KEGG   PATHWAY: ec00760
Entry
ec00760                     Pathway                                
Name
Nicotinate and nicotinamide metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
ec00760  Nicotinate and nicotinamide metabolism
ec00760

Module
M00115  NAD biosynthesis, aspartate => quinolinate => NAD [PATH:ec00760]
M00622  Nicotinate degradation, nicotinate => fumarate [PATH:ec00760]
M00810  Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde [PATH:ec00760]
M00811  Nicotine degradation, pyrrolidine pathway, nicotine => succinate semialdehyde [PATH:ec00760]
M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:ec00760]
Other DBs
UMBBD: nic
GO: 0046497 0006769
Enzyme
1.1.1.291   
1.1.1.328   
1.13.11.9   
1.14.13.10   
1.14.13.114   
1.14.13.163   
1.17.1.5   
1.17.2.1   
1.17.3.3   
1.2.1.16   
1.2.1.24   
1.2.1.79   
1.2.1.83   
1.2.3.1   
1.3.7.1   
1.4.1.21   
1.4.2.2   
1.4.2.3   
1.4.3.16   
1.5.3.19   
1.5.3.21   
1.5.3.5   
1.5.3.6   
1.5.99.14   
1.5.99.4   
1.6.1.1   
2.1.1.1   
2.3.1.286   
2.4.2.1   
2.4.2.12   
2.4.2.19   
2.4.99.20   
2.5.1.72   
2.7.1.173   
2.7.1.22   
2.7.1.23   
2.7.7.1   
2.7.7.18   
3.1.3.5   
3.2.2.14   
3.2.2.3   
3.2.2.5   
3.2.2.6   
3.5.1.106   
3.5.1.107   
3.5.1.19   
3.5.1.42   
3.5.2.18   
3.6.1.22   
3.6.1.9   
3.7.1.19   
4.1.3.32   
4.2.1.85   
5.2.1.1   
5.3.3.6   
5.4.99.4   
6.3.1.5   
6.3.4.21   
6.3.5.1   
7.1.1.1   
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00745  Nicotine
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16386  (R)-Nicotine
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  N-Methylmyosmine
Reference
PMID:13475371
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
PMID:16894175
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
PMID:11514508
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
PMID:16321959
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
PMID:21953451
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
Related
pathway
ec00020  Citrate cycle (TCA cycle)
ec00250  Alanine, aspartate and glutamate metabolism
ec00380  Tryptophan metabolism
ec00620  Pyruvate metabolism
ec00660  C5-Branched dibasic acid metabolism
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
KO pathway
ko00760   
LinkDB

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