PATHWAY: bna00020 Help
Entry
Name
Citrate cycle (TCA cycle) - Brassica napus (rape)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:
M00009 ], but contain genes for specific segments [MD:
M00010 M00011 ].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ortholog table
Module
bna_M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:bna00020 ]
bna_M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:bna00020 ]
Other DBs
Organism
Brassica napus (rape) [GN:
bna ]
Gene
106362170 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
106345997 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like isoform X2 [KO:K00658 ] [EC:2.3.1.61 ]
106347319 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
106390036 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial isoform X2 [KO:K00658 ] [EC:2.3.1.61 ]
106413867 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
106411033 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
106421000 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
111201421 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
106358341 succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
106366291 succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial-like isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
111211824 succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial-like isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
111203424 succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial-like isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
125575052 succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial-like isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
106428670 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
106399446 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
125597776 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
106440390 succinate dehydrogenase subunit 3-1, mitochondrial-like isoform X1 [KO:K00236 ]
106419495 succinate dehydrogenase subunit 3-1, mitochondrial-like isoform X1 [KO:K00236 ]
106438284 succinate dehydrogenase subunit 4, mitochondrial-like [KO:K25801 ]
106450504 succinate dehydrogenase subunit 4, mitochondrial-like [KO:K25801 ]
106375942 pyruvate dehydrogenase E1 component subunit beta-2, chloroplastic isoform X1 [KO:K00162 ] [EC:1.2.4.1 ]
106361600 pyruvate dehydrogenase E1 component subunit beta-2, chloroplastic-like isoform X1 [KO:K00162 ] [EC:1.2.4.1 ]
106349412 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627 ] [EC:2.3.1.12 ]
106348460 dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial isoform X2 [KO:K00627 ] [EC:2.3.1.12 ]
106345655 dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
106345762 dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
106367039 dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627 ] [EC:2.3.1.12 ]
106418616 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627 ] [EC:2.3.1.12 ]
106448576 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
106445677 dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial-like isoform X2 [KO:K00627 ] [EC:2.3.1.12 ]
106382003 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627 ] [EC:2.3.1.12 ]
106390709 dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
106389162 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial isoform X4 [KO:K00627 ] [EC:2.3.1.12 ]
106390448 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
111213384 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
125609061 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
Compound
C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate
C05381 3-Carboxy-1-hydroxypropyl-ThPP
C15972 Enzyme N6-(lipoyl)lysine
C15973 Enzyme N6-(dihydrolipoyl)lysine
C16254 [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
Authors
Nishizuka Y (ed).
Title
[Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1980)
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Michal G.
Title
Biochemical Pathways
Journal
Wiley (1999)
Related pathway
bna00053 Ascorbate and aldarate metabolism
bna00250 Alanine, aspartate and glutamate metabolism
bna00280 Valine, leucine and isoleucine degradation
bna00630 Glyoxylate and dicarboxylate metabolism
KO pathway
LinkDB
All DBs