KEGG   REACTION: R12939
Entry
R12939                      Reaction                               
Name
chorismate:L-glutamine aminotransferase (2-amino-4-deoxychorismate-forming)
Definition
Chorismate + 2 L-Glutamine + H2O <=> 4-Amino-4-deoxychorismate + 2 L-Glutamate + Ammonia
Equation
C00251 + 2 C00064 + C00001 <=> C11355 + 2 C00025 + C00014
Comment
three-step reaction (see R00256+R12937+R12938)
Reaction class
RC01418  C00251_C11355
Enzyme
2.6.1.123
Pathway
rn00790  Folate biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.123
     R12939  Chorismate + 2 L-Glutamine + H2O <=> 4-Amino-4-deoxychorismate + 2 L-Glutamate + Ammonia
Orthology
K25575  4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) component II [EC:2.6.1.123]
K25578  4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) component I [EC:2.6.1.123]
LinkDB

KEGG   REACTION: R00256
Entry
R00256                      Reaction                               
Name
L-glutamine amidohydrolase
Definition
L-Glutamine + H2O <=> L-Glutamate + Ammonia
Equation
C00064 + C00001 <=> C00025 + C00014
Comment
ec 2.6.1.85 (see R01716, R00256+R05552)
ec 6.3.4.2 (see R00573, R00256+R00571)
ec 6.3.5.4 (see R00578, R00256+R00483)
ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
ec 2.6.1.123 (see R12939, R00256+R12937+R12938)
Reaction class
RC00010  C00025_C00064
RC02798  C00014_C00064
Enzyme
1.4.1.13        1.4.1.14        1.4.7.1         2.6.1.85        
2.6.1.123       3.5.1.2         3.5.1.38        4.3.2.10        
4.3.3.6         6.3.4.2         6.3.5.2         6.3.5.4         
6.3.5.5         6.3.5.13
Pathway
rn00220  Arginine biosynthesis
rn00250  Alanine, aspartate and glutamate metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.13
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
    1.4.1.14
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
   1.4.7  With an iron-sulfur protein as acceptor
    1.4.7.1
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
 2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.85
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
    2.6.1.123
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.2
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
    3.5.1.38
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
 4. Lyase reactions
  4.3  Carbon-nitrogen lyases
   4.3.2  Amidine-lyases
    4.3.2.10
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
   4.3.3  Amine-lyases
    4.3.3.6
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.2
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.2
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
    6.3.5.4
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
    6.3.5.5
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
    6.3.5.13
     R00256  L-Glutamine + H2O <=> L-Glutamate + Ammonia
Orthology
K01425  glutaminase [EC:3.5.1.2]
K01954  carbamoyl-phosphate synthase [EC:6.3.5.5]
K01955  carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
K01956  carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
K05597  glutamin-(asparagin-)ase [EC:3.5.1.38]
K11540  carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
K11541  carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2]
K23265  phosphoribosylformylglycinamidine synthase subunit PurQ / glutaminase [EC:6.3.5.3 3.5.1.2]
Other DBs
RHEA: 15892
LinkDB

KEGG   REACTION: R12937
Entry
R12937                      Reaction                               
Definition
Chorismate + Ammonia <=> 2-Amino-2-deoxyisochorismate + H2O
Equation
C00251 + C00014 <=> C18054 + C00001
Comment
the second step of three-step reaction (see R12939, R00256+R12937+R12938)
Reaction class
RC02387  C00251_C18054
Enzyme
2.6.1.123
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.123
     R12937  Chorismate + Ammonia <=> 2-Amino-2-deoxyisochorismate + H2O
LinkDB

KEGG   REACTION: R12938
Entry
R12938                      Reaction                               
Definition
2-Amino-2-deoxyisochorismate + Ammonia <=> 4-Amino-4-deoxychorismate + Ammonia
Equation
C18054 + C00014 <=> C11355 + C00014
Comment
the last step of three-step reaction (see R12939, R00256+R12937+R12938)
Enzyme
2.6.1.123
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.123
     R12938  2-Amino-2-deoxyisochorismate + Ammonia <=> 4-Amino-4-deoxychorismate + Ammonia
LinkDB

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