KEGG   MODULE: M00563
Entry
M00563            Pathway   Module                                 
Name
Methanogenesis, methylamine/dimethylamine/trimethylamine => methane
Definition
K14082 ((K16177-K16176),(K16179-K16178),(K14084-K14083)) K00399+K00401+K00402 (K22480+K22481+K22482,K03388+K03389+K03390,K08264+K08265,K03388+K03389+K03390+K14127+(K14126+K14128,K22516+K00125))
Diagram
M00563

Orthology
K14082  
mtbA; [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase [EC:2.1.1.247] [RN:R09998]
K16176  
mtmB; methylamine---corrinoid protein Co-methyltransferase [EC:2.1.1.248] [RN:R09998]
K16177  
mtmC; monomethylamine corrinoid protein [RN:R09998]
K16178  
mtbB; dimethylamine---corrinoid protein Co-methyltransferase [EC:2.1.1.249] [RN:R09999]
K16179  
mtbC; dimethylamine corrinoid protein [RN:R09999]
K14083  
mttB; trimethylamine---corrinoid protein Co-methyltransferase [EC:2.1.1.250] [RN:R09124]
K14084  
mttC; trimethylamine corrinoid protein [RN:R09124]
K00399+K00401+K00402  
methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541]
K22480+K22481+K22482  
heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931]
K03388+K03389+K03390  
heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944]
K08264+K08265  
heterodisulfide reductase [EC:1.8.98.1] [RN:R04540]
K14126+K14128  
F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943]
K14127  
F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.8.98.5 1.8.98.6] [RN:R11943 R11944]
K22516+K00125  
formate dehydrogenase (coenzyme F420) [EC:1.8.98.6] [RN:R11944]
Class
Pathway modules; Energy metabolism; Methane metabolism
Pathway
map00680  Methane metabolism
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R09998  
R09999  
R09124  
R04541  
R11931,R04540,R11928,R11943,R11944  
Compound
C00218  Methylamine
C03920  2-(Methylthio)ethanesulfonate
C00543  Dimethylamine
C00565  Trimethylamine
C04628  Coenzyme B
C01438  Methane
C04832  Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide
Reference
PMID:9642198
  Authors
Burke SA, Lo SL, Krzycki JA
  Title
Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine.
  Journal
J Bacteriol 180:3432-40 (1998)
DOI:10.1128/JB.180.13.3432-3440.1998
Reference
PMID:20847933
  Authors
Rother M, Krzycki JA
  Title
Selenocysteine, pyrrolysine, and the unique energy metabolism of methanogenic archaea.
  Journal
Archaea 2010:453642 (2010)
DOI:10.1155/2010/453642
Reference
PMID:15882413
  Authors
Pritchett MA, Metcalf WW
  Title
Genetic, physiological and biochemical characterization of multiple methanol methyltransferase isozymes in Methanosarcina acetivorans C2A.
  Journal
Mol Microbiol 56:1183-94 (2005)
DOI:10.1111/j.1365-2958.2005.04616.x
Reference
PMID:16096277
  Authors
Soares JA, Zhang L, Pitsch RL, Kleinholz NM, Jones RB, Wolff JJ, Amster J, Green-Church KB, Krzycki JA
  Title
The residue mass of L-pyrrolysine in three distinct methylamine methyltransferases.
  Journal
J Biol Chem 280:36962-9 (2005)
DOI:10.1074/jbc.M506402200
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