KEGG   PATHWAY: dpz04150
Entry
dpz04150                    Pathway                                
Name
mTOR signaling pathway - Daphnia pulicaria
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
dpz04150  mTOR signaling pathway
dpz04150

Organism
Daphnia pulicaria [GN:dpz]
Gene
124341364  large neutral amino acids transporter small subunit 2-like [KO:K13780]
124352615  Y+L amino acid transporter 2-like [KO:K13780]
124352616  Y+L amino acid transporter 2-like isoform X1 [KO:K13780]
124329102  large neutral amino acids transporter small subunit 1-like [KO:K13780]
124322684  sodium-coupled neutral amino acid transporter 9-like [KO:K14995]
124343200  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
124348975  V-type proton ATPase subunit B [KO:K02147]
124343278  V-type proton ATPase subunit C-like [KO:K02148]
124336424  V-type proton ATPase subunit D-like [KO:K02149]
124336427  V-type proton ATPase subunit D-like [KO:K02149]
124336428  V-type proton ATPase subunit D-like [KO:K02149]
124337152  V-type proton ATPase subunit E-like [KO:K02150]
124316592  V-type proton ATPase subunit F-like [KO:K02151]
124325324  V-type proton ATPase subunit G-like [KO:K02152]
124344033  ragulator complex protein LAMTOR1-like isoform X1 [KO:K20397]
124327340  ragulator complex protein LAMTOR2-like [KO:K20398]
124341689  ragulator complex protein LAMTOR3-like [KO:K04370]
124327607  ragulator complex protein LAMTOR5 homolog [KO:K16344]
124314134  folliculin-like isoform X1 [KO:K09594]
124348877  uncharacterized protein LOC124348877 [KO:K20401]
124350723  ras-related GTP-binding protein A [KO:K16185]
124310932  GATOR complex protein MIOS-A-like [KO:K20407]
124338053  nucleoporin SEH1-like [KO:K14299]
124314585  GATOR complex protein WDR24-like [KO:K20408]
124351287  GATOR complex protein WDR59-like isoform X1 [KO:K20409]
124337113  protein SEC13 homolog [KO:K14004]
124337690  protein SEC13 homolog [KO:K14004]
124352643  GATOR complex protein Iml1-like [KO:K20404]
124310820  GATOR complex protein NPRL2-like [KO:K20405]
124343045  GATOR complex protein NPRL3-like [KO:K20406]
124343264  S-phase kinase-associated protein 2-like [KO:K03875]
124328833  regulatory-associated protein of mTOR-like [KO:K07204]
124342381  serine/threonine-protein kinase mTOR-like [KO:K07203] [EC:2.7.11.1]
124336249  target of rapamycin complex subunit lst8-like [KO:K08266]
124315135  TELO2-interacting protein 1 homolog [KO:K20403]
124312782  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
124340832  phosphatidate phosphatase LPIN3-like isoform X1 [KO:K15728] [EC:3.1.3.4]
124312066  serine/threonine-protein kinase unc-51-like [KO:K08269] [EC:2.7.11.1]
124311502  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
124349303  eukaryotic translation initiation factor 4E type 2-like isoform X1 [KO:K03259]
124350765  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
124350613  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
124316178  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
124341284  40S ribosomal protein S6-like [KO:K02991]
124320969  40S ribosomal protein S6-like [KO:K02991]
124320376  STE20-related kinase adapter protein alpha-like isoform X1 [KO:K08271]
124343711  protein Mo25-like [KO:K08272]
124348967  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
124310841  tuberin-like [KO:K07207]
124336377  TBC1 domain family member 7-like [KO:K20396]
124311840  GTP-binding protein Rheb-like [KO:K07208]
124327196  protein wingless-like [KO:K03209]
124337063  protein Wnt-2b-A-like [KO:K00182]
124337172  protein Wnt-2b-B-like [KO:K00182]
124337173  protein Wnt-2b-B-like [KO:K00182]
124344528  protein Wnt-4-like [KO:K00408]
124335965  protein Wnt-4-like [KO:K00408]
124337938  protein Wnt-5b-like [KO:K00444]
124327205  protein Wnt-6-like [KO:K00445]
124337939  protein Wnt-7b-like [KO:K00572]
124311273  protein Wnt-8-like isoform X1 [KO:K00714]
124327181  protein Wnt-10b-like [KO:K01357]
124340962  frizzled-7-B-like [KO:K02432]
124348891  frizzled-5-like [KO:K02375]
124331356  low-density lipoprotein receptor-related protein 6-like [KO:K03068]
124342623  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
124341659  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
124349081  growth factor receptor-bound protein 2 [KO:K04364]
124342294  son of sevenless homolog 2-like [KO:K03099]
124321132  GTPase HRas [KO:K07827]
124310935  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
124313106  dual specificity mitogen-activated protein kinase kinase 1-like isoform X1 [KO:K04368] [EC:2.7.12.2]
124313193  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124312478  ribosomal protein S6 kinase 2 beta-like [KO:K04373] [EC:2.7.11.1]
124337040  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
124336876  uncharacterized protein LOC124336876 isoform X1 [KO:K02649]
124342342  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
124343484  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
124311062  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124344159  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
124341022  RAC serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124326200  target of rapamycin complex 2 subunit MAPKAP1-like [KO:K20410]
124344303  rapamycin-insensitive companion of mTOR-like [KO:K08267]
124342143  ras-like GTP-binding protein Rho1 [KO:K04513]
124336843  ras-like GTP-binding protein Rho1 [KO:K04513]
124337868  protein kinase C, brain isozyme-like isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
dpz00561  Glycerolipid metabolism
dpz04140  Autophagy - animal
KO pathway
ko04150   
LinkDB

DBGET integrated database retrieval system