KEGG   PATHWAY: char00564
Entry
char00564                   Pathway                                
Name
Glycerophospholipid metabolism - Clupea harengus (Atlantic herring)
Class
Metabolism; Lipid metabolism
Pathway map
char00564  Glycerophospholipid metabolism
char00564

Module
char_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:char00564]
char_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:char00564]
char_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:char00564]
Other DBs
GO: 0006650
Organism
Clupea harengus (Atlantic herring) [GN:char]
Gene
105908915  gpd1l; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
105899339  gpd1a; glycerol-3-phosphate dehydrogenase 1a [KO:K00006] [EC:1.1.1.8]
105900688  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
122129873  gpd1b; glycerol-3-phosphate dehydrogenase 1b [KO:K00006] [EC:1.1.1.8]
105912406  gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
105902648  glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
105911370  gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X3 [KO:K00629] [EC:2.3.1.15]
105902707  gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
105894891  glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
105890389  gpat3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
105890903  glycerol-3-phosphate acyltransferase 4-like isoform X1 [KO:K13506] [EC:2.3.1.15]
105902903  agpat9l; glycerol-3-phosphate acyltransferase 3-like [KO:K13506] [EC:2.3.1.15]
105902549  agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
105890895  agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
105913330  agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
105911612  agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
105905059  lclat1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
105896376  mboat2a; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
105905486  mboat1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
105894439  mboat2b; lysophospholipid acyltransferase 2b [KO:K13517] [EC:2.3.1.51 2.3.1.-]
122132048  gnpat; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
105899822  dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
105907334  gnpat2; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
122130802  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
122128766  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
122129107  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
105895834  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
122130299  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
105890223  phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
122131294  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
105905761  ppap2d; LOW QUALITY PROTEIN: phosphatidic acid phosphatase type 2D [KO:K01080] [EC:3.1.3.4]
105894630  plpp1a; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
105912588  plpp2a; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
105907782  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
105900642  lpin2; phosphatidate phosphatase LPIN2 isoform X2 [KO:K15728] [EC:3.1.3.4]
122130726  zgc:123305 isoform X1 [KO:K15728] [EC:3.1.3.4]
105911211  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
105894751  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
105907332  phosphatidate phosphatase LPIN1-like isoform X1 [KO:K15728] [EC:3.1.3.4]
105904649  plpp5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
105909624  plpp4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
105892362  dgkzb; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
105897929  dgkab; diacylglycerol kinase, alpha b isoform X2 [KO:K00901] [EC:2.7.1.107]
105902585  dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
105893156  diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
105903077  si:dkey-172j4.3; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
105889160  dgkza; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
105911428  diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
105909302  diacylglycerol kinase delta isoform X3 [KO:K00901] [EC:2.7.1.107]
105893385  dgkh; diacylglycerol kinase eta isoform X8 [KO:K00901] [EC:2.7.1.107]
105892294  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
105902621  chpt1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
105900362  cept1b; choline/ethanolaminephosphotransferase 1b isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
105906821  choline/ethanolaminephosphotransferase 1-like [KO:K13644] [EC:2.7.8.1 2.7.8.2]
105908425  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
105894705  pld1b; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
105905900  si:ch211-168k14.2; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
105906633  pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
105908265  5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
105909746  pld3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
105905128  lcat; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
105899085  phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
105900258  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
105899090  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
116221742  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
122130731  pla2g10; group 10 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
105904001  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105902630  pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
116219163  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
105895799  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
116223326  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
105895737  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
105910777  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
116218983  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
122129428  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
122131250  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
105910565  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
105890870  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
105890871  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
105910569  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
105910564  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
105903837  pla2g6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
116223878  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
122130951  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
116223567  plb1; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
116220989  phospholipase A and acyltransferase 4-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105912257  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
116225191  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
116225192  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105911111  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105912283  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
116221529  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105912268  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
122130381  phospholipase A and acyltransferase 2-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
122130382  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
122130384  phospholipase A and acyltransferase 4-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
122133002  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105899785  lpcat2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
105892033  lpcat1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
105905509  lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
105908829  lpcat4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
116222417  lpcat3; lysophospholipid acyltransferase 5 isoform X1 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
105894791  lypla1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
105905162  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
105892170  lypla2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
105891666  pnpla7b; LOW QUALITY PROTEIN: patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
105889125  patatin-like phospholipase domain-containing protein 7 isoform X2 [KO:K14676] [EC:3.1.1.5]
122129495  patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
105891039  pnpla6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
105899545  gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
105895983  choline O-acetyltransferase-like [KO:K00623] [EC:2.3.1.6]
105909460  chata; choline O-acetyltransferase isoform X1 [KO:K00623] [EC:2.3.1.6]
105895574  ache; acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
105912030  chkb; choline/ethanolamine kinase isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
105904520  chka; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
105890693  phospho1; probable phosphatase phospho1 isoform X2 [KO:K06124] [EC:3.1.3.75]
105891411  probable phosphatase phospho1 [KO:K06124] [EC:3.1.3.75]
105899180  pcyt1aa; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
105911039  pcyt1ab; phosphate cytidylyltransferase 1A, choline b [KO:K00968] [EC:2.7.7.15]
105905232  pcyt1ba; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
105894950  pcyt1bb; phosphate cytidylyltransferase 1B, choline b [KO:K00968] [EC:2.7.7.15]
105904193  selenoi; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
105895906  etnk2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
105897560  etnk1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
105911294  ethanolamine kinase 1-like isoform X1 [KO:K00894] [EC:2.7.1.82]
105908955  ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
105905797  ethanolamine-phosphate cytidylyltransferase-like [KO:K00967] [EC:2.7.7.14]
105903574  pmt; phosphoethanolamine methyltransferase isoform X2 [KO:K05929] [EC:2.1.1.103]
105904746  etnppl; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
105896465  pemt; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
105901205  cds1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
105890027  cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
105913278  pla1a; phospholipase A1 member A isoform X3 [KO:K13618] [EC:3.1.1.111]
105905321  ptdss1b; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
105910423  ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
122129537  pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
105908602  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
105909475  crls1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
105900142  tafazzin [KO:K13511] [EC:2.3.1.-]
105894464  lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2 [KO:K13514] [EC:2.3.1.-]
105912001  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
105901672  mboat7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
char00010  Glycolysis / Gluconeogenesis
char00260  Glycine, serine and threonine metabolism
char00561  Glycerolipid metabolism
char00562  Inositol phosphate metabolism
char00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
char00565  Ether lipid metabolism
char00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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