KEGG   Homo sapiens (human): 1646
Entry
1646              CDS       T01001                                 
Symbol
AKR1C2, AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
Name
(RefSeq) aldo-keto reductase family 1 member C2
  KO
K00089  3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.213 1.1.1.357]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa01100  Metabolic pathways
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05208  Chemical carcinogenesis - reactive oxygen species
Module
hsa_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Network
nt06019  Steroid hormone biosynthesis
nt06226  KEAP1-NRF2 signaling (cancer)
nt06250  DNA adduct formation (cancer)
nt06251  CYP-mediated ROS formation (cancer)
  Element
N01381  NNK to DNA adducts
N01382  NNK to DNA adducts
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
N01413  Metals to KEAP1-NRF2 signalig pathway
N01802  Dihydrotestosterone biosynthesis
Disease
H00607  46,XY gonadal dysgenesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    1646 (AKR1C2)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    1646 (AKR1C2)
   05208 Chemical carcinogenesis - reactive oxygen species
    1646 (AKR1C2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     1646 (AKR1C2)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     1646 (AKR1C2)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 1646
NCBI-ProteinID: NP_001345
OMIM: 600450
HGNC: 385
Ensembl: ENSG00000151632
UniProt: P52895
Structure
LinkDB
Position
10:complement(4987775..5018000)
AA seq 323 aa
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY
NT seq 972 nt   +upstreamnt  +downstreamnt
atggattcgaaataccagtgtgtgaagctgaatgatggtcacttcatgcctgtcctggga
tttggcacctatgcgcctgcagaggttcctaaaagtaaagctctagaggccgtcaaattg
gcaatagaagccgggttccaccatattgattctgcacatgtttacaataatgaggagcag
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggagcaattcccatcgaccagagttggtccgaccagccttggaa
aggtcactgaaaaatcttcaattggactatgttgacctctatcttattcattttccagtg
tctgtaaagccaggtgaggaagtgatcccaaaagatgaaaatggaaaaatactatttgac
acagtggatctctgtgccacatgggaggccatggagaagtgtaaagatgcaggattggcc
aagtccatcggggtgtccaacttcaaccacaggctgctggagatgatcctcaacaagcca
gggctcaagtacaagcctgtctgcaaccaggtggaatgtcatccttacttcaaccagaga
aaactgctggatttctgcaagtcaaaagacattgttctggttgcctatagtgctctggga
tcccatcgagaagaaccatgggtggacccgaactccccggtgctcttggaggacccagtc
ctttgtgccttggcaaaaaagcacaagcgaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcgcatcagacagaac
gtgcaggtgtttgaattccagttgacttcagaggagatgaaagccatagatggcctaaac
agaaatgtgcgatatttgacccttgatatttttgctggcccccctaattatccattttct
gatgaatattaa

KEGG   Homo sapiens (human): 873
Entry
873               CDS       T01001                                 
Symbol
CBR1, CBR, PG-9-KR, SDR21C1, hCBR1
Name
(RefSeq) carbonyl reductase 1
  KO
K00079  carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa00790  Folate biosynthesis
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa01100  Metabolic pathways
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06250  DNA adduct formation (cancer)
  Element
N01381  NNK to DNA adducts
N01382  NNK to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    873 (CBR1)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    873 (CBR1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    873 (CBR1)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    873 (CBR1)
   05208 Chemical carcinogenesis - reactive oxygen species
    873 (CBR1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.184  carbonyl reductase (NADPH)
     873 (CBR1)
    1.1.1.189  prostaglandin-E2 9-reductase
     873 (CBR1)
    1.1.1.197  15-hydroxyprostaglandin dehydrogenase (NADP+)
     873 (CBR1)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR
Other DBs
NCBI-GeneID: 873
NCBI-ProteinID: NP_001748
OMIM: 114830
HGNC: 1548
Ensembl: ENSG00000159228
UniProt: P16152 A0A384NL53
Structure
LinkDB
Position
21:36070024..36073164
AA seq 277 aa
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
NT seq 834 nt   +upstreamnt  +downstreamnt
atgtcgtccggcatccatgtagcgctggtgactggaggcaacaagggcatcggcttggcc
atcgtgcgcgacctgtgccggctgttctcgggggacgtggtgctcacggcgcgggacgtg
acgcggggccaggcggccgtacagcagctgcaggcggagggcctgagcccgcgcttccac
cagctggacatcgacgatctgcagagcatccgcgccctgcgcgacttcctgcgcaaggag
tacgggggcctggacgtgctggtcaacaacgcgggcatcgccttcaaggttgctgatccc
acaccctttcatattcaagctgaagtgacgatgaaaacaaatttctttggtacccgagat
gtgtgcacagaattactccctctaataaaaccccaagggagagtggtgaacgtatctagc
atcatgagcgtcagagcccttaaaagctgcagcccagagctgcagcagaagttccgcagt
gagaccatcactgaggaggagctggtggggctcatgaacaagtttgtggaggatacaaag
aagggagtgcaccagaaggagggctggcccagcagcgcatacggggtgacgaagattggc
gtcaccgttctgtccaggatccacgccaggaaactgagtgagcagaggaaaggggacaag
atcctcctgaatgcctgctgcccagggtgggtgagaactgacatggcgggacccaaggcc
accaagagcccagaagaaggtgcagagacccctgtgtacttggcccttttgcccccagat
gctgagggtccccatggacaatttgtttcagagaagagagttgaacagtggtga

KEGG   Homo sapiens (human): 3290
Entry
3290              CDS       T01001                                 
Symbol
HSD11B1, 11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1
Name
(RefSeq) hydroxysteroid 11-beta dehydrogenase 1
  KO
K15680  corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa01100  Metabolic pathways
hsa05204  Chemical carcinogenesis - DNA adducts
Module
hsa_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Network
nt06019  Steroid hormone biosynthesis
nt06250  DNA adduct formation (cancer)
  Element
N00309  Cortisone reduction
N01381  NNK to DNA adducts
N01382  NNK to DNA adducts
Disease
H01111  Cortisone reductase deficiency
Drug target
Carbenoxolone (DG00024): D01899 D07615
Enoxolone: D00156<JP>
Glycyrrhizic acid (DG03217): D02028 D02264 D04987
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    3290 (HSD11B1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    3290 (HSD11B1)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    3290 (HSD11B1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.146  11beta-hydroxysteroid dehydrogenase
     3290 (HSD11B1)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR THF_DHG_CYH_C DUF1776 2-Hacid_dh_C Pyr_redox_2 Shikimate_DH Pyr_redox_3 NAD_binding_2 AdoHcyase_NAD
Other DBs
NCBI-GeneID: 3290
NCBI-ProteinID: NP_001193670
OMIM: 600713
HGNC: 5208
Ensembl: ENSG00000117594
UniProt: P28845 X5D2L1
Structure
LinkDB
Position
1:209686179..209734929
AA seq 292 aa
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
NT seq 879 nt   +upstreamnt  +downstreamnt
atggcttttatgaaaaaatatctcctccccattctggggctcttcatggcctactactac
tattctgcaaacgaggaattcagaccagagatgctccaaggaaagaaagtgattgtcaca
ggggccagcaaagggatcggaagagagatggcttatcatctggcgaagatgggagcccat
gtggtggtgacagcgaggtcaaaagaaactctacagaaggtggtatcccactgcctggag
cttggagcagcctcagcacactacattgctggcaccatggaagacatgaccttcgcagag
caatttgttgcccaagcaggaaagctcatgggaggactagacatgctcattctcaaccac
atcaccaacacttctttgaatctttttcatgatgatattcaccatgtgcgcaaaagcatg
gaagtcaacttcctcagttacgtggtcctgactgtagctgccttgcccatgctgaagcag
agcaatggaagcattgttgtcgtctcctctctggctgggaaagtggcttatccaatggtt
gctgcctattctgcaagcaagtttgctttggatgggttcttctcctccatcagaaaggaa
tattcagtgtccagggtcaatgtatcaatcactctctgtgttcttggcctcatagacaca
gaaacagccatgaaggcagtttctgggatagtccatatgcaagcagctccaaaggaggaa
tgtgccctggagatcatcaaagggggagctctgcgccaagaagaagtgtattatgacagc
tcactctggaccactcttctgatcagaaatccatgcaggaagatcctggaatttctctac
tcaacgagctataatatggacagattcataaacaagtag

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