KEGG PATHWAY: rn00460

PATHWAY: rn00460

Entry

rn00460                     Pathway

Name

Cyanoamino acid metabolism

Class

Metabolism; Metabolism of other amino acids

Pathway map

rn00460

Cyanoamino acid metabolism

Module

M00369

Cyanogenic glycoside biosynthesis, tyrosine => dhurrin [PATH:rn00460]

Other DBs

GO:	0033052 0019756

Reaction

R00152

hydrogen cyanide aminohydrolase

R00483

L-aspartate:ammonia ligase (AMP-forming)

R00485

L-asparagine amidohydrolase

R00486

3-cyano-L-alanine aminohydrolase

R00524

formamide amidohydrolase

R00730

L-tyrosine,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)

R00945

5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase

R01267

L-asparagine hydro-lyase (3-cyanoalanine-forming)

R01408

formamide hydro-lyase (cyanide-forming)

R01410

R01553

acetone-cyanohydrin acetone-lyase (cyanide-forming)

R01650

R01767

mandelonitrile benzaldehyde-lyase (cyanide-forming)

R01887

gamma-amino-gamma-cyanobutanoate aminohydrolase

R02558

(R)-prunasin beta-D-glucohydrolase

R02676

4-hydroxymandelonitrile hydroxybenzaldehyde-lyase

R02985

amygdalin beta-glucosidase

R03524

L-cysteine hydrogen-sulfide-lyase (adding HCN)

R03542

alpha-aminopropiononitrile aminohydrolase

R03625

UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase

R03970

(5-glutamyl)-peptide:amino-acid 5-glutamyltransferase

R03971

gamma-glutamyl-beta-aminopropiononitrile amidohydrolase

R04296

UDPglucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase

R04460

N-hydroxy-L-tyrosine,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)

R05704

glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)

R05728

(E)-4-hydroxyphenylacetaldehyde oxime,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase

R06614

3-cyano-L-alanine carboxy-lyase (3-aminopropiononitrile-forming)

R07190

R07638

(Z)-phenylacetaldehyde-oxime hydro-lyase

R09358

(2R)-2-hydroxy-2-methylbutanenitrile butan-2-one-lyase (cyanide forming)

R09579

L-phenylalanine,NADPH:oxygen oxidoreductase (N-hydroxylating)

R09580

N-hydroxy-L-phenylalanine,NADPH:oxygen oxidoreductase (N-hydroxylating)

R09581

R10027

L-isoleucine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)

R10028

N-hydroxy-L-isoleucine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)

R10029

R10030

R10031

L-valine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)

R10032

N-hydroxy-L-valine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)

R10033

R10034

R10035

beta-D-glucoside glucohydrolase

R10036

R10037

UDP-glucose:(2R)-2-hydroxy-2-methylbutanenitrile beta-D-glucosyltransferase

R10038

R10039

beta-D-glucoside glucohydrolase

R10040

beta-D-glucoside glucohydrolase

R10041

R10638

UDP-D-glucose:(R)-mandelonitrile beta-D-glucosyltransferase

R10639

R11639

R11640

R11641

R11642

R11733

phenylacetonitrile,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase [(R)-mandelonitrile-forming]

Compound

C00014

Ammonia

C00037

Glycine

C00049

L-Aspartate

C00065

L-Serine

C00079

L-Phenylalanine

C00082

L-Tyrosine

C00097

L-Cysteine

C00152

L-Asparagine

C00183

L-Valine

C00302

Glutamate

C00407

L-Isoleucine

C00488

Formamide

C00561

Mandelonitrile

C00844

Prunasin

C01326

Hydrogen cyanide

C01401

Alanine

C01594

Linamarin

C02512

3-Cyano-L-alanine

C02659

Acetone cyanohydrin

C03004

N-Hydroxy-L-tyrosine

C03219

(E)-2-Methylpropanal oxime

C03742

(S)-4-Hydroxymandelonitrile

C04350

(E)-4-Hydroxyphenylacetaldehyde oxime

C05143

Dhurrin

C05670

3-Aminopropiononitrile

C05711

gamma-Glutamyl-beta-cyanoalanine

C05714

alpha-Aminopropiononitrile

C05715

gamma-Amino-gamma-cyanobutanoate

C06114

gamma-Glutamyl-beta-aminopropiononitrile

C08325

Amygdalin

C08334

Lotaustralin

C15503

N,N-Dihydroxy-L-tyrosine

C16074

Phenylacetonitrile

C16075

(Z)-Phenylacetaldehyde oxime

C18796

(2R)-2-Hydroxy-2-methylbutanenitrile

C19491

(E)-2-Methylbutanal oxime

C19712

N-Hydroxy-L-phenylalanine

C19714

(E)-Phenylacetaldoxime

C19715

N,N-Dihydroxy-L-phenylalanine

C20310

N-Hydroxy-L-isoleucine

C20311

N,N-Dihydroxy-L-isoleucine

C20312

(Z)-2-Methylbutanal oxime

C20313

N-Hydroxy-L-valine

C20314

N,N-Dihydroxy-L-valine

C20315

(Z)-2-Methylpropanal oxime

Reference

PMID:11575729

Authors

Maruyama A, Saito K, Ishizawa K

Title

Beta-cyanoalanine synthase and cysteine synthase from potato: molecular cloning, biochemical characterization, and spatial and hormonal regulation.

Journal

Plant Mol Biol 46:749-60 (2001)
DOI:10.1023/A:1011629703784

Reference

PMID:10636899

Authors

Andersen MD, Busk PK, Svendsen I, Moller BL

Title

Cytochromes P-450 from cassava (Manihot esculenta Crantz) catalyzing the first steps in the biosynthesis of the cyanogenic glucosides linamarin and lotaustralin. Cloning, functional expression in Pichia pastoris, and substrate specificity of the isolated recombinant enzymes.

Journal

J Biol Chem 275:1966-75 (2000)
DOI:10.1074/jbc.275.3.1966

Reference

Authors

Hickel A, Hasslacher M, Griengl H.

Title

Hydroxynitrile lyases: Functions and properties

Journal

Physiol Plant 98:891-898 (1996)
DOI:10.1111/j.1399-3054.1996.tb06700.x

Related
pathway

rn00250

Alanine, aspartate and glutamate metabolism