KEGG   PATHWAY: gat00564
Entry
gat00564                    Pathway                                
Name
Glycerophospholipid metabolism - Gasterosteus aculeatus (three-spined stickleback)
Class
Metabolism; Lipid metabolism
Pathway map
gat00564  Glycerophospholipid metabolism
gat00564

Module
gat_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:gat00564]
gat_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:gat00564]
gat_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:gat00564]
Other DBs
GO: 0006650
Organism
Gasterosteus aculeatus (three-spined stickleback) [GN:gat]
Gene
120835442  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
120829557  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
120810063  gpd1l; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
120811156  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
120821942  gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
120830496  gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
120818949  gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
120832112  glycerol-3-phosphate acyltransferase 4-like isoform X1 [KO:K13506] [EC:2.3.1.15]
120830393  glycerol-3-phosphate acyltransferase 4-like [KO:K13506] [EC:2.3.1.15]
120830568  agpat9l; glycerol-3-phosphate acyltransferase 3-like [KO:K13506] [EC:2.3.1.15]
120831986  agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
120833910  agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
120820427  agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
120820632  agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
120832885  lclat1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
120832424  mboat2a; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
120810087  mboat1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
120814789  mboat2b; lysophospholipid acyltransferase 2b [KO:K13517] [EC:2.3.1.51 2.3.1.-]
120807794  gnpat; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
120807937  gnpat2; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
120819488  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
120830862  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
120831999  plpp1a; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
120832659  plpp2a; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
120824229  plpp2b; phospholipid phosphatase 2b [KO:K01080] [EC:3.1.3.4]
120824879  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
120827610  ppap2d; phosphatidic acid phosphatase type 2D [KO:K01080] [EC:3.1.3.4]
120814816  plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
120815689  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
120835029  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
120807936  lpin1b; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
120816548  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
120810450  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
120812082  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
120831192  plpp5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
120820760  plpp4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
120833818  diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
120833925  dgkh; LOW QUALITY PROTEIN: diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
120835011  dgkab; diacylglycerol kinase, alpha b isoform X1 [KO:K00901] [EC:2.7.1.107]
120816270  LOW QUALITY PROTEIN: diacylglycerol kinase delta-like [KO:K00901] [EC:2.7.1.107]
120829418  dgkaa; diacylglycerol kinase, alpha a [KO:K00901] [EC:2.7.1.107]
120816798  dgkza; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
120816927  diacylglycerol kinase theta-like [KO:K00901] [EC:2.7.1.107]
120825105  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
120809666  dgkzb; uncharacterized protein dgkzb isoform X1 [KO:K00901] [EC:2.7.1.107]
120818423  dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
120810350  dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
120817677  chpt1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
120835360  cept1b; choline/ethanolaminephosphotransferase 1b isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
120833442  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
120812048  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
120821943  pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
120832553  5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
120817223  pld7; 5'-3' exonuclease PLD4 isoform X1 [KO:K16860] [EC:3.1.4.4]
120824116  pld3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
120809156  lcat; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
120812211  phosphatidylcholine-sterol acyltransferase-like [KO:K00650] [EC:2.3.1.43]
120831709  pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120831982  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
120830332  group 3 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
120830660  pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120824927  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120825705  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
120826042  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
120821017  group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
120821050  group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
120828517  pla2g10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120823990  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
120828307  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
120824588  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
120832966  plb1; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
120807779  phospholipase B1, membrane-associated-like isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
120833445  phospholipase A and acyltransferase 4-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120818246  rarres3l; retinoic acid receptor responder 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120818247  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120818248  phospholipase A and acyltransferase 4-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120819691  plaat1l; phospholipase A and acyltransferase 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120814521  phospholipase A and acyltransferase 4-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120833708  lpcat2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
120810600  lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
120826708  lpcat1; lysophosphatidylcholine acyltransferase 1 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
120822049  lpcat4; lysophospholipid acyltransferase LPCAT4 isoform X1 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
120810839  lpcat3; lysophospholipid acyltransferase 5 isoform X1 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
120811770  lypla1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
120809157  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
120812214  phospholipase A2 group XV-like isoform X1 [KO:K06129] [EC:3.1.1.5]
120826342  lypla2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
120831909  pnpla7a; patatin-like phospholipase domain-containing protein 7a isoform X1 [KO:K14676] [EC:3.1.1.5]
120830455  pnpla7b; patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
120825660  pnpla6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
120808384  gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
120819616  choline O-acetyltransferase-like [KO:K00623] [EC:2.3.1.6]
120820971  chata; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
120822201  ache; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
120817112  cAMP-regulated D2 protein [KO:K01049] [EC:3.1.1.7]
120808835  chkb; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
120809580  chka; choline kinase alpha [KO:K14156] [EC:2.7.1.32 2.7.1.82]
120819233  probable phosphatase phospho1 [KO:K06124] [EC:3.1.3.75]
120828454  phospho1; probable phosphatase phospho1 isoform X1 [KO:K06124] [EC:3.1.3.75]
120811573  pcyt1ba; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
120821585  choline-phosphate cytidylyltransferase B-like [KO:K00968] [EC:2.7.7.15]
120815938  pcyt1aa; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
120807847  selenoi; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
120835507  etnk2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
120817949  etnk1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
120809846  zgc:113516; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
120824798  pcyt2; LOW QUALITY PROTEIN: ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
120828512  ethanolamine-phosphate cytidylyltransferase-like isoform X1 [KO:K00967] [EC:2.7.7.14]
120818402  pmt; phosphoethanolamine methyltransferase [KO:K05929] [EC:2.1.1.103]
120821495  etnppl; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
120819624  pemt; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
120830679  cds1; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
120830776  cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
120834343  pla1a; LOW QUALITY PROTEIN: phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
120810045  ptdss1a; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
120826248  ptdss1b; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
120809238  ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
120831742  pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
120819526  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
120820536  crls1; LOW QUALITY PROTEIN: cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
120829285  taz; tafazzin [KO:K13511] [EC:2.3.1.-]
120808010  lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1 [KO:K13514] [EC:2.3.1.-]
120827912  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
120811050  mboat7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
gat00010  Glycolysis / Gluconeogenesis
gat00260  Glycine, serine and threonine metabolism
gat00561  Glycerolipid metabolism
gat00562  Inositol phosphate metabolism
gat00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
gat00565  Ether lipid metabolism
gat00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

DBGET integrated database retrieval system