KEGG   REACTION: R00256
Entry
R00256                      Reaction                               
Name
L-glutamine amidohydrolase
Definition
L-Glutamine + H2O <=> L-Glutamate + Ammonia
Equation
C00064 + C00001 <=> C00025 + C00014
Comment
ec 2.6.1.85 (see R01716, R00256+R05552)
ec 6.3.4.2 (see R00573, R00256+R00571)
ec 6.3.5.4 (see R00578, R00256+R00483)
ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
ec 2.6.1.123 (see R12939, R00256+R12937+R12938)
Reaction class
RC00010  C00025_C00064
RC02798  C00014_C00064
Enzyme
1.4.1.13        1.4.1.14        1.4.7.1         2.6.1.85        
2.6.1.123       3.5.1.2         3.5.1.38        4.3.2.10        
4.3.3.6         6.3.4.2         6.3.5.2         6.3.5.4         
6.3.5.5         6.3.5.13
Pathway
rn00220  Arginine biosynthesis
rn00250  Alanine, aspartate and glutamate metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.13
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
    1.4.1.14
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
   1.4.7  With an iron-sulfur protein as acceptor
    1.4.7.1
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
 2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.85
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
    2.6.1.123
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.2
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
    3.5.1.38
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
 4. Lyase reactions
  4.3  Carbon-nitrogen lyases
   4.3.2  Amidine-lyases
    4.3.2.10
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
   4.3.3  Amine-lyases
    4.3.3.6
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.2
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.2
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
    6.3.5.4
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
    6.3.5.5
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
    6.3.5.13
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
Orthology
K01425  glutaminase [EC:3.5.1.2]
K01954  carbamoyl-phosphate synthase [EC:6.3.5.5]
K01955  carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
K01956  carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
K05597  glutamin-(asparagin-)ase [EC:3.5.1.38]
K11540  carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
K11541  carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2]
K23265  phosphoribosylformylglycinamidine synthase subunit PurQ / glutaminase [EC:6.3.5.3 3.5.1.2]
Other DBs
RHEA: 15892
LinkDB

KEGG   REACTION: R10948
Entry
R10948                      Reaction                               
Name
ATP:HCO3- phosphotransferase
Definition
ATP + HCO3- <=> ADP + Carboxyphosphate
Equation
C00002 + C00288 <=> C00008 + C20969
Comment
a part of multi-step reaction (see R00575, R00256+R10948+R10949+R01395)
Reaction class
RC00002  C00002_C00008
RC03314  C00288_C20969
Enzyme
6.3.5.5
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.5
     R10948  ATP + HCO3- <=> ADP + Carboxyphosphate
Orthology
K01954  carbamoyl-phosphate synthase [EC:6.3.5.5]
K01955  carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
K01956  carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
K11540  carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
K11541  carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2]
Other DBs
RHEA: 46747
LinkDB

KEGG   REACTION: R10949
Entry
R10949                      Reaction                               
Definition
Ammonia + Carboxyphosphate <=> Carbamate + Orthophosphate
Equation
C00014 + C20969 <=> C01563 + C00009
Comment
a part of multi-step reaction (see R00575, R00256+R10948+R10949+R01395)
Enzyme
6.3.5.5
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.5
     R10949  Ammonia + Carboxyphosphate <=> Carbamate + Orthophosphate
Orthology
K01954  carbamoyl-phosphate synthase [EC:6.3.5.5]
K01955  carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
K01956  carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
K11540  carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
K11541  carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2]
Other DBs
RHEA: 46751
LinkDB

KEGG   REACTION: R01395
Entry
R01395                      Reaction                               
Name
ATP:carbamate phosphotransferase
Definition
ATP + Carbamate <=> ADP + Carbamoyl phosphate
Equation
C00002 + C01563 <=> C00008 + C00169
Comment
the first step of the two-step reaction (see R00150, R01395+R12185)
the last step of the multi-step reaction (see R00575, R00256+R10948+R10949+R01395)
Reaction class
RC00002  C00002_C00008
RC00043  C00169_C01563
Enzyme
2.7.2.2         6.3.5.5
Pathway
rn00910  Nitrogen metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.7  Transferring phosphorus-containing groups
   2.7.2  Phosphotransferases with a carboxy group as acceptor
    2.7.2.2
     R01395  ATP + Carbamate <=> ADP + Carbamoyl phosphate
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.5
     R01395  ATP + Carbamate <=> ADP + Carbamoyl phosphate
Orthology
K00926  carbamate kinase [EC:2.7.2.2]
K01954  carbamoyl-phosphate synthase [EC:6.3.5.5]
K01955  carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
K01956  carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
K11540  carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
K11541  carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2]
Other DBs
RHEA: 30758
LinkDB

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