KEGG   MODULE: M00373
Entry
M00373            Pathway   Module                                 
Name
Ethylmalonyl pathway
Definition
K00626 K00023 K17865 K14446 K14447 K14448 K14449 K08691 K14451
K01965+K01966 K05606 K01847
Diagram
M00373

Orthology
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
K00023  
acetoacetyl-CoA reductase [EC:1.1.1.36] [RN:R01977]
K17865  
3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55] [RN:R03027]
K14446  
crotonyl-CoA carboxylase/reductase [EC:1.3.1.85] [RN:R09291]
K14447  
ethylmalonyl-CoA mutase [EC:5.4.99.63] [RN:R09292]
K14448  
(2S)-methylsuccinyl-CoA dehydrogenase [EC:1.3.8.12] [RN:R09293]
K14449  
2-methylfumaryl-CoA hydratase [EC:4.2.1.148] [RN:R05076]
K08691  
malyl-CoA lyase [EC:4.1.3.24] [RN:R00934 R00473]
K14451  
(3S)-malyl-CoA thioesterase [RN:R10612]
K01965+K01966  
propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859]
K05606  
methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] [RN:R02765 R09979]
K01847  
methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833]
Class
Pathway modules; Carbohydrate metabolism; Other carbohydrate metabolism
Pathway
map00630  Glyoxylate and dicarboxylate metabolism
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R00238  
R01977  
R03027  
R09291  
R09979  
R09292  
R09293  
R05076  
R00934  
R00473  
R10612  
R01859  
R02765  
R00833  
Compound
C00024  Acetyl-CoA
C00332  Acetoacetyl-CoA
C03561  (R)-3-Hydroxybutanoyl-CoA
C00877  Crotonoyl-CoA
C18026  (2S)-Ethylmalonyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C06028  2-Methylfumaryl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C00100  Propanoyl-CoA
C00048  Glyoxylate
C04348  L-Malyl-CoA
C00149  (S)-Malate
C00683  (S)-Methylmalonyl-CoA
C01213  (R)-Methylmalonyl-CoA
C00091  Succinyl-CoA
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
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