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Entry Name Dioxin degradation
Description Dioxins and dioxin-like compounds, including PCDDs, PCDFs and PCBs, are persistent organic pollutants (POPs) that are resistant to environmental degradation. However, POPs can be degraded by certain microorganisms with acquisition of a novel set of enzymes, such as biphenyl degradation by Paraburkholderia xenovorans LB400 involving four novel enzymes encoded in operon-like structures [MD:
M00543 ]. DDT, another POP, and carbazol are also known to be degraded in similar pathways.
Class Metabolism; Xenobiotics biodegradation and metabolismBRITE hierarchy
Pathway map Ortholog table Module M00543 Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate [PATH:ko00621 ]
M00544 Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate [PATH:ko00621 ]
Other DBs Orthology K14599 dibenzofuran dioxygenase subunit alpha [EC:1.14.12.-]
K14600 dibenzofuran dioxygenase subunit beta [EC:1.14.12.-]
K22715 dibenzofuran dioxygenase subunit alpha [EC:1.14.12.-]
K22716 dibenzofuran dioxygenase subunit beta [EC:1.14.12.-]
K15749 2,2',3-trihydroxybiphenyl dioxygenase [EC:1.13.11.-]
K22717 2-hydroxy-6-oxo-6-(2-hydroxyphenoxy)-hexa-2,4-dienoate hydrolase [EC:3.7.1.-]
K18087 biphenyl 2,3-dioxygenase ferredoxin component
K18088 biphenyl 2,3-dioxygenase ferredoxin reductase component [EC:1.18.1.3 ]
K15752 carbazole 1,9a-dioxygenase ferredoxin component
K15753 carbazole 1,9a-dioxygenase ferredoxin reductase component
K15754 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase, small subunit [EC:1.13.11.-]
K15755 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase, large subunit [EC:1.13.11.-]
K15756 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase [EC:3.7.1.13 ]
K22676 cis-2,3-dihydrobiphenyl-2,3-diol/cis-2,3-dihydrodiol-DDE dehydrogenase [EC:1.3.1.-]
K22677 2,6-dioxo-6-phenylhexa-3-enoate/TCOA hydrolase [EC:3.7.1.-]
Compound C00596 2-Hydroxy-2,4-pentadienoate
C01273 2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
C03569 2,2',3-Trihydroxybiphenyl
C03589 4-Hydroxy-2-oxopentanoate
C04596 1,1-Dichloro-2,2-bis(4-chlorophenyl)ethylene
C06585 cis-2,3-Dihydro-2,3-dihydroxy-4'-chlorobiphenyl
C06586 2,3-Dihydroxy-4'-chlorobiphenyl
C06587 2-Hydroxy-6-oxo-6-(4'-chlorophenyl)-hexa-2,4-dienoate
C06589 cis-2,3-Dihydro-2,3-dihydroxybiphenyl
C06644 1,1-Dichloro-2-(dihydroxy-4'-chlorophenyl)-2-(4'-chlorophenyl)ethylene
C06645 6-Oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7E-trienoate
C06646 2-(4'-Chlorophenyl)-3,3-dichloropropenoate
C07557 2,3,7,8-Tetrachlorodibenzodioxin
C07731 2-Hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate
C07733 2,2',3-Trihydroxydiphenylether
C07734 2-Hydroxy-6-oxo-6-(2-hydroxyphenoxy)-hexa-2,4-dienoate
C08061 2'-Aminobiphenyl-2,3-diol
C08062 2-Hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate
C11057 3,4,3',4'-Tetrachlorobiphenyl
C11353 2-Hydroxy-3-chloropenta-2,4-dienoate
C14573 3,3',4,4',5-Pentachlorobiphenyl
C18099 1,2,3,7,8-Pentachlorodibenzodioxin
C18100 1,2,3,4,7,8-Hexachlorodibenzodioxin
C18101 1,2,3,6,7,8-Hexachlorodibenzodioxin
C18102 1,2,3,7,8,9-Hexachlorodibenzodioxin
C18103 1,2,3,4,6,7,8-Heptachlorodibenzodioxin
C18104 2,3,7,8-Tetrachlorodibenzofuran
C18105 1,2,3,7,8-Pentachlorodibenzofuran
C18106 2,3,4,7,8-Pentachlorodibenzofuran
C18107 1,2,3,4,7,8-Hexachlorodibenzofuran
C18108 1,2,3,7,8,9-Hexachlorodibenzofuran
C18109 1,2,3,6,7,8-Hexachlorodibenzofuran
C18110 2,3,4,6,7,8-Hexachlorodibenzofuran
C18111 1,2,3,4,6,7,8-Heptachlorodibenzofuran
C18112 1,2,3,4,7,8,9-Heptachlorodibenzofuran
C18113 1,2,3,4,6,7,8,9-Octachlorodibenzofuran
C18114 3,4,4',5-Tetrachlorobiphenyl
C18115 3,4,5,3',4',5'-Hexachlorobiphenyl
C18116 2,3,4,3',4'-Pentachlorobiphenyl
C18117 2,3,4,4',5-Pentachlorobiphenyl
C18118 2,3',4,4',5-Pentachlorobiphenyl
C18119 2,3',4,4',5'-Pentachlorobiphenyl
C18120 2,3,3',4,4',5-Hexachlorobiphenyl
C18121 2,3,3',4,4',5'-Hexachlorobiphenyl
C18122 2,3',4,4',5,5'-Hexachlorobiphenyl
C18123 2,3,3',4,4',5,5'-Heptachlorobiphenyl
C18180 1,2,3,4,6,7,8,9-Octachlorodibenzo-p-dioxin
C21859 cis-3-[2,2-Dichloro-1-(4-chlorophenyl)vinyl]-6-chlorocyclohexa-3,5-diene-1,2-diol
Reference Authors Nojiri H, Omori T.
Title Molecular bases of aerobic bacterial degradation of dioxins: involvement of angular dioxygenation.
Journal Reference Authors Jin S, Zhu T, Xu X, Xu Y.
Title Biodegradation of dibenzofuran by Janibacter terrae strain XJ-1.
Journal Reference Authors Nojiri H, Habe H, Omori T.
Title Bacterial degradation of aromatic compounds via angular dioxygenation.
Journal Reference Authors Kasuga K, Habe H, Chung JS, Yoshida T, Nojiri H, Yamane H, Omori T.
Title Isolation and characterization of the genes encoding a novel oxygenase component of angular dioxygenase from the gram-positive dibenzofuran-degrader Terrabacter sp. strain DBF63.
Journal Reference Authors Vezina J, Barriault D, Sylvestre M
Title Family shuffling of soil DNA to change the regiospecificity of Burkholderia xenovorans LB400 biphenyl dioxygenase.
Journal Reference Authors Ouchiyama N, Miyachi S, Omori T
Title Cloning and nucleotide sequence of carbazole catabolic genes from Pseudomonas stutzeri strain OM1, isolated from activated sludge.
Journal Reference Authors Sato SI, Ouchiyama N, Kimura T, Nojiri H, Yamane H, Omori T
Title Cloning of genes involved in carbazole degradation of Pseudomonas sp. strain CA10: nucleotide sequences of genes and characterization of meta-cleavage enzymes and hydrolase.
Journal Reference Authors Nguyen PA, Trinh TH, Fukumitsu Y, Shimodaira J, Miyauchi K, Tokuda M, Kasai D, Masai E, Fukuda M
Title Gene cluster and regulation system for 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (DDE) degradation in Janibacter sp. TYM3221.
Journal Related LinkDB All DBs
