KEGG   PATHWAY: sbar00362
Entry
sbar00362                   Pathway                                
Name
Benzoate degradation - Sphingobium fuliginis KK22
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
sbar00362  Benzoate degradation
sbar00362

Module
sbar_M00548  Benzene degradation, benzene => catechol [PATH:sbar00362]
sbar_M00568  Catechol ortho-cleavage, catechol => 3-oxoadipate [PATH:sbar00362]
sbar_M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA [PATH:sbar00362]
Other DBs
UMBBD: benz2 benz abs
GO: 0043639
Organism
Sphingobium fuliginis KK22 [GN:sbar]
Gene
H5V43_22280  Rieske 2Fe-2S domain-containing protein [KO:K05549] [EC:1.14.12.10 1.14.12.-]
H5V43_22285  nuclear transport factor 2 family protein [KO:K05550] [EC:1.14.12.10 1.14.12.-]
H5V43_22415  1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase [KO:K05783] [EC:1.3.1.25 1.3.1.-]
H5V43_16730  catechol 1,2-dioxygenase [KO:K03381] [EC:1.13.11.1]
H5V43_16720  muconate cycloisomerase [KO:K01856] [EC:5.5.1.1]
H5V43_16725  catC; muconolactone Delta-isomerase [KO:K03464] [EC:5.3.3.4]
H5V43_16750  pcaD; 3-oxoadipate enol-lactonase [KO:K01055] [EC:3.1.1.24]
H5V43_03560  thiolase family protein [KO:K00632] [EC:2.3.1.16]
H5V43_16745  pcaF; 3-oxoadipyl-CoA thiolase [KO:K07823] [EC:2.3.1.174]
H5V43_20600  toluene monooxygenase [KO:K16249]
H5V43_20595  phenol hydroxylase [KO:K16243] [EC:1.14.13.244 1.14.13.243]
H5V43_20590  MmoB/DmpM family protein [KO:K16244] [EC:1.14.13.244 1.14.13.243]
H5V43_20585  YHS domain-containing protein [KO:K16242] [EC:1.14.13.244 1.14.13.243]
H5V43_20580  phenol hydroxylase subunit P4 [KO:K16245] [EC:1.14.13.244 1.14.13.243]
H5V43_20575  2Fe-2S iron-sulfur cluster binding domain-containing protein [KO:K16246] [EC:1.14.13.244 1.14.13.243]
H5V43_20610  catechol 2,3-dioxygenase [KO:K00446] [EC:1.13.11.2]
H5V43_22315  catechol 2,3-dioxygenase [KO:K00446] [EC:1.13.11.2]
H5V43_22190  alpha/beta fold hydrolase [KO:K10216] [EC:3.7.1.9]
H5V43_22310  alpha/beta fold hydrolase [KO:K10216] [EC:3.7.1.9]
H5V43_22330  fumarylacetoacetate hydrolase family protein [KO:K02554] [EC:4.2.1.80]
H5V43_20655  fumarylacetoacetate hydrolase family protein [KO:K18364] [EC:4.2.1.80 4.2.1.132]
H5V43_20330  dmpG; 4-hydroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
H5V43_22340  dmpG; 4-hydroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
H5V43_20635  dmpG; 4-hydroxy-2-oxovalerate aldolase [KO:K18365] [EC:4.1.3.39 4.1.3.43]
H5V43_20325  acetaldehyde dehydrogenase (acetylating) [KO:K04073] [EC:1.2.1.10]
H5V43_22335  acetaldehyde dehydrogenase (acetylating) [KO:K04073] [EC:1.2.1.10]
H5V43_20640  acetaldehyde dehydrogenase (acetylating) [KO:K18366] [EC:1.2.1.10 1.2.1.87]
H5V43_20660  2-hydroxymuconic semialdehyde dehydrogenase [KO:K10217] [EC:1.2.1.32 1.2.1.85]
H5V43_22325  2-hydroxymuconic semialdehyde dehydrogenase [KO:K10217] [EC:1.2.1.32 1.2.1.85]
H5V43_03075  4-oxalocrotonate tautomerase family protein [KO:K01821] [EC:5.3.2.6]
H5V43_20645  tautomerase family protein [KO:K01821] [EC:5.3.2.6]
H5V43_22350  2-hydroxymuconate tautomerase family protein [KO:K01821] [EC:5.3.2.6]
H5V43_20650  4-oxalocrotonate decarboxylase [KO:K01617] [EC:4.1.1.77]
H5V43_22345  fumarylacetoacetate hydrolase family protein [KO:K01617] [EC:4.1.1.77]
H5V43_18945  carboxymuconolactone decarboxylase family protein [KO:K01607] [EC:4.1.1.44]
H5V43_19295  carboxymuconolactone decarboxylase family protein [KO:K01607] [EC:4.1.1.44]
H5V43_19495  carboxymuconolactone decarboxylase family protein [KO:K01607] [EC:4.1.1.44]
H5V43_19565  carboxymuconolactone decarboxylase family protein [KO:K01607] [EC:4.1.1.44]
H5V43_22445  RraA family protein [KO:K10218] [EC:4.1.3.17]
H5V43_22450  RraA family protein [KO:K10218] [EC:4.1.3.17]
H5V43_06820  enoyl-CoA hydratase/isomerase family protein [KO:K01782] [EC:1.1.1.35 4.2.1.17 5.1.2.3]
H5V43_05105  enoyl-CoA hydratase/isomerase family protein [KO:K07516] [EC:1.1.1.35]
H5V43_14155  enoyl-CoA hydratase/isomerase family protein [KO:K07516] [EC:1.1.1.35]
H5V43_19000  enoyl-CoA hydratase/isomerase family protein [KO:K07516] [EC:1.1.1.35]
H5V43_20340  enoyl-CoA hydratase/isomerase family protein [KO:K07516] [EC:1.1.1.35]
H5V43_17435  acyl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
H5V43_06790  enoyl-CoA hydratase/isomerase family protein [KO:K01692] [EC:4.2.1.17]
H5V43_14580  3-hydroxybutyryl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
H5V43_05155  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
H5V43_05830  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
H5V43_06505  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
H5V43_06815  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
H5V43_09615  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
H5V43_09680  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H5V43_14095  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
H5V43_18015  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
H5V43_19140  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
H5V43_20335  acetyl-CoA C-acyltransferase family protein [KO:K00626] [EC:2.3.1.9]
H5V43_21080  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
H5V43_21325  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
H5V43_21755  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00084  Acetaldehyde
C00090  Catechol
C00091  Succinyl-CoA
C00146  Phenol
C00156  4-Hydroxybenzoate
C00180  Benzoate
C00196  2,3-Dihydroxybenzoate
C00230  3,4-Dihydroxybenzoate
C00332  Acetoacetyl-CoA
C00512  Benzoyl-CoA
C00527  Glutaryl-CoA
C00530  Hydroquinone
C00587  3-Hydroxybenzoate
C00596  2-Hydroxy-2,4-pentadienoate
C00628  2,5-Dihydroxybenzoate
C00682  2-Hydroxymuconate semialdehyde
C00846  3-Oxoadipate
C00877  Crotonoyl-CoA
C01063  Pimeloyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C01163  3-Carboxy-cis,cis-muconate
C01278  2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C01407  Benzene
C01751  Resorcinol
C02222  2-Maleylacetate
C02232  3-Oxoadipyl-CoA
C02411  Glutaconyl-1-CoA
C02480  cis,cis-Muconate
C02501  2-Hydroxymuconate
C02519  4-Methoxybenzoate
C02814  Benzene-1,2,4-triol
C02949  4-Hydroxybenzoyl-CoA
C03453  gamma-Oxalocrotonate
C03586  2-Oxo-2,3-dihydrofuran-5-acetate
C03589  4-Hydroxy-2-oxopentanoate
C03671  2-Pyrone-4,6-dicarboxylate
C03676  3-Hydroxy-cis,cis-muconate
C04091  cis-1,2-Dihydrobenzene-1,2-diol
C04115  4-Carboxy-4-hydroxy-2-oxoadipate
C04324  (1E,3E)-4-Hydroxybuta-1,3-diene-1,2,4-tricarboxylate
C04434  (1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
C04480  3-Carboxy-2-hydroxymuconate semialdehyde
C04484  4-Carboxy-2-hydroxymuconate semialdehyde
C04553  3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C05375  2-Hydroxy-2-hydropyrone-4,6-dicarboxylate
C06033  Parapyruvate
C06035  4-Methylene-2-oxoglutarate
C06321  (1R,6S)-1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate
C06322  Cyclohexa-1,5-diene-1-carbonyl-CoA
C06333  2-Aminobenzenesulfonate
C06336  3-Sulfocatechol
C06714  3-Hydroxypimeloyl-CoA
C06715  3-Oxopimeloyl-CoA
C06723  6-Carboxyhex-2-enoyl-CoA
C06749  6-Hydroxycyclohex-1-ene-1-carbonyl-CoA
C09809  Cyclohexa-2,5-diene-1-carbonyl-CoA
C09810  Cyclohexa-1,4-diene-1-carbonyl-CoA
C09811  Cyclohex-1-ene-1-carbonyl-CoA
C09812  2-Hydroxycyclohexane-1-carbonyl-CoA
C09813  2-Oxocyclohexane-1-carbonyl-CoA
C09821  6-Oxocyclohex-1-ene-1-carbonyl-CoA
C09822  Cyclohexane-1-carboxylate
C09823  Cyclohexane-1-carbonyl-CoA
C14144  5-Carboxy-2-pentenoyl-CoA
C14610  (S)-5-Oxo-2,5-dihydrofuran-2-acetate
C19682  3,4-Didehydroadipyl-CoA
C19683  3,4-Didehydroadipyl-CoA semialdehyde
C19684  2,3-Epoxy-2,3-dihydrobenzoyl-CoA
C21298  2,6-Dihydroxybenzoate
Reference
  Authors
Carmona M, Zamarro MT, Blazquez B, Durante-Rodriguez G, Juarez JF, Valderrama JA, Barragan MJ, Garcia JL, Diaz E
  Title
Anaerobic catabolism of aromatic compounds: a genetic and genomic view.
  Journal
Microbiol Mol Biol Rev 73:71-133 (2009)
DOI:10.1128/MMBR.00021-08
Reference
  Authors
Hara H, Masai E, Miyauchi K, Katayama Y, Fukuda M.
  Title
Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6.
  Journal
J Bacteriol 185:41-50 (2003)
DOI:10.1128/JB.185.1.41-50.2003
Reference
  Authors
Maruyama K, Shibayama T, Ichikawa A, Sakou Y, Yamada S, Sugisaki H.
  Title
Cloning and characterization of the genes encoding enzymes for the protocatechuate meta-degradation pathway of Pseudomonas ochraceae NGJ1.
  Journal
Biosci Biotechnol Biochem 68:1434-41 (2004)
DOI:10.1271/bbb.68.1434
Reference
  Authors
Mampel J, Ruff J, Junker F, Cook AM.
  Title
The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.
  Journal
Microbiology 145 ( Pt 11):3255-64 (1999)
DOI:10.1099/00221287-145-11-3255
Reference
PMID:8002948
  Authors
Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM.
  Title
Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
  Journal
Biochem J 300 ( Pt 2):429-36 (1994)
DOI:10.1042/bj3000429
Reference
PMID:8990279
  Authors
Harwood CS, Gibson J.
  Title
Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
  Journal
J Bacteriol 179:301-9 (1997)
DOI:10.1128/JB.179.2.301-309.1997
Reference
  Authors
Peters F, Shinoda Y, McInerney MJ, Boll M.
  Title
Cyclohexa-1,5-diene-1-carbonyl-coenzyme A (CoA) hydratases of Geobacter metallireducens and Syntrophus aciditrophicus: Evidence for a common benzoyl-CoA degradation pathway in facultative and strict anaerobes.
  Journal
J Bacteriol 189:1055-60 (2007)
DOI:10.1128/JB.01467-06
Reference
  Authors
Cowles CE, Nichols NN, Harwood CS.
  Title
BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida.
  Journal
J Bacteriol 182:6339-46 (2000)
DOI:10.1128/JB.182.22.6339-6346.2000
Reference
  Authors
Smith MA, Weaver VB, Young DM, Ornston LN.
  Title
Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1.
  Journal
Appl Environ Microbiol 69:524-32 (2003)
DOI:10.1128/AEM.69.1.524-532.2003
Reference
  Authors
Kuntze K, Shinoda Y, Moutakki H, McInerney MJ, Vogt C, Richnow HH, Boll M
  Title
6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.
  Journal
Environ Microbiol 10:1547-56 (2008)
DOI:10.1111/j.1462-2920.2008.01570.x
Reference
  Authors
Pelletier DA, Harwood CS
  Title
2-Hydroxycyclohexanecarboxyl coenzyme A dehydrogenase, an enzyme characteristic of the anaerobic benzoate degradation pathway used by Rhodopseudomonas palustris.
  Journal
J Bacteriol 182:2753-60 (2000)
DOI:10.1128/JB.182.10.2753-2760.2000
Reference
  Authors
Elshahed MS, Bhupathiraju VK, Wofford NQ, Nanny MA, McInerney MJ
  Title
Metabolism of benzoate, cyclohex-1-ene carboxylate, and cyclohexane carboxylate by "Syntrophus aciditrophicus" strain SB in syntrophic association with H(2)-using microorganisms.
  Journal
Appl Environ Microbiol 67:1728-38 (2001)
DOI:10.1128/AEM.67.4.1728-1738.2001
Reference
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol Microbiol 79:359-74 (2011)
DOI:10.1111/j.1365-2958.2010.07448.x
Related
pathway
sbar00010  Glycolysis / Gluconeogenesis
sbar00020  Citrate cycle (TCA cycle)
sbar00350  Tyrosine metabolism
sbar00360  Phenylalanine metabolism
sbar00361  Chlorocyclohexane and chlorobenzene degradation
sbar00627  Aminobenzoate degradation
sbar00790  Folate biosynthesis
KO pathway
ko00362   
LinkDB

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