Homo sapiens (human): 3932
Help
Entry
3932 CDS
T01001
Symbol
LCK, IMD22, LSK, YT16, p56lck, pp58lck
Name
(RefSeq) LCK proto-oncogene, Src family tyrosine kinase
KO
K05856
lymphocyte cell-specific protein tyrosine kinase [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04064
NF-kappa B signaling pathway
hsa04380
Osteoclast differentiation
hsa04650
Natural killer cell mediated cytotoxicity
hsa04658
Th1 and Th2 cell differentiation
hsa04659
Th17 cell differentiation
hsa04660
T cell receptor signaling pathway
hsa05135
Yersinia infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05340
Primary immunodeficiency
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06183
Yersinia
nt06537
TCR/BCR signaling
Element
N00511
HTLV-1 Tax to E47-mediated transcription
N01106
TCR-PLCG-ITPR signaling pathway
N01107
Yersinia YopH to TCR-NFAT signaling pathway
Disease
H00093
Combined immunodeficiency
Drug target
Dasatinib (
DG00714
):
D03658
<JP>
D06414
<JP/US>
D12609
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
3932 (LCK)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
3932 (LCK)
04660 T cell receptor signaling pathway
3932 (LCK)
04658 Th1 and Th2 cell differentiation
3932 (LCK)
04659 Th17 cell differentiation
3932 (LCK)
09158 Development and regeneration
04380 Osteoclast differentiation
3932 (LCK)
09160 Human Diseases
09161 Cancer: overview
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
3932 (LCK)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
3932 (LCK)
09171 Infectious disease: bacterial
05135 Yersinia infection
3932 (LCK)
09163 Immune disease
05340 Primary immunodeficiency
3932 (LCK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
3932 (LCK)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
3932 (LCK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
3932 (LCK)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
SRC family
3932 (LCK)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Centrosome formation proteins
Kinases and associated factors
3932 (LCK)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
SH3_1
SH3_2
SH3_9
ABC1
Haspin_kinase
SH3_3
SH3_16
Kdo
Motif
Other DBs
NCBI-GeneID:
3932
NCBI-ProteinID:
NP_001036236
OMIM:
153390
HGNC:
6524
Ensembl:
ENSG00000182866
UniProt:
P06239
A0A0S2Z3Y8
Structure
PDB
LinkDB
All DBs
Position
1:32251265..32286165
Genome browser
AA seq
509 aa
AA seq
DB search
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
NT seq
1530 nt
NT seq
+upstream
nt +downstream
nt
atgggctgtggctgcagctcacacccggaagatgactggatggaaaacatcgatgtgtgt
gagaactgccattatcccatagtcccactggatggcaagggcacgctgctcatccgaaat
ggctctgaggtgcgggacccactggttacctacgaaggctccaatccgccggcttcccca
ctgcaagacaacctggttatcgctctgcacagctatgagccctctcacgacggagatctg
ggctttgagaagggggaacagctccgcatcctggagcagagcggcgagtggtggaaggcg
cagtccctgaccacgggccaggaaggcttcatccccttcaattttgtggccaaagcgaac
agcctggagcccgaaccctggttcttcaagaacctgagccgcaaggacgcggagcggcag
ctcctggcgcccgggaacactcacggctccttcctcatccgggagagcgagagcaccgcg
ggatcgttttcactgtcggtccgggacttcgaccagaaccagggagaggtggtgaaacat
tacaagatccgtaatctggacaacggtggcttctacatctcccctcgaatcacttttccc
ggcctgcatgaactggtccgccattacaccaatgcttcagatgggctgtgcacacggttg
agccgcccctgccagacccagaagccccagaagccgtggtgggaggacgagtgggaggtt
cccagggagacgctgaagctggtggagcggctgggggctggacagttcggggaggtgtgg
atggggtactacaacgggcacacgaaggtggcggtgaagagcctgaagcagggcagcatg
tccccggacgccttcctggccgaggccaacctcatgaagcagctgcaacaccagcggctg
gttcggctctacgctgtggtcacccaggagcccatctacatcatcactgaatacatggag
aatgggagtctagtggattttctcaagaccccttcaggcatcaagttgaccatcaacaaa
ctcctggacatggcagcccaaattgcagaaggcatggcattcattgaagagcggaattat
attcatcgtgaccttcgggctgccaacattctggtgtctgacaccctgagctgcaagatt
gcagactttggcctagcacgcctcattgaggacaacgagtacacagccagggagggggcc
aagtttcccattaagtggacagcgccagaagccattaactacgggacattcaccatcaag
tcagatgtgtggtcttttgggatcctgctgacggaaattgtcacccacggccgcatccct
tacccagggatgaccaacccggaggtgattcagaacctggagcgaggctaccgcatggtg
cgccctgacaactgtccagaggagctgtaccaactcatgaggctgtgctggaaggagcgc
ccagaggaccggcccacctttgactacctgcgcagtgtgctggaggacttcttcacggcc
acagagggccagtaccagcctcagccttga
Homo sapiens (human): 2534
Help
Entry
2534 CDS
T01001
Symbol
FYN, SLK, SYN, p59-FYN
Name
(RefSeq) FYN proto-oncogene, Src family tyrosine kinase
KO
K05703
tyrosine-protein kinase Fyn [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04071
Sphingolipid signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04360
Axon guidance
hsa04380
Osteoclast differentiation
hsa04510
Focal adhesion
hsa04520
Adherens junction
hsa04611
Platelet activation
hsa04650
Natural killer cell mediated cytotoxicity
hsa04660
T cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04725
Cholinergic synapse
hsa05020
Prion disease
hsa05130
Pathogenic Escherichia coli infection
hsa05416
Viral myocarditis
Network
nt06180
Pathogenic Escherichia coli
nt06183
Yersinia
nt06465
Prion disease
nt06537
TCR/BCR signaling
Element
N01093
Escherichia EspJ/Tir to Actin signaling pathway
N01106
TCR-PLCG-ITPR signaling pathway
N01204
PRNP-PI3K-NOX2 signaling pathway
N01205
Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway
Drug target
Dasatinib (
DG00714
):
D03658
<JP>
D06414
<JP/US>
D12609
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04072 Phospholipase D signaling pathway
2534 (FYN)
04071 Sphingolipid signaling pathway
2534 (FYN)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
2534 (FYN)
04520 Adherens junction
2534 (FYN)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
2534 (FYN)
04650 Natural killer cell mediated cytotoxicity
2534 (FYN)
04660 T cell receptor signaling pathway
2534 (FYN)
04664 Fc epsilon RI signaling pathway
2534 (FYN)
09156 Nervous system
04725 Cholinergic synapse
2534 (FYN)
09158 Development and regeneration
04360 Axon guidance
2534 (FYN)
04380 Osteoclast differentiation
2534 (FYN)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
2534 (FYN)
09164 Neurodegenerative disease
05020 Prion disease
2534 (FYN)
09166 Cardiovascular disease
05416 Viral myocarditis
2534 (FYN)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
2534 (FYN)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
2534 (FYN)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
2534 (FYN)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
SRC family
2534 (FYN)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
2534 (FYN)
Endocytosis
Lipid raft mediated endocytosis
Flotillin-dependent endocytosis
2534 (FYN)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
SH3_1
SH3_9
SH3_2
SH3_10
SH3_3
Haspin_kinase
ABC1
zf-RING_14
Motif
Other DBs
NCBI-GeneID:
2534
NCBI-ProteinID:
NP_002028
OMIM:
137025
HGNC:
4037
Ensembl:
ENSG00000010810
UniProt:
P06241
Structure
PDB
LinkDB
All DBs
Position
6:complement(111660332..111873452)
Genome browser
AA seq
537 aa
AA seq
DB search
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
NT seq
1614 nt
NT seq
+upstream
nt +downstream
nt
atgggctgtgtgcaatgtaaggataaagaagcaacaaaactgacggaggagagggacggc
agcctgaaccagagctctgggtaccgctatggcacagaccccacccctcagcactacccc
agcttcggtgtgacctccatccccaactacaacaacttccacgcagccgggggccaagga
ctcaccgtctttggaggtgtgaactcttcgtctcatacggggaccttgcgtacgagagga
ggaacaggagtgacactctttgtggccctttatgactatgaagcacggacagaagatgac
ctgagttttcacaaaggagaaaaatttcaaatattgaacagctcggaaggagattggtgg
gaagcccgctccttgacaactggagagacaggttacattcccagcaattatgtggctcca
gttgactctatccaggcagaagagtggtactttggaaaacttggccgaaaagatgctgag
cgacagctattgtcctttggaaacccaagaggtacctttcttatccgcgagagtgaaacc
accaaaggtgcctattcactttctatccgtgattgggatgatatgaaaggagaccatgtc
aaacattataaaattcgcaaacttgacaatggtggatactacattaccacccgggcccag
tttgaaacacttcagcagcttgtacaacattactcagagagagctgcaggtctctgctgc
cgcctagtagttccctgtcacaaagggatgccaaggcttaccgatctgtctgtcaaaacc
aaagatgtctgggaaatccctcgagaatccctgcagttgatcaagagactgggaaatggg
cagtttggggaagtatggatgggtacctggaatggaaacacaaaagtagccataaagact
cttaaaccaggcacaatgtcccccgaatcattccttgaggaagcgcagatcatgaagaag
ctgaagcacgacaagctggtccagctctatgcagtggtgtctgaggagcccatctacatc
gtcaccgagtatatgaacaaaggaagtttactggatttcttaaaagatggagaaggaaga
gctctgaaattaccaaatcttgtggacatggcagcacaggtggctgcaggaatggcttac
atcgagcgcatgaattatatccatagagatctgcgatcagcaaacattctagtggggaat
ggactcatatgcaagattgctgacttcggattggcccgattgatagaagacaatgagtac
acagcaagacaaggtgcaaagttccccatcaagtggacggcccccgaggcagccctgtac
gggaggttcacaatcaagtctgacgtgtggtcttttggaatcttactcacagagctggtc
accaaaggaagagtgccatacccaggcatgaacaaccgggaggtgctggagcaggtggag
cgaggctacaggatgccctgcccgcaggactgccccatctctctgcatgagctcatgatc
cactgctggaaaaaggaccctgaagaacgccccacttttgagtacttgcagagcttcctg
gaagactactttaccgcgacagagccccagtaccaacctggtgaaaacctgtaa
Homo sapiens (human): 7535
Help
Entry
7535 CDS
T01001
Symbol
ZAP70, ADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70
Name
(RefSeq) zeta chain of T cell receptor associated protein kinase 70
KO
K07360
tyrosine-protein kinase ZAP-70 [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04014
Ras signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa04658
Th1 and Th2 cell differentiation
hsa04659
Th17 cell differentiation
hsa04660
T cell receptor signaling pathway
hsa05135
Yersinia infection
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05340
Primary immunodeficiency
Network
nt06183
Yersinia
nt06537
TCR/BCR signaling
Element
N01106
TCR-PLCG-ITPR signaling pathway
Disease
H00093
Combined immunodeficiency
H02540
Infantile-onset multisystem autoimmune disease
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
7535 (ZAP70)
04064 NF-kappa B signaling pathway
7535 (ZAP70)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
7535 (ZAP70)
04660 T cell receptor signaling pathway
7535 (ZAP70)
04658 Th1 and Th2 cell differentiation
7535 (ZAP70)
04659 Th17 cell differentiation
7535 (ZAP70)
09160 Human Diseases
09161 Cancer: overview
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
7535 (ZAP70)
09171 Infectious disease: bacterial
05135 Yersinia infection
7535 (ZAP70)
09163 Immune disease
05340 Primary immunodeficiency
7535 (ZAP70)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
7535 (ZAP70)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
7535 (ZAP70)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
SYK family
7535 (ZAP70)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
ABC1
Haspin_kinase
Kdo
Motif
Other DBs
NCBI-GeneID:
7535
NCBI-ProteinID:
NP_001070
OMIM:
176947
HGNC:
12858
Ensembl:
ENSG00000115085
UniProt:
P43403
Structure
PDB
LinkDB
All DBs
Position
2:97713576..97756364
Genome browser
AA seq
619 aa
AA seq
DB search
MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP
IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD
AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT
SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR
KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG
PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF
GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY
KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL
ASKVEGPPGSTQKAEAACA
NT seq
1860 nt
NT seq
+upstream
nt +downstream
nt
atgccagaccccgcggcgcacctgcccttcttctacggcagcatctcgcgtgccgaggcc
gaggagcacctgaagctggcgggcatggcggacgggctcttcctgctgcgccagtgcctg
cgctcgctgggcggctatgtgctgtcgctcgtgcacgatgtgcgcttccaccactttccc
atcgagcgccagctcaacggcacctacgccattgccggcggcaaagcgcactgtggaccg
gcagagctctgcgagttctactcgcgcgaccccgacgggctgccctgcaacctgcgcaag
ccgtgcaaccggccgtcgggcctcgagccgcagccgggggtcttcgactgcctgcgagac
gccatggtgcgtgactacgtgcgccagacgtggaagctggagggcgaggccctggagcag
gccatcatcagccaggccccgcaggtggagaagctcattgctacgacggcccacgagcgg
atgccctggtaccacagcagcctgacgcgtgaggaggccgagcgcaaactttactctggg
gcgcagaccgacggcaagttcctgctgaggccgcggaaggagcagggcacatacgccctg
tccctcatctatgggaagacggtgtaccactacctcatcagccaagacaaggcgggcaag
tactgcattcccgagggcaccaagtttgacacgctctggcagctggtggagtatctgaag
ctgaaggcggacgggctcatctactgcctgaaggaggcctgccccaacagcagtgccagc
aacgcctcaggggctgctgctcccacactcccagcccacccatccacgttgactcatcct
cagagacgaatcgacaccctcaactcagatggatacacccctgagccagcacgcataacg
tccccagacaaaccgcggccgatgcccatggacacgagcgtgtatgagagcccctacagc
gacccagaggagctcaaggacaagaagctcttcctgaagcgcgataacctcctcatagct
gacattgaacttggctgcggcaactttggctcagtgcgccagggcgtgtaccgcatgcgc
aagaagcagatcgacgtggccatcaaggtgctgaagcagggcacggagaaggcagacacg
gaagagatgatgcgcgaggcgcagatcatgcaccagctggacaacccctacatcgtgcgg
ctcattggcgtctgccaggccgaggccctcatgctggtcatggagatggctgggggcggg
ccgctgcacaagttcctggtcggcaagagggaggagatccctgtgagcaatgtggccgag
ctgctgcaccaggtgtccatggggatgaagtacctggaggagaagaactttgtgcaccgt
gacctggcggcccgcaacgtcctgctggttaaccggcactacgccaagatcagcgacttt
ggcctctccaaagcactgggtgccgacgacagctactacactgcccgctcagcagggaag
tggccgctcaagtggtacgcacccgaatgcatcaacttccgcaagttctccagccgcagc
gatgtctggagctatggggtcaccatgtgggaggccttgtcctacggccagaagccctac
aagaagatgaaagggccggaggtcatggccttcatcgagcagggcaagcggatggagtgc
ccaccagagtgtccacccgaactgtacgcactcatgagtgactgctggatctacaagtgg
gaggatcgccccgacttcctgaccgtggagcagcgcatgcgagcctgttactacagcctg
gccagcaaggtggaagggcccccaggcagcacacagaaggctgaggctgcctgtgcctga
DBGET
integrated database retrieval system
