KEGG   PATHWAY: map00946
Entry
map00946                    Pathway                                
Name
Degradation of flavonoids
Description
Flavonoids are polyphenolic compounds with the C6-C3-C6 skeleton structure. Natural flavonoids, including their O-glycoside and C-glycoside forms, are synthesized as plant secondary metabolites and thus ubiquitously found in foods of plant origin. Because of the potential health benefits of dietary flavonoids, there has been much interest in characterizing the involvement of gut microbiome and identifying key metabolites and their interactions. For example, equol metabolized from soy products [MD:M00966] is known to have estrogenic activity.
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
map00946  Degradation of flavonoids
map00946

Module
M00966  Equol biosynthesis, daidzein => equol [PATH:map00946]
M00967  Flavone degradation, luteolin/apigenin => DHCA/phloretate [PATH:map00946]
Reference
  Authors
Goris T, Cuadrat RRC, Braune A.
  Title
Flavonoid-Modifying Capabilities of the Human Gut Microbiome-An In Silico Study.
  Journal
Nutrients 13:2688 (2021)
DOI:10.3390/nu13082688
Reference
  Authors
Shimada Y, Takahashi M, Miyazawa N, Abiru Y, Uchiyama S, Hishigaki H
  Title
Identification of a novel dihydrodaidzein racemase essential for biosynthesis of equol from daidzein in Lactococcus sp. strain 20-92.
  Journal
Appl Environ Microbiol 78:4902-7 (2012)
DOI:10.1128/AEM.00410-12
Reference
  Authors
Maria Marin A, de la Torre J, Ricardo Marques Oliveira A, Barison A, Satie Chubatsu L, Adele Monteiro R, de Oliveira Pedrosa F, Maltempi de Souza E, Wassem R, Duque E, Ramos JL.
  Title
Genetic and functional characterization of a novel meta-pathway for degradation of naringenin in Herbaspirillum seropedicae SmR1.
  Journal
Environ Microbiol 18:4653-4661 (2016)
DOI:10.1111/1462-2920.13313
Reference
  Authors
Mayo B, Vazquez L, Florez AB.
  Title
Equol: A Bacterial Metabolite from The Daidzein Isoflavone and Its Presumed Beneficial Health Effects.
  Journal
Nutrients 11:E2231 (2019)
DOI:10.3390/nu11092231
Related
pathway
map00020  Citrate cycle (TCA cycle)
map00941  Flavonoid biosynthesis
map00943  Isoflavonoid biosynthesis
map00944  Flavone and flavonol biosynthesis
KO pathway
ko00946   
LinkDB

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