KEGG   MODULE: M00357
Entry
M00357            Pathway   Module                                 
Name
Methanogenesis, acetate => methane
Definition
((K00925 K00625),K01895) (K00193+K00197+K00194) (K00577+K00578+K00579+K00580+K00581-K00582-K00583+K00584) (K00399+K00401+K00402) (K22480+K22481+K22482,K03388+K03389+K03390,K08264+K08265,K03388+K03389+K03390+K14127+(K14126+K14128,K22516+K00125))
Diagram
M00357

Orthology
K00925  
acetate kinase [EC:2.7.2.1] [RN:R00315]
K00625  
phosphate acetyltransferase [EC:2.3.1.8] [RN:R00230]
K01895  
acetyl-CoA synthetase [EC:6.2.1.1] [RN:R00235]
K00193+K00197+K00194  
acetyl-CoA decarbonylase/synthase complex [EC:2.3.1.-] [RN:R09096]
K00577+K00578+K00579+K00580+K00581-K00582-K00583+K00584  
tetrahydromethanopterin S-methyltransferase [EC:7.2.1.4] [RN:R04347]
K00399+K00401+K00402  
methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541]
K22480+K22481+K22482  
heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931]
K03388+K03389+K03390  
heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944]
K08264+K08265  
heterodisulfide reductase [EC:1.8.98.1] [RN:R04540]
K14126+K14128  
F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943]
K14127  
F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.8.98.5 1.8.98.6] [RN:R11943 R11944]
K22516+K00125  
formate dehydrogenase (coenzyme F420) [EC:1.8.98.6] [RN:R11944]
Class
Pathway modules; Energy metabolism; Methane metabolism
Pathway
map00680  Methane metabolism
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R00315  
R00230  
R00235  
R09096  
R04347  
R04541  
R11931,R04540,R11928,R11943,R11944  
Compound
C00033  Acetate
C00227  Acetyl phosphate
C00024  Acetyl-CoA
C04488  5-Methyl-5,6,7,8-tetrahydromethanopterin
C03576  Coenzyme M
C03920  2-(Methylthio)ethanesulfonate
C04628  Coenzyme B
C01438  Methane
C04832  Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide
Reference
PMID:18378594
  Authors
Liu Y, Whitman WB
  Title
Metabolic, phylogenetic, and ecological diversity of the methanogenic archaea.
  Journal
Ann N Y Acad Sci 1125:171-89 (2008)
DOI:10.1196/annals.1419.019
Reference
PMID:16024727
  Authors
Welander PV, Metcalf WW
  Title
Loss of the mtr operon in Methanosarcina blocks growth on methanol, but not methanogenesis, and reveals an unknown methanogenic pathway.
  Journal
Proc Natl Acad Sci U S A 102:10664-9 (2005)
DOI:10.1073/pnas.0502623102
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