KEGG   MODULE: M00102
Entry
M00102            Pathway   Module                                 
Name
Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
Definition
K00801 K00511 K01852 K05917 K00222 K07750 K07748 K09827 K00559 K09829 K00227 K09831 K00223
Diagram
M00102

Orthology
K00801  
farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21] [RN:R00702 R02872]
K00511  
squalene monooxygenase [EC:1.14.14.17] [RN:R02874]
K01852  
lanosterol synthase [EC:5.4.99.7] [RN:R03199]
K05917  
sterol 14alpha-demethylase [EC:1.14.14.154] [RN:R05640]
K00222  
delta14-sterol reductase [EC:1.3.1.70] [RN:R05639]
K07750  
methylsterol monooxygenase [EC:1.14.18.9] [RN:R07509 R12403]
K07748  
sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [EC:1.1.1.170] [RN:R07494 R12404]
K09827  
3-keto steroid reductase [EC:1.1.1.270] [RN:R07495 R12405]
K00559  
sterol 24-C-methyltransferase [EC:2.1.1.41] [RN:R04427]
K09829  
C-8 sterol isomerase [EC:5.-.-.-] [RN:R07497]
K00227  
Delta7-sterol 5-desaturase [EC:1.14.19.20] [RN:R07491]
K09831  
sterol 22-desaturase [EC:1.14.19.41] [RN:R07506]
K00223  
Delta24(24(1))-sterol reductase [EC:1.3.1.71] [RN:R05641]
Class
Pathway modules; Lipid metabolism; Sterol biosynthesis
Pathway
map00100  Steroid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R00702  
R02872  
R02874  
R03199  
R05640  
R05639  
R07509  
R07494  
R07495  
R12403  
R12404  
R12405  
R04427  
R07497  
R07491  
R07506  
R05641  
R03677  
Compound
C00448  trans,trans-Farnesyl diphosphate
C03428  Presqualene diphosphate
C00751  Squalene
C01054  (S)-2,3-Epoxysqualene
C01724  Lanosterol
C11455  4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
C05108  14-Demethyllanosterol
C15808  4alpha-Methylzymosterol-4-carboxylate
C15816  3-Keto-4-methylzymosterol
C05103  4alpha-Methylzymosterol
C22112  4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol
C22136  Zymosterone
C05437  Zymosterol
C04525  Fecosterol
C15777  Episterol
C15780  5-Dehydroepisterol
C05440  Ergosta-5,7,22,24(28)-tetraen-3beta-ol
C01694  Ergosterol
C05441  Vitamin D2
Reference
PMID:14554200
  Authors
Veen M, Stahl U, Lang C
  Title
Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae.
  Journal
FEMS Yeast Res 4:87-95 (2003)
DOI:10.1016/S1567-1356(03)00126-0
Reference
PMID:30042199
  Authors
Bhattacharya S, Esquivel BD, White TC
  Title
Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in Saccharomyces cerevisiae.
  Journal
mBio 9:e01291-18 (2018)
DOI:10.1128/mBio.01291-18
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