KEGG   Homo sapiens (human): 84557
Entry
84557             CDS       T01001                                 
Symbol
MAP1LC3A, ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3
Name
(RefSeq) microtubule associated protein 1 light chain 3 alpha
  KO
K10435  microtubule-associated protein 1 light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04216  Ferroptosis
hsa04371  Apelin signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06182  Shigella
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
  Element
N00156  Autophagy-vesicle nucleation/elongation/maturation, LC3-II formation
N01137  PINK-Parkin-mediated autophagosome formation
N01139  Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01721  Autophagosome and lysosome fusion, tethering factor
N01722  Autophagosome and lysosome fusion, tethering factor, GRASP55
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    84557 (MAP1LC3A)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    84557 (MAP1LC3A)
   04137 Mitophagy - animal
    84557 (MAP1LC3A)
  09143 Cell growth and death
   04216 Ferroptosis
    84557 (MAP1LC3A)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    84557 (MAP1LC3A)
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    84557 (MAP1LC3A)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    84557 (MAP1LC3A)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    84557 (MAP1LC3A)
   05022 Pathways of neurodegeneration - multiple diseases
    84557 (MAP1LC3A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    84557 (MAP1LC3A)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    84557 (MAP1LC3A)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    84557 (MAP1LC3A)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    84557 (MAP1LC3A)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Other mitophagy factors
    84557 (MAP1LC3A)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Microtubule-associated proteins (MAPs)
     84557 (MAP1LC3A)
SSDB
Motif
Pfam: ATG8 APG12
Other DBs
NCBI-GeneID: 84557
NCBI-ProteinID: NP_115903
OMIM: 601242
HGNC: 6838
Ensembl: ENSG00000101460
UniProt: Q9H492
Structure
LinkDB
Position
20:34546844..34560345
AA seq 121 aa
MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM
SELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFG
F
NT seq 366 nt   +upstreamnt  +downstreamnt
atgccctcagaccggcctttcaagcagcggcggagcttcgccgaccgctgtaaggaggta
cagcagatccgcgaccagcaccccagcaaaatcccggtgatcatcgagcgctacaagggt
gagaagcagctgcccgtcctggacaagaccaagtttttggtcccggaccatgtcaacatg
agcgagttggtcaagatcatccggcgccgcctgcagctgaaccccacgcaggccttcttc
ctgctggtgaaccagcacagcatggtgagtgtgtccacgcccatcgcggacatctacgag
caggagaaagacgaggacggcttcctctatatggtctacgcctcccaggaaaccttcggc
ttctga

KEGG   Homo sapiens (human): 81631
Entry
81631             CDS       T01001                                 
Symbol
MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a
Name
(RefSeq) microtubule associated protein 1 light chain 3 beta
  KO
K10435  microtubule-associated protein 1 light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04216  Ferroptosis
hsa04371  Apelin signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06182  Shigella
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
  Element
N00156  Autophagy-vesicle nucleation/elongation/maturation, LC3-II formation
N01137  PINK-Parkin-mediated autophagosome formation
N01139  Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01721  Autophagosome and lysosome fusion, tethering factor
N01722  Autophagosome and lysosome fusion, tethering factor, GRASP55
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    81631 (MAP1LC3B)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    81631 (MAP1LC3B)
   04137 Mitophagy - animal
    81631 (MAP1LC3B)
  09143 Cell growth and death
   04216 Ferroptosis
    81631 (MAP1LC3B)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    81631 (MAP1LC3B)
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    81631 (MAP1LC3B)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    81631 (MAP1LC3B)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    81631 (MAP1LC3B)
   05022 Pathways of neurodegeneration - multiple diseases
    81631 (MAP1LC3B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    81631 (MAP1LC3B)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    81631 (MAP1LC3B)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    81631 (MAP1LC3B)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    81631 (MAP1LC3B)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Other mitophagy factors
    81631 (MAP1LC3B)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Microtubule-associated proteins (MAPs)
     81631 (MAP1LC3B)
SSDB
Motif
Pfam: ATG8 APG12 Rad60-SLD
Other DBs
NCBI-GeneID: 81631
NCBI-ProteinID: NP_073729
OMIM: 609604
HGNC: 13352
Ensembl: ENSG00000140941
UniProt: Q9GZQ8 Q658J6
Structure
LinkDB
Position
16:87392336..87404774
AA seq 125 aa
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM
SELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFG
MKLSV
NT seq 378 nt   +upstreamnt  +downstreamnt
atgccgtcggagaagaccttcaagcagcgccgcaccttcgaacaaagagtagaagatgtc
cgacttattcgagagcagcatccaaccaaaatcccggtgataatagaacgatacaagggt
gagaagcagcttcctgttctggataaaacaaagttccttgtacctgaccatgtcaacatg
agtgagctcatcaagataattagaaggcgcttacagctcaatgctaatcaggccttcttc
ctgttggtgaacggacacagcatggtcagcgtctccacaccaatctcagaggtgtatgag
agtgagaaagatgaagatggattcctgtacatggtctatgcctcccaggagacgttcggg
atgaaattgtcagtgtaa

KEGG   Homo sapiens (human): 643246
Entry
643246            CDS       T01001                                 
Symbol
MAP1LC3B2, ATG8G
Name
(RefSeq) microtubule associated protein 1 light chain 3 beta 2
  KO
K10435  microtubule-associated protein 1 light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04216  Ferroptosis
hsa04371  Apelin signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06182  Shigella
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
  Element
N00156  Autophagy-vesicle nucleation/elongation/maturation, LC3-II formation
N01137  PINK-Parkin-mediated autophagosome formation
N01139  Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01721  Autophagosome and lysosome fusion, tethering factor
N01722  Autophagosome and lysosome fusion, tethering factor, GRASP55
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    643246 (MAP1LC3B2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    643246 (MAP1LC3B2)
   04137 Mitophagy - animal
    643246 (MAP1LC3B2)
  09143 Cell growth and death
   04216 Ferroptosis
    643246 (MAP1LC3B2)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    643246 (MAP1LC3B2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    643246 (MAP1LC3B2)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    643246 (MAP1LC3B2)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    643246 (MAP1LC3B2)
   05022 Pathways of neurodegeneration - multiple diseases
    643246 (MAP1LC3B2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    643246 (MAP1LC3B2)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    643246 (MAP1LC3B2)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    643246 (MAP1LC3B2)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    643246 (MAP1LC3B2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Other mitophagy factors
    643246 (MAP1LC3B2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Microtubule-associated proteins (MAPs)
     643246 (MAP1LC3B2)
SSDB
Motif
Pfam: ATG8 APG12 Rad60-SLD ATG5_UblB
Other DBs
NCBI-GeneID: 643246
NCBI-ProteinID: NP_001078950
OMIM: 620673
HGNC: 34390
Ensembl: ENSG00000258102
UniProt: A6NCE7
LinkDB
Position
12:116559381..116576606
AA seq 125 aa
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM
SELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVCASQETFG
MKLSV
NT seq 378 nt   +upstreamnt  +downstreamnt
atgccgtcggagaagaccttcaagcagcggcgcaccttcgaacaaagagtagaagatgtc
cgacttattcgagagcagcatccaaccaaaatcccggtgataatagaacgatacaagggt
gagaagcagcttcctgttctggataaaacaaagttccttgtacctgaccatgtcaacatg
agtgagctcatcaagataattagaaggcgcttacagctcaatgctaatcaggccttcttc
ctgttggtgaacggacacagcatggtcagcgtctccacaccaatctcagaggtgtatgag
agtgagaaagatgaagatggattcctgtacatggtctgtgcctcccaggagacgttcggg
atgaaattgtcagtgtaa

KEGG   Homo sapiens (human): 440738
Entry
440738            CDS       T01001                                 
Symbol
MAP1LC3C, ATG8J, LC3C
Name
(RefSeq) microtubule associated protein 1 light chain 3 gamma
  KO
K10435  microtubule-associated protein 1 light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04216  Ferroptosis
hsa04371  Apelin signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06182  Shigella
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
  Element
N00156  Autophagy-vesicle nucleation/elongation/maturation, LC3-II formation
N01137  PINK-Parkin-mediated autophagosome formation
N01139  Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01721  Autophagosome and lysosome fusion, tethering factor
N01722  Autophagosome and lysosome fusion, tethering factor, GRASP55
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    440738 (MAP1LC3C)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    440738 (MAP1LC3C)
   04137 Mitophagy - animal
    440738 (MAP1LC3C)
  09143 Cell growth and death
   04216 Ferroptosis
    440738 (MAP1LC3C)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    440738 (MAP1LC3C)
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    440738 (MAP1LC3C)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    440738 (MAP1LC3C)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    440738 (MAP1LC3C)
   05022 Pathways of neurodegeneration - multiple diseases
    440738 (MAP1LC3C)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    440738 (MAP1LC3C)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    440738 (MAP1LC3C)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    440738 (MAP1LC3C)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    440738 (MAP1LC3C)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Other mitophagy factors
    440738 (MAP1LC3C)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Microtubule-associated proteins (MAPs)
     440738 (MAP1LC3C)
SSDB
Motif
Pfam: ATG8 APG12
Other DBs
NCBI-GeneID: 440738
NCBI-ProteinID: NP_001004343
OMIM: 609605
HGNC: 13353
Ensembl: ENSG00000197769
UniProt: Q9BXW4
Structure
LinkDB
Position
1:complement(241995490..242001393)
AA seq 147 aa
MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLV
PQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYA
SQETFGCLESAAPRDGSSLEDRPCNPL
NT seq 444 nt   +upstreamnt  +downstreamnt
atgccgcctccacagaaaatcccaagcgtcagacccttcaagcagaggaaaagcttggca
atcagacaagaggaagttgctggaatccgggcaaagttccccaacaaaatcccggtggta
gtggagcgctaccccagggagacgttcctgcccccgctggacaaaaccaagttcctggtc
ccgcaggagctgaccatgacccagttcctcagcatcatccggagccgcatggtcctgaga
gccacggaagccttttacttgctggtgaacaacaagagcctggtcagcatgagcgcaacc
atggcagagatctacagagactacaaggatgaggatggcttcgtgtacatgacctacgcc
tcccaggagacatttggctgcctggagtcagcagcccccagggatgggagcagccttgag
gacagaccctgcaatcctctctag

KEGG   COMPOUND: C00350
Entry
C00350                      Compound                               
Name
Phosphatidylethanolamine;
(3-Phosphatidyl)ethanolamine;
(3-Phosphatidyl)-ethanolamine;
Cephalin;
O-(1-beta-Acyl-2-acyl-sn-glycero-3-phospho)ethanolamine;
1-Acyl-2-acyl-sn-glycero-3-phosphoethanolamine;
L-1-Phosphatidylethanolamine
Formula
C7H12NO8PR2
Structure
Remark
ATC code: A05BA10
Comment
Generic compound in reaction hierarchy
Reaction
R02051 R02052 R02053 R02054 R02055 R02056 R02057 R04480
R04864 R05923 R05924 R07376 R08107 R11062 R11204 R11205
R11555 R11556 R11557 R12202 R12351 R12702
Pathway
map00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
map00564  Glycerophospholipid metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04136  Autophagy - other
map04138  Autophagy - yeast
map04140  Autophagy - animal
map04723  Retrograde endocannabinoid signaling
map05130  Pathogenic Escherichia coli infection
map05167  Kaposi sarcoma-associated herpesvirus infection
Module
M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC
M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE
M00093  Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06182  Shigella
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
Enzyme
2.1.1.17        2.3.1.23        2.3.1.40        2.7.8.1         
2.7.8.29        2.7.8.42        2.7.8.43        2.7.8.-         
2.7.-.-         3.1.1.4         3.1.1.32        3.1.4.3         
3.1.4.4         4.1.1.65
Brite
Compounds with biological roles [BR:br08001]
 Lipids
  Phospholipids
   Glycerophospholipids
    C00350  Phosphatidylethanolamine
Lipids [BR:br08002]
 GP  Glycerophospholipids
  GP02 Glycerophosphoethanolamines
   GP0201 Diacylglycerophosphoethanolamines
    C00350  1-Acyl-2-acyl-sn-glycero-3-phosphoethanolamine
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A05 BILE AND LIVER THERAPY
   A05B LIVER THERAPY, LIPOTROPICS
    A05BA Liver therapy
     A05BA10 Phospholipids
      C00350  Phosphatidylethanolamine
Other DBs
CAS: 39382-08-6
PubChem: 3643
ChEBI: 16038
LinkDB
KCF data

ATOM        19
            1   C1c C    24.0320  -15.8183
            2   C1b C    24.0437  -17.6595
            3   C1b C    24.0437  -14.0877
            4   O7a O    22.4646  -15.8473
            5   O2b O    25.3780  -17.6595
            6   O7a O    25.3780  -14.0877
            7   C7a C    21.1302  -15.8473
            8   P1b P    26.7064  -17.6595
            9   C7a C    26.7064  -14.0877
            10  O6a O    21.1245  -14.5072
            11  R   R    19.8017  -15.8473
            12  O2b O    28.0408  -17.6595
            13  O1c O    26.7707  -18.9996
            14  O1c O    26.7064  -16.2727
            15  O6a O    26.7707  -12.7534
            16  R   R    28.0408  -14.0877
            17  C1b C    29.1946  -16.9952
            18  C1b C    30.3541  -17.6595
            19  N1a N    31.5077  -16.9952
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     6   9 1
            9     7  10 2
            10    7  11 1
            11    8  12 1
            12    8  13 1
            13    8  14 2
            14    9  15 2
            15    9  16 1
            16   12  17 1
            17   17  18 1
            18   18  19 1

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