KEGG   Homo sapiens (human): 9212
Entry
9212              CDS       T01001                                 
Symbol
AURKB, AIK2, AIM-1, AIM1, ARK-2, ARK2, AurB, IPL1, PPP1R48, STK-1, STK12, STK5, aurkb-sv1, aurkb-sv2
Name
(RefSeq) aurora kinase B
  KO
K11479  aurora kinase B [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
hsa04110  Cell cycle
Network
nt06512  Chromosome cohesion and segregation
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01485  Cohesin dissociation in prophase
N01499  Modifying of condensin II subunits
N01500  Modifying of condensin I subunits
N01526  Organization of the outer kinetochore
N01529  Recruitment and formation of the MCC
N01531  CENPE interaction with NDC80 complex
N01536  Dephosphorylation of kinetochore
N01561  Microtubule depolymerization
N01563  Inhibition of Kif2A
Drug target
Ilorasertib: D10423
Tinengotinib: D12545
Tozasertib (DG01365): D08279 D08344
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    9212 (AURKB)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    9212 (AURKB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    9212 (AURKB)
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    9212 (AURKB)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    9212 (AURKB)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     9212 (AURKB)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  AUR family [OT]
   9212 (AURKB)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     9212 (AURKB)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CPC (chromosomal passenger complex)
     9212 (AURKB)
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     9212 (AURKB)
  Sister chromatid separation proteins
   Aurora kinases
    9212 (AURKB)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1
Other DBs
NCBI-GeneID: 9212
NCBI-ProteinID: NP_001300879
OMIM: 604970
HGNC: 11390
Ensembl: ENSG00000178999
UniProt: Q96GD4
Structure
LinkDB
Position
17:complement(8204731..8210575)
AA seq 344 aa
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
NT seq 1035 nt   +upstreamnt  +downstreamnt
atggcccagaaggagaactcctacccctggccctacggccgacagacggctccatctggc
ctgagcaccctgccccagcgagtcctccggaaagagcctgtcaccccatctgcacttgtc
ctcatgagccgctccaatgtccagcccacagctgcccctggccagaaggtgatggagaat
agcagtgggacacccgacatcttaacgcggcacttcacaattgatgactttgagattggg
cgtcctctgggcaaaggcaagtttggaaacgtgtacttggctcgggagaagaaaagccat
ttcatcgtggcgctcaaggtcctcttcaagtcccagatagagaaggagggcgtggagcat
cagctgcgcagagagatcgaaatccaggcccacctgcaccatcccaacatcctgcgtctc
tacaactatttttatgaccggaggaggatctacttgattctagagtatgccccccgcggg
gagctctacaaggagctgcagaagagctgcacatttgacgagcagcgaacagccacgatc
atggaggagttggcagatgctctaatgtactgccatgggaagaaggtgattcacagagac
ataaagccagaaaatctgctcttagggctcaagggagagctgaagattgctgacttcggc
tggtctgtgcatgcgccctccctgaggaggaagacaatgtgtggcaccctggactacctg
cccccagagatgattgaggggcgcatgcacaatgagaaggtggatctgtggtgcattgga
gtgctttgctatgagctgctggtggggaacccaccctttgagagtgcatcacacaacgag
acctatcgccgcatcgtcaaggtggacctaaagttccccgcttccgtgcccatgggagcc
caggacctcatctccaaactgctcaggcataacccctcggaacggctgcccctggcccag
gtctcagcccacccttgggtccgggccaactctcggagggtgctgcctccctctgccctt
caatctgtcgcctga

KEGG   Homo sapiens (human): 3619
Entry
3619              CDS       T01001                                 
Symbol
INCENP
Name
(RefSeq) inner centromere protein
  KO
K11515  inner centromere protein
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01526  Organization of the outer kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    3619 (INCENP)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CPC (chromosomal passenger complex)
     3619 (INCENP)
SSDB
Motif
Pfam: INCENP_N INCENP_ARK-bind
Other DBs
NCBI-GeneID: 3619
NCBI-ProteinID: NP_001035784
OMIM: 604411
HGNC: 6058
Ensembl: ENSG00000149503
UniProt: Q9NQS7
Structure
LinkDB
Position
11:62124011..62153169
AA seq 918 aa
MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP
SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV
LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE
QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP
QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS
QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE
RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS
SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS
SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQ
RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE
QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH
QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA
EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA
KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRK
PIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSP
PLQGARVPSSLAYSLKKH
NT seq 2757 nt   +upstreamnt  +downstreamnt
atggggacgacggccccagggcccattcacctgctggagctatgtgaccagaagctcatg
gagtttctctgcaacatggataataaggacttggtgtggcttgaggaaatccaagaggag
gccgagcgcatgttcaccagagaattcagcaaagagccagagctgatgcccaaaacacct
tctcagaagaaccgacggaagaagagacggatttcttatgttcaggatgaaaacagagat
cccatcaggagaaggttatcccgcagaaagtctcggagcagccagctgagctcccgacgc
ctccgcagcaaggacagtgtagagaagctggctacagtggtcggggagaacggctccgtc
ctgcggcgtgtgacccgtgctgcggctgcagctgccgcggctaccatggcattggctgca
ccttcttcacccacccctgagtctcccacgatgctgactaagaagcccgaggataaccac
acccagtgccagctggtgcctgtggtggagatcggcatcagtgagcgccagaatgctgag
cagcatgtcacccagctcatgtccaccgagcctctgccccgcactctgtccccgactcca
gcttcagccacagctccaacctcccagggcatcccgacatcagatgaggaatcaacacct
aagaagtcgaaggccaggatactggagtccatcacagtgagctccctgatggctacaccc
caggaccccaagggtcaaggggtcgggacggggcggtctgcgtctaagctcaggattgcg
caggtctcccctggcccacgggactcgccagcctttccagattctccatggcgggagcgg
gtgctggctcccatcctgccggataacttctccacgcccacgggctctcgcacggactct
caatcggtgcggcacagcccgatcgccccgtcttccccgagtccccaagtcttagcccag
aagtactctctggtggccaaacaggaaagtgttgtccgcagggcgagcagaaggcttgcc
aagaagactgccgaagagccagctgcctctggccgcatcatctgtcacagttacctggag
aggctcctgaatgttgaggtgccccagaaagttggttctgagcagaaggaaccccccgag
gaggctgagcctgtggcggcagctgagccagaggtccctgagaacaatggaaataactcg
tggccccacaatgacacggagattgccaacagcacacccaacccgaagcctgcagccagc
agcccggaaacaccctctgcagggcagcaagaggccaagacggaccaagcagatggaccc
agagagccaccgcagagtgccaggaggaagcgcagctacaagcaggccgtgagtgagctg
gacgaggagcagcacctggaggatgaggagctgcagccccccaggagcaagaccccttcc
tcaccctgcccagccagcaaggtggtacggcccctccggacctttctgcacacagtgcag
aggaaccagatgctcatgaccccgacctcagccccacgcagcgtcatgaagtcctttatt
aagcgcaacactcccctgcgcatggaccccaagtgcagcttcgtcgagaaggagcggcag
cgcctggagaatctgcggcggaaggaggaggccgagcagctgcgcaggcagaaggtggag
gaggacaagcggcggcggctggaggaggtgaagctgaagcgtgaggaacgcctccgcaag
gtgctgcaggcccgcgagcgggtggagcagatgaaggaggagaagaagaagcagattgag
cagaagtttgctcagatcgacgagaagactgagaaggccaaggaggagcggctggcagag
gagaaggccaagaaaaaggcggcggccaagaagatggaggaggtggaagcacgcaggaag
caggaagaggaggcacgtaggctcaggtggctgcagcaggaggaggaagagcggcggcac
caagagctgctgcagaagaagaaggaagaggagcaggagcggctgcggaaggcggccgag
gctaagcggctggcagagcagcgggagcaggagcggcgggagcaggagcggcgcgagcag
gagcggcgcgagcaggagcggcgggagcaggagcggcgcgagcaggagcgacagctggca
gagcaggagcgtcggcgggagcaggagcggctccaggccgagagggagctgcaggagcgg
gagaaggccctgcggctgcagaaggagcagctgcagagggaactggaggagaagaagaag
aaggaagagcagcagcgtctggctgagcggcagctgcaggaggagcaagagaagaaagcc
aaggaggcagcaggggccagcaaggccctgaatgtgactgtggacgtgcagtctccagct
tgtacctcatatcagatgactccgcaagggcacagggcccctcccaagatcaacccagat
aactacgggatggatctgaatagcgacgactccaccgatgatgaggcccatccccggaag
cccatccccacctgggcccgaggcaccccgctcagccaggctatcattcaccagtactac
cacccaccgaaccttctggagctctttggaaccattctcccactggacttggaggatatc
ttcaagaagagcaagccccgctatcacaagcgcaccagctctgctgtctggaactcaccg
cccctgcagggcgccagggtccccagcagcctggcctacagcctgaagaagcactga

KEGG   Homo sapiens (human): 55143
Entry
55143             CDS       T01001                                 
Symbol
CDCA8, BOR, BOREALIN, DasraB, MESRGP
Name
(RefSeq) cell division cycle associated 8
  KO
K11514  Borealin
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01526  Organization of the outer kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    55143 (CDCA8)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CPC (chromosomal passenger complex)
     55143 (CDCA8)
SSDB
Motif
Pfam: Borealin Nbl1_Borealin_N F-box Axin_b-cat_bind
Other DBs
NCBI-GeneID: 55143
NCBI-ProteinID: NP_001243804
OMIM: 609977
HGNC: 14629
Ensembl: ENSG00000134690
UniProt: Q53HL2
Structure
LinkDB
Position
1:37692516..37709719
AA seq 280 aa
MAPRKGSSRVAKTNSLRRRKLASFLKDFDREVEIRIKQIESDRQNLLKEVDNLYNIEILR
LPKALREMNWLDYFALGGNKQALEEAATADLDITEINKLTAEAIQTPLKSAKTRKVIQVD
EMIVEEEEEEENERKNLQTARVKRCPPSKKRTQSIQGKGKGKRSSRANTVTPAVGRLEVS
MVKPTPGLTPRFDSRVFKTPGLRTPAAGERIYNISGNGSPLADSKEIFLTVPVGGGESLR
LLASDLQRHSIAQLDPEALGNIKKLSNRLAQICSSIRTHK
NT seq 843 nt   +upstreamnt  +downstreamnt
atggctcctaggaagggcagtagtcgggtggccaagaccaactccttacggaggcggaag
ctcgcctcctttctgaaagacttcgaccgtgaagtggaaatacgaatcaagcaaattgag
tcagacaggcagaacctcctcaaggaggtggataacctctacaacatcgagatcctgcgg
ctccccaaggctctgcgcgagatgaactggcttgactacttcgcccttggaggaaacaaa
caggccctggaagaggcggcaacagctgacctggatatcaccgaaataaacaaactaaca
gcagaagctattcagacacccctgaaatctgccaaaacacgaaaggtaatacaggtagat
gaaatgatagtggaagaggaagaagaagaagaaaatgaacgtaagaatcttcaaactgca
agagtcaaaaggtgtcctccatccaagaagagaactcagtccatacaaggaaaaggaaaa
gggaaaaggtcaagccgtgctaacactgttaccccagccgtgggccgattggaggtgtcc
atggtcaaaccaactccaggcctgacacccaggtttgactcaagggtcttcaagacccct
ggcctgcgtactccagcagcaggagagcggatttacaacatctcagggaatggcagccct
cttgctgacagcaaagagatcttcctcactgtgccagtgggcggcggagagagcctgcga
ttattggccagtgacttgcagaggcacagtattgcccagctggatccagaggccttggga
aacattaagaagctctccaaccgtctcgcccaaatctgcagcagcatacggacccacaaa
tga

KEGG   Homo sapiens (human): 332
Entry
332               CDS       T01001                                 
Symbol
BIRC5, API4, EPR-1
Name
(RefSeq) baculoviral IAP repeat containing 5
  KO
K08731  baculoviral IAP repeat-containing protein 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04390  Hippo signaling pathway
hsa05161  Hepatitis B
hsa05200  Pathways in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05210  Colorectal cancer
Network
nt06162  Hepatitis B virus (HBV)
nt06214  PI3K signaling (cancer)
nt06215  WNT signaling (cancer)
nt06230  Cell cycle (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06271  Endometrial cancer
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00057  Mutation-inactivated APC to Wnt signaling pathway
N00058  Mutation-activated CTNNB1 to Wnt signaling pathway
N00533  HBV HBx to Crosstalk between extrinsic and intrinsic apoptotic pathways
N01337  NNK/NNN to CHRNA7-E2F signaling pathway
N01339  NNK/NNN to PI3K signaling pathway
N01526  Organization of the outer kinetochore
Drug target
Gataparsen (DG01431): D09909 D09910
Sepantronium bromide: D10164
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    332 (BIRC5)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    332 (BIRC5)
   04215 Apoptosis - multiple species
    332 (BIRC5)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    332 (BIRC5)
   05207 Chemical carcinogenesis - receptor activation
    332 (BIRC5)
  09162 Cancer: specific types
   05210 Colorectal cancer
    332 (BIRC5)
  09172 Infectious disease: viral
   05161 Hepatitis B
    332 (BIRC5)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    332 (BIRC5)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    332 (BIRC5)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    332 (BIRC5)
Peptidases and inhibitors [BR:hsa01002]
 Peptidase inhibitors
  Family I32: IAP family
   332 (BIRC5)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CPC (chromosomal passenger complex)
     332 (BIRC5)
SSDB
Motif
Pfam: BIR
Other DBs
NCBI-GeneID: 332
NCBI-ProteinID: NP_001159
OMIM: 603352
HGNC: 593
Ensembl: ENSG00000089685
UniProt: O15392 A0A0B4J1S3
Structure
LinkDB
Position
17:78214253..78225635
AA seq 142 aa
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFC
FKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNK
KKEFEETAEKVRRAIEQLAAMD
NT seq 429 nt   +upstreamnt  +downstreamnt
atgggtgccccgacgttgccccctgcctggcagccctttctcaaggaccaccgcatctct
acattcaagaactggcccttcttggagggctgcgcctgcaccccggagcggatggccgag
gctggcttcatccactgccccactgagaacgagccagacttggcccagtgtttcttctgc
ttcaaggagctggaaggctgggagccagatgacgaccccatagaggaacataaaaagcat
tcgtccggttgcgctttcctttctgtcaagaagcagtttgaagaattaacccttggtgaa
tttttgaaactggacagagaaagagccaagaacaaaattgcaaaggaaaccaacaataag
aagaaagaatttgaggaaactgcggagaaagtgcgccgtgccatcgagcagctggctgcc
atggattga

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