KEGG   PATHWAY: efo00564
Entry
efo00564                    Pathway                                
Name
Glycerophospholipid metabolism - Epinephelus fuscoguttatus (brown-marbled grouper)
Class
Metabolism; Lipid metabolism
Pathway map
efo00564  Glycerophospholipid metabolism
efo00564

Module
efo_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:efo00564]
efo_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:efo00564]
efo_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:efo00564]
Other DBs
GO: 0006650
Organism
Epinephelus fuscoguttatus (brown-marbled grouper) [GN:efo]
Gene
125885001  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
125891896  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
125893075  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
125884975  gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
125889980  gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
125880750  gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
125890370  glycerol-3-phosphate acyltransferase 4-like [KO:K13506] [EC:2.3.1.15]
125890540  agpat9l; glycerol-3-phosphate acyltransferase 3-like [KO:K13506] [EC:2.3.1.15]
125906242  gpat3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
125906269  glycerol-3-phosphate acyltransferase 4-like [KO:K13506] [EC:2.3.1.15]
125878653  agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
125903645  agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
125899650  agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
125903704  agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
125901105  lclat1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
125897461  mboat2b; lysophospholipid acyltransferase 2b [KO:K13517] [EC:2.3.1.51 2.3.1.-]
125893512  mboat1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
125901136  mboat2a; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
125896782  gnpat; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
125896847  gnpat2; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
125881206  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
125895952  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
125896279  plpp2b; phospholipid phosphatase 2b [KO:K01080] [EC:3.1.3.4]
125890989  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
125878549  plpp1a; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
125886319  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
125879784  ppap2d; phosphatidic acid phosphatase type 2D [KO:K01080] [EC:3.1.3.4]
125901148  plpp2a; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
125901596  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
125882044  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
125901926  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
125902675  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
125896845  phosphatidate phosphatase LPIN1-like isoform X1 [KO:K15728] [EC:3.1.3.4]
125901067  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
125890553  plpp5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
125903822  plpp4; phospholipid phosphatase 4 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
125895423  dgkab; diacylglycerol kinase, alpha b [KO:K00901] [EC:2.7.1.107]
125883188  dgki; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
125884381  si:dkey-172j4.3; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
125885077  diacylglycerol kinase zeta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
125891803  dgkaa; diacylglycerol kinase, alpha a isoform X1 [KO:K00901] [EC:2.7.1.107]
125886555  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
125892952  dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
125899304  diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
125899428  dgkh; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
125887110  dgkzb; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
125888599  LOW QUALITY PROTEIN: diacylglycerol kinase delta-like [KO:K00901] [EC:2.7.1.107]
125894800  diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
125882866  chpt1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
125892361  cept1b; choline/ethanolaminephosphotransferase 1b isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
125882227  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
125898123  pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
125901452  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
125889304  pld3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
125900549  5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
125894137  pld7; 5'-3' exonuclease PLD3 isoform X1 [KO:K16860] [EC:3.1.4.4]
125887086  lcat; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
125889965  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
125889967  pla2g1b; LOW QUALITY PROTEIN: phospholipase A2 [KO:K01047] [EC:3.1.1.4]
125890982  group 3 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
125903431  pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
125886317  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
125879456  pla2g10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
125886500  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
125905527  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
125905528  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
125906063  pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
125888369  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
125895445  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
125885353  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125885971  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
125897513  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
125897553  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
125900561  plb1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
125901056  si:dkey-177p2.18; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
125884798  plaat1l; phospholipase A and acyltransferase 1 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
125900886  phospholipase A and acyltransferase 4-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
125894848  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
125904569  lpcat1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
125904582  lpcat2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
125893431  lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
125884146  lpcat4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
125893134  lpcat3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
125881900  lypla1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
125887087  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
125905127  lypla2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
125890229  pnpla7b; patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
125885499  pnpla6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
125906225  pnpla7a; patatin-like phospholipase domain-containing protein 7a isoform X1 [KO:K14676] [EC:3.1.1.5]
125897183  gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
125903176  chata; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
125881098  choline O-acetyltransferase-like [KO:K00623] [EC:2.3.1.6]
125884071  ache; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
125882473  cAMP-regulated D2 protein [KO:K01049] [EC:3.1.1.7]
125886726  chkb; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
125887553  chka; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
125880015  phospho1; probable phosphatase phospho1 isoform X1 [KO:K06124] [EC:3.1.3.75]
125880873  probable phosphatase phospho1 [KO:K06124] [EC:3.1.3.75]
125902082  pcyt1aa; choline-phosphate cytidylyltransferase A isoform X1 [KO:K00968] [EC:2.7.7.15]
125898295  pcyt1bb; phosphate cytidylyltransferase 1B, choline b [KO:K00968] [EC:2.7.7.15]
125881778  pcyt1ba; choline-phosphate cytidylyltransferase B [KO:K00968] [EC:2.7.7.15]
125897101  selenoi; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
125882848  etnk1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
125891002  etnk2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
125887334  zgc:113516; ethanolamine kinase 1 isoform X1 [KO:K00894] [EC:2.7.1.82]
125886003  pcyt2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
125879959  ethanolamine-phosphate cytidylyltransferase-like isoform X1 [KO:K00967] [EC:2.7.7.14]
125894551  pmt; phosphoethanolamine methyltransferase isoform X1 [KO:K05929] [EC:2.1.1.103]
125883555  etnppl; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
125880773  pemt; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
125890113  cds1; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
125890328  cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
125900199  pla1a; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
125904978  ptdss1b; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
125892724  ptdss1a; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
125887035  ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
125906311  pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
125881106  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
125903541  crls1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
125891226  tafazzin; tafazzin isoform X1 [KO:K13511] [EC:2.3.1.-]
125896523  lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1 [KO:K13514] [EC:2.3.1.-]
125879638  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
125879639  LOW QUALITY PROTEIN: CDP-diacylglycerol--inositol 3-phosphatidyltransferase-like [KO:K00999] [EC:2.7.8.11]
125892590  mboat7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
efo00010  Glycolysis / Gluconeogenesis
efo00260  Glycine, serine and threonine metabolism
efo00561  Glycerolipid metabolism
efo00562  Inositol phosphate metabolism
efo00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
efo00565  Ether lipid metabolism
efo00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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