KEGG   PATHWAY: one04068
Entry
one04068                    Pathway                                
Name
FoxO signaling pathway - Oncorhynchus nerka (sockeye salmon)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
one04068  FoxO signaling pathway
one04068

Other DBs
GO: 0009267
Organism
Oncorhynchus nerka (sockeye salmon) [GN:one]
Gene
115135570  transforming growth factor beta-1 proprotein-like [KO:K13375]
115101394  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
115130946  transforming growth factor beta-2 proprotein-like [KO:K13376]
115106696  transforming growth factor beta-2 proprotein-like [KO:K13376]
115141421  transforming growth factor beta-2 proprotein-like [KO:K13376]
115122909  transforming growth factor beta-3 proprotein-like [KO:K13377]
115138506  transforming growth factor beta-3 proprotein-like [KO:K13377]
115146230  transforming growth factor beta-3 proprotein-like [KO:K13377]
115104841  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
115130252  TGF-beta receptor type-1-like isoform X1 [KO:K04674] [EC:2.7.11.30]
115114475  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
115103031  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
115111341  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
115129607  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
115131753  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
115128230  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
115111251  smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
115131545  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115125499  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115139688  mothers against decapentaplegic homolog 4-like [KO:K04501]
115102988  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115128452  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115108285  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
115116369  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
115117588  serine/threonine-protein kinase STK11-like isoform X1 [KO:K07298] [EC:2.7.11.1]
115120700  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
115121030  LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
115101074  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
115145089  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
115111016  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
115120136  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
115123805  5'-AMP-activated protein kinase subunit beta-1-like isoform X1 [KO:K07199]
115117386  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
115104898  5'-AMP-activated protein kinase subunit gamma-2-like isoform X1 [KO:K07200]
115129620  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
115130174  5'-AMP-activated protein kinase subunit gamma-2-like isoform X1 [KO:K07200]
115143168  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
115114493  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
115139868  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
115103014  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
115127966  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
115141941  nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
115145267  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
115115928  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
115110042  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
115105866  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
115130681  setd7; histone-lysine N-methyltransferase SETD7 isoform X1 [KO:K11431] [EC:2.1.1.364]
115110408  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115104263  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115144480  LOW QUALITY PROTEIN: histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
115113829  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
115135319  NAD-dependent protein deacetylase sirtuin-1-like [KO:K11411] [EC:2.3.1.286]
115113398  NAD-dependent protein deacetylase sirtuin-1-like isoform X1 [KO:K11411] [EC:2.3.1.286]
115138147  solute carrier family 2, facilitated glucose transporter member 4-like [KO:K07191]
115133603  solute carrier family 2, facilitated glucose transporter member 4-like [KO:K07191]
115128757  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
115135343  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115119601  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
115130519  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115106409  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115144005  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115113414  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115146824  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115135215  stk4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
115107064  insulin-like growth factor I isoform X1 [KO:K05459]
115133034  insulin-like growth factor I isoform X1 [KO:K05459]
115109402  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
115134267  LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
115104644  insulin [KO:K04526]
115129128  insulin-like [KO:K04526]
115124592  insulin-like [KO:K04526]
115145273  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
115102893  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
115136269  insulin receptor substrate 1-B-like [KO:K16172]
115105617  insulin receptor substrate 1-B-like [KO:K16172]
115106778  LOW QUALITY PROTEIN: insulin receptor substrate 1-B-like [KO:K16172]
115138064  insulin receptor substrate 1-B-like isoform X1 [KO:K16172]
115133536  insulin receptor substrate 1-B-like [KO:K16172]
115118046  insulin receptor substrate 2-like [KO:K07187]
115101466  insulin receptor substrate 2-B-like [KO:K07187]
115124666  insulin receptor substrate 2-B-like [KO:K07187]
115133282  insulin receptor substrate 2-B-like [KO:K07187]
115127142  insulin receptor substrate 2-like [KO:K07187]
115134579  insulin receptor substrate 2-like [KO:K07187]
115141974  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
115136609  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
115114142  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115132207  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115108455  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115103316  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115112007  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
115121421  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
115145315  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
115108180  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115114221  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115125089  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115114621  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115102907  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115109150  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115147159  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
115103245  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115143876  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
115106552  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
115143915  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
115106499  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
115106755  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
115140184  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
115135099  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115106356  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115144052  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115113222  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115103883  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115135438  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115141982  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115136593  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115144345  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115138454  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115107835  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115139339  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115146263  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115146827  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115103843  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115131388  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
115115172  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
115136862  serine/threonine-protein kinase Sgk2-like isoform X1 [KO:K13303] [EC:2.7.11.1]
115131946  serine/threonine-protein kinase Sgk2-like isoform X1 [KO:K13303] [EC:2.7.11.1]
115102166  serine/threonine-protein kinase Sgk2-like [KO:K13303] [EC:2.7.11.1]
115104930  serine/threonine-protein kinase Sgk3-like isoform X1 [KO:K13304] [EC:2.7.11.1]
115130140  serine/threonine-protein kinase Sgk3-like isoform X1 [KO:K13304] [EC:2.7.11.1]
115125933  forkhead box protein O1-A-like [KO:K07201]
115134609  forkhead box protein O1-A-like [KO:K07201]
115134925  forkhead box protein O1-A-like [KO:K07201]
115122914  forkhead box protein O3-like [KO:K09408]
115138754  forkhead box protein O3-like isoform X1 [KO:K09408]
115108045  forkhead box protein O3-like [KO:K09408]
115145912  forkhead box protein O3-like [KO:K09408]
115129443  forkhead box protein O4-like [KO:K12358]
115130671  foxo4; forkhead box protein O4 [KO:K12358]
115114960  forkhead box protein O3-like [KO:K17847]
115141240  forkhead box protein O6-like [KO:K17847]
115138749  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
115108031  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
115139274  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
115145920  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
115112024  homer protein homolog 1-like isoform X1 [KO:K15010]
115101014  homer protein homolog 1-like [KO:K15010]
115108173  homer protein homolog 3-like isoform X1 [KO:K15010]
115114232  homer protein homolog 3-like isoform X1 [KO:K15010]
115109139  homer protein homolog 3-like isoform X1 [KO:K15010]
115103238  homer protein homolog 3-like isoform X1 [KO:K15010]
115117289  homer protein homolog 1-like [KO:K15010]
115143086  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K17848]
115120536  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2-like [KO:K17848]
115102523  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K17848]
115140943  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K17848]
115110428  casein kinase I [KO:K08960] [EC:2.7.11.1]
115110515  casein kinase I-like [KO:K08960] [EC:2.7.11.1]
115112909  casein kinase I-like [KO:K08960] [EC:2.7.11.1]
115144185  casein kinase I-like [KO:K08960] [EC:2.7.11.1]
115117812  interleukin-6-like [KO:K05405]
115119806  interleukin-6 [KO:K05405]
115122049  il10; interleukin-10 [KO:K05443]
115104128  signal transducer and activator of transcription 3-like isoform X1 [KO:K04692]
115110281  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
115129161  egf; pro-epidermal growth factor [KO:K04357]
115104890  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
115130182  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
115114592  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
115102928  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
115104286  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
115110639  growth factor receptor-bound protein 2 [KO:K04364]
115142448  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
115103712  growth factor receptor-bound protein 2-like [KO:K04364]
115103977  son of sevenless homolog 1-like isoform X1 [KO:K03099]
115142668  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
115120056  son of sevenless homolog 2-like [KO:K03099]
115134169  hras; GTPase HRas [KO:K02833]
115109509  GTPase HRas-like [KO:K02833]
115134119  GTPase KRas isoform X1 [KO:K07827]
115109544  GTPase KRas isoform X1 [KO:K07827]
115131882  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
115111809  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
115140270  serine/threonine-protein kinase A-Raf-like isoform X1 [KO:K08845] [EC:2.7.11.1]
115144888  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115108309  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
115114736  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115145247  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115110004  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115135470  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115105636  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115143529  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115107039  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115107040  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
115132056  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
115132526  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115133058  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115133059  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115102640  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115102646  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
115134093  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115109568  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115143073  cyclin-dependent kinase 2-like isoform X1 [KO:K02206] [EC:2.7.11.22]
115141071  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
115145225  protein arginine N-methyltransferase 1-like isoform X1 [KO:K11434] [EC:2.1.1.319]
115109980  protein arginine N-methyltransferase 1 isoform X1 [KO:K11434] [EC:2.1.1.319]
115142188  forkhead box protein G1-like [KO:K09385]
115136317  forkhead box protein G1-like [KO:K09385]
115137597  forkhead box protein G1-like [KO:K09385]
115113144  forkhead box protein G1-like [KO:K09385]
115139016  forkhead box protein G1-like [KO:K09385]
115146603  forkhead box protein G1-like [KO:K09385]
115112810  G2/mitotic-specific cyclin-B1-like [KO:K05868]
115122380  G2/mitotic-specific cyclin-B1-like [KO:K05868]
115101145  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
115136595  cntd2; cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770]
115112265  G2/mitotic-specific cyclin-B2-like [KO:K21770]
115113650  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
115123879  G2/mitotic-specific cyclin-B3-like [KO:K21771]
115112096  G1/S-specific cyclin-D1-like [KO:K04503]
115113563  G1/S-specific cyclin-D1 [KO:K04503]
115109686  G1/S-specific cyclin-D1-like [KO:K04503]
115107053  G1/S-specific cyclin-D2-like [KO:K10151]
115133053  G1/S-specific cyclin-D2-like [KO:K10151]
115134045  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
115109603  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
115109930  G1/S-specific cyclin-D2-like [KO:K10151]
115106046  cyclin-G2-like [KO:K10146]
115139831  cyclin-G2-like isoform X1 [KO:K10146]
115116290  cyclin-G2-like [KO:K10146]
115115324  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
115120846  cyclin-dependent kinase 4 inhibitor D-like [KO:K06623]
115143202  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
115106937  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
115145897  cyclin-dependent kinase inhibitor 1C-like [KO:K06625]
115133180  cyclin-dependent kinase inhibitor 1B-like [KO:K06625]
115106841  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
115133262  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
115134429  cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
115124613  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
115133993  retinoblastoma-like protein 2 [KO:K16332]
115109645  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
115118350  serine/threonine-protein kinase PLK2-like [KO:K08861] [EC:2.7.11.21]
115111697  serine/threonine-protein kinase PLK2-like [KO:K08861] [EC:2.7.11.21]
115140155  serine/threonine-protein kinase PLK2-like [KO:K08861] [EC:2.7.11.21]
115114415  serine/threonine-protein kinase PLK3-like [KO:K08862] [EC:2.7.11.21]
115103092  serine/threonine-protein kinase PLK3-like [KO:K08862] [EC:2.7.11.21]
115138550  serine/threonine-protein kinase PLK4-like isoform X1 [KO:K08863] [EC:2.7.11.21]
115146181  serine/threonine-protein kinase PLK4-like isoform X1 [KO:K08863] [EC:2.7.11.21]
115128891  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115119683  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
115111867  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115145189  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
115101822  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
115108158  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
115114885  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
115109117  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
115140609  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115147014  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115147015  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115117493  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115129399  CD40 ligand-like [KO:K04389]
115131153  CD40 ligand-like isoform X1 [KO:K04389]
115107419  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
115145481  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
115113146  bcl-2-like protein 11 [KO:K16341]
115135008  bcl-2-like protein 11 isoform X1 [KO:K16341]
115104989  tumor necrosis factor ligand superfamily member 10-like isoform X1 [KO:K04721]
115131017  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
115114157  B-cell lymphoma 6 protein-like [KO:K15618]
115124480  bcl6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
115103302  B-cell lymphoma 6 protein homolog isoform X1 [KO:K15618]
115135085  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 isoform X1 [KO:K15464]
115104824  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
115126837  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
115117456  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
115111952  atg12; ubiquitin-like protein ATG12 [KO:K08336]
115135424  gamma-aminobutyric acid receptor-associated protein-like isoform X1 [KO:K08341]
115138144  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
115101198  gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1 [KO:K08341]
115133616  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
115109316  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
115140802  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
115103924  catalase-like [KO:K03781] [EC:1.11.1.6]
115142636  catalase-like isoform X1 [KO:K03781] [EC:1.11.1.6]
115134617  catalase-like isoform X1 [KO:K03781] [EC:1.11.1.6]
115108020  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
115141870  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
115104854  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
115142862  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
115130229  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
115110372  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
115143979  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
115106445  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
115144289  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
115144542  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
115108704  g6pc2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
115105871  il7r; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
115125716  interleukin-7 receptor subunit alpha-like isoform X1 [KO:K05072]
115122744  Krueppel-like factor 2 isoform X1 [KO:K17845]
115108231  Krueppel-like factor 2 [KO:K17845]
115102889  Krueppel-like factor 2 [KO:K17845]
115109206  Krueppel-like factor 2 [KO:K17845]
115108139  sphingosine 1-phosphate receptor 1 [KO:K04288]
115108214  sphingosine 1-phosphate receptor 4-like [KO:K04293]
115109187  sphingosine 1-phosphate receptor 4-like [KO:K04293]
115134151  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
115134152  rag2; V(D)J recombination-activating protein 2 [KO:K10988]
115139248  fbxo25; F-box only protein 25 isoform X1 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
one00010  Glycolysis / Gluconeogenesis
one00020  Citrate cycle (TCA cycle)
one00190  Oxidative phosphorylation
one04010  MAPK signaling pathway
one04110  Cell cycle
one04120  Ubiquitin mediated proteolysis
one04140  Autophagy - animal
one04210  Apoptosis
one04350  TGF-beta signaling pathway
one04910  Insulin signaling pathway
KO pathway
ko04068   
LinkDB

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