KEGG   PATHWAY: pcad00564
Entry
pcad00564                   Pathway                                
Name
Glycerophospholipid metabolism - Physeter catodon (sperm whale)
Class
Metabolism; Lipid metabolism
Pathway map
pcad00564  Glycerophospholipid metabolism
pcad00564

Module
pcad_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:pcad00564]
pcad_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:pcad00564]
pcad_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:pcad00564]
Other DBs
GO: 0006650
Organism
Physeter catodon (sperm whale) [GN:pcad]
Gene
102984944  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein isoform X4 [KO:K00006] [EC:1.1.1.8]
102996836  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
102974522  glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
102978831  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
102981610  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
102996060  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2 [KO:K00629] [EC:2.3.1.15]
102994984  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
102985087  GPAT3; glycerol-3-phosphate acyltransferase 3 isoform X1 [KO:K13506] [EC:2.3.1.15]
102976926  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2 [KO:K13509] [EC:2.3.1.51]
102981564  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
102978078  1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
102974402  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
102979245  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [KO:K19007] [EC:2.3.1.51]
102981385  LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
102983583  MBOAT1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
102990041  MBOAT2; lysophospholipid acyltransferase 2 isoform X4 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
102987012  GNPAT; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
102975974  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X6 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
102994205  PLPP2; LOW QUALITY PROTEIN: phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
102975027  PLPP1; phospholipid phosphatase 1 isoform X3 [KO:K01080] [EC:3.1.3.4]
102994990  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
102991729  phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
102991043  LPIN3; phosphatidate phosphatase LPIN3 isoform X2 [KO:K15728] [EC:3.1.3.4]
102980075  phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
102991565  LPIN2; phosphatidate phosphatase LPIN2 isoform X6 [KO:K15728] [EC:3.1.3.4]
102987378  PLPP4; phospholipid phosphatase 4 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
102992027  PLPP5; LOW QUALITY PROTEIN: phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
102986835  DGKE; diacylglycerol kinase epsilon isoform X4 [KO:K00901] [EC:2.7.1.107]
102995302  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
102984215  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
102994216  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
102996943  DGKA; diacylglycerol kinase alpha isoform X2 [KO:K00901] [EC:2.7.1.107]
102991347  DGKD; diacylglycerol kinase delta isoform X2 [KO:K00901] [EC:2.7.1.107]
102979328  DGKH; diacylglycerol kinase eta isoform X4 [KO:K00901] [EC:2.7.1.107]
102987733  DGKI; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
102987759  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
102992298  DGKB; diacylglycerol kinase beta isoform X3 [KO:K00901] [EC:2.7.1.107]
102976930  CHPT1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
102988749  CEPT1; choline/ethanolaminephosphotransferase 1 isoform X4 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
102978946  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
102986218  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
102980414  PLD4; 5'-3' exonuclease PLD4 isoform X1 [KO:K16860] [EC:3.1.4.4]
102990999  PLD3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
114483914  LCAT; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
102981090  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102974314  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102989306  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102989577  PLA2G2F; LOW QUALITY PROTEIN: group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102973811  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102988713  PLA2G5; phospholipase A2 group V isoform X2 [KO:K01047] [EC:3.1.1.4]
102989842  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102989284  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102994568  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
102977405  group IIE secretory phospholipase A2 isoform X2 [KO:K01047] [EC:3.1.1.4]
102985111  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
102984239  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X2 [KO:K16342] [EC:3.1.1.4]
102983188  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
102983681  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
114487280  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
102988839  phospholipase A and acyltransferase 3 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102973278  LPCAT2; lysophosphatidylcholine acyltransferase 2 isoform X2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
102983136  LPCAT1; lysophosphatidylcholine acyltransferase 1 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
102978188  LPCAT4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
102986639  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
102983036  LYPLA1; acyl-protein thioesterase 1 isoform X1 [KO:K06128] [EC:3.1.1.5]
102974897  acyl-protein thioesterase 1-like [KO:K06128] [EC:3.1.1.5]
112063988  acyl-protein thioesterase 1-like [KO:K06128] [EC:3.1.1.5]
112065503  LOW QUALITY PROTEIN: acyl-protein thioesterase 1-like [KO:K06128] [EC:3.1.1.5]
102983593  PLA2G15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
102974351  LYPLA2; acyl-protein thioesterase 2 isoform X1 [KO:K06130] [EC:3.1.1.5]
102986244  PNPLA6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
102976465  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
102973373  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
102996571  ACHE; acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
102994710  CHKA; choline kinase alpha isoform X3 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
102980773  CHKB; choline/ethanolamine kinase isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
102979410  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X5 [KO:K06124] [EC:3.1.3.75]
112063314  LOW QUALITY PROTEIN: phosphoethanolamine/phosphocholine phosphatase-like [KO:K06124] [EC:3.1.3.75]
102986176  PCYT1A; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
102983775  PCYT1B; choline-phosphate cytidylyltransferase B isoform X2 [KO:K00968] [EC:2.7.7.15]
102996555  SELENOI; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
102983660  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
102979884  ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
102983523  PCYT2; ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
102979831  ETNPPL; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
102996143  PEMT; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
102990800  CDS1; phosphatidate cytidylyltransferase 1 isoform X3 [KO:K00981] [EC:2.7.7.41]
102992589  CDS2; phosphatidate cytidylyltransferase 2 isoform X1 [KO:K00981] [EC:2.7.7.41]
102974952  ADPRH; ADP-ribosylarginine hydrolase isoform X4 [KO:K13618] [EC:3.1.1.111]
102978104  PTDSS1; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
102994437  PTDSS2; phosphatidylserine synthase 2 isoform X2 [KO:K08730] [EC:2.7.8.29]
102993676  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
102979923  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
102988304  CRLS1; cardiolipin synthase (CMP-forming) isoform X1 [KO:K08744] [EC:2.7.8.41]
102978310  TAFAZZIN; tafazzin isoform X5 [KO:K13511] [EC:2.3.1.-]
102986697  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1 [KO:K13514] [EC:2.3.1.-]
102992559  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [KO:K00999] [EC:2.7.8.11]
102975509  CDP-diacylglycerol--inositol 3-phosphatidyltransferase-like [KO:K00999] [EC:2.7.8.11]
102981585  MBOAT7; lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
pcad00010  Glycolysis / Gluconeogenesis
pcad00260  Glycine, serine and threonine metabolism
pcad00561  Glycerolipid metabolism
pcad00562  Inositol phosphate metabolism
pcad00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
pcad00565  Ether lipid metabolism
pcad00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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