctccccttgcctattctggag
ccggtcaaaaacccctgctctgtcaaagaccagacgccactccaactttctgtagaagat
accacctctccaaataccaagccgtgcccacctactcccaccaccccagaaacatcccct
cctcctcctcctcctcctccttcatctactccttgttcagctcacctgaccccctcctcc
ctgttcccttcctccctggaatcatcatcggaacagaaattctataactttgtgatcctc
cacgccagggcagacgaacacatcgccctgcgggttcgggagaagctggaggcccttggc
gtgcccgacggggccaccttctgcgaggatttccaggtgccggggcgcggggagctgagc
tgcctgcaggacgccatagaccactcagctttcatcatcctacttctcacctccaacttc
gactgtcgcctgagcctgcaccaggtgaaccaagccatgatgagcaacctcacgcgacag
gggtcgccagactgtgtcatccccttcctgcccctggagagctccccggcccagctcagc
tccgacacggccagcctgctctccgggctggtgcggctggacgaacactcccagatcttc
gccaggaaggtggccaacaccttcaagccccacaggcttcaggcccgaaaggccatgtgg
aggaaggaacaggacacccgagccctgcgggaacagagccaacacctggacggtgagcgg
atgcaggcggcggcactgaacgcagcctactcagcctacctccagagctacttgtcctac
caggcacagatggagcagctccaggtggcttttgggagccacatgtcatttgggactggg
gcgccctatggggctcgaatgccctttgggggccaggtgcccctgggagccccgccaccc
tttcccacttggccggggtgcccgcagccgccacccctgcacgcatggcaggctggcacc
cccccaccgccctccccacagccagcagcctttccacagtcactgcccttcccgcagtcc
ccagccttccctacggcctcacccgcaccccctcagagcccagggctgcaacccctcatt
atccaccacgcacagatggtacagctggggctgaacaaccacatgtggaaccagagaggg
tcccaggcgcccgaggacaagacgcaggaggcagaatga
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