KEGG   PATHWAY: mmu04978
Entry
mmu04978                    Pathway                                
Name
Mineral absorption - Mus musculus (house mouse)
Description
Minerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an intracellular messenger in muscle contraction/relaxation, neural networks, the immune system, and endocrine/exocrine cells. Iron, copper, and other metals are required for redox reactions (as cofactors) and for oxygen transport and binding (in hemoglobin and myoglobin). Many enzymes require specific metal atoms to complete their catalytic functions. Animal tissues need moderate quantities of some elements (Ca, P, K, Na, Mg, S, and Cl) and trace amounts of others (Mn, Fe, I, Co, Cr, Cu, Zn, and Se). The minerals are absorbed by either passive or active transport systems through the intestinal mucosa, often using specialized transport proteins, such as ferritin for Fe3+ and vitamin D-induced protein for calcium.
Class
Organismal Systems; Digestive system
Pathway map
mmu04978  Mineral absorption
mmu04978

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
20505  Slc34a1; solute carrier family 34 (sodium phosphate), member 1 [KO:K14683]
20531  Slc34a2; solute carrier family 34 (sodium phosphate), member 2 [KO:K14683]
142681  Slc34a3; solute carrier family 34 (sodium phosphate), member 3 [KO:K14683]
22337  Vdr; vitamin D (1,25-dihydroxyvitamin D3) receptor [KO:K08539]
225997  Trpm6; transient receptor potential cation channel, subfamily M, member 6 [KO:K04981] [EC:2.7.11.1]
58800  Trpm7; transient receptor potential cation channel, subfamily M, member 7 [KO:K04982] [EC:2.7.11.1]
64177  Trpv6; transient receptor potential cation channel, subfamily V, member 6 [KO:K04975]
20541  Slc8a1; solute carrier family 8 (sodium/calcium exchanger), member 1 [KO:K05849]
110891  Slc8a2; solute carrier family 8 (sodium/calcium exchanger), member 2 [KO:K05849]
110893  Slc8a3; solute carrier family 8 (sodium/calcium exchanger), member 3 [KO:K05849]
67972  Atp2b1; ATPase, Ca++ transporting, plasma membrane 1 [KO:K05850] [EC:7.2.2.10]
320707  Atp2b3; ATPase, Ca++ transporting, plasma membrane 3 [KO:K05850] [EC:7.2.2.10]
381290  Atp2b4; ATPase, Ca++ transporting, plasma membrane 4 [KO:K05850] [EC:7.2.2.10]
11941  Atp2b2; ATPase, Ca++ transporting, plasma membrane 2 [KO:K05850] [EC:7.2.2.10]
12309  S100g; S100 calcium binding protein G [KO:K14734]
13487  Slc26a3; solute carrier family 26, member 3 [KO:K14078]
171429  Slc26a6; solute carrier family 26, member 6 [KO:K14704]
320718  Slc26a9; solute carrier family 26, member 9 [KO:K14706]
12724  Clcn2; chloride channel, voltage-sensitive 2 [KO:K05011]
105243  Slc9a3; solute carrier family 9 (sodium/hydrogen exchanger), member 3 [KO:K12040]
20537  Slc5a1; solute carrier family 5 (sodium/glucose cotransporter), member 1 [KO:K14158]
333669  Gm5134; predicted gene 5134 [KO:K14158]
74338  Slc6a19; solute carrier family 6 (neurotransmitter transporter), member 19 [KO:K05334]
11928  Atp1a1; ATPase, Na+/K+ transporting, alpha 1 polypeptide [KO:K01539] [EC:7.2.2.13]
98660  Atp1a2; ATPase, Na+/K+ transporting, alpha 2 polypeptide [KO:K01539] [EC:7.2.2.13]
232975  Atp1a3; ATPase, Na+/K+ transporting, alpha 3 polypeptide [KO:K01539] [EC:7.2.2.13]
27222  Atp1a4; ATPase, Na+/K+ transporting, alpha 4 polypeptide [KO:K01539] [EC:7.2.2.13]
67821  Atp1b4; ATPase Na+/K+ transporting, beta 4 polypeptide [KO:K01540]
11931  Atp1b1; ATPase, Na+/K+ transporting, beta 1 polypeptide [KO:K01540]
11932  Atp1b2; ATPase, Na+/K+ transporting, beta 2 polypeptide [KO:K01540]
11933  Atp1b3; ATPase, Na+/K+ transporting, beta 3 polypeptide [KO:K01540]
11936  Fxyd2; FXYD domain-containing ion transport regulator 2 [KO:K01538]
52466  Slc46a1; solute carrier family 46, member 1 [KO:K14613]
15368  Hmox1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
15369  Hmox2; heme oxygenase 2 [KO:K21418] [EC:1.14.14.18]
73649  Cybrd1; cytochrome b reductase 1 [KO:K08370] [EC:7.2.1.3]
18174  Slc11a2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 [KO:K21398]
14319  Fth1; ferritin heavy polypeptide 1 [KO:K00522] [EC:1.16.3.1]
14325  Ftl1; ferritin light polypeptide 1 [KO:K13625]
434624  Ftl1-ps2; ferritin light polypeptide, pseudogene 2 [KO:K13625]
53945  Slc40a1; solute carrier family 40 (iron-regulated transporter), member 1 [KO:K14685]
15203  Heph; hephaestin [KO:K14735] [EC:1.16.3.1]
244698  Hephl1; hephaestin-like 1 [KO:K14735] [EC:1.16.3.1]
22041  Trf; transferrin [KO:K14736]
71775  Inhca; inhibitor of carbonic anhydrase [KO:K14736]
72027  Slc39a4; solute carrier family 39 (zinc transporter), member 4 [KO:K14710]
22782  Slc30a1; solute carrier family 30 (zinc transporter), member 1 [KO:K14688]
20529  Slc31a1; solute carrier family 31, member 1 [KO:K14686]
70358  Steap1; six transmembrane epithelial antigen of the prostate 1 [KO:K14737] [EC:1.16.1.-]
74051  Steap2; six transmembrane epithelial antigen of prostate 2 [KO:K14738] [EC:1.16.1.-]
17750  Mt2; metallothionein 2 [KO:K14739]
17748  Mt1; metallothionein 1 [KO:K14739]
11927  Atox1; antioxidant 1 copper chaperone [KO:K07213]
11979  Atp7b; ATPase, Cu++ transporting, beta polypeptide [KO:K17686] [EC:7.2.2.8]
11977  Atp7a; ATPase, Cu++ transporting, alpha polypeptide [KO:K17686] [EC:7.2.2.8]
Compound
C00009  Orthophosphate
C00031  D-Glucose
C00032  Heme
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00073  L-Methionine
C00076  Calcium cation
C00078  L-Tryptophan
C00079  L-Phenylalanine
C00080  H+
C00123  L-Leucine
C00124  D-Galactose
C00148  L-Proline
C00152  L-Asparagine
C00183  L-Valine
C00188  L-Threonine
C00238  Potassium cation
C00288  HCO3-
C00305  Magnesium cation
C00407  L-Isoleucine
C00698  Cl-
C01330  Sodium cation
C01673  Calcitriol
C14818  Fe2+
C14819  Fe3+
Reference
PMID:18277073
  Authors
Perez AV, Picotto G, Carpentieri AR, Rivoira MA, Peralta Lopez ME, Tolosa de Talamoni NG
  Title
Minireview on regulation of intestinal calcium absorption. Emphasis on molecular mechanisms of transcellular pathway.
  Journal
Digestion 77:22-34 (2008)
DOI:10.1159/000116623
Reference
PMID:18598134
  Authors
Khanal RC, Nemere I
  Title
Regulation of intestinal calcium transport.
  Journal
Annu Rev Nutr 28:179-96 (2008)
DOI:10.1146/annurev.nutr.010308.161202
Reference
PMID:15618484
  Authors
Hoenderop JG, Nilius B, Bindels RJ
  Title
Calcium absorption across epithelia.
  Journal
Physiol Rev 85:373-422 (2005)
DOI:10.1152/physrev.00003.2004
Reference
PMID:12520535
  Authors
Bouillon R, Van Cromphaut S, Carmeliet G
  Title
Intestinal calcium absorption: Molecular vitamin D mediated mechanisms.
  Journal
J Cell Biochem 88:332-9 (2003)
DOI:10.1002/jcb.10360
Reference
PMID:17943492
  Authors
Chua AC, Graham RM, Trinder D, Olynyk JK
  Title
The regulation of cellular iron metabolism.
  Journal
Crit Rev Clin Lab Sci 44:413-59 (2007)
DOI:10.1080/10408360701428257
Reference
PMID:18636652
  Authors
West AR, Oates PS
  Title
Mechanisms of heme iron absorption: current questions and controversies.
  Journal
World J Gastroenterol 14:4101-10 (2008)
DOI:10.3748/wjg.14.4101
Reference
PMID:17194590
  Authors
Dunn LL, Rahmanto YS, Richardson DR
  Title
Iron uptake and metabolism in the new millennium.
  Journal
Trends Cell Biol 17:93-100 (2007)
DOI:10.1016/j.tcb.2006.12.003
Reference
PMID:16565477
  Authors
Donovan A, Roy CN, Andrews NC
  Title
The ins and outs of iron homeostasis.
  Journal
Physiology (Bethesda) 21:115-23 (2006)
DOI:10.1152/physiol.00052.2005
Reference
PMID:18779306
  Authors
Lonnerdal B
  Title
Intestinal regulation of copper homeostasis: a developmental perspective.
  Journal
Am J Clin Nutr 88:846S-50S (2008)
DOI:10.1093/ajcn/88.3.846S
Reference
PMID:18779302
  Authors
Prohaska JR
  Title
Role of copper transporters in copper homeostasis.
  Journal
Am J Clin Nutr 88:826S-9S (2008)
DOI:10.1093/ajcn/88.3.826S
Reference
PMID:20120011
  Authors
Wang X, Zhou B
  Title
Dietary zinc absorption: A play of Zips and ZnTs in the gut.
  Journal
IUBMB Life 62:176-82 (2010)
DOI:10.1002/iub.291
Reference
PMID:19400752
  Authors
Lichten LA, Cousins RJ
  Title
Mammalian zinc transporters: nutritional and physiologic regulation.
  Journal
Annu Rev Nutr 29:153-76 (2009)
DOI:10.1146/annurev-nutr-033009-083312
Reference
PMID:18301276
  Authors
Quamme GA
  Title
Recent developments in intestinal magnesium absorption.
  Journal
Curr Opin Gastroenterol 24:230-5 (2008)
DOI:10.1097/MOG.0b013e3282f37b59
Reference
PMID:19448074
  Authors
Donowitz M, Mohan S, Zhu CX, Chen TE, Lin R, Cha B, Zachos NC, Murtazina R, Sarker R, Li X
  Title
NHE3 regulatory complexes.
  Journal
J Exp Biol 212:1638-46 (2009)
DOI:10.1242/jeb.028605
Reference
PMID:21054167
  Authors
Kato A, Romero MF
  Title
Regulation of Electroneutral NaCl Absorption by the Small Intestine.
  Journal
Annu Rev Physiol 73:261-81 (2011)
DOI:10.1146/annurev-physiol-012110-142244
Reference
PMID:19729436
  Authors
Sabbagh Y, O'Brien SP, Song W, Boulanger JH, Stockmann A, Arbeeny C, Schiavi SC
  Title
Intestinal npt2b plays a major role in phosphate absorption and homeostasis.
  Journal
J Am Soc Nephrol 20:2348-58 (2009)
DOI:10.1681/ASN.2009050559
Reference
PMID:16431934
  Authors
Marks J, Srai SK, Biber J, Murer H, Unwin RJ, Debnam ES
  Title
Intestinal phosphate absorption and the effect of vitamin D: a comparison of rats with mice.
  Journal
Exp Physiol 91:531-7 (2006)
DOI:10.1113/expphysiol.2005.032516
Related
pathway
mmu00860  Porphyrin metabolism
mmu04530  Tight junction
mmu04973  Carbohydrate digestion and absorption
mmu04974  Protein digestion and absorption
KO pathway
ko04978   
LinkDB

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