KEGG   MODULE: M00307
Entry
M00307            Pathway   Module                                 
Name
Pyruvate oxidation, pyruvate => acetyl-CoA
Definition
((K00163,K00161+K00162)+K00627+K00382-K13997),K00169+K00170+K00171+(K00172,K00189),K03737
Diagram
M00307

Orthology
K00163,K00161,K00162,K00627,K00382,K13997  
pyruvate dehydrogenase complex [EC:1.2.4.1 2.3.1.12 1.8.1.4] [RN:R00209 R00014 R03270 R02569 R07618]
K00169,K00170,K00171,K00172,K00189,K03737  
pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196]
Class
Pathway modules; Carbohydrate metabolism; Central carbohydrate metabolism
Pathway
map00010  Glycolysis / Gluconeogenesis
map00020  Citrate cycle (TCA cycle)
map00620  Pyruvate metabolism
map00785  Lipoic acid metabolism
map01200  Carbon metabolism
map01210  2-Oxocarboxylic acid metabolism
map01100  Metabolic pathways
Reaction
R00209,R01196  
R00014  
R03270  
R02569  
R07618  
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C15972  Enzyme N6-(lipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
RModule
RM044  2-Oxocarboxylic acid conversion to its CoA derivative
Comment
The oxidative decarboxylation of pyruvate to acetyl-CoA is catalyzed by the pyruvate dehydrogenase complex as part of aerobic respiration or by pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1].
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