Entry Name Pancreatic secretion
Description The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map Ortholog table Other DBs Orthology K04131 muscarinic acetylcholine receptor M3
K04194 cholecystokinin A receptor
K04634 guanine nucleotide-binding protein G(q) subunit alpha
K07884 Ras-related protein Rab-3D
K07901 Ras-related protein Rab-8A
K07904 Ras-related protein Rab-11A
K07886 Ras-related protein Rab-27B
K04353 Ras-related protein Rap-1A
K07836 Ras-related protein Rap-1B
K04513 Ras homolog gene family, member A
K04392 Ras-related C3 botulinum toxin substrate 1
K09632 chymotrypsin-like protease [EC:3.4.21.-]
K04958 inositol 1,4,5-triphosphate receptor type 1
K04959 inositol 1,4,5-triphosphate receptor type 2
K04960 inositol 1,4,5-triphosphate receptor type 3
K14077 two pore calcium channel protein 2
K05027 calcium-activated chloride channel regulator 1
K05028 calcium-activated chloride channel regulator 2
K05030 calcium-activated chloride channel regulator 3/4
K04964 transient receptor potential cation channel subfamily C member 1
K10951 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
K01539 sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13 ]
K01540 sodium/potassium-transporting ATPase subunit beta
K01538 sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
K04926 potassium voltage-gated channel KQT-like subfamily member 1
K04936 potassium large conductance calcium-activated channel subfamily M alpha member 1
K05742 solute carrier family 9 (sodium/hydrogen exchanger), member 1
K13855 solute carrier family 4 (anion exchanger), member 2
K04632 guanine nucleotide-binding protein G(s) subunit alpha
K05031 cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6 ]
K14078 solute carrier family 26 (chloride anion exchanger), member 3
K13575 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C13051 Nicotinic acid adenine dinucleotide phosphate
Reference Authors Petersen OH, Tepikin AV
Title Polarized calcium signaling in exocrine gland cells.
Journal Reference Authors Williams JA
Title Regulation of acinar cell function in the pancreas.
Journal Reference Authors Williams JA
Title Regulation of pancreatic acinar cell function.
Journal Reference Authors Bi Y, Williams JA
Title Receptor biology and signal transduction in pancreatic acinar cells.
Journal Reference Authors Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
Title Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
Journal Reference Authors Kanno T
Title Ca2+ signaling in the pancreatic acinus.
Journal Pancreas 16:273-6 (1998)
Reference Authors Heitzmann D, Warth R
Title Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Journal Reference Authors Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
Title Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
Journal Reference Authors Chu JY, Yung WH, Chow BK
Title Secretin: a pleiotrophic hormone.
Journal Reference Authors Siu FK, Lam IP, Chu JY, Chow BK
Title Signaling mechanisms of secretin receptor.
Journal Reference Authors Steward MC, Ishiguro H, Case RM
Title Mechanisms of bicarbonate secretion in the pancreatic duct.
Journal Reference Authors Kim D, Steward MC
Title The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
Journal Reference Authors Whitcomb DC, Lowe ME
Title Human pancreatic digestive enzymes.
Journal Reference Authors Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
Title Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
Journal Reference Authors Cancela JM, Churchill GC, Galione A
Title Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
Journal Reference Authors Parekh AB
Title Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
Journal Reference Authors Williams JA, Chen X, Sabbatini ME
Title Small G proteins as key regulators of pancreatic digestive enzyme secretion.
Journal Related ko04973 Carbohydrate digestion and absorption
ko04974 Protein digestion and absorption
ko04975 Fat digestion and absorption
ko04977 Vitamin digestion and absorption
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