KEGG   PATHWAY: aang00564
Entry
aang00564                   Pathway                                
Name
Glycerophospholipid metabolism - Anguilla anguilla (European eel)
Class
Metabolism; Lipid metabolism
Pathway map
aang00564  Glycerophospholipid metabolism
aang00564

Module
aang_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:aang00564]
aang_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:aang00564]
aang_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:aang00564]
Other DBs
GO: 0006650
Organism
Anguilla anguilla (European eel) [GN:aang]
Gene
118224228  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
118211278  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
118211877  gpd1l; glycerol-3-phosphate dehydrogenase 1-like protein isoform X1 [KO:K00006] [EC:1.1.1.8]
118207205  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
118223318  gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
118217874  gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
118237359  gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
118206301  gpat4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
118206816  agpat9l; glycerol-3-phosphate acyltransferase 3-like isoform X1 [KO:K13506] [EC:2.3.1.15]
118212762  agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X1 [KO:K13509] [EC:2.3.1.51]
118223445  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma-like [KO:K13523] [EC:2.3.1.51 2.3.1.-]
118217896  agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
118214154  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma-like [KO:K13523] [EC:2.3.1.51 2.3.1.-]
118220922  agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
118209805  lclat1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
118230445  mboat2b; lysophospholipid acyltransferase 2b [KO:K13517] [EC:2.3.1.51 2.3.1.-]
118213437  mboat1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
118233634  membrane-bound O-acyltransferase domain-containing protein 2-like isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
118229909  gnpat; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
118229948  si:ch73-21k16.5; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
118220164  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
118216912  ppap2d; phosphatidic acid phosphatase type 2D [KO:K01080] [EC:3.1.3.4]
118230230  plpp2a; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
118206280  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
118212415  phospholipid phosphatase 1-like isoform X1 [KO:K01080] [EC:3.1.3.4]
118225802  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
118226072  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
118229947  lpin1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
118211519  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
118225294  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
118233049  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
118217738  plpp4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
118237559  plpp5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
118236398  diacylglycerol kinase delta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
118215376  diacylglycerol kinase zeta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
118222876  si:dkey-172j4.3; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
118210202  diacylglycerol kinase delta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
118216550  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
118223219  diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
118210555  dgkab; diacylglycerol kinase, alpha b [KO:K00901] [EC:2.7.1.107]
118223744  diacylglycerol kinase eta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
118224539  dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
118231757  diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
118232361  dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
118207469  dgkaa; diacylglycerol kinase, alpha a isoform X1 [KO:K00901] [EC:2.7.1.107]
118214094  dgkh; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
118227626  dgkza; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
118231580  chpt1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
118211219  cept1b; choline/ethanolaminephosphotransferase 1b isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
118208133  choline/ethanolaminephosphotransferase 1-like [KO:K13644] [EC:2.7.8.1 2.7.8.2]
118222292  si:ch211-168k14.2; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
118235981  pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
118229901  pld1a; phospholipase D1a isoform X1 [KO:K01115] [EC:3.1.4.4]
118223653  phospholipase D2-like isoform X1 [KO:K01115] [EC:3.1.4.4]
118226286  phospholipase D1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
118209720  pld3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
118224790  5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
118215008  lcat; phosphatidylcholine-sterol acyltransferase isoform X1 [KO:K00650] [EC:2.3.1.43]
118210292  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
118216871  zgc:92162; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118206214  group 3 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
118218149  pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
118212276  pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118213221  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
118227256  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118221580  phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
118221669  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
118237576  pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118237578  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
118237579  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
118230091  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
118225096  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
118233579  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
118233574  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
118220923  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
118222237  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
118228831  phospholipase B1, membrane-associated-like isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
118223241  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
118223242  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
118221212  plaat1l; phospholipase A and acyltransferase 1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
118233785  lpcat1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
118227630  lpcat2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
118231834  lpcat4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
118211506  lpcat3; lysophospholipid acyltransferase 5 isoform X1 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
118225451  lypla1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
118215009  pla2g15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
118233310  lypla2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
118213108  pnpla7a; patatin-like phospholipase domain-containing protein 7a isoform X1 [KO:K14676] [EC:3.1.1.5]
118220300  pnpla6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
118237541  pnpla7b; patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
118229954  gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
118217564  choline O-acetyltransferase-like [KO:K00623] [EC:2.3.1.6]
118219722  choline O-acetyltransferase-like [KO:K00623] [EC:2.3.1.6]
118235637  acetylcholinesterase-like isoform X1 [KO:K01049] [EC:3.1.1.7]
118223027  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
118223028  acetylcholinesterase-like [KO:K01049] [EC:3.1.1.7]
118219154  choline/ethanolamine kinase-like [KO:K14156] [EC:2.7.1.32 2.7.1.82]
118232194  chkb; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
118215143  chka; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
118216665  phospho1; probable phosphatase phospho1 isoform X1 [KO:K06124] [EC:3.1.3.75]
118221039  probable phosphatase phospho1 [KO:K06124] [EC:3.1.3.75]
118235251  choline-phosphate cytidylyltransferase B-like isoform X1 [KO:K00968] [EC:2.7.7.15]
118210286  pcyt1ab; phosphate cytidylyltransferase 1, choline, alpha b [KO:K00968] [EC:2.7.7.15]
118230158  choline-phosphate cytidylyltransferase A-like isoform X1 [KO:K00968] [EC:2.7.7.15]
118230703  selenoi; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
118233430  ethanolaminephosphotransferase 1-like isoform X1 [KO:K00993] [EC:2.7.8.1]
118210578  etnk2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
118231503  etnk1; ethanolamine kinase 1 isoform X1 [KO:K00894] [EC:2.7.1.82]
118214869  zgc:113516; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
118220297  pcyt2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
118223416  phosphomethylethanolamine N-methyltransferase-like isoform X1 [KO:K05929] [EC:2.1.1.103]
118223417  phosphomethylethanolamine N-methyltransferase-like [KO:K05929] [EC:2.1.1.103]
118227962  etnppl; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
118217294  pemt; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
118206404  cds1; phosphatidate cytidylyltransferase 1 isoform X1 [KO:K00981] [EC:2.7.7.41]
118213464  phosphatidate cytidylyltransferase 2-like isoform X1 [KO:K00981] [EC:2.7.7.41]
118237375  cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
118214478  pla1a; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
118236404  ptdss1a; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
118215578  ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
118212735  pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
118221710  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
118213210  crls1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
118211212  taz; tafazzin isoform X1 [KO:K13511] [EC:2.3.1.-]
118230770  lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
118220279  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
118235387  mboat7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
aang00010  Glycolysis / Gluconeogenesis
aang00260  Glycine, serine and threonine metabolism
aang00561  Glycerolipid metabolism
aang00562  Inositol phosphate metabolism
aang00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
aang00565  Ether lipid metabolism
aang00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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