Homo sapiens (human): 7040
Help
Entry
7040 CDS
T01001
Symbol
TGFB1, CED, DPD1, IBDIMDE, LAP, TGF-beta1, TGFB, TGFbeta
Name
(RefSeq) transforming growth factor beta 1
KO
K13375
transforming growth factor beta-1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04068
FoxO signaling pathway
hsa04110
Cell cycle
hsa04148
Efferocytosis
hsa04218
Cellular senescence
hsa04350
TGF-beta signaling pathway
hsa04380
Osteoclast differentiation
hsa04390
Hippo signaling pathway
hsa04659
Th17 cell differentiation
hsa04672
Intestinal immune network for IgA production
hsa04926
Relaxin signaling pathway
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05144
Malaria
hsa05145
Toxoplasmosis
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05166
Human T-cell leukemia virus 1 infection
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05210
Colorectal cancer
hsa05211
Renal cell carcinoma
hsa05212
Pancreatic cancer
hsa05220
Chronic myeloid leukemia
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05321
Inflammatory bowel disease
hsa05323
Rheumatoid arthritis
hsa05410
Hypertrophic cardiomyopathy
hsa05414
Dilated cardiomyopathy
hsa05415
Diabetic cardiomyopathy
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06162
Hepatitis B virus (HBV)
nt06218
TGFB signaling (cancer)
nt06225
HIF-1 signaling (cancer)
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06263
Hepatocellular carcinoma
nt06264
Renal cell carcinoma
nt06276
Chronic myeloid leukemia
nt06507
TGFB signaling
nt06535
Efferocytosis
Element
N00063
TGF-beta signaling pathway
N00079
HIF-1 signaling pathway
N00080
Loss of VHL to HIF-1 signaling pathway
N00081
Mutation-inactivated VHL to HIF-1 signaling pathway
N00531
HBV HBx to TGF-beta signaling pathway
N01460
Plasmin mediated activation of latent TGF-beta
N01773
PTGS2-PGE2-TGFB1 pathway
N01781
Activation of LXRs by oxysterols
Disease
H00083
Allograft rejection
H00084
Graft-versus-host disease
H00218
Cystic fibrosis
H00434
Camurati-Engelmann disease
H02669
Inflammatory bowel disease, immunodeficiency, and encephalopathy
Drug target
Fresolimumab:
D09620
Linavonkibart:
D12801
Livmoniplimab:
D12793
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
7040 (TGFB1)
04350 TGF-beta signaling pathway
7040 (TGFB1)
04390 Hippo signaling pathway
7040 (TGFB1)
04068 FoxO signaling pathway
7040 (TGFB1)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
7040 (TGFB1)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
7040 (TGFB1)
09143 Cell growth and death
04110 Cell cycle
7040 (TGFB1)
04218 Cellular senescence
7040 (TGFB1)
09150 Organismal Systems
09151 Immune system
04659 Th17 cell differentiation
7040 (TGFB1)
04672 Intestinal immune network for IgA production
7040 (TGFB1)
09152 Endocrine system
04926 Relaxin signaling pathway
7040 (TGFB1)
09158 Development and regeneration
04380 Osteoclast differentiation
7040 (TGFB1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
7040 (TGFB1)
05205 Proteoglycans in cancer
7040 (TGFB1)
09162 Cancer: specific types
05210 Colorectal cancer
7040 (TGFB1)
05212 Pancreatic cancer
7040 (TGFB1)
05225 Hepatocellular carcinoma
7040 (TGFB1)
05226 Gastric cancer
7040 (TGFB1)
05220 Chronic myeloid leukemia
7040 (TGFB1)
05211 Renal cell carcinoma
7040 (TGFB1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
7040 (TGFB1)
05161 Hepatitis B
7040 (TGFB1)
09171 Infectious disease: bacterial
05152 Tuberculosis
7040 (TGFB1)
09174 Infectious disease: parasitic
05146 Amoebiasis
7040 (TGFB1)
05144 Malaria
7040 (TGFB1)
05145 Toxoplasmosis
7040 (TGFB1)
05140 Leishmaniasis
7040 (TGFB1)
05142 Chagas disease
7040 (TGFB1)
09163 Immune disease
05323 Rheumatoid arthritis
7040 (TGFB1)
05321 Inflammatory bowel disease
7040 (TGFB1)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
7040 (TGFB1)
05414 Dilated cardiomyopathy
7040 (TGFB1)
05415 Diabetic cardiomyopathy
7040 (TGFB1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
7040 (TGFB1)
04933 AGE-RAGE signaling pathway in diabetic complications
7040 (TGFB1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03110 Chaperones and folding catalysts [BR:
hsa03110
]
7040 (TGFB1)
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:
hsa04052
]
7040 (TGFB1)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
7040 (TGFB1)
Chaperones and folding catalysts [BR:
hsa03110
]
Intramolecular chaperones
Others
7040 (TGFB1)
Cytokines and neuropeptides [BR:
hsa04052
]
Cytokines
Transforming growth factors (RSTK binding)
7040 (TGFB1)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Growth factors/receptors
7040 (TGFB1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
TGFb_propeptide
TGF_beta
Motif
Other DBs
NCBI-GeneID:
7040
NCBI-ProteinID:
NP_000651
OMIM:
190180
HGNC:
11766
Ensembl:
ENSG00000105329
UniProt:
P01137
A0A499FJK2
Structure
PDB
LinkDB
All DBs
Position
19:complement(41330323..41353922)
Genome browser
AA seq
390 aa
AA seq
DB search
MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
NT seq
1173 nt
NT seq
+upstream
nt +downstream
nt
atgccgccctccgggctgcggctgctgccgctgctgctaccgctgctgtggctactggtg
ctgacgcctggccggccggccgcgggactatccacctgcaagactatcgacatggagctg
gtgaagcggaagcgcatcgaggccatccgcggccagatcctgtccaagctgcggctcgcc
agccccccgagccagggggaggtgccgcccggcccgctgcccgaggccgtgctcgccctg
tacaacagcacccgcgaccgggtggccggggagagtgcagaaccggagcccgagcctgag
gccgactactacgccaaggaggtcacccgcgtgctaatggtggaaacccacaacgaaatc
tatgacaagttcaagcagagtacacacagcatatatatgttcttcaacacatcagagctc
cgagaagcggtacctgaacccgtgttgctctcccgggcagagctgcgtctgctgaggctc
aagttaaaagtggagcagcacgtggagctgtaccagaaatacagcaacaattcctggcga
tacctcagcaaccggctgctggcacccagcgactcgccagagtggttatcttttgatgtc
accggagttgtgcggcagtggttgagccgtggaggggaaattgagggctttcgccttagc
gcccactgctcctgtgacagcagggataacacactgcaagtggacatcaacgggttcact
accggccgccgaggtgacctggccaccattcatggcatgaaccggcctttcctgcttctc
atggccaccccgctggagagggcccagcatctgcaaagctcccggcaccgccgagccctg
gacaccaactattgcttcagctccacggagaagaactgctgcgtgcggcagctgtacatt
gacttccgcaaggacctcggctggaagtggatccacgagcccaagggctaccatgccaac
ttctgcctcgggccctgcccctacatttggagcctggacacgcagtacagcaaggtcctg
gccctgtacaaccagcataacccgggcgcctcggcggcgccgtgctgcgtgccgcaggcg
ctggagccgctgcccatcgtgtactacgtgggccgcaagcccaaggtggagcagctgtcc
aacatgatcgtgcgctcctgcaagtgcagctga
Homo sapiens (human): 19
Help
Entry
19 CDS
T01001
Symbol
ABCA1, ABC-1, ABC1, CERP, HDLCQTL13, HDLDT1, HPALP1, TGD
Name
(RefSeq) ATP binding cassette subfamily A member 1
KO
K05641
ATP-binding cassette, subfamily A (ABC1), member 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa02010
ABC transporters
hsa04148
Efferocytosis
hsa04975
Fat digestion and absorption
hsa04979
Cholesterol metabolism
hsa05417
Lipid and atherosclerosis
Network
nt06535
Efferocytosis
Element
N01748
Find-me signal (LPC)
N01781
Activation of LXRs by oxysterols
Disease
H00159
Tangier disease
H00930
Hypoalphalipoproteinemia
H02505
Atherosclerosis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09131 Membrane transport
02010 ABC transporters
19 (ABCA1)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
19 (ABCA1)
09150 Organismal Systems
09154 Digestive system
04975 Fat digestion and absorption
19 (ABCA1)
04979 Cholesterol metabolism
19 (ABCA1)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
19 (ABCA1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
02000 Transporters [BR:
hsa02000
]
19 (ABCA1)
Transporters [BR:
hsa02000
]
ABC transporters, eukaryotic type
ABCA (ABC1) subfamily
ABCA1, 2, 3, 4, 7, 12, 13 subgroups
19 (ABCA1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ABC_tran
ABC2_membrane_3
AAA_21
DUF4162
AAA_23
Mst1_SARAH
Motif
Other DBs
NCBI-GeneID:
19
NCBI-ProteinID:
NP_005493
OMIM:
600046
HGNC:
29
Ensembl:
ENSG00000165029
UniProt:
O95477
B7XCW9
B2RUU2
Structure
PDB
LinkDB
All DBs
Position
9:complement(104781006..104928155)
Genome browser
AA seq
2261 aa
AA seq
DB search
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKA
MPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDT
SMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILH
KVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPIL
RTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQI
YQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTPYCNDLMK
NLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELS
PKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGS
VYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVFTG
ITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVV
EQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIV
YEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFV
FLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFAS
LLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTW
YIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVS
IQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIL
GKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVG
LPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQ
GRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLS
SCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDI
GHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAE
TSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVK
GWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQ
PWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAP
VPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDL
TGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKK
HLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQK
GENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQER
VSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLAL
LLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNIN
DILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEG
VVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKI
YRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSN
IHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEK
YAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLT
SHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFG
LAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNF
AKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV
NT seq
6786 nt
NT seq
+upstream
nt +downstream
nt
atggcttgttggcctcagctgaggttgctgctgtggaagaacctcactttcagaagaaga
caaacatgtcagctgctgctggaagtggcctggcctctatttatcttcctgatcctgatc
tctgttcggctgagctacccaccctatgaacaacatgaatgccattttccaaataaagcc
atgccctctgcaggaacacttccttgggttcaggggattatctgtaatgccaacaacccc
tgtttccgttacccgactcctggggaggctcccggagttgttggaaactttaacaaatcc
attgtggctcgcctgttctcagatgctcggaggcttcttttatacagccagaaagacacc
agcatgaaggacatgcgcaaagttctgagaacattacagcagatcaagaaatccagctca
aacttgaagcttcaagatttcctggtggacaatgaaaccttctctgggttcctgtatcac
aacctctctctcccaaagtctactgtggacaagatgctgagggctgatgtcattctccac
aaggtatttttgcaaggctaccagttacatttgacaagtctgtgcaatggatcaaaatca
gaagagatgattcaacttggtgaccaagaagtttctgagctttgtggcctaccaagggag
aaactggctgcagcagagcgagtacttcgttccaacatggacatcctgaagccaatcctg
agaacactaaactctacatctcccttcccgagcaaggagctggctgaagccacaaaaaca
ttgctgcatagtcttgggactctggcccaggagctgttcagcatgagaagctggagtgac
atgcgacaggaggtgatgtttctgaccaatgtgaacagctccagctcctccacccaaatc
taccaggctgtgtctcgtattgtctgcgggcatcccgagggaggggggctgaagatcaag
tctctcaactggtatgaggacaacaactacaaagccctctttggaggcaatggcactgag
gaagatgctgaaaccttctatgacaactctacaactccttactgcaatgatttgatgaag
aatttggagtctagtcctctttcccgcattatctggaaagctctgaagccgctgctcgtt
gggaagatcctgtatacacctgacactccagccacaaggcaggtcatggctgaggtgaac
aagaccttccaggaactggctgtgttccatgatctggaaggcatgtgggaggaactcagc
cccaagatctggaccttcatggagaacagccaagaaatggaccttgtccggatgctgttg
gacagcagggacaatgaccacttttgggaacagcagttggatggcttagattggacagcc
caagacatcgtggcgtttttggccaagcacccagaggatgtccagtccagtaatggttct
gtgtacacctggagagaagctttcaacgagactaaccaggcaatccggaccatatctcgc
ttcatggagtgtgtcaacctgaacaagctagaacccatagcaacagaagtctggctcatc
aacaagtccatggagctgctggatgagaggaagttctgggctggtattgtgttcactgga
attactccaggcagcattgagctgccccatcatgtcaagtacaagatccgaatggacatt
gacaatgtggagaggacaaataaaatcaaggatgggtactgggaccctggtcctcgagct
gacccctttgaggacatgcggtacgtctgggggggcttcgcctacttgcaggatgtggtg
gagcaggcaatcatcagggtgctgacgggcaccgagaagaaaactggtgtctatatgcaa
cagatgccctatccctgttacgttgatgacatctttctgcgggtgatgagccggtcaatg
cccctcttcatgacgctggcctggatttactcagtggctgtgatcatcaagggcatcgtg
tatgagaaggaggcacggctgaaagagaccatgcggatcatgggcctggacaacagcatc
ctctggtttagctggttcattagtagcctcattcctcttcttgtgagcgctggcctgcta
gtggtcatcctgaagttaggaaacctgctgccctacagtgatcccagcgtggtgtttgtc
ttcctgtccgtgtttgctgtggtgacaatcctgcagtgcttcctgattagcacactcttc
tccagagccaacctggcagcagcctgtgggggcatcatctacttcacgctgtacctgccc
tacgtcctgtgtgtggcatggcaggactacgtgggcttcacactcaagatcttcgctagc
ctgctgtctcctgtggcttttgggtttggctgtgagtactttgccctttttgaggagcag
ggcattggagtgcagtgggacaacctgtttgagagtcctgtggaggaagatggcttcaat
ctcaccacttcggtctccatgatgctgtttgacaccttcctctatggggtgatgacctgg
tacattgaggctgtctttccaggccagtacggaattcccaggccctggtattttccttgc
accaagtcctactggtttggcgaggaaagtgatgagaagagccaccctggttccaaccag
aagagaatatcagaaatctgcatggaggaggaacccacccacttgaagctgggcgtgtcc
attcagaacctggtaaaagtctaccgagatgggatgaaggtggctgtcgatggcctggca
ctgaatttttatgagggccagatcacctccttcctgggccacaatggagcggggaagacg
accaccatgtcaatcctgaccgggttgttccccccgacctcgggcaccgcctacatcctg
ggaaaagacattcgctctgagatgagcaccatccggcagaacctgggggtctgtccccag
cataacgtgctgtttgacatgctgactgtcgaagaacacatctggttctatgcccgcttg
aaagggctctctgagaagcacgtgaaggcggagatggagcagatggccctggatgttggt
ttgccatcaagcaagctgaaaagcaaaacaagccagctgtcaggtggaatgcagagaaag
ctatctgtggccttggcctttgtcgggggatctaaggttgtcattctggatgaacccaca
gctggtgtggacccttactcccgcaggggaatatgggagctgctgctgaaataccgacaa
ggccgcaccattattctctctacacaccacatggatgaagcggacgtcctgggggacagg
attgccatcatctcccatgggaagctgtgctgtgtgggctcctccctgtttctgaagaac
cagctgggaacaggctactacctgaccttggtcaagaaagatgtggaatcctccctcagt
tcctgcagaaacagtagtagcactgtgtcatacctgaaaaaggaggacagtgtttctcag
agcagttctgatgctggcctgggcagcgaccatgagagtgacacgctgaccatcgatgtc
tctgctatctccaacctcatcaggaagcatgtgtctgaagcccggctggtggaagacata
gggcatgagctgacctatgtgctgccatatgaagctgctaaggagggagcctttgtggaa
ctctttcatgagattgatgaccggctctcagacctgggcatttctagttatggcatctca
gagacgaccctggaagaaatattcctcaaggtggccgaagagagtggggtggatgctgag
acctcagatggtaccttgccagcaagacgaaacaggcgggccttcggggacaagcagagc
tgtcttcgcccgttcactgaagatgatgctgctgatccaaatgattctgacatagaccca
gaatccagagagacagacttgctcagtgggatggatggcaaagggtcctaccaggtgaaa
ggctggaaacttacacagcaacagtttgtggcccttttgtggaagagactgctaattgcc
agacggagtcggaaaggattttttgctcagattgtcttgccagctgtgtttgtctgcatt
gcccttgtgttcagcctgatcgtgccaccctttggcaagtaccccagcctggaacttcag
ccctggatgtacaacgaacagtacacatttgtcagcaatgatgctcctgaggacacggga
accctggaactcttaaacgccctcaccaaagaccctggcttcgggacccgctgtatggaa
ggaaacccaatcccagacacgccctgccaggcaggggaggaagagtggaccactgcccca
gttccccagaccatcatggacctcttccagaatgggaactggacaatgcagaacccttca
cctgcatgccagtgtagcagcgacaaaatcaagaagatgctgcctgtgtgtcccccaggg
gcaggggggctgcctcctccacaaagaaaacaaaacactgcagatatccttcaggacctg
acaggaagaaacatttcggattatctggtgaagacgtatgtgcagatcatagccaaaagc
ttaaagaacaagatctgggtgaatgagtttaggtatggcggcttttccctgggtgtcagt
aatactcaagcacttcctccgagtcaagaagttaatgatgccatcaaacaaatgaagaaa
cacctaaagctggccaaggacagttctgcagatcgatttctcaacagcttgggaagattt
atgacaggactggacaccaaaaataatgtcaaggtgtggttcaataacaagggctggcat
gcaatcagctctttcctgaatgtcatcaacaatgccattctccgggccaacctgcaaaag
ggagagaaccctagccattatggaattactgctttcaatcatcccctgaatctcaccaag
cagcagctctcagaggtggctctgatgaccacatcagtggatgtccttgtgtccatctgt
gtcatctttgcaatgtccttcgtcccagccagctttgtcgtattcctgatccaggagcgg
gtcagcaaagcaaaacacctgcagttcatcagtggagtgaagcctgtcatctactggctc
tctaattttgtctgggatatgtgcaattacgttgtccctgccacactggtcattatcatc
ttcatctgcttccagcagaagtcctatgtgtcctccaccaatctgcctgtgctagccctt
ctacttttgctgtatgggtggtcaatcacacctctcatgtacccagcctcctttgtgttc
aagatccccagcacagcctatgtggtgctcaccagcgtgaacctcttcattggcattaat
ggcagcgtggccacctttgtgctggagctgttcaccgacaataagctgaataatatcaat
gatatcctgaagtccgtgttcttgatcttcccacatttttgcctgggacgagggctcatc
gacatggtgaaaaaccaggcaatggctgatgccctggaaaggtttggggagaatcgcttt
gtgtcaccattatcttgggacttggtgggacgaaacctcttcgccatggccgtggaaggg
gtggtgttcttcctcattactgttctgatccagtacagattcttcatcaggcccagacct
gtaaatgcaaagctatctcctctgaatgatgaagatgaagatgtgaggcgggaaagacag
agaattcttgatggtggaggccagaatgacatcttagaaatcaaggagttgacgaagata
tatagaaggaagcggaagcctgctgttgacaggatttgcgtgggcattcctcctggtgag
tgctttgggctcctgggagttaatggggctggaaaatcatcaactttcaagatgttaaca
ggagataccactgttaccagaggagatgctttccttaacaaaaatagtatcttatcaaac
atccatgaagtacatcagaacatgggctactgccctcagtttgatgccatcacagagctg
ttgactgggagagaacacgtggagttctttgcccttttgagaggagtcccagagaaagaa
gttggcaaggttggtgagtgggcgattcggaaactgggcctcgtgaagtatggagaaaaa
tatgctggtaactatagtggaggcaacaaacgcaagctctctacagccatggctttgatc
ggcgggcctcctgtggtgtttctggatgaacccaccacaggcatggatcccaaagcccgg
cggttcttgtggaattgtgccctaagtgttgtcaaggaggggagatcagtagtgcttaca
tctcatagtatggaagaatgtgaagctctttgcactaggatggcaatcatggtcaatgga
aggttcaggtgccttggcagtgtccagcatctaaaaaataggtttggagatggttataca
atagttgtacgaatagcagggtccaacccggacctgaagcctgtccaggatttctttgga
cttgcatttcctggaagtgttctaaaagagaaacaccggaacatgctacaataccagctt
ccatcttcattatcttctctggccaggatattcagcatcctctcccagagcaaaaagcga
ctccacatagaagactactctgtttctcagacaacacttgaccaagtatttgtgaacttt
gccaaggaccaaagtgatgatgaccacttaaaagacctctcattacacaaaaaccagaca
gtagtggacgttgcagttctcacatcttttctacaggatgagaaagtgaaagaaagctat
gtatga
Homo sapiens (human): 246
Help
Entry
246 CDS
T01001
Symbol
ALOX15, 12-LOX, 15-LOX, 15-LOX-1, LOG15
Name
(RefSeq) arachidonate 15-lipoxygenase
KO
K00460
arachidonate 15-lipoxygenase [EC:
1.13.11.33
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00590
Arachidonic acid metabolism
hsa00591
Linoleic acid metabolism
hsa01100
Metabolic pathways
hsa04148
Efferocytosis
hsa04216
Ferroptosis
hsa04217
Necroptosis
hsa04726
Serotonergic synapse
Network
nt06525
Ferroptosis
nt06535
Efferocytosis
Element
N01590
Arachidonate/Adrenic acid metabolism
N01781
Activation of LXRs by oxysterols
Drug target
Utreloxastat:
D12510
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00590 Arachidonic acid metabolism
246 (ALOX15)
00591 Linoleic acid metabolism
246 (ALOX15)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
246 (ALOX15)
09143 Cell growth and death
04216 Ferroptosis
246 (ALOX15)
04217 Necroptosis
246 (ALOX15)
09150 Organismal Systems
09156 Nervous system
04726 Serotonergic synapse
246 (ALOX15)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.13.11 With incorporation of two atoms of oxygen
1.13.11.33 arachidonate 15-lipoxygenase
246 (ALOX15)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Lipoxygenase
PLAT
Motif
Other DBs
NCBI-GeneID:
246
NCBI-ProteinID:
NP_001131
OMIM:
152392
HGNC:
433
Ensembl:
ENSG00000161905
UniProt:
P16050
LinkDB
All DBs
Position
17:complement(4630919..4641678)
Genome browser
AA seq
662 aa
AA seq
DB search
MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
NT seq
1989 nt
NT seq
+upstream
nt +downstream
nt
atgggtctctaccgcatccgcgtgtccactggggcctcgctctatgccggttccaacaac
caggtgcagctgtggctggtcggccagcacggggaggcggcgctcgggaagcgactgtgg
cccgcacggggcaaggagacagaactcaaggtggaagtaccggagtatctggggccgctg
ctgtttgtgaaactgcgcaaacggcacctccttaaggacgacgcctggttctgcaactgg
atctctgtgcagggccccggagccggggacgaggtcaggttcccttgttaccgctgggtg
gagggcaacggcgtcctgagcctgcctgaaggcaccggccgcactgtgggcgaggaccct
cagggcctgttccagaaacaccgggaagaagagctggaagagagaaggaagttgtaccgg
tggggaaactggaaggacgggttaattctgaatatggctggggccaaactatatgacctc
cctgtggatgagcgatttctggaagacaagagagttgactttgaggtttcgctggccaag
gggctggccgacctcgctatcaaagactctctaaatgttctgacttgctggaaggatcta
gatgacttcaaccggattttctggtgtggtcagagcaagctggctgagcgcgtgcgggac
tcctggaaggaagatgccttatttgggtaccagtttcttaatggcgccaaccccgtggtg
ctgaggcgctctgctcaccttcctgctcgcctagtgttccctccaggcatggaggaactg
caggcccagctggagaaggagctggagggaggcacactgttcgaagctgacttctccctg
ctggatgggatcaaggccaacgtcattctctgtagccagcagcacctggctgcccctcta
gtcatgctgaaattgcagcctgatgggaaactcttgcccatggtcatccagctccagctg
ccccgcacaggatccccaccacctccccttttcttgcctacggatcccccaatggcctgg
cttctggccaaatgctgggtgcgcagctctgacttccagctccatgagctgcagtctcat
cttctgaggggacacttgatggctgaggtcattgttgtggccaccatgaggtgcctgccg
tcgatacatcctatcttcaagcttataattccccacctgcgatacaccctggaaattaac
gtccgggccaggactgggctggtctctgacatgggaattttcgaccagataatgagcact
ggtgggggaggccacgtgcagctgctcaagcaagctggagccttcctaacctacagctcc
ttctgtccccctgatgacttggccgaccgggggctcctgggagtgaagtcttccttctat
gcccaagatgcgctgcggctctgggaaatcatctatcggtatgtggaaggaatcgtgagt
ctccactataagacagacgtggctgtgaaagacgacccagagctgcagacctggtgtcga
gagatcactgaaatcgggctgcaaggggcccaggaccgagggtttcctgtctctttacag
gctcgggaccaggtttgccactttgtcaccatgtgtatcttcacctgcaccggccaacac
gcctctgtgcacctgggccagctggactggtactcttgggtgcctaatgcaccctgcacg
atgcggctgcccccgccaaccaccaaggatgcaacgctggagacagtgatggcgacactg
cccaacttccaccaggcttctctccagatgtccatcacttggcagctgggcagacgccag
cccgttatggtggctgtgggccagcatgaggaggagtatttttcgggccctgagcctaag
gctgtgctgaagaagttcagggaggagctggctgccctggataaggaaattgagatccgg
aatgcaaagctggacatgccctacgagtacctgcggcccagcgtggtggaaaacagtgtg
gccatctaa
Homo sapiens (human): 10461
Help
Entry
10461 CDS
T01001
Symbol
MERTK, MER, RP38, Tyro12, c-Eyk, c-mer
Name
(RefSeq) MER proto-oncogene, tyrosine kinase
KO
K05117
c-mer proto-oncogene tyrosine kinase [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04148
Efferocytosis
Network
nt06535
Efferocytosis
Element
N01751
Macrophage EPO signaling
N01762
MERTK-mediated recognition and engulfment
N01775
Inactivation of CaMKII by inducing SERCA2
N01781
Activation of LXRs by oxysterols
Disease
H00527
Retinitis pigmentosa
Drug target
Zanzalintinib (
DG03273
):
D12650
D12651
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
10461 (MERTK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
10461 (MERTK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
10461 (MERTK)
Protein kinases [BR:
hsa01001
]
Receptor tyrosine kinases (RTK)
AXL family
10461 (MERTK)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
Ig_3
Ig_2
fn3
ig
I-set
V-set
Ig_6
Pkinase_fungal
DUF4833
Motif
Other DBs
NCBI-GeneID:
10461
NCBI-ProteinID:
NP_006334
OMIM:
604705
HGNC:
7027
Ensembl:
ENSG00000153208
UniProt:
Q12866
Structure
PDB
LinkDB
All DBs
Position
2:111898607..112029561
Genome browser
AA seq
999 aa
AA seq
DB search
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ
PALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVP
NIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKIN
NEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNE
QPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSI
LISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVS
CMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY
RISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFI
PAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE
EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS
VMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMS
SQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL
HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK
SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD
PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPD
SIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGE
RLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
NT seq
3000 nt
NT seq
+upstream
nt +downstream
nt
atggggccggccccgctgccgctgctgctgggcctcttcctccccgcgctctggcgtaga
gctatcactgaggcaagggaagaagccaagccttacccgctattcccgggaccttttcca
gggagcctgcaaactgaccacacaccgctgttatcccttcctcacgccagtgggtaccag
cctgccttgatgttttcaccaacccagcctggaagaccacatacaggaaacgtagccatt
ccccaggtgacctctgtcgaatcaaagcccctaccgcctcttgccttcaaacacacagtt
ggacacataatactttctgaacataaaggtgtcaaatttaattgctcaatcagtgtacct
aatatataccaggacaccacaatttcttggtggaaagatgggaaggaattgcttggggca
catcatgcaattacacagttttatccagatgatgaagttacagcaataatcgcttccttc
agcataaccagtgtgcagcgttcagacaatgggtcgtatatctgtaagatgaaaataaac
aatgaagagatcgtgtctgatcccatctacatcgaagtacaaggacttcctcactttact
aagcagcctgagagcatgaatgtcaccagaaacacagccttcaacctcacctgtcaggct
gtgggcccgcctgagcccgtcaacattttctgggttcaaaacagtagccgtgttaacgaa
cagcctgaaaaatccccctccgtgctaactgttccaggcctgacggagatggcggtcttc
agttgtgaggcccacaatgacaaagggctgaccgtgtccaagggagtgcagatcaacatc
aaagcaattccctccccaccaactgaagtcagcatccgtaacagcactgcacacagcatt
ctgatctcctgggttcctggttttgatggatactccccgttcaggaattgcagcattcag
gtcaaggaagctgatccgctgagtaatggctcagtcatgatttttaacacctctgcctta
ccacatctgtaccaaatcaagcagctgcaagccctggctaattacagcattggtgtttcc
tgcatgaatgaaataggctggtctgcagtgagcccttggattctagccagcacgactgaa
ggagccccatcagtagcacctttaaatgtcactgtgtttctgaatgaatctagtgataat
gtggacatcagatggatgaagcctccgactaagcagcaggatggagaactggtgggctac
cggatatcccacgtgtggcagagtgcagggatttccaaagagctcttggaggaagttggc
cagaatggcagccgagctcggatctctgttcaagtccacaatgctacgtgcacagtgagg
attgcagccgtcaccagagggggagttgggcccttcagtgatccagtgaaaatatttatc
cctgcacacggttgggtagattatgccccctcttcaactccggcgcctggcaacgcagat
cctgtgctcatcatctttggctgcttttgtggatttattttgattgggttgattttatac
atctccttggccatcagaaaaagagtccaggagacaaagtttgggaatgcattcacagag
gaggattctgaattagtggtgaattatatagcaaagaaatccttctgtcggcgagccatt
gaacttaccttacatagcttgggagtcagtgaggaactacaaaataaactagaagatgtt
gtgattgacaggaatcttctaattcttggaaaaattctgggtgaaggagagtttgggtct
gtaatggaaggaaatcttaagcaggaagatgggacctctctgaaagtggcagtgaagacc
atgaagttggacaactcttcacagcgggagatcgaggagtttctcagtgaggcagcgtgc
atgaaagacttcagccacccaaatgtcattcgacttctaggtgtgtgtatagaaatgagc
tctcaaggcatcccaaagcccatggtaattttacccttcatgaaatacggggacctgcat
acttacttactttattcccgattggagacaggaccaaagcatattcctctgcagacacta
ttgaagttcatggtggatattgccctgggaatggagtatctgagcaacaggaattttctt
catcgagatttagctgctcgaaactgcatgttgcgagatgacatgactgtctgtgttgcg
gacttcggcctctctaagaagatttacagtggcgattattaccgccaaggccgcattgct
aagatgcctgttaaatggatcgccatagaaagtcttgcagaccgagtctacacaagtaaa
agtgatgtgtgggcatttggcgtgaccatgtgggaaatagctacgcggggaatgactccc
tatcctggggtccagaaccatgagatgtatgactatcttctccatggccacaggttgaag
cagcccgaagactgcctggatgaactgtatgaaataatgtactcttgctggagaaccgat
cccttagaccgccccaccttttcagtattgaggctgcagctagaaaaactcttagaaagt
ttgcctgacgttcggaaccaagcagacgttatttacgtcaatacacagttgctggagagc
tctgagggcctggcccagggctccacccttgctccactggacttgaacatcgaccctgac
tctataattgcctcctgcactccccgcgctgccatcagtgtggtcacagcagaagttcat
gacagcaaacctcatgaaggacggtacatcctgaatgggggcagtgaggaatgggaagat
ctgacttctgccccctctgctgcagtcacagctgaaaagaacagtgttttaccgggggag
agacttgttaggaatggggtctcctggtcccattcgagcatgctgcccttgggaagctca
ttgcccgatgaacttttgtttgctgacgactcctcagaaggctcagaagtcctgatgtga
DBGET
integrated database retrieval system
