KEGG   PATHWAY: pov00600
Entry
pov00600                    Pathway                                
Name
Sphingolipid metabolism - Paralichthys olivaceus (Japanese flounder)
Class
Metabolism; Lipid metabolism
Pathway map
pov00600  Sphingolipid metabolism
pov00600

Module
pov_M00066  Lactosylceramide biosynthesis [PATH:pov00600]
pov_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:pov00600]
pov_M00094  Ceramide biosynthesis [PATH:pov00600]
pov_M00099  Sphingosine biosynthesis [PATH:pov00600]
pov_M00100  Sphingosine degradation [PATH:pov00600]
Other DBs
GO: 0006665
Organism
Paralichthys olivaceus (Japanese flounder) [GN:pov]
Gene
109636637  sptlc3; serine palmitoyltransferase 3 isoform X1 [KO:K00654] [EC:2.3.1.50]
109626562  sptlc1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
109628005  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
109632546  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
109640169  kdsr; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
109625614  cers1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
109639172  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
109641126  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
109633297  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
109625338  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
109624784  cers3; ceramide synthase 3 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
109623996  ceramide synthase 2-like [KO:K24622] [EC:2.3.1.297 2.3.1.298]
109631475  cers6; ceramide synthase 6 isoform X1 [KO:K23727] [EC:2.3.1.291]
109635609  cers5; ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
109635146  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
109639561  asah1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
109645044  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
109636589  acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
109637865  acer2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
109628290  acer3; alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
109628141  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
109639876  degs1; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
109638309  sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
109632771  sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1 [KO:K04714] [EC:2.7.8.27]
109634760  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27]
109628807  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
109635344  smpd2; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
109633546  sphingomyelin phosphodiesterase 5-like isoform X1 [KO:K12352] [EC:3.1.4.12]
109623716  smpd3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
109644384  smpd4; sphingomyelin phosphodiesterase 4 [KO:K12353] [EC:3.1.4.12]
109626677  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
109634142  enpp7; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
109648137  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
109630663  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
109624489  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
109632871  cerk; ceramide kinase [KO:K04715] [EC:2.7.1.138]
109636493  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
109633928  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
109627434  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
109625771  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
109625796  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
109626273  plpp1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
109636941  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
109646992  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
109648136  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
109636161  sgpp1; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
109634441  sgpp2; sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
109644606  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
109639502  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
109627230  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
109633239  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
109633624  sgpl1; sphingosine-1-phosphate lyase 1 isoform X1 [KO:K01634] [EC:4.1.2.27]
109648145  ugcg; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
109633045  gba; glucosylceramidase [KO:K01201] [EC:3.2.1.45]
109634830  gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
109625355  beta-1,4-galactosyltransferase 6-like [KO:K07553] [EC:2.4.1.274]
109635241  b4galt5; beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
109637716  glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
109637829  ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
109639554  galc; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
109627347  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
109626514  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
109638198  gal3st1; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
109624039  arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
109643484  neu1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
109628749  neu3; sialidase-3 [KO:K12357] [EC:3.2.1.18]
109630073  sialidase-4-like [KO:K12357] [EC:3.2.1.18]
109627050  gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
109630534  beta-1,4 N-acetylgalactosaminyltransferase 1-like isoform X1 [KO:K00725] [EC:2.4.1.92]
109629415  b4galnt1; beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X1 [KO:K00725] [EC:2.4.1.92]
109626227  hexb; beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
109640827  gm2a; ganglioside GM2 activator [KO:K12383]
109633764  psap; prosaposin isoform X1 [KO:K12382]
109638084  prosaposin-like [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
pov00260  Glycine, serine and threonine metabolism
pov00601  Glycosphingolipid biosynthesis - lacto and neolacto series
pov00603  Glycosphingolipid biosynthesis - globo and isoglobo series
pov00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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