KEGG   Homo sapiens (human): 8318
Entry
8318              CDS       T01001                                 
Symbol
CDC45, CDC45L, CDC45L2, MGORS7, PORC-PI-1
Name
(RefSeq) cell division cycle 45
  KO
K06628  cell division control protein 45
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
Network
nt06509  DNA replication
  Element
N01468  DNA replication licensing
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
N01473  DNA replication termination
N01474  TRAIP-dependent replisome disassembly
Disease
H01889  Meier-Gorlin syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    8318 (CDC45)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    8318 (CDC45)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   Other initiation factors
    8318 (CDC45)
SSDB
Motif
Pfam: CDC45
Other DBs
NCBI-GeneID: 8318
NCBI-ProteinID: NP_003495
OMIM: 603465
HGNC: 1739
Ensembl: ENSG00000093009
UniProt: O75419
Structure
LinkDB
Position
22:19479466..19520612
AA seq 566 aa
MFVSDFRKEFYEVVQSQRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELET
AFLEHKEQFHYFILINCGANVDLLDILQPDEDTIFFVCDTHRPVNVVNVYNDTQIKLLIK
QDDDLEVPAYEDIFRDEEEDEEHSGNDSDGSEPSEKRTRLEEEIVEQTMRRRQRREWEAR
RRDILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVT
DVGVLQRHVSRHNHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARF
KLWSVHGQKRLQEFLADMGLPLKQVKQKFQAMDISLKENLREMIEESANKFGMKDMRVQT
FSIHFGFKHKFLASDVVFATMSLMESPEKDGSGTDHFIQALDSLSRSNLDKLYHGLELAK
KQLRATQQTIASCLCTNLVISQGPFLYCSLMEGTPDVMLFSRPASLSLLSKHLLKSFVCS
TKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHN
HFDLSVIELKAEDRSKFLDALISLLS
NT seq 1701 nt   +upstreamnt  +downstreamnt
atgttcgtgtccgatttccgcaaagagttctacgaggtggtccagagccagagggtcctt
ctcttcgtggcctcggacgtggatgctctgtgtgcgtgcaagatccttcaggccttgttc
cagtgtgaccacgtgcaatatacgctggttccagtttctgggtggcaagaacttgaaact
gcatttcttgagcataaagaacagtttcattattttattctcataaactgtggagctaat
gtagacctattggatattcttcaacctgatgaagacactatattctttgtgtgtgacacc
cataggccagtcaatgtcgtcaatgtatacaacgatacccagatcaaattactcattaaa
caagatgatgaccttgaagttcccgcctatgaagacatcttcagggatgaagaggaggat
gaagagcattcaggaaatgacagtgatgggtcagagccttctgagaagcgcacacggtta
gaagaggagatagtggagcaaaccatgcggaggaggcagcggcgagagtgggaggcccgg
agaagagacatcctctttgactacgagcagtatgaatatcatgggacatcgtcagccatg
gtgatgtttgagctggcttggatgctgtccaaggacctgaatgacatgctgtggtgggcc
atcgttggactaacagaccagtgggtgcaagacaagatcactcaaatgaaatacgtgact
gatgttggtgtcctgcagcgccacgtttcccgccacaaccaccggaacgaggatgaggag
aacacactctccgtggactgcacacggatctcctttgagtatgacctccgcctggtgctc
taccagcactggtccctccatgacagcctgtgcaacaccagctataccgcagccaggttc
aagctgtggtctgtgcatggacagaagcggctccaggagttccttgcagacatgggtctt
cccctgaagcaggtgaagcagaagttccaggccatggacatctccttgaaggagaatttg
cgggaaatgattgaagagtctgcaaataaatttgggatgaaggacatgcgcgtgcagact
ttcagcattcattttgggttcaagcacaagtttctggccagcgacgtggtctttgccacc
atgtctttgatggagagccccgagaaggatggctcagggacagatcacttcatccaggct
ctggacagcctctccaggagtaacctggacaagctgtaccatggcctggaactcgccaag
aagcagctgcgagccacccagcagaccattgccagctgcctttgcaccaacctcgtcatc
tcccaggggcctttcctgtactgctctctcatggagggcactccagatgtcatgctgttc
tctaggccggcatccctaagcctgctcagcaaacacctgctcaagtcctttgtgtgttcg
acaaagaaccggcgctgcaaactgctgcccctggtgatggctgcccccctgagcatggag
catggcacagtgaccgtggtgggcatccccccagagaccgacagctcggacaggaagaac
ttttttgggagggcgtttgagaaggcagcggaaagcaccagctcccggatgctgcacaac
cattttgacctctcagtaattgagctgaaagctgaggatcggagcaagtttctggacgca
cttatttccctcctgtcctag

KEGG   Homo sapiens (human): 4171
Entry
4171              CDS       T01001                                 
Symbol
MCM2, BM28, CCNL1, CDCL1, D3S3194, DFNA70, MITOTIN, cdc19
Name
(RefSeq) minichromosome maintenance complex component 2
  KO
K02540  DNA replication licensing factor MCM2 [EC:5.6.2.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa04110  Cell cycle
Network
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01450  Break induced replication
N01468  DNA replication licensing
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
N01473  DNA replication termination
N01474  TRAIP-dependent replisome disassembly
Disease
H00604  Deafness, autosomal dominant
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    4171 (MCM2)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    4171 (MCM2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    4171 (MCM2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    4171 (MCM2)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.3  DNA 5'-3' helicase
     4171 (MCM2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   pre-RC (pre-replication complex)
    4171 (MCM2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Other centriole associated proteins
    4171 (MCM2)
SSDB
Motif
Pfam: MCM MCM_OB MCM_lid MCM_N MCM2_N Mg_chelatase AAA_3 AAA_5 AAA_lid_2 AAA Sigma54_activ_2
Other DBs
NCBI-GeneID: 4171
NCBI-ProteinID: NP_004517
OMIM: 116945
HGNC: 6944
Ensembl: ENSG00000073111
UniProt: P49736
Structure
LinkDB
Position
3:127598411..127622436
AA seq 904 aa
MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTE
GPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQR
DREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGH
SVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAR
EHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQL
HLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGP
FEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHN
NYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFAS
IAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVS
SRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSI
HEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDIL
CVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVL
KKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARI
HLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLV
AEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMI
LQQF
NT seq 2715 nt   +upstreamnt  +downstreamnt
atggcggaatcatcggaatccttcaccatggcatccagcccggcccagcgtcggcgaggc
aatgatcctctcacctccagccctggccgaagctcccggcgtactgatgccctcacctcc
agccctggccgtgaccttccaccatttgaggatgagtccgaggggctcctaggcacagag
gggcccctggaggaagaagaggatggagaggagctcattggagatggcatggaaagggac
taccgcgccatcccagagctggacgcctatgaggccgagggactggctctggatgatgag
gacgtagaggagctgacggccagtcagagggaggcagcagagcgggccatgcggcagcgt
gaccgggaggctggccggggcctgggccgcatgcgccgtgggctcctgtatgacagcgat
gaggaggacgaggagcgccctgcccgcaagcgccgccaggtggagcgggccacggaggac
ggcgaggaggacgaggagatgatcgagagcatcgagaacctggaggatctcaaaggccac
tctgtgcgcgagtgggtgagcatggcgggcccccggctggagatccaccaccgcttcaag
aacttcctgcgcactcacgtcgacagccacggccacaacgtcttcaaggagcgcatcagc
gacatgtgcaaagagaaccgtgagagcctggtggtgaactatgaggacttggcagccagg
gagcacgtgctggcctacttcctgcctgaggcaccggcggagctgctgcagatctttgat
gaggctgccctggaggtggtactggccatgtaccccaagtacgaccgcatcaccaaccac
atccatgtccgcatctcccacctgcctctggtggaggagctgcgctcgctgaggcagctg
catctgaaccagctgatccgcaccagtggggtggtgaccagctgcactggcgtcctgccc
cagctcagcatggtcaagtacaactgcaacaagtgcaatttcgtcctgggtcctttctgc
cagtcccagaaccaggaggtgaaaccaggctcctgtcctgagtgccagtcggccggcccc
tttgaggtcaacatggaggagaccatctatcagaactaccagcgtatccgaatccaggag
agtccaggcaaagtggcggctggccggctgccccgctccaaggacgccattctcctcgca
gatctggtggacagctgcaagccaggagacgagatagagctgactggcatctatcacaac
aactatgatggctccctcaacactgccaatggcttccctgtctttgccactgtcatccta
gccaaccacgtggccaagaaggacaacaaggttgctgtaggggaactgaccgatgaagat
gtgaagatgatcactagcctctccaaggatcagcagatcggagagaagatctttgccagc
attgctccttccatctatggtcatgaagacatcaagagaggcctggctctggccctgttc
ggaggggagcccaaaaacccaggtggcaagcacaaggtacgtggtgatatcaacgtgctc
ttgtgcggagaccctggcacagcgaagtcgcagtttctcaagtatattgagaaagtgtcc
agccgagccatcttcaccactggccagggggcgtcggctgtgggcctcacggcgtatgtc
cagcggcaccctgtcagcagggagtggaccttggaggctggggccctggttctggctgac
cgaggagtgtgtctcattgatgaatttgacaagatgaatgaccaggacagaaccagcatc
catgaggccatggagcaacagagcatctccatctcgaaggctggcatcgtcacctccctg
caggctcgctgcacggtcattgctgccgccaaccccataggagggcgctacgacccctcg
ctgactttctctgagaacgtggacctcacagagcccatcatctcacgctttgacatcctg
tgtgtggtgagggacaccgtggacccagtccaggacgagatgctggcccgcttcgtggtg
ggcagccacgtcagacaccaccccagcaacaaggaggaggaggggctggccaatggcagc
gctgctgagcccgccatgcccaacacgtatggcgtggagcccctgccccaggaggtcctg
aagaagtacatcatctacgccaaggagagggtccacccgaagctcaaccagatggaccag
gacaaggtggccaagatgtacagtgacctgaggaaagaatctatggcgacaggcagcatc
cccattacggtgcggcacatcgagtccatgatccgcatggcggaggcccacgcgcgcatc
catctgcgggactatgtgatcgaagacgacgtcaacatggccatccgcgtgatgctggag
agcttcatagacacacagaagttcagcgtcatgcgcagcatgcgcaagacttttgcccgc
tacctttcattccggcgtgacaacaatgagctgttgctcttcatactgaagcagttagtg
gcagagcaggtgacatatcagcgcaaccgctttggggcccagcaggacactattgaggtc
cctgagaaggacttggtggataaggctcgtcagatcaacatccacaacctctctgcattt
tatgacagtgagctcttcaggatgaacaagttcagccacgacctgaaaaggaaaatgatc
ctgcagcagttctga

KEGG   Homo sapiens (human): 4172
Entry
4172              CDS       T01001                                 
Symbol
MCM3, HCC5, P1-MCM3, P1.h, RLFB
Name
(RefSeq) minichromosome maintenance complex component 3
  KO
K02541  DNA replication licensing factor MCM3 [EC:5.6.2.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa04110  Cell cycle
Network
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01450  Break induced replication
N01468  DNA replication licensing
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
N01473  DNA replication termination
N01474  TRAIP-dependent replisome disassembly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    4172 (MCM3)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    4172 (MCM3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    4172 (MCM3)
   03036 Chromosome and associated proteins [BR:hsa03036]
    4172 (MCM3)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.3  DNA 5'-3' helicase
     4172 (MCM3)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   pre-RC (pre-replication complex)
    4172 (MCM3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Other centriole associated proteins
    4172 (MCM3)
SSDB
Motif
Pfam: MCM MCM_OB MCM_lid MCM_N Mg_chelatase AAA_3 AAA_5 Sigma54_activat
Other DBs
NCBI-GeneID: 4172
NCBI-ProteinID: NP_002379
OMIM: 602693
HGNC: 6945
Ensembl: ENSG00000112118
UniProt: P25205 A0A0S2Z4T1
Structure
LinkDB
Position
6:complement(52264015..52284742)
AA seq 808 aa
MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEK
RANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCF
LSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEE
NNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGT
YRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLA
KSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLC
TAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRT
AIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFD
LLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQ
DTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQ
DSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEK
EKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQV
HTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEEPF
SSVEIQAALSKMQDDNQVMVSEGIIFLI
NT seq 2427 nt   +upstreamnt  +downstreamnt
atggcgggtaccgtggtgctggacgatgtggagctgcgggaggctcagagagattacctg
gacttcctggacgacgaggaagaccagggaatttatcagagcaaagttcgggagctgatc
agtgacaaccaataccggctgattgtcaatgtgaatgacctgcgcaggaaaaacgagaag
agggctaaccggcttctgaacaatgcctttgaggagctggttgccttccagcgggcctta
aaggattttgtggcctccattgatgctacctatgccaagcagtatgaggagttctacgta
ggactggaaggcagctttggctccaagcacgtctccccgcggactcttacctcctgcttc
ctcagctgtgtggtctgtgtggagggcattgtcactaaatgttctctagttcgtcccaaa
gtcgtccgcagtgtccactactgtcctgctactaagaagaccatagagcgacgttattct
gatctcaccaccctggtggcctttccctccagctctgtctatcctaccaaggatgaggag
aacaatccccttgagacagaatatggcctttctgtctacaaggatcaccagaccatcacc
atccaggagatgccggagaaggccccagccggccagctcccccgctctgtggacgtcatt
ctggatgatgacttggtggataaagcgaagcctggtgaccgggttcaggtggtgggaacc
taccgttgccttcctggaaagaagggaggctacacctctgggaccttcaggactgtcctg
attgcctgtaatgttaagcagatgagcaaggatgctcagccctctttctctgctgaggat
atagccaagatcaagaagttcagtaaaacccgatccaaggatatctttgaccagctggcc
aagtcattggccccaagtatccatgggcatgactatgtcaagaaagcaatcctctgcttg
ctcttgggaggggtggaacgagacctagaaaatggcagccacatccgtggggacatcaat
attcttctaataggagacccatccgttgccaagtctcagcttctgcggtatgtgctttgc
actgcaccccgagctatccccaccactggccggggctcctctggagtgggtctgacggct
gctgtcaccacagaccaggaaacaggagagcgccgtctggaagcaggggccatggtcctg
gctgaccgaggcgtggtttgcattgatgaatttgacaaaatgtctgacatggatcgcaca
gccatccatgaagtgatggagcagggtcgagtgaccattgccaaggctggcatccatgct
cggctgaatgcccgctgcagtgttttggcagctgccaaccctgtctacggcaggtatgac
cagtataagactccaatggagaacattgggctacaggactcactgctgtcacgatttgac
ttgctcttcatcatgctggatcagatggatcctgagcaggatcgggagatctcagaccat
gtccttcggatgcaccgttacagagcacctggggagcaggatggcgatgctatgcccttg
ggtagtgctgtggatatcctggccacagatgatcccaactttagccaggaagatcagcag
gacacccagatttatgagaagcatgacaaccttctacatgggaccaagaagaaaaaggag
aagatggtgagtgcagcattcatgaagaagtacatccatgtggccaaaatcatcaagcct
gtcctgacacaggagtcggccacctacattgcagaagagtattcacgcctgcgcagccag
gatagcatgagctcagacaccgccaggacatctccagttacagcccgaacactggaaact
ctgattcgactggccacagcccatgcgaaggcccgcatgagcaagactgtggacctgcag
gatgcagaggaagctgtggagttggtccagtatgcttactttaagaaggttctggagaag
gagaagaaacgtaagaagcgaagtgaggatgaatcagagacagaagatgaagaggagaaa
agccaagaggaccaggagcagaagaggaagagaaggaagactcgccagccagatgccaaa
gatggggattcatacgacccctatgacttcagtgacacagaggaggaaatgcctcaagta
cacactccaaagacggcagactcacaggagaccaaggaatcccagaaagtggagttgagt
gaatccaggttgaaggcattcaaggtggccctcttggatgtgttccgggaagctcatgcg
cagtcaatcggcatgaatcgcctcacagaatccatcaaccgggacagcgaagagcccttc
tcttcagttgagatccaggctgctctgagcaagatgcaggatgacaatcaggtcatggtg
tctgagggcatcatcttcctcatctga

KEGG   Homo sapiens (human): 4173
Entry
4173              CDS       T01001                                 
Symbol
MCM4, CDC21, CDC54, IMD54, NKCD, NKGCD, P1-CDC21, hCdc21
Name
(RefSeq) minichromosome maintenance complex component 4
  KO
K02212  DNA replication licensing factor MCM4 [EC:5.6.2.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa04110  Cell cycle
Network
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01450  Break induced replication
N01468  DNA replication licensing
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
N01473  DNA replication termination
N01474  TRAIP-dependent replisome disassembly
Disease
H00094  Immunodeficiency associated with DNA repair defects
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    4173 (MCM4)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    4173 (MCM4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    4173 (MCM4)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.3  DNA 5'-3' helicase
     4173 (MCM4)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   pre-RC (pre-replication complex)
    4173 (MCM4)
SSDB
Motif
Pfam: MCM MCM_OB MCM_lid MCM_N Mg_chelatase AAA_5 MCM4_WHD AAA_3 AAA Elf1
Other DBs
NCBI-GeneID: 4173
NCBI-ProteinID: NP_005905
OMIM: 602638
HGNC: 6947
Ensembl: ENSG00000104738
UniProt: P33991 B4DLA6
Structure
LinkDB
Position
8:47960941..47978160
AA seq 863 aa
MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQ
SPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGS
AQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKE
EENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMA
VNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQ
EAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPED
MPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIH
YRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGI
LLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSA
VGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAK
AGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDR
RLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKI
GSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGI
VDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMF
EEALRALADDDFLTVTGKTVRLL
NT seq 2592 nt   +upstreamnt  +downstreamnt
atgtcgtccccggcgtcgaccccgagccgccgcggcagccggcgtggaagggccaccccc
gcccagacgcctcggagtgaggatgccaggtcatctccctctcagagacgtagaggcgag
gattccacctccacgggggagttgcagccgatgccaacctcgcctggagtggacctgcag
agccctgctgcgcaggacgtgctgttttccagccctccccaaatgcattcttcagctatc
cctcttgactttgatgttagttcaccactgacatacggcactcccagctctcgggtagag
ggaaccccaagaagtggtgttaggggcacacctgtgagacagaggcctgacctgggctct
gcacagaagggcctgcaagtggatctgcagtctgacggggcagcagcagaagatatagtg
gcaagtgagcagtctctaggccaaaaacttgtgatctggggaacagatgtaaatgtggca
gcatgcaaagaaaactttcagagatttcttcagcgttttattgaccctctggctaaagaa
gaagaaaatgttggcatagatattactgaacctctatacatgcaacgacttggggagatt
aatgttattggtgagccatttttaaatgtgaactgtgaacacatcaaatcatttgacaaa
aatttgtacagacaactcatctcttacccacaggaagttattccaacttttgacatggct
gtcaatgaaatcttctttgaccgttaccctgactcaatcttagaacatcagattcaagta
agaccattcaacgcattgaagactaagaatatgagaaacctgaatccagaagacattgac
cagctcatcaccatcagcggcatggtgatcaggacatcccagctgattcccgagatgcag
gaggccttcttccagtgccaagtgtgtgcccacacgacccgggtggagatggaccgcggc
cgcattgcagagcccagtgtgtgcgggcgctgccacaccacccacagcatggcactcatc
cacaaccgctccctcttctctgacaagcagatgatcaagcttcaggagtctccggaagac
atgcctgcagggcagacaccacacacagttatcctgtttgctcacaatgatctcgttgac
aaggtccagcctggggacagagtgaatgttacaggcatctatcgagctgtgcctattcga
gtcaatccaagagtgagtaatgtgaagtctgtctacaaaacccacattgatgtcattcat
tatcggaaaacggatgcaaaacgtctgcatggccttgatgaagaagcagaacagaaactt
ttttcagagaaacgtgtggaattgcttaaggaactttccaggaaaccagacatttatgag
aggcttgcttcagccttggctccaagcatttatgaacatgaagatataaagaagggaatt
ttgcttcagctctttggcgggacaaggaaggattttagtcacactggaaggggcaaattt
cgggctgagatcaacatcttgctgtgtggcgaccctggtaccagcaagtcccagctgctg
cagtacgtgtacaacctcgtccccaggggccagtacacgtctgggaagggctccagtgca
gttggcctcactgcgtacgtaatgaaagaccctgagacaaggcagctggtcctgcagaca
ggtgctcttgtcctgagtgacaacggcatctgctgtatcgatgagttcgacaagatgaat
gaaagtacaagatcggtattgcatgaagtcatggaacagcagactctgtccattgcaaag
gctgggatcatctgtcagctcaatgcgcgcacctctgtcctggcagcagcaaatcccatt
gagtctcagtggaatcctaaaaaaacaaccattgaaaacatccagctgcctcatacttta
ttatcaaggtttgatttgatcttcctcttgctggaccctcaggacgaagcctatgacagg
cgtctggctcaccacctggtcgcactgtactaccagagcgaggagcaggcagaggaggag
ctcctggacatggcggtgctaaaggactacattgcctacgcgcacagcaccatcatgccg
cggctaagtgaggaagccagccaggctctcatcgaggcttatgtagacatgaggaagatt
ggcagtagccggggaatggtttctgcataccctcgacagctagagtcattaatccgctta
gcagaagcccatgctaaagtaagattgtctaacaaagttgaagccattgatgtggaagag
gccaaacgcctccatcgggaagctctgaagcagtctgcaactgatccccggactggcatc
gtggacatatctattcttactacggggatgagtgccacctctcgtaaacggaaagaagaa
ttagctgaagcattgaaaaagcttattttatctaagggcaaaacaccagctctaaaatac
cagcaactttttgaagatattcggggacaatctgacatagcaattactaaagatatgttt
gaagaagcactgcgtgccctggcagatgatgatttcctgacagtgactgggaagaccgtg
cgcttgctctga

KEGG   Homo sapiens (human): 4174
Entry
4174              CDS       T01001                                 
Symbol
MCM5, CDC46, MGORS8, P1-CDC46
Name
(RefSeq) minichromosome maintenance complex component 5
  KO
K02209  DNA replication licensing factor MCM5 [EC:5.6.2.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa04110  Cell cycle
Network
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01450  Break induced replication
N01468  DNA replication licensing
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
N01473  DNA replication termination
N01474  TRAIP-dependent replisome disassembly
Disease
H01889  Meier-Gorlin syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    4174 (MCM5)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    4174 (MCM5)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    4174 (MCM5)
   03036 Chromosome and associated proteins [BR:hsa03036]
    4174 (MCM5)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.3  DNA 5'-3' helicase
     4174 (MCM5)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   pre-RC (pre-replication complex)
    4174 (MCM5)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Other centrosome duplication proteins
     4174 (MCM5)
SSDB
Motif
Pfam: MCM MCM_OB MCM_lid MCM_N Mg_chelatase AAA_5 AAA_3 Sigma54_activat
Other DBs
NCBI-GeneID: 4174
NCBI-ProteinID: NP_006730
OMIM: 602696
HGNC: 6948
Ensembl: ENSG00000100297
UniProt: P33992 B1AHB0
Structure
LinkDB
Position
22:35400140..35455031
AA seq 734 aa
MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELK
RHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV
LQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLT
NIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGE
MPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQ
VDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGG
SRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMR
DPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNS
RCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLH
VSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDS
DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV
EGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGE
IQHRMQRKVLYRLK
NT seq 2205 nt   +upstreamnt  +downstreamnt
atgtcgggattcgacgatcctggcattttctacagcgacagcttcgggggcgacgcccag
gccgacgaggggcaggcccgcaaatcgcagctgcagaggcgcttcaaggagttcctgcgg
cagtaccgagtgggcaccgaccgcacgggcttcaccttcaaatacagggatgaactcaag
cggcattacaacctgggggagtactggattgaggtggagatggaggatctggccagcttt
gatgaggacctggccgactacttgtacaagcagccagccgagcacctgcagctgctggag
gaagctgccaaggaggtagctgatgaggtgacccggccccggccttctggggaggaggtg
ctccaggacatccaggtcatgctcaagtcggacgccagcccttccagcattcgtagcctg
aagtcggacatgatgtcacacctggtgaagatccctggcatcatcatcgcggcctctgcg
gtccgtgccaaggccacccgcatctctatccagtgccgcagctgccgcaacaccctcacc
aacattgccatgcgccctggcctcgagggctatgccctgcccaggaagtgcaacacagat
caggctgggcgccccaaatgcccattggacccgtacttcatcatgcccgacaaatgcaaa
tgcgtggacttccagaccctgaagctgcaggagctgcctgatgcagtcccccacggggag
atgcccagacacatgcagctctactgcgacaggtacctgtgtgacaaggtcgtccctggg
aacagggttaccatcatgggcatctactccatcaagaagtttggcctgactaccagcagg
ggccgtgacagggtgggcgtgggcatccgaagctcctacatccgtgtcctgggcatccag
gtggacacagatggctctggccgcagctttgctggggccgtgagcccccaggaggaggag
gagttccgtcgcctggctgccctcccaaatgtctatgaggtcatctccaagagcatcgcc
ccctccatctttgggggcacagacatgaagaaggccattgcctgcctgctctttgggggc
tcccgaaagaggctccctgatggacttactcgccgaggagacatcaacctgctgatgcta
ggggaccctgggacagccaagtcccagcttctgaagtttgtggagaagtgttctcccatt
ggggtatacacgtctgggaaaggcagcagcgcagctggactgacagcctcggtgatgagg
gacccttcgtcccggaatttcatcatggagggcggagccatggtcctggccgatggtggg
gtcgtctgtattgacgagtttgacaagatgcgagaagatgaccgtgtggcaatccacgaa
gccatggagcagcagaccatctctatcgccaaggctgggatcaccaccaccctgaactcc
cgctgctccgtcctggctgctgccaactcagtgttcggccgctgggatgagacgaagggg
gaggacaacattgacttcatgcccaccatcttgtcgcgcttcgacatgatcttcatcgtc
aaggatgagcacaatgaggagagggatgtgatgctggccaagcatgtcatcactctgcac
gtgagcgcactgacacagacacaggctgtggagggcgagattgacctggccaagctgaag
aagtttattgcctactgccgagtgaagtgtggcccccggctgtcagcagaggctgcagag
aaactgaagaaccgctacatcatcatgcggagcggggcccgtcagcacgagagggacagt
gaccgccgctccagcatccccatcactgtgcggcagctggaggccattgtgcgcatcgcg
gaagccctcagcaagatgaagctgcagcccttcgccacagaggcagatgtggaggaggcc
ctgcggctcttccaagtgtccacgttggatgctgccttgtccggtaccctgtcaggggtg
gagggcttcaccagccaggaggaccaggagatgctgagccgcatcgagaagcagctcaag
cgccgctttgccattggctcccaggtgtctgagcacagcatcatcaaggacttcaccaag
cagaaatacccggagcacgccatccacaaggtgctgcagctcatgctgcggcgcggcgag
atccagcatcgcatgcagcgcaaggttctctaccgcctcaagtga

KEGG   Homo sapiens (human): 4175
Entry
4175              CDS       T01001                                 
Symbol
MCM6, MCG40308, Mis5, P105MCM
Name
(RefSeq) minichromosome maintenance complex component 6
  KO
K02542  DNA replication licensing factor MCM6 [EC:5.6.2.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa04110  Cell cycle
Network
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01450  Break induced replication
N01468  DNA replication licensing
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
N01473  DNA replication termination
N01474  TRAIP-dependent replisome disassembly
Disease
H02575  Lactose intolerance, adult type
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    4175 (MCM6)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    4175 (MCM6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    4175 (MCM6)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.3  DNA 5'-3' helicase
     4175 (MCM6)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   pre-RC (pre-replication complex)
    4175 (MCM6)
SSDB
Motif
Pfam: MCM MCM_OB MCM6_C MCM_lid MCM_N Mg_chelatase AAA_3 AAA_5 Sigma54_activat
Other DBs
NCBI-GeneID: 4175
NCBI-ProteinID: NP_005906
OMIM: 601806
HGNC: 6949
Ensembl: ENSG00000076003
UniProt: Q14566
Structure
LinkDB
Position
2:complement(135839626..135876443)
AA seq 821 aa
MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNT
LVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTR
HKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNIC
RNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGD
KCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLA
CCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHG
NDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTS
GKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQ
TISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDEC
NEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKH
LRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVE
TPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEY
CRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRL
THYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED
NT seq 2466 nt   +upstreamnt  +downstreamnt
atggacctcgcggcggcagcggagccgggcgccggcagccagcacctggaggtccgcgac
gaggtggccgagaagtgccagaaactgttcctggacttcttggaggagtttcagagcagc
gatggagaaattaaatacttgcaattagcagaggaactgattcgtcctgagagaaacaca
ttggttgtgagttttgtggacctggaacaatttaaccagcaactttccaccaccattcaa
gaggagttctatagagtttacccttacctgtgtcgggccttgaaaacattcgtcaaagac
cgtaaagagatccctcttgccaaggatttttatgttgcattccaagacctgcctaccaga
cacaagattcgagagctcacctcatccagaattggtttgctcactcgcatcagtgggcag
gtggtgcggactcacccagttcacccagagcttgtgagcggaacttttctgtgcttggac
tgtcagacagtgatcagggatgtagaacagcagttcaaatacacacagccaaacatctgc
cgaaatccagtttgtgccaacaggaggagattcttactggatacaaataaatcaagattt
gttgattttcaaaaggttcgtattcaagagacccaagctgagcttcctcgagggagtatc
ccccgcagtttagaagtaattttaagggctgaagctgtggaatcagctcaagctggtgac
aagtgtgactttacagggacactgattgttgtgcctgacgtctccaagcttagcacacca
ggagcacgtgcagaaactaattcccgtgtcagtggtgttgatggatatgagacagaaggc
attcgaggactccgggcccttggtgttagggacctttcttataggctggtctttcttgcc
tgctgtgttgcgccaaccaacccaaggtttggggggaaagagctcagagatgaggaacag
acagctgagagcattaagaaccaaatgactgtgaaagaatgggagaaagtgtttgagatg
agtcaagataaaaatctataccacaatctttgtaccagcctgttccctactatacatggc
aatgatgaagtaaaacggggtgtcctgctgatgctctttggtggcgttccaaagacaaca
ggagaagggacctctcttcgaggggacataaatgtttgcattgttggtgacccaagtaca
gctaagagccaatttctcaagcacgtggaggagttcagccccagagctgtctacaccagt
ggtaaagcgtccagtgctgctggcttaacagcagctgttgtgagagatgaagaatctcat
gagtttgtcattgaggctggagctttgatgttggctgataatggtgtgtgttgtattgat
gaatttgataagatggacgtgcgggatcaagttgctattcatgaagctatggaacagcag
accatatccatcactaaagcaggagtgaaggctactctgaacgcccggacgtccattttg
gcagcagcaaacccaatcagtggacactatgacagatcaaaatcattgaaacagaatata
aatttgtcagctcccatcatgtcccgattcgatctcttctttatccttgtggatgaatgt
aatgaggttacagattatgccattgccaggcgcatagtagatttgcattcaagaattgag
gaatcaattgatcgtgtctattccctcgatgatatcagaagatatcttctctttgcaaga
cagtttaaacccaagatttccaaagagtcagaggacttcattgtggagcaatataaacat
ctccgccagagagatggttctggagtgaccaagtcttcatggaggattacagtgcgacag
cttgagagcatgattcgtctctctgaagctatggctcggatgcactgctgtgatgaggtc
caacctaaacatgtgaaggaagctttccggttactgaataaatcaatcatccgtgtggaa
acacctgatgtcaatctagatcaagaggaagagatccagatggaggtagatgagggtgct
ggtggcatcaatggtcatgctgacagccctgctcctgtgaacgggatcaatggctacaat
gaagacataaatcaagagtctgctcccaaagcctccttaaggctgggcttctctgagtac
tgccgaatctctaaccttattgtgcttcacctcagaaaggtggaagaagaagaggacgag
tcagcattaaagaggagcgagcttgttaactggtacttgaaggaaatcgaatcagagata
gactctgaagaagaacttataaataaaaaaagaatcatagagaaagttattcatcgactc
acacactatgatcatgttctaattgagctcacccaggctggattgaaaggctccacagag
ggaagtgagagctatgaagaagatccctacttggtagttaaccctaactacttgctcgaa
gattga

KEGG   Homo sapiens (human): 4176
Entry
4176              CDS       T01001                                 
Symbol
MCM7, CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104
Name
(RefSeq) minichromosome maintenance complex component 7
  KO
K02210  DNA replication licensing factor MCM7 [EC:5.6.2.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa04110  Cell cycle
Network
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01450  Break induced replication
N01468  DNA replication licensing
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
N01473  DNA replication termination
N01474  TRAIP-dependent replisome disassembly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    4176 (MCM7)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    4176 (MCM7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    4176 (MCM7)
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    4176 (MCM7)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.3  DNA 5'-3' helicase
     4176 (MCM7)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     4176 (MCM7)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   pre-RC (pre-replication complex)
    4176 (MCM7)
SSDB
Motif
Pfam: MCM MCM_OB MCM_lid MCM_N Mg_chelatase AAA_5 AAA_3 MCM_bind Mg_chelatase_C AAA_lid_2
Other DBs
NCBI-GeneID: 4176
NCBI-ProteinID: NP_005907
OMIM: 600592
HGNC: 6950
Ensembl: ENSG00000166508
UniProt: P33993 C6EMX8 A0A0S2Z4A5
Structure
LinkDB
Position
7:complement(100092728..100101397)
AA seq 719 aa
MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDP
ELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVR
SPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVA
TYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEH
SDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEA
HRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVG
GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLR
DSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNA
RCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYV
HQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATY
TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADV
IFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV
NT seq 2160 nt   +upstreamnt  +downstreamnt
atggcactgaaggactacgcgctagagaaggaaaaggttaagaagttcttacaagagttc
taccaggatgatgaactcgggaagaagcagttcaagtatgggaaccagttggttcggctg
gctcatcgggaacaggtggctctgtatgtggacctggacgacgtagccgaggatgacccc
gagttggtggactcaatttgtgagaatgccaggcgctacgcgaagctctttgctgatgcc
gtacaagagctgctgcctcagtacaaggagagggaagtggtaaataaagatgtcctggac
gtttacattgagcatcggctaatgatggagcagcggagtcgggaccctgggatggtccga
agcccccagaaccagtaccctgctgaactcatgcgcagatttgagctgtattttcaaggc
cctagcagcaacaagcctcgtgtgatccgggaagtgcgggctgactctgtggggaagttg
gtaactgtgcgtggaatcgtcactcgtgtctctgaagtcaaacccaagatggtggtggcc
acttacacttgtgaccagtgtggggcagagacctaccagccgatccagtctcccactttc
atgcctctgatcatgtgcccaagccaggagtgccaaaccaaccgctcaggagggcggctg
tatctgcagacacggggctccagattcatcaaattccaggagatgaagatgcaagaacat
agtgatcaggtgcctgtgggaaatatccctcgtagtatcacggtgctggtagaaggagag
aacacaaggattgcccagcctggagaccacgtcagcgtcactggtattttcttgccaatc
ctgcgcactgggttccgacaggtggtacagggtttactctcagaaacctacctggaagcc
catcggattgtgaagatgaacaagagtgaggatgatgagtctggggctggagagctcacc
agggaggagctgaggcaaattgcagaggaggatttctacgaaaagctggcagcttcaatc
gccccagaaatatacgggcatgaagatgtgaagaaggcactgctgctcctgctagtcggg
ggtgtggaccagtctcctcgaggcatgaaaatccggggcaacatcaacatctgtctgatg
ggggatcctggtgtggccaagtctcagctcctgtcatacattgatcgactggcgcctcgc
agccagtacacaacaggccggggctcctcaggagtggggcttacggcagctgtgctgaga
gactccgtgagtggagaactgaccttagagggtggggccctggtgctggctgaccagggt
gtgtgctgcattgatgagttcgacaagatggctgaggccgaccgcacagccatccacgag
gtcatggagcagcagaccatctccattgccaaggccggcattctcaccacactcaatgcc
cgctgctccatcctggctgccgccaaccctgcctacgggcgctacaaccctcgccgcagc
ctggagcagaacatacagctacctgctgcactgctctcccggtttgacctcctctggctg
attcaggaccggcccgaccgagacaatgacctacggttggcccagcacatcacctatgtg
caccagcacagccggcagcccccctcccagtttgaacctctggacatgaagctcatgagg
cgttacatagccatgtgccgcgagaagcagcccatggtgccagagtctctggctgactac
atcacagcagcatacgtggagatgaggcgagaggcttgggctagtaaggatgccacctat
acttctgcccggaccctgctggctatcctgcgcctttccactgctctggcacgtctgaga
atggtggatgtggtggagaaagaagatgtgaatgaagccatcaggctaatggagatgtca
aaggactctcttctaggagacaaggggcagacagctaggactcagagaccagcagatgtg
atatttgccaccgtccgtgaactggtctcagggggccgaagtgtccggttctctgaggca
gagcagcgctgtgtatctcgtggcttcacacccgcccagttccaggcggctctggatgaa
tatgaggagctcaatgtctggcaggtcaatgcttcccggacacggatcacttttgtctga

KEGG   Homo sapiens (human): 9837
Entry
9837              CDS       T01001                                 
Symbol
GINS1, IMD55, PSF1
Name
(RefSeq) GINS complex subunit 1
  KO
K10732  GINS complex subunit 1
Organism
hsa  Homo sapiens (human)
Network
nt06509  DNA replication
  Element
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
N01473  DNA replication termination
N01474  TRAIP-dependent replisome disassembly
Disease
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    9837 (GINS1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   GINS complex
    9837 (GINS1)
SSDB
Motif
Pfam: Sld5
Other DBs
NCBI-GeneID: 9837
NCBI-ProteinID: NP_066545
OMIM: 610608
HGNC: 28980
Ensembl: ENSG00000101003
UniProt: Q14691
Structure
LinkDB
Position
20:25407673..25448563
AA seq 196 aa
MFCEKAMELIRELHRAPEGQLPAFNEDGLRQVLEEMKALYEQNQSDVNEAKSGGRSDLIP
TIKFRHCSLLRNRRCTVAYLYDRLLRIRALRWEYGSVLPNALRFHMAAEEMEWFNNYKRS
LATYMRSLGGDEGLDITQDMKPPKSLYIEVRCLKDYGEFEVDDGTSVLLKKNSQHFLPRW
KCEQLIRQGVLEHILS
NT seq 591 nt   +upstreamnt  +downstreamnt
atgttctgcgaaaaagccatggaactgatccgcgagctgcatcgcgcgcccgaagggcaa
ctgcctgccttcaacgaggatggactcagacaagttctggaggagatgaaagctttgtat
gaacaaaaccagtctgatgtgaatgaagcaaagtcaggtggacgaagtgatttgatacca
actatcaaatttcgacactgttctctgttaagaaatcgacgctgcactgtagcatacctg
tatgaccgcttgcttcggatcagagcactcagatgggaatatggtagcgtcttgccaaat
gcattacgatttcacatggctgctgaagaaatggagtggtttaataattataaaagatct
cttgctacttatatgaggtcactgggaggagatgaaggtttggacattacacaggatatg
aaaccaccaaaaagcctatatattgaagtccggtgtctaaaagactatggagaatttgaa
gttgatgatggcacttcagtcctattaaaaaaaaatagccagcactttttacctcgatgg
aaatgtgagcagctgatcagacaaggagtcctggagcacatcctgtcatga

KEGG   Homo sapiens (human): 51659
Entry
51659             CDS       T01001                                 
Symbol
GINS2, HSPC037, PSF2, Pfs2
Name
(RefSeq) GINS complex subunit 2
  KO
K10733  GINS complex subunit 2
Organism
hsa  Homo sapiens (human)
Network
nt06509  DNA replication
  Element
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
N01473  DNA replication termination
N01474  TRAIP-dependent replisome disassembly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    51659 (GINS2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   GINS complex
    51659 (GINS2)
SSDB
Motif
Pfam: Sld5
Other DBs
NCBI-GeneID: 51659
NCBI-ProteinID: NP_057179
OMIM: 610609
HGNC: 24575
Ensembl: ENSG00000131153
UniProt: Q9Y248
Structure
LinkDB
Position
16:complement(85676198..85688954)
AA seq 185 aa
MDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVEVPLWLAINLKQRQKCRL
LPPEWMDVEKLEKMRDHERKEETFTPMPSPYYMELTKLLLNHASDNIPKADEIRTLVKDM
WDTRIAKLRVSADSFVRQQEAHAKLDNLTLMEINTSGTFLTQALNHMYKLRTNLQPLEST
QSQDF
NT seq 558 nt   +upstreamnt  +downstreamnt
atggacgctgccgaggtcgaattcctcgccgagaaggagctggttaccattatccccaac
ttcagtctggacaagatctacctcatcgggggggacctggggccttttaaccctggttta
cccgtggaagtgcccctgtggctggcgattaacctgaaacaaagacagaaatgtcgcctg
ctccctccagagtggatggatgtagaaaagttggagaagatgagggatcatgaacgaaag
gaagaaacttttaccccaatgcccagcccttactacatggaacttacgaagctcctgtta
aatcatgcttcagacaacatcccgaaggcagacgaaatccggaccctggtcaaggatatg
tgggacactcgtatagccaaactccgagtgtctgctgacagctttgtgagacagcaggag
gcacatgccaagctggataacttgaccttgatggagatcaacaccagcgggactttcctc
acacaagcgctcaaccacatgtacaaactccgcacgaacctccagcctctggagagtact
cagtctcaggacttctag

KEGG   Homo sapiens (human): 64785
Entry
64785             CDS       T01001                                 
Symbol
GINS3, PSF3
Name
(RefSeq) GINS complex subunit 3
  KO
K10734  GINS complex subunit 3
Organism
hsa  Homo sapiens (human)
Network
nt06509  DNA replication
  Element
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
N01473  DNA replication termination
N01474  TRAIP-dependent replisome disassembly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    64785 (GINS3)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   GINS complex
    64785 (GINS3)
SSDB
Motif
Pfam: Sld5
Other DBs
NCBI-GeneID: 64785
NCBI-ProteinID: NP_073607
OMIM: 610610
HGNC: 25851
Ensembl: ENSG00000181938
UniProt: Q9BRX5 A0A0S2Z5L0
Structure
LinkDB
Position
16:58392471..58406147
AA seq 216 aa
MSEAYFRVESGALGPEENFLSLDDILMSHEKLPVRTETAMPRLGAFFLERSAGAETDNAV
PQGSKLELPLWLAKGLFDNKRRILSVELPKIYQEGWRTVFSADPNVVDLHKMGPHFYGFG
SQLLHFDSPENADISQSLLQTFIGRFRRIMDSSQNAYNEDTSALVARLDEMERGLFQTGQ
KGLNDFQCWEKGQASQITASNLVQNYKKRKFTDMED
NT seq 651 nt   +upstreamnt  +downstreamnt
atgtcagaggcttatttccgagtggagtcgggtgcgctggggcctgaggagaactttctt
tctttggacgacatcctgatgtcccacgagaagctgccggtgcgcacggagaccgccatg
cctcgccttggcgctttcttcctggagcggagcgcaggcgccgagactgacaacgcggtc
ccacagggttccaagcttgaactacccttgtggctggcaaaaggactttttgacaacaag
cgacggatcctttctgtggaactccccaagatctaccaagagggttggaggactgtgttc
agtgcagatcccaatgtggtggacctccacaaaatggggccccatttctacgggtttggc
tcccagctcctgcattttgacagtcccgagaatgcagacatttcccagtctctgctgcag
acttttatcggacgttttcgccgcatcatggactcctcacagaatgcttacaacgaagac
acttcagccctggtagccaggctagacgagatggagaggggcttatttcaaacagggcag
aaaggactgaatgactttcagtgttgggagaaggggcaggcttctcagatcacagcttcc
aacctcgttcagaattacaagaagagaaaattcactgatatggaagactga

KEGG   Homo sapiens (human): 84296
Entry
84296             CDS       T01001                                 
Symbol
GINS4, SLD5
Name
(RefSeq) GINS complex subunit 4
  KO
K10735  GINS complex subunit 4
Organism
hsa  Homo sapiens (human)
Network
nt06509  DNA replication
  Element
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
N01473  DNA replication termination
N01474  TRAIP-dependent replisome disassembly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    84296 (GINS4)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   GINS complex
    84296 (GINS4)
SSDB
Motif
Pfam: SLD5_C Sld5
Other DBs
NCBI-GeneID: 84296
NCBI-ProteinID: NP_115712
OMIM: 610611
HGNC: 28226
Ensembl: ENSG00000147536
UniProt: Q9BRT9
Structure
LinkDB
Position
8:41529261..41545030
AA seq 223 aa
MTEEVDFLGQDSDGGSEEVVLTPAELIERLEQAWMNEKFAPELLESKPEIVECVMEQLEH
MEENLRRAKREDLKVSIHQMEMERIRYVLSSYLRCRLMKIEKFFPHVLEKEKTRPEGEPS
SLSPEELAFAREFMANTESYLKNVALKHMPPNLQKVDLFRAVPKPDLDSYVFLRVRERQE
NILVEPDTDEQRDYVIDLEKGSQHLIRYKTIAPLVASGAVQLI
NT seq 672 nt   +upstreamnt  +downstreamnt
atgaccgaagaagtggatttcctgggacaggactctgatgggggtagtgaggaagtggtc
ctaactcctgcagagctcattgaaagattggagcaggcctggatgaatgaaaagtttgcc
cctgagctgctggagagcaagcctgagattgtagaatgtgtcatggaacagctggagcac
atggaagaaaatctcaggagagccaaaagggaggacctgaaggtcagcatccaccaaatg
gagatggagaggatccgctacgtcctcagcagctacttgcggtgtcgcctcatgaagata
gagaagtttttccctcatgtccttgagaaggaaaaaacacgtcctgagggggagccttcc
agcctctcgccggaagagttggcctttgccagagagttcatggcgaacacagagtcctat
ctgaaaaatgtcgccttgaagcacatgccccctaacttacagaaggtggacctctttcgg
gcagttcccaaaccagatctagattcttacgtgtttctgagagtgagagaacgacaagaa
aacatactggtagaaccagacacagatgagcagagggactacgtgattgacctggagaag
ggctcacagcacttgatccgatacaaaaccattgcacctctggttgcatctggagctgtc
cagctaatttaa

KEGG   Homo sapiens (human): 55388
Entry
55388             CDS       T01001                                 
Symbol
MCM10, CNA43, DNA43, IMD80, PRO2249
Name
(RefSeq) minichromosome maintenance 10 replication initiation factor
  KO
K10736  minichromosome maintenance protein 10
Organism
hsa  Homo sapiens (human)
Network
nt06509  DNA replication
  Element
N01471  Origin unwinding and elongation
Disease
H02525  Disorders of innate immunity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    55388 (MCM10)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   Other initiation factors
    55388 (MCM10)
SSDB
Motif
Pfam: Mcm10 zf-primase DUF5763
Other DBs
NCBI-GeneID: 55388
NCBI-ProteinID: NP_877428
OMIM: 609357
HGNC: 18043
Ensembl: ENSG00000065328
UniProt: Q7L590
LinkDB
Position
10:13161558..13211110
AA seq 875 aa
MDEEEDNLSLLTALLEENESALDCNSEENNFLTRENGEPDAFDELFDADGDGESYTEEAD
DGETGETRDEKENLATLFGDMEDLTDEEEVPASQSTENRVLPAPAPRREKTNEELQEELR
NLQEQMKALQEQLKVTTIKQTASPARLQKSPVEKSPRPPLKERRVQRIQESTCFSAELDV
PALPRTKRVARTPKASPPDPKSSSSRMTSAPSQPLQTISRNKPSGITRGQIVGTPGSSGE
TTQPICVEAFSGLRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVI
LKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMK
PKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQY
KKLSAKRADLQSTFSGGRIPKKFARRGTSLKERLCQDGFYYGGVSSASYAASIAAAVAPK
KKIQTTLSNLVVKGTNLIIQETRQKLGIPQKSLSCSEEFKELMDLPTCGARNLKQHLAKA
TASGIMGSPKPAIKSISASALLKQQKQRMLEMRRRKSEEIQKRFLQSSSEVESPAVPSSS
RQPPAQPPRTGSEFPRLEGAPATMTPKLGRGVLEGDDVLFYDESPPPRPKLSALAEAKKL
AAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERVEKNTMFSSQAEDELEPARKKRR
EQLAYLESEEFQKILKAKSKHTGILKEAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRV
VTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKCPCGNRSISLDRLPNKHCSNCGLYK
WERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK
NT seq 2628 nt   +upstreamnt  +downstreamnt
atggatgaggaggaagacaatctgtctctgctgaccgcactgctggaagaaaatgagtca
gccttggattgtaattcagaagaaaataacttcttgacgcgggaaaatggcgagcccgac
gcatttgatgagctctttgatgccgacggcgacggtgaatcttatacagaagaggctgat
gatggagaaacaggagagacaagagacgaaaaggaaaatctggccactctctttggagat
atggaggacttaacagatgaagaagaagttcccgcatcacagtcaactgaaaatagggtc
ctccctgctcctgcccccaggcgagagaaaacgaatgaagagttgcaagaggaattaagg
aatttgcaagagcaaatgaaggccttacaagagcagctaaaagtaacaacaattaaacag
acagcaagcccagcccgtctgcaaaaatcccctgtagagaagtctccccggccacctctt
aaggagaggagagttcagagaattcaggagtcaacatgcttttctgcggagcttgatgtc
cctgcgctaccaagaaccaagagggtggctcgaacaccaaaggcttcacctccagatccc
aaaagctcatcttcaaggatgacaagtgcaccctcccaacccctacagacgatttctcgg
aacaaacctagtgggataactagaggtcaaattgtggggaccccaggaagttctggggaa
acgactcaacccatctgtgtggaagccttctctggtctgcggctcaggcggcctcgagta
tcctccacagaaatgaacaagaaaatgaccggccgaaaactgatcagactgtctcagatc
aaggaaaagatggccagagagaagctggaagaaatagattgggtgacatttggggttata
ttgaagaaggttacgccacagagtgtgaatagtggaaaaaccttcagcatatggaaactg
aatgatcttcgtgacctgacacaatgtgtgtccttgttcttatttggagaagttcacaaa
gcgctctggaagacggagcaggggactgtcgtagggatcctcaatgccaaccccatgaag
cccaaggatggttcagaggaggtgtgtttatctatcgatcatcctcagaaggtcttaatt
atgggtgaagctcttgacctgggaacctgtaaagccaagaagaagaatggagagccgtgc
acgcagactgtgaatttgcgtgactgtgagtactgtcagtaccatgtccaggctcagtac
aagaagctcagcgcaaagcgtgcggatctgcagtccaccttctctggaggacgaattcca
aagaagtttgcccgcagaggcaccagcctcaaagaacggctgtgccaagatggcttttac
tacggaggggtttcttctgcctcgtatgcagcttcaattgcagcagctgtggctcctaag
aagaagattcaaaccactctgagtaatctggttgttaagggcacaaacttgatcatccag
gaaacacggcaaaaactcggaataccccagaagagcctgtcttgctctgaggagttcaag
gaactgatggacctgccgacgtgtggagccaggaacttaaaacaacatttagccaaagcc
acagcttcagggattatggggagcccaaaaccagccatcaagtccatctcggcctcagca
ctcttgaagcaacagaagcagcggatgttggagatgaggagaaggaaatcagaagaaata
cagaagcgatttctgcagagctcaagtgaagttgagagcccagctgtgccatcttcatca
agacagccccctgctcagcctccacggacaggatccgagttccccaggctggagggagcc
ccggccacaatgacgcccaagctggggcgaggtgtcttggaaggagatgatgttctcttt
tatgatgagtcaccaccaccaagaccaaaactgagtgctttagcagaagccaaaaagtta
gctgctatcaccaaattaagggcaaaaggccaggttcttacaaaaacaaacccaaacagc
attaagaagaaacaaaaggaccctcaggacatcctggaggtgaaggaacgtgtagaaaaa
aacaccatgttttcttctcaagctgaggatgaattggagcctgccaggaaaaaaaggaga
gaacaacttgcctatctggaatctgaggaatttcagaaaatcctaaaagcaaaatcaaaa
cacacaggcatcctgaaagaggccgaggctgagatgcaggagcgctactttgagccactg
gtgaaaaaagaacaaatggaagaaaagatgagaaacatcagagaagtgaagtgccgtgtc
gtgacatgcaagacgtgcgcctatacccacttcaagctgctggagacctgcgtcagtgag
cagcatgaataccactggcatgatggtgtgaagaggtttttcaaatgtccctgtggaaac
agaagcatctccttggacagactcccgaacaagcactgcagtaactgtggcctctacaaa
tgggaacgggacggaatgctaaaggaaaagactggtccaaagataggaggagaaactctg
ttaccaagaggagaagaacatgctaaatttctgaacagccttaaataa

KEGG   Homo sapiens (human): 11169
Entry
11169             CDS       T01001                                 
Symbol
WDHD1, AND-1, AND1, CHTF4, CTF4
Name
(RefSeq) WD repeat and HMG-box DNA binding protein 1
  KO
K11274  chromosome transmission fidelity protein 4
Organism
hsa  Homo sapiens (human)
Network
nt06509  DNA replication
  Element
N01471  Origin unwinding and elongation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    11169 (WDHD1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Sister chromatid cohesion proteins
   Other sister chromatid cohesion factors
    11169 (WDHD1)
SSDB
Motif
Pfam: Mcl1_mid Ctf4_C WD40 ANAPC4_WD40 eIF2A HMG_box
Other DBs
NCBI-GeneID: 11169
NCBI-ProteinID: NP_009017
OMIM: 608126
HGNC: 23170
Ensembl: ENSG00000198554
UniProt: O75717
Structure
LinkDB
Position
14:complement(54938949..55027099)
AA seq 1129 aa
MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC
ALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKI
VDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKC
NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSP
CGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLL
ENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDD
EDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPF
YDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATH
LSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICL
GQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLG
VQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTP
ICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIAT
EKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFR
CVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKK
LNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKS
GAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPI
IKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKT
GFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEA
KKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE
NT seq 3390 nt   +upstreamnt  +downstreamnt
atgcctgccacacggaagccaatgagatatgggcatacagagggacacacggaggtctgt
tttgatgattctgggagttttattgtgacttgtggaagtgatggtgatgtgaggatttgg
gaagacttggatgatgatgatcctaagttcattaatgttggagaaaaggcatattcatgt
gctttgaagagtggaaaactggtcactgcagtttctaataatactattcaagtccacaca
tttcctgaaggagttccagatggtatattgactcgcttcactacaaatgcaaaccatgtg
gtctttaatggggatggtactaaaattgctgctggatctagtgattttctagtcaaaatt
gtggatgtgatggatagcagccaacagaaaacatttcgaggacatgatgcccctgtttta
agtctttcctttgatcctaaggacatctttctggcatcagctagttgtgatggatctgtc
agagtgtggcaaatttcagatcagacatgtgctattagttggccactgctacaaaaatgc
aacgatgtgataaatgcaaaatcaatctgcagacttgcttggcagccaaaaagtgggaag
ttactggcaattcctgtggaaaaatctgttaagctatatagaagagaatcttggagtcat
caatttgatctttcagataatttcatctctcagaccctcaatatagtaacctggtctccc
tgtgggcaatatttagctgcaggtagtattaatggtctaatcatagtttggaatgtggaa
accaaagactgcatggaaagggtgaaacatgagaaaggttatgcaatttgtggtctggca
tggcatcctacttgtggtcgaatatcgtatactgatgcggaaggaaatctagggcttcta
gagaatgtttgtgaccccagtggaaagacatcaagcagtaaggtatctagcagagtggaa
aaggattataatgatctttttgatggagatgatatgagtaatgctggtgattttctaaat
gacaatgcagttgagatcccttctttttcaaaagggattataaatgatgatgaggatgat
gaagacctcatgatggcttcaggtcgtcctagacagcgaagtcacatcctagaagatgat
gaaaactcagttgatatttcaatgctaaaaactggttctagtcttctcaaagaggaggag
gaagatggtcaagaaggcagcattcacaatctaccacttgtaacatcccaaaggccattt
tatgatggacccatgccaactccccggcaaaagccatttcagtcaggttctacaccgttg
catctcactcacagattcatggtgtggaactctattggaattattcgctgctataatgat
gagcaagacaatgccatagatgtggagttccatgatacctccatacaccatgcaacacac
ttatcaaacactttgaattatacaatagcagatctttcccacgaagctattttgttggca
tgtgaaagcactgatgaactagcaagcaagcttcactgcctgcactttagttcttgggat
tcaagcaaagagtggataatagacttgcctcagaatgaggatattgaagccatatgtctc
ggtcaaggatgggctgctgccgctactagtgccctgcttcttcgattgtttactattgga
ggggttcaaaaagaggtattcagccttgctggacctgtggtgtcaatggcaggacatgga
gaacagcttttcattgtttatcacagaggtacaggatttgatggggatcagtgccttgga
gttcaactgctagagctggggaaaaagaaaaaacaaattttgcatggtgaccctcttcct
cttacaaggaaatcctaccttgcatggattgggttttcagctgaaggtaccccttgttac
gtggattcagaaggaattgttcgaatgcttaacagaggacttggtaatacgtggactcct
atatgtaatacaagagagcactgcaaaggaaaatctgatcactactgggtggttggtatc
catgaaaatccccagcaactaaggtgcattccttgtaaaggttctcggtttcccccaacc
cttccacgccctgctgttgctatattatcctttaagcttccttactgtcagattgcaaca
gagaaaggacaaatggaggagcaattttggcgttcagttatatttcacaaccaccttgat
tatttagctaaaaatggttatgaatatgaagagagcactaaaaatcaagcaacaaaagag
caacaggaacttttaatgaaaatgcttgcgctttcttgtaaactggagcgagaattccgt
tgtgtggaacttgctgatctaatgactcaaaatgctgtgaatttagccattaaatatgct
tctcgctctcggaaattaatactggctcaaaaactaagtgaactggctgtagagaaggca
gccgaattgacagcaacccaggtggaagaggaagaagaagaagaagatttcagaaaaaag
ctgaatgctggttacagcaatactgctacagagtggagccaaccaaggttcagaaatcaa
gttgaagaagatgctgaggacagtggagaagctgatgatgaagaaaaaccagaaatacat
aagcctggacagaactcgttttccaaaagtacaaattcctctgatgtttcagctaagtca
ggtgcagttacctttagcagccaaggacgagtaaatccctttaaggtatcagccagttcc
aaagaaccagccatgtcaatgaattcagcacgttcaactaatattttagacaatatgggc
aaatcatccaagaaatccactgcacttagtcgaactacaaataatgaaaagtctcccatt
ataaagcctctgattccaaagccgaagcctaagcaggcatctgcagcatcctatttccag
aaaagaaattctcaaactaataaaactgaggaagtgaaagaagaaaatcttaaaaatgta
ttatctgaaaccccagctatatgtcctcctcaaaacactgaaaaccaaaggccaaagacc
gggttccagatgtggttagaagaaaatagaagtaatattttgtctgacaatcctgacttt
tcagatgaagcagacataataaaagaaggaatgattcgatttagagtattgtcaactgaa
gaaagaaaggtgtgggctaacaaagccaaaggagaaacggcaagtgaaggaactgaagca
aagaagcgaaaacgtgtggttgatgaaagtgatgaaacagaaaaccaggaagaaaaagca
aaagagaacctgaatttgtctaaaaagcagaaacctttagatttttctacaaatcagaaa
ctatcagcttttgcatttaagcaggagtaa

KEGG   Homo sapiens (human): 5422
Entry
5422              CDS       T01001                                 
Symbol
POLA1, NSX, PDR, POLA, VEODS, p180
Name
(RefSeq) DNA polymerase alpha 1, catalytic subunit
  KO
K02320  DNA polymerase alpha subunit A [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
Network
nt06509  DNA replication
  Element
N01471  Origin unwinding and elongation
Disease
H00658  X-linked syndromic intellectual developmental disorder
H02484  X-linked reticulate pigmentary disorder with systemic manifestations
Drug target
Clofarabine: D03546<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5422 (POLA1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5422 (POLA1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5422 (POLA1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase alpha / primase complex
    5422 (POLA1)
SSDB
Motif
Pfam: DNA_pol_B DNA_pol_B_exo1 zf-DNA_Pol DNA_pol_alpha_N DNA_pol_B_2 DUF1744 MTR4_beta-barrel
Other DBs
NCBI-GeneID: 5422
NCBI-ProteinID: NP_058633
OMIM: 312040
HGNC: 9173
Ensembl: ENSG00000101868
UniProt: P09884
Structure
LinkDB
Position
X:24693918..24996986
AA seq 1462 aa
MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEE
VDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDK
RNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMI
LKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEE
EQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSF
LPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVF
LFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEK
IATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTN
TSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVM
AFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKE
VIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWS
KIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTER
VVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTL
MGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYA
GGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPE
LPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCL
GFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFK
LGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIV
RRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALT
KDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQK
QDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDAL
LGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPL
TFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQ
PEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQF
LSRSGYSEVNLSKLFAGCAVKS
NT seq 4389 nt   +upstreamnt  +downstreamnt
atggcacctgtgcacggcgacgactctctgtcagattcagggagttttgtatcttctcga
gcccggcgagaaaaaaaatcaaagaaggggcgccaagaagccctagaaagactgaaaaag
gctaaagctggtgagaagtataaatatgaagtcgaggacttcacaggtgtttatgaagaa
gttgatgaagaacagtattcgaagctggttcaggcacgccaggatgatgactggattgtg
gatgatgatggtattggctatgtggaagatggccgagagatttttgatgatgaccttgaa
gatgatgcccttgatgctgatgagaaaggaaaagatggtaaagcacgcaataaagacaag
aggaatgtaaagaagctcgcagtgacaaaaccgaacaacattaagtcaatgttcattgct
tgtgctggaaagaaaactgcagataaagctgtagacttgtccaaggatggtctgctaggt
gacattctacaggatcttaacactgagacacctcaaataactccaccacctgtaatgata
ctgaagaagaaaagatccattggagcttcaccgaatcctttctctgtgcacaccgccacg
gcagttccttcaggaaaaattgcttcccctgtctccagaaaggagcctccattaactcct
gttcctcttaaacgtgctgaatttgctggcgatgatgtacaggtcgagagtacagaagaa
gagcaggagtcaggggcaatggagtttgaagatggtgactttgatgagcccatggaagtt
gaagaggtggacctggagcctatggctgccaaggcttgggacaaagagagtgagccagca
gaggaagtgaaacaagaggcggattctgggaaagggaccgtgtcctacttaggaagtttt
ctcccggatgtctcttgttgggacattgatcaagaaggtgatagcagtttctcagtgcaa
gaagttcaagtggattccagtcacctcccattggtaaaaggggcagatgaggaacaagta
ttccacttttattggttggatgcttatgaggatcagtacaaccaaccaggtgtggtattt
ctgtttgggaaagtttggattgaatcagccgagacccatgtgagctgttgtgtcatggtg
aaaaatatcgagcgaacgctttacttccttccccgtgaaatgaaaattgatctaaatacg
gggaaagaaacaggaactccaatttcaatgaaggatgtttatgaggaatttgatgagaaa
atagcaacaaaatataaaattatgaagttcaagtctaagccagtggaaaagaactatgct
tttgagatacctgatgttccagaaaaatctgagtacttggaagttaaatactcggctgaa
atgccacagcttcctcaagatttgaaaggagaaactttttctcatgtatttgggaccaac
acatctagcctggaactgttcttgatgaacagaaagatcaaaggaccttgttggcttgaa
gtaaaaagtccacagctcttgaatcagccagtcagttggtgtaaagttgaggcaatggct
ttgaaaccagacctggtgaatgtaattaaggatgtcagtccaccaccgcttgtcgtgatg
gctttcagcatgaagacaatgcagaatgcaaagaaccatcaaaatgagattattgctatg
gcagctttggtccatcacagttttgcattggataaagcagccccaaagcctccctttcag
tcacacttctgtgttgtgtctaaaccaaaggactgtatttttccatatgctttcaaagaa
gtcattgagaaaaagaatgtgaaggttgaggttgctgcaacagaaagaacactgctaggt
tttttccttgcaaaagttcacaaaattgatcctgatatcattgtgggtcataatatttat
gggtttgaactggaagtactactgcagagaattaatgtgtgcaaagctcctcactggtcc
aagataggtcgactgaagcgatccaacatgccaaagcttgggggccggagtggatttggt
gaaagaaatgctacctgtggtcgaatgatctgtgatgtggaaatttcagcaaaggaattg
attcgttgtaaaagctaccatctgtctgaacttgttcagcagattctaaaaactgaaagg
gttgtaatcccaatggaaaatatacaaaatatgtacagtgaatcttctcaactgttatac
ctgttggaacacacctggaaagatgccaagttcattttgcagatcatgtgtgagctaaat
gttcttccattagcattgcagatcactaacatcgctgggaacattatgtccaggacgctg
atgggtggacgatccgagcgtaacgagttcttgttgcttcatgcattttacgaaaacaac
tatattgtgcctgacaagcagattttcagaaagcctcagcaaaaactgggagatgaagat
gaagaaattgatggagataccaataaatacaagaaaggacgtaagaaagcagcttatgct
ggaggcttggttttggaccccaaagttggtttttatgataagttcattttgcttctggac
ttcaacagtctatatccttccatcattcaggaatttaacatttgttttacaacagtacaa
agagttgcttcagaggcacagaaagttacagaggatggagaacaagaacagatccctgag
ttgccagatccaagcttagaaatgggcattttgcccagagagatccggaaactggtagaa
cggagaaaacaagtcaaacagctaatgaaacagcaagacttaaatccagaccttattctt
cagtatgacattcgacagaaggctttgaagctcacagcgaacagtatgtatggttgcctg
ggattttcctatagcagattttacgccaaaccactggctgccttggtgacatacaaagga
agggagattttgatgcatacgaaagagatggtacaaaagatgaatcttgaagttatttat
ggagatacagattcaattatgataaacaccaatagcaccaatctggaagaagtatttaag
ttgggaaacaaggtaaaaagtgaagtgaataagttgtacaaactgcttgaaatagacatt
gatggggttttcaagtctctgctactgctgaaaaaaaagaagtacgctgctctggttgtt
gagccaacgtcggatgggaattatgtcaccaaacaggagctcaaaggattagatatagtt
agaagagattggtgtgatcttgctaaagacactggaaactttgtgattggccagattctt
tctgatcaaagccgggacactatagtggaaaacattcagaagaggctgatagaaattgga
gaaaatgtgctaaatggcagtgtcccagtgagccagtttgaaattaacaaggcattgaca
aaggatccccaggattaccctgataaaaaaagcctacctcatgtacatgttgccctctgg
ataaattctcaaggaggcagaaaggtgaaagctggagatactgtgtcatatgtcatctgt
caggatggatcaaacctcactgcaagtcagagggcctatgcgcctgagcagctgcagaaa
caggataatctaaccattgacacccagtactacctggcccagcagatccacccagtcgtg
gctcggatctgtgaaccaatagacggaattgatgctgtcctcattgcaacgtggttggga
cttgaccccacccaatttagagttcatcattatcataaagatgaagagaatgatgctcta
cttggtggcccagcacagctcactgatgaagagaaatacagggactgtgaaagattcaaa
tgtccatgccctacatgtggaactgagaatatttatgataatgtctttgatggttcggga
acagatatggagcccagcttgtatcgttgcagtaacatcgattgtaaggcttcacctctg
acctttacagtacaactgagcaacaaattgatcatggacattagacgtttcattaaaaag
tactatgatggctggttgatatgtgaagagccaacctgtcgcaatcgaactcgtcacctt
ccccttcaattctcccgaactgggcctctttgcccagcctgcatgaaagctacacttcaa
ccagagtattctgacaagtccctgtacacccagctgtgcttttaccggtacatttttgat
gcggagtgtgcactggagaaacttactaccgatcatgagaaagataaattgaagaagcaa
ttttttacccccaaagttctgcaggactacagaaaactcaagaacacagcagagcaattc
ttgtcccgaagtggctactccgaagtgaatctgagcaaactcttcgctggttgtgccgtg
aaatcctaa

KEGG   Homo sapiens (human): 23649
Entry
23649             CDS       T01001                                 
Symbol
POLA2
Name
(RefSeq) DNA polymerase alpha 2, accessory subunit
  KO
K02321  DNA polymerase alpha subunit B
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
Network
nt06509  DNA replication
  Element
N01471  Origin unwinding and elongation
Drug target
Clofarabine: D03546<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    23649 (POLA2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    23649 (POLA2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase alpha / primase complex
    23649 (POLA2)
SSDB
Motif
Pfam: DNA_pol_E_B Pol_alpha_B_N
Other DBs
NCBI-GeneID: 23649
NCBI-ProteinID: NP_002680
OMIM: 620063
HGNC: 30073
Ensembl: ENSG00000014138
UniProt: Q14181
Structure
LinkDB
Position
11:65261962..65305985
AA seq 598 aa
MSASAQQLAEELQIFGLDCEEALIEKLVELCVQYGQNEEGMVGELIAFCTSTHKVGLTSE
ILNSFEHEFLSKRLSKARHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGS
QKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGV
SWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAF
TPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPVDLSELKEYSLFPGQ
VVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPL
LDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHL
VFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFGLTSTDLLFHL
GAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLII
PSELRYFVKDVLGCVCVNPGRLTKGQVGGTFARLYLRRPAADGAERQSPCIAVQVVRI
NT seq 1797 nt   +upstreamnt  +downstreamnt
atgtccgcatccgcccagcagctggcggaggagctgcagatcttcggcctagactgcgag
gaggctctaattgagaaattggtagagctttgtgttcagtatggacagaatgaggaggga
atggtaggcgagcttatagccttctgcaccagcacacataaagttggccttacctcagag
atcctgaactcttttgagcatgagtttctgagcaaaagattatcgaaagccaggcatagt
acctgcaaggacagtggccatgcaggagctagagacattgtttccattcaagagctaatt
gaagtggaagaagaagaggaaatcctcttgaactcttacaccacaccttcaaagggttct
cagaagcgagctatctctaccccagaaacccccctaacaaaaaggagtgtgtcaactcgt
agcccccatcagctactctcaccgtcaagtttctctccaagtgctactccctcccagaaa
tacaactcacgaagtaaccgaggagaagtggttacctccttcggcttagcacagggagta
tcttggtctgggagaggaggagctggaaacatcagcctgaaggtcttgggatgtccagag
gcactaactgggagctacaaatccatgtttcagaagctcccagacattcgagaagttctg
acctgtaagatagaagaacttggcagcgaactcaaggaacattacaagattgaagctttc
actcctttgctagccccagcacaggagcctgtcactctgctgggccagattggctgtgat
agcaacgggaagctgaacaacaagtcagtgattctcgagggagaccgggaacattcctcg
ggtgctcaaattccagtggatttatctgagcttaaggaatattctctgtttcctggacag
gttgtaattatggaaggaatcaacaccactggtaggaaacttgttgccaccaaactctac
gagggtgtgccacttccattttatcagcccactgaagaggatgcagactttgagcaaagc
atggtcctggttgcctgtggaccatacaccacatctgacagcatcacgtatgaccccctg
cttgacctgattgctgtcatcaaccatgaccggccagatgtctgcatcctgtttggccct
ttcctggatgctaagcatgaacaggtggagaattgtctactgacaagtccatttgaagac
attttcaagcagtgtctacgaacaattattgaaggcacaagaagctccggctcccacctt
gtctttgtcccgtcattgagagatgtgcaccatgagcctgtgtacccccagccgcctttc
agctactccgatctgtctcgagaggacaaaaagcaagtacagtttgtgtccgagccctgc
agcctctccataaacggagtgatcttcggcttgacatccacagatctgcttttccacctg
ggggccgaggagatcagtagttcttccggaacttcagacagattcagccgaatactcaag
cacatcttgacccagaggagctactacccactctacccgccccaagaagacatggccatt
gactatgagtcgttctatgtttacgcacagctgcctgtcaccccagatgtcctcatcatc
ccgtcagagctgaggtacttcgtgaaggatgtcctcggctgtgtctgtgtgaaccctggg
cgccttaccaaagggcaggtgggaggcaccttcgcccgactctaccttaggaggccggca
gcggacggggcagagaggcagagcccatgcattgctgtgcaggtcgtcaggatctga

KEGG   Homo sapiens (human): 5557
Entry
5557              CDS       T01001                                 
Symbol
PRIM1, PDIL, p49
Name
(RefSeq) DNA primase subunit 1
  KO
K02684  DNA primase small subunit [EC:2.7.7.102]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
Network
nt06509  DNA replication
  Element
N01471  Origin unwinding and elongation
Disease
H02625  Primordial dwarfism-immunodeficiency-lipodystrophy syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5557 (PRIM1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5557 (PRIM1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.102  DNA primase AEP
     5557 (PRIM1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase alpha / primase complex
    5557 (PRIM1)
SSDB
Motif
Pfam: DNA_primase_S ASXH
Other DBs
NCBI-GeneID: 5557
NCBI-ProteinID: NP_000937
OMIM: 176635
HGNC: 9369
Ensembl: ENSG00000198056
UniProt: P49642
Structure
LinkDB
Position
12:complement(56731580..56752323)
AA seq 420 aa
METFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSF
NNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRR
CCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSA
VRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESW
DKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNIKNDKYGPWLEWEIMLQY
CFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAI
STNEEEKEENEAESDVKHRTRDYKKTSLAPYVKVFEHFLENLDKSRKGELLKKSDLQKDF
NT seq 1263 nt   +upstreamnt  +downstreamnt
atggagacgtttgaccccaccgagctgcccgagctgcttaaactttattaccggaggctc
tttccctactctcagtactatcgctggctcaactacggtggagtgataaagaattacttt
caacaccgtgaattttcattcacattgaaagatgatatttacattcgctaccaatccttc
aacaaccagagtgatctggaaaaggagatgcagaaaatgaatccatacaagattgatata
ggcgcagtatattctcacagacccaatcaacacaatacagtgaagctgggagctttccag
gctcaggaaaaagaactggtatttgacattgacatgacagactatgacgatgtgaggaga
tgttgtagttctgcagacatatgtcctaagtgctggaccctcatgacaatggccatacgc
atcattgacagagcattgaaggaggactttggatttaagcatcgtctctgggtatattct
ggaaggagaggtgttcattgttgggtctgtgatgaatcagttagaaaactgtcttctgca
gtacgttctgggatagttgagtatttgagccttgtaaagggtggtcaagacgttaaaaag
aaagttcacctaagtgaaaaaattcacccttttatcagaaaatctataaacataataaaa
aaatactttgaagaatatgccttggttaatcaagatattctcgaaaataaagaaagctgg
gataagattttagcccttgttcctgaaacaattcatgatgaacttcaacaaagcttccaa
aagtctcacaattcacttcagcgttgggagcacttgaagaaagtagccagcagatatcag
aataacatcaaaaatgacaaatatggaccctggctggagtgggagattatgctccagtac
tgttttccacggctggatatcaatgtcagcaaaggaatcaatcatctactgaagagccct
tttagtgttcatcctaaaacaggtcgcatatctgtgcctattgatttgcagaaagtggac
cagtttgatccatttactgttccgaccataagcttcatctgccgtgaattggatgccatt
tccactaatgaagaggaaaaagaggagaatgaagctgaatctgatgtcaaacatagaacc
agagattataagaagaccagtctagcaccttatgtgaaagtttttgaacattttcttgaa
aatctggataaatcccgaaaaggagaacttcttaagaagagtgatttacaaaaagatttc
tga

KEGG   Homo sapiens (human): 5558
Entry
5558              CDS       T01001                                 
Symbol
PRIM2, PRIM2A, p58
Name
(RefSeq) DNA primase subunit 2
  KO
K02685  DNA primase large subunit
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
Network
nt06509  DNA replication
  Element
N01471  Origin unwinding and elongation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5558 (PRIM2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5558 (PRIM2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase alpha / primase complex
    5558 (PRIM2)
SSDB
Motif
Pfam: DNA_primase_lrg
Other DBs
NCBI-GeneID: 5558
NCBI-ProteinID: NP_000938
OMIM: 176636
HGNC: 9370
Ensembl: ENSG00000146143
UniProt: P49643
Structure
LinkDB
Position
6:57221540..57646850
AA seq 509 aa
MEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLG
VSYVKGTEQYQSKLESELRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWF
IQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIVASSPSLSGLKLGF
ESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLPAV
QSDERLQPLLNHLSHSYTGQDYSTQGNVGKISLDQIDLLSTKSFPPCMRQLHKALRENHH
LRHGGRMQYGLFLKGIGLTLEQALQFWKQEFIKGKMDPDKFDKGYSYNIRHSFGKEGKRT
DYTPFSCLKIILSNPPSQGDYHGCPFRHSDPELLKQKLQSYKISPGGISQILDLVKGTHY
QVACQKYFEMIHNVDDCGFSLNHPNQFFCESQRILNGGKDIKKEPIQPETPQPKPSVQKT
KDASSALASLNSSLEMDMEGLEDYFSEDS
NT seq 1530 nt   +upstreamnt  +downstreamnt
atggagttttctggaagaaagtggaggaagctgaggttggcaggtgaccagaggaatgct
tcctaccctcattgccttcagttttacttgcagccaccttctgaaaacatatctttaata
gaatttgaaaacttggctattgatagagttaaattgttaaaatcagttgaaaatcttgga
gtgagctatgtgaaaggaactgaacaataccagagtaagttggagagtgagcttcggaag
ctcaagttttcctacagagaaaacttagaagatgaatatgaaccacgaagaagagatcat
atttctcattttattttgcggcttgcttattgccagtctgaagaacttagacgctggttc
attcaacaagaaatggatctccttcgatttagatttagtattttacccaaggataaaatt
caggatttcttaaaggatagccaattgcagtttgaggctataagtgatgaagagaagact
cttcgagaacaggagattgttgcctcatcaccaagtttaagtggacttaagttggggttc
gagtccatttataagatcccttttgctgatgctctggatttgtttcgaggaaggaaagtc
tatttggaagatggctttgcttacgtaccacttaaggacattgtggcaatcatcctgaat
gaatttagagccaaactgtccaaggctttggcattaacagccaggtccttgcctgctgtg
cagtctgatgaaagacttcagcctctgctcaatcacctcagtcattcctacactggccaa
gattacagtacccagggaaatgttgggaagatttctttagatcagattgatttgctttct
accaaatccttcccaccttgcatgcgtcagttacataaagccttgcgggaaaatcaccat
cttcgtcatggaggccgaatgcagtatggcctatttctgaagggcattggtttaactttg
gaacaggcattgcagttctggaagcaagaatttatcaaaggaaagatggatccagacaag
tttgataaaggttactcttacaacatccgtcacagctttggaaaggaaggcaagaggaca
gactatacacctttcagttgcctgaagattattctgtccaatccaccaagccaaggggat
tatcatgggtgcccattccgtcacagtgatccagagctgctgaagcaaaagttgcagtca
tacaagatctctcctggagggataagccagattttggatttagtaaaggggacacattac
caggtagcctgtcaaaaatactttgagatgatacacaatgtggatgattgtggcttttct
ttgaatcatcctaatcagttcttttgtgagagccaacgtattctaaatggtggtaaagac
ataaagaaggaacctatccaaccagaaactcctcaacccaaaccaagtgtccagaaaacc
aaggatgcatcatctgctctggcctctttaaattcctctctggaaatggatatggaagga
ctagaagattactttagtgaagattcttag

KEGG   Homo sapiens (human): 5426
Entry
5426              CDS       T01001                                 
Symbol
POLE, CRCS12, FILS, IMAGEI, POLE1
Name
(RefSeq) DNA polymerase epsilon, catalytic subunit
  KO
K02324  DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
Disease
H00020  Colorectal cancer
H02369  IMAGE-I syndrome
H02370  FILS syndrome
H02568  Polymerase proofreading-associated polyposis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5426 (POLE)
   03410 Base excision repair
    5426 (POLE)
   03420 Nucleotide excision repair
    5426 (POLE)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5426 (POLE)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5426 (POLE)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5426 (POLE)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase epsilon complex
    5426 (POLE)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase epsilon complex
      5426 (POLE)
SSDB
Motif
Pfam: DUF1744 DNA_pol_B_exo1 DNA_pol_B DNA_pol_B_exo2 RNase_H_2 APP_N Translat_reg
Other DBs
NCBI-GeneID: 5426
NCBI-ProteinID: NP_006222
OMIM: 174762
HGNC: 9177
Ensembl: ENSG00000177084
UniProt: Q07864
Structure
LinkDB
Position
12:complement(132623762..132687342)
AA seq 2286 aa
MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKT
GWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFL
SKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQ
DHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHV
AHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMI
DGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMV
TYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVG
SHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFA
LCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYV
GGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVC
DEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPG
ANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEK
RRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLS
AAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGA
NIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIM
VKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFN
EDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSK
AANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYII
SRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSA
IQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEA
SEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPA
LGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLR
RTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGAS
YRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVH
LGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALF
GIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETD
LKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYG
VLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRH
NHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTIL
QSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVV
GWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLG
SSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPS
NYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNW
NILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGA
VGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNP
ALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRS
CNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLV
CLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQK
NPQLGH
NT seq 6861 nt   +upstreamnt  +downstreamnt
atgtctctgaggagcggcgggcggcggcgcgcggacccaggcgcggatggcgaggccagc
agggatgatggcgccacttcctcagtttcggcactcaagcgcctggaacggagtcagtgg
acggataagatggatttgcggtttggttttgagcggctgaaggagcctggtgagaagaca
ggctggctcattaacatgcatcctaccgagattttagatgaagataagcgcttaggcagt
gcagtggattactactttattcaagatgacggaagcagatttaaggtggctttgccctat
aaaccgtatttctacattgcgaccagaaagggttgtgagcgagaagtttcatcttttctc
tccaagaagtttcagggcaaaattgcaaaagtggagactgtccccaaagaggatctggac
ttgccaaatcacttggtgggtttgaagcgaaattacatcaggctgtccttccacactgtg
gaggatcttgtcaaagtgaggaaggagatctcccctgccgtgaagaagaacagggagcag
gatcacgccagcgacgcgtacacagctctgctttccagtgttctgcagaggggcggtgtc
attactgatgaagaggaaacctctaagaagatagctgaccagttggacaacattgtggac
atgcgcgagtacgatgttccctaccacatccgcctctccattgacctgaagatccacgtg
gctcattggtacaatgtcagataccgaggaaatgcttttccggtagaaatcacccgccga
gatgaccttgttgaacgacctgaccctgtggttttggcatttgacattgagacgaccaaa
ctgcccctcaagtttcctgatgctgagacagaccagattatgatgatttcctacatgatc
gatggccagggctacctcatcaccaacagggagattgtttcagaagatattgaagatttt
gagttcacccccaagccagaatatgaaggccccttttgtgtcttcaatgaacccgatgag
gctcatctgatccaaaggtggtttgaacacgtccaggagaccaaacccaccatcatggtc
acctacaacggggacttttttgactggccatttgtggaggcccgggcagcagtccacggt
ctgagcatgcagcaggagataggcttccagaaggacagccagggggagtacaaggcgccc
cagtgcatccacatggactgcctcaggtgggtgaagagggacagttaccttcctgtgggc
agtcataatctcaaggcggccgccaaggccaagctaggctatgatcccgtggagctagac
ccggaggacatgtgccggatggccacggagcagccccagactctggccacgtattctgtg
tcagatgctgtcgccacttactacctgtacatgaagtacgtccacccattcatctttgct
ctgtgcaccattattcccatggagcccgacgaggtgctgcggaagggctctggcactctg
tgtgaggccttgctgatggtgcaggccttccacgccaacatcatcttccccaacaagcaa
gagcaggagttcaataagctgacggacgacggacacgtgctggactctgagacctacgtc
gggggccacgtggaggccctcgagtctggggttttccgcagcgatatcccttgccggttt
aggatgaatcctgccgcctttgacttcctgctgcagcgggttgagaagaccttgcgccac
gcccttgaggaagaggagaaagtgcctgtggagcaagtcaccaactttgaagaggtgtgt
gatgagattaagagcaagcttgcctccctgaaggacgttcccagccgcatcgagtgtcca
ctcatctaccacctggacgtgggggccatgtaccccaacatcatcctgaccaaccgcctg
cagccctctgccatggtggacgaagccacctgtgctgcctgtgacttcaataagcctgga
gcaaactgccagcggaagatggcctggcagtggaggggcgagttcatgccagccagtcgc
agcgaataccatcggatccagcaccagctggagtcagagaagttcccccccttgttccca
gaggggccagctcgggcctttcatgaactgtcccgcgaggaacaggcgaaatacgagaag
agaaggctggcggattactgccggaaagcctacaagaagatccacatcaccaaggtggaa
gagcgtctcaccaccatctgccagcgggaaaactccttctacgtggacaccgtgcgtgcc
ttccgggacaggcgttacgagttcaaagggctccacaaggtgtggaaaaagaagctctcg
gcggccgtggaggtgggcgacgcggctgaggtgaagcgctgcaagaacatggaggtgctg
tatgactcgctgcagctggcccacaagtgcatcctgaactccttctatggctatgtcatg
cgcaagggggctcgctggtactccatggagatggctggcatcgtctgcttcacaggggcc
aacatcatcacccaggcacgggagctgatcgagcagattgggaggcccttagagctggac
acagatggtatatggtgcgtcctgcccaacagcttcccagaaaattttgtcttcaagacg
accaatgtgaagaagcccaaagtgaccatctcctacccaggcgccatgttgaacatcatg
gtcaaggaaggcttcaccaatgaccagtaccaggagctggctgagccgtcctcactcacc
tacgtcacccgctcagagaacagcatcttttttgaggttgatgggccctaccttgccatg
attcttccagcctccaaggaagaaggcaagaaattgaagaagaggtatgctgtgttcaat
gaagacggttctctggctgagctcaagggctttgaggtcaaacgccgcggggaactgcag
ctgattaagatcttccaatcctcggtgtttgaggccttcctcaagggcagcacgctggaa
gaggtgtatggctctgtagccaaggtggctgactactggctggacgtgctgtacagcaag
gcagccaacatgcctgactctgagctattcgagctcatctctgagaaccgttccatgtct
cggaagctggaagattacggggagcagaagtctacgtccatcagcacagcaaagcgcctg
gccgagttcctgggagaccagatggtcaaggatgcagggctgagttgccgctacatcatc
tcccgcaagcccgagggctcccctgtcacggagagggccatcccacttgccattttccaa
gcagagcccacggtgaggaagcactttctccggaaatggctcaagagctcttcccttcaa
gactttgatattcgagcaattctggattgggactactacattgagcggctgggaagcgcc
atccagaagatcatcaccatccctgcggccctgcagcaggtaaagaacccagtgccacgt
gtcaaacaccccgactggctgcacaaaaaactgctggagaagaatgatgtctacaagcag
aagaagatcagtgagctcttcaccctggagggcaggagacaggtcacgatggccgaggcc
tcagaagacagtccgaggccaagtgctcctgacatggaggacttcggcctcgtaaagctg
cctcacccagcagcccctgtcactgtgaagaggaagcgagttctttgggagagccaggag
gagtcccaggacctcacgccgactgtgccctggcaggaaatcttggggcagcctcccgcc
ctgggaaccagccaggaggaatggcttgtctggctccggttccacaagaagaagtggcag
ctgcaggcccggcagcgcctcgcccgcaggaagaggcagcgtctggagtcggcagagggt
gtgctcaggcccggggccatccgggatggtcctgccacggggctggggagcttcttgcga
agaactgcccgcagcatcctggaccttccgtggcagattgtgcagatcagcgagaccagc
caggccggcctgttcaggctgtgggcgctcgttggcagtgacttgcactgcatcaggctg
agcatcccccgtgtgttctacgtgaaccagcgagtcgctaaagcggaggagggtgcttcg
tatcgcaaggtaaatcgggtccttcctcgctccaacatggtctacaatctctatgagtat
tcagtgccagaggacatgtaccaggaacacatcaacgagatcaacgctgagctgtcagcg
ccagacatcgagggcgtatatgagactcaggttccgttactgttccgggccctggtgcac
ctgggctgtgtgtgtgtggtcaataaacagctggtgaggcacctttcaggctgggaagca
gagacctttgctcttgagcacctggagatgcgctctctggcccagttcagctacctggaa
ccagggagtatccgccatatctacctgtaccaccacgcacaggcccacaaagcgctcttc
gggatcttcatcccctcacagcgcagggcatccgtctttgtgctggacactgtgcgcagc
aaccagatgcccagccttggcgccctgtactcagcagagcacggcctcctcctggagaag
gtgggccctgagctcctgccaccccccaaacacaccttcgaagttcgggcagaaactgac
ctgaagaccatctgcagagccatccagcgattcctgctcgcctacaaggaggagcgccgg
gggcccacactcatcgctgttcagtccagctgggagctgaagaggctggccagtgaaatt
cctgtcttggaggaattcccactggtgcctatctgtgtggctgacaagatcaactatggg
gtcctggactggcagcgccatggagcccggcgcatgatccgtcactacctcaacctggac
acctgcctgtcgcaggccttcgagatgagcaggtactttcacattcccattgggaaccta
ccagaggacatctccacattcggctccgacctcttctttgcccgccacctccagcgccac
aaccacctgctctggctgtcccctacagcccgccctgacctgggtggaaaggaggctgat
gacaactgtcttgtcatggagttcgatgaccaagccactgttgagatcaacagttcaggc
tgttactccacagtgtgtgtggagctggaccttcagaacctggccgtcaacaccattctc
cagtctcaccatgtcaacgacatggagggggccgacagcatggggatcagcttcgacgtg
atccagcaggcctccctggaggacatgatcacgggtggtcaggctgccagtgccccggcc
agctacgatgagacagccctgtgctctaacaccttcaggatcctgaagagcatggtcgtg
ggctgggtgaaggagatcacccagtaccacaacatctatgcagacaaccaggtgatgcac
ttctaccgctggcttcggtcgccatcctctctgcttcatgaccctgccctgcaccgcaca
ctccacaacatgatgaagaagctcttcctgcagctcatcgctgagttcaagcgcctgggg
tcatcagtcatctacgccaacttcaaccgcatcatcctctgtacaaagaagcgccgtgtg
gaagatgccatcgcttacgtggagtacatcaccagcagcatccattcaaaggagaccttc
cattctctgacaatttctttctctcgatgctgggaatttcttctctggatggatccatct
aactatggcggaatcaaaggaaaagtttcatctcgtattcactgtggactgcaagactcc
cagaaagcagggggagcagaggatgagcaggaaaatgaggacgatgaggaggaaagagat
ggggaggaggaggaagaggcggaggaatccaacgtggaggatttactggaaaacaactgg
aacattttgcagtttttgccacaggcagcctcctgccagaactacttcctcatgattgtt
tcagcgtacatcgtggccgtgtaccactgcatgaaggacgggctgaggcgcagtgctcca
gggagcacccccgtgaggaggaggggggccagccagctctcccaggaggccgagggggcg
gtcggagcccttcccggaatgatcaccttctctcaggattatgtcgcaaatgagctcact
cagagcttcttcaccatcactcagaagattcagaagaaagtcacaggctctcggaactcc
actgagctctcagagatgtttcctgtcctccccggttcccacttgctgctcaataaccct
gccctggagttcatcaaatacgtgtgcaaggtgctgtccctggacaccaacatcacaaac
caggtgaataagctgaaccgagacctgcttcgcctggtggatgtcggcgagttctccgag
gaggcccagttccgagacccctgccgctcctacgtgcttcctgaggtcatctgccgcagc
tgtaacttctgccgcgacctggacctgtgtaaagactcttccttctcagaggatggggcg
gtcctgcctcagtggctctgctccaactgtcaggcgccctacgactcctctgccatcgag
atgacgctggtggaagttctacagaagaagctgatggccttcaccctgcaggacctggtc
tgcctgaagtgccgcggggtgaaggagaccagcatgcctgtgtactgcagctgcgcggga
gacttcgccctcaccatccacacccaggtcttcatggaacagatcggaatattccggaac
attgcccagcactacggcatgtcgtacctcctggagaccctggagtggctgctgcagaag
aacccacagctgggccattag

KEGG   Homo sapiens (human): 5427
Entry
5427              CDS       T01001                                 
Symbol
POLE2, DPE2
Name
(RefSeq) DNA polymerase epsilon 2, accessory subunit
  KO
K02325  DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5427 (POLE2)
   03410 Base excision repair
    5427 (POLE2)
   03420 Nucleotide excision repair
    5427 (POLE2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5427 (POLE2)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5427 (POLE2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5427 (POLE2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase epsilon complex
    5427 (POLE2)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase epsilon complex
      5427 (POLE2)
SSDB
Motif
Pfam: DNA_pol_E_B Dpoe2NT DUF3689
Other DBs
NCBI-GeneID: 5427
NCBI-ProteinID: NP_002683
OMIM: 602670
HGNC: 9178
Ensembl: ENSG00000100479
UniProt: P56282
Structure
LinkDB
Position
14:complement(49643555..49688214)
AA seq 527 aa
MAPERLRSRALSAFKLRGLLLRGEAIKYLTEALQSISELELEDKLEKIINAVEKQPLSSN
MIERSVVEAAVQECSQSVDETIEHVFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLF
GTPRDKAEMFRERYTILHQRTHRHELFTPPVIGSHPDESGSKFQLKTIETLLGSTTKIGD
AIVLGMITQLKEGKFFLEDPTGTVQLDLSKAQFHSGLYTEACFVLAEGWFEDQVFHVNAF
GFPPTEPSSTTRAYYGNINFFGGPSNTSVKTSAKLKQLEEENKDAMFVFLSDVWLDQVEV
LEKLRIMFAGYSPAPPTCFILCGNFSSAPYGKNQVQALKDSLKTLADIICEYPDIHQSSR
FVFVPGPEDPGFGSILPRPPLAESITNEFRQRVPFSVFTTNPCRIQYCTQEITVFREDLV
NKMCRNCVRFPSSNLAIPNHFVKTILSQGHLTPLPLYVCPVYWAYDYALRVYPVPDLLVI
ADKYDPFTTTNTECLCINPGSFPRSGFSFKVFYPSNKTVEDSKLQGF
NT seq 1584 nt   +upstreamnt  +downstreamnt
atggcgccggagcggctgcggagccgggcgctctccgccttcaagttgcggggcttgctg
ctccgtggtgaagctattaagtacctcacagaagctcttcagtctatcagtgaattagag
cttgaagataaactggaaaagataattaatgcagttgagaagcaacccttgtcatcaaac
atgattgaacgatctgtggtggaagcagcagtccaggaatgcagtcagtctgttgatgaa
actatagagcacgttttcaatatcataggagcatttgatattccacgctttgtgtacaat
tcagaaagaaaaaaatttcttcctctgttaatgaccaaccaccctgcaccaaatttattt
ggaacaccaagagataaagcagagatgtttcgtgagcgatataccattttgcaccagagg
acccacaggcatgaattatttactcctccggtgataggttctcaccctgatgaaagcgga
agcaaattccagcttaaaacaatagaaaccttattgggtagtacaaccaaaatcggagat
gcgattgttcttggaatgataacgcagttaaaagagggaaaattttttctggaagatcct
actggaacagtccaactagaccttagtaaagctcagttccatagtggtttatacacagag
gcatgctttgtcttagcagaaggttggtttgaagatcaagtgtttcatgtcaatgccttt
ggatttccacccactgagccctctagtactactagggcatactatggaaatattaatttt
tttggaggtccttctaatacatctgtgaagacttctgcaaaactaaaacagctagaagag
gagaataaagatgctatgtttgtgtttttatctgatgtttggttggaccaggtggaagta
ttggaaaaacttcgcataatgtttgctggttattcaccagcacctccaacctgctttatt
ctgtgtggtaatttttcatctgcaccatatggaaaaaatcaagttcaagctttgaaagat
tccctaaaaactttggcagatataatatgtgaatacccagatattcaccaaagtagtcgt
tttgtgtttgtacctggtccagaggatcctggatttggttccatcttaccaaggccacca
cttgctgaaagcatcactaatgaattcagacaaagggtaccattttcagtttttactact
aatccttgcagaattcagtactgtacacaggaaattactgtcttccgtgaagacttagta
aataaaatgtgcagaaactgcgtccgttttcctagcagcaatttggctattcctaatcac
tttgtaaagactatcttatcccaaggacatctgactcccctacctctttatgtctgccca
gtgtattgggcatatgactatgctttgagagtgtatcctgtgcccgatctacttgtcatt
gcagacaaatatgatcctttcactacgacaaataccgaatgcctctgcataaaccctggc
tcttttccaagaagtggattttcattcaaagttttttatccttctaataagacagtagaa
gatagcaaacttcaaggcttttga

KEGG   Homo sapiens (human): 54107
Entry
54107             CDS       T01001                                 
Symbol
POLE3, CHARAC17, CHRAC17, CHRAC2, YBL1, p17
Name
(RefSeq) DNA polymerase epsilon 3, accessory subunit
  KO
K02326  DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03082  ATP-dependent chromatin remodeling
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    54107 (POLE3)
   03410 Base excision repair
    54107 (POLE3)
   03420 Nucleotide excision repair
    54107 (POLE3)
  09126 Chromosome
   03082 ATP-dependent chromatin remodeling
    54107 (POLE3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    54107 (POLE3)
   03036 Chromosome and associated proteins [BR:hsa03036]
    54107 (POLE3)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    54107 (POLE3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     54107 (POLE3)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase epsilon complex
    54107 (POLE3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Chromatin remodeling factors
   CHRAC complex
    54107 (POLE3)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase epsilon complex
      54107 (POLE3)
SSDB
Motif
Pfam: CBFD_NFYB_HMF Histone CENP-T_C BUD22 CIS_TMP DUF5427 SpoU_methylase DUF4746 TAF Myc_N RNA_pol_3_Rpc31 Pox_Ag35 DDHD CDC45 DUF6080 V_ATPase_I NOA36
Other DBs
NCBI-GeneID: 54107
NCBI-ProteinID: NP_001265184
OMIM: 607267
HGNC: 13546
Ensembl: ENSG00000148229
UniProt: Q9NRF9
LinkDB
Position
9:complement(113407235..113410749)
AA seq 147 aa
MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGK
RKTLNASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKTDSEEQD
KSRDEDNDEDEERLEEEEQNEEEEVDN
NT seq 444 nt   +upstreamnt  +downstreamnt
atggcggagaggcccgaggacctaaacctgcccaatgccgtgatcaccaggatcatcaag
gaggcgctcccggacggtgtcaacatctccaaggaggcccggagcgccatctcccgcgcc
gccagcgtcttcgtgctgtacgccacatcctgtgctaacaactttgcaatgaaaggaaag
cggaagacgctgaatgccagtgatgtgctctcagccatggaagagatggagttccagcgg
ttcgttaccccattgaaagaagctctggaagcatataggcgggagcagaaaggcaagaag
gaggcctcagagcaaaagaagaaggacaaagacaaaaaaacagactcggaagagcaagac
aagagcagggatgaggacaatgatgaagacgaagaaaggctggaagaagaagaacagaat
gaagaggaagaagtagacaactga

KEGG   Homo sapiens (human): 56655
Entry
56655             CDS       T01001                                 
Symbol
POLE4, YHHQ1, p12
Name
(RefSeq) DNA polymerase epsilon 4, accessory subunit
  KO
K03506  DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    56655 (POLE4)
   03410 Base excision repair
    56655 (POLE4)
   03420 Nucleotide excision repair
    56655 (POLE4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    56655 (POLE4)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    56655 (POLE4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     56655 (POLE4)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase epsilon complex
    56655 (POLE4)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase epsilon complex
      56655 (POLE4)
SSDB
Motif
Pfam: CBFD_NFYB_HMF Histone TAF CENP-T_C
Other DBs
NCBI-GeneID: 56655
NCBI-ProteinID: NP_063949
OMIM: 607269
HGNC: 18755
Ensembl: ENSG00000115350
UniProt: Q9NR33
LinkDB
Position
2:74958643..74970128
AA seq 117 aa
MAAAAAAGSGTPREEEGPAGEAAASQPQAPTSVPGARLSRLPLARVKALVKADPDVTLAG
QEAIFILARAAELFVETIAKDAYCCAQQGKRKTLQRRDLDNAIEAVDEFAFLEGTLD
NT seq 354 nt   +upstreamnt  +downstreamnt
atggcggcggcggcggcggcaggaagcgggacgccccgagaggaggagggacctgctggg
gaggcagcggcctcgcagccccaggccccaacgagtgtgcctggggctcgtctctcgagg
ttgcctctggcgcgagtgaaggccttggtgaaggcagatcccgacgtgacgctagcggga
caggaagccatcttcattctggcacgagccgcggaactgtttgtggagaccattgcaaaa
gatgcctactgttgcgctcagcagggaaaaaggaaaacccttcagaggagagacttggat
aatgcaatagaagctgtggatgaatttgcttttctggaaggtactttagattga

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